Found: 10

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  • Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.

    Published in:
    Angewandte Chemie, 2019, v. 131, n. 2, p. 525, doi. 10.1002/ange.201810179
    By:
    • Vazquez‐Rodriguez, Saleta;
    • Wright, Miranda;
    • Rogers, Catherine M.;
    • Cribbs, Adam P.;
    • Velupillai, Srikannathasan;
    • Philpott, Martin;
    • Lee, Henry;
    • Dunford, James E.;
    • Huber, Kilian V. M.;
    • Robers, Matthew B.;
    • Vasta, James D.;
    • Thezenas, Marie‐Laetitia;
    • Bonham, Sarah;
    • Kessler, Benedikt;
    • Bennett, James;
    • Fedorov, Oleg;
    • Raynaud, Florence;
    • Donovan, Adam;
    • Blagg, Julian;
    • Bavetsias, Vassilios
    Publication type:
    Article

  • Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.

    Published in:
    Angewandte Chemie International Edition, 2019, v. 58, n. 2, p. 515, doi. 10.1002/anie.201810179
    By:
    • Vazquez‐Rodriguez, Saleta;
    • Wright, Miranda;
    • Rogers, Catherine M.;
    • Cribbs, Adam P.;
    • Velupillai, Srikannathasan;
    • Philpott, Martin;
    • Lee, Henry;
    • Dunford, James E.;
    • Huber, Kilian V. M.;
    • Robers, Matthew B.;
    • Vasta, James D.;
    • Thezenas, Marie‐Laetitia;
    • Bonham, Sarah;
    • Kessler, Benedikt;
    • Bennett, James;
    • Fedorov, Oleg;
    • Raynaud, Florence;
    • Donovan, Adam;
    • Blagg, Julian;
    • Bavetsias, Vassilios
    Publication type:
    Article

  • Application of BRET to monitor ligand binding to GPCRs.

    Published in:
    Nature Methods, 2015, v. 12, n. 7, p. 661, doi. 10.1038/nmeth.3398
    By:
    • Stoddart, Leigh A;
    • Johnstone, Elizabeth K M;
    • Wheal, Amanda J;
    • Goulding, Joëlle;
    • Robers, Matthew B;
    • Machleidt, Thomas;
    • Wood, Keith V;
    • Hill, Stephen J;
    • Pfleger, Kevin D G
    Publication type:
    Article

  • Dual targeting of the androgen receptor and PI3K/AKT/mTOR pathways in prostate cancer models improves antitumor efficacy and promotes cell apoptosis.

    Published in:
    Molecular Oncology, 2024, v. 18, n. 3, p. 726, doi. 10.1002/1878-0261.13577
    By:
    • Sugawara, Tatsuo;
    • Nevedomskaya, Ekaterina;
    • Heller, Simon;
    • Böhme, Annika;
    • Lesche, Ralf;
    • von Ahsen, Oliver;
    • Grünewald, Sylvia;
    • Nguyen, Holly M.;
    • Corey, Eva;
    • Baumgart, Simon J.;
    • Georgi, Victoria;
    • Pütter, Vera;
    • Fernández‐Montalván, Amaury;
    • Vasta, James D.;
    • Robers, Matthew B.;
    • Politz, Oliver;
    • Mumberg, Dominik;
    • Haendler, Bernard
    Publication type:
    Article

  • Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells.

    Published in:
    Molecules, 2023, v. 28, n. 7, p. 2950, doi. 10.3390/molecules28072950
    By:
    • Yang, Xuan;
    • Smith, Jeffery L.;
    • Beck, Michael T.;
    • Wilkinson, Jennifer M.;
    • Michaud, Ani;
    • Vasta, James D.;
    • Robers, Matthew B.;
    • Willson, Timothy M.
    Publication type:
    Article

  • Target engagement and drug residence time can be observed in living cells with BRET.

    Published in:
    Nature Communications, 2015, v. 6, n. 12, p. 10091, doi. 10.1038/ncomms10091
    By:
    • Robers, Matthew B.;
    • Dart, Melanie L.;
    • Woodroofe, Carolyn C.;
    • Zimprich, Chad A.;
    • Kirkland, Thomas A.;
    • Machleidt, Thomas;
    • Kupcho, Kevin R.;
    • Levin, Sergiy;
    • Hartnett, James R.;
    • Zimmerman, Kristopher;
    • Niles, Andrew L.;
    • Ohana, Rachel Friedman;
    • Daniels, Danette L.;
    • Slater, Michael;
    • Wood, Monika G.;
    • Cong, Mei;
    • Cheng, Yi-Qiang;
    • Wood, Keith V.
    Publication type:
    Article

  • Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.

    Published in:
    Science Translational Medicine, 2018, v. 10, n. 431, p. 1, doi. 10.1126/scitranslmed.aam8460
    By:
    • Wagner, Florence F.;
    • Benajiba, Lina;
    • Campbell, Arthur J.;
    • Weïwer, Michel;
    • Sacher, Joshua R.;
    • Gale, Jennifer P.;
    • Ross, Linda;
    • Puissant, Alexandre;
    • Alexe, Gabriela;
    • Conway, Amy;
    • Back, Morgan;
    • Pikman, Yana;
    • Galinsky, Ilene;
    • DeAngelo, Daniel J.;
    • Stone, Richard M.;
    • Kaya, Taner;
    • Shi, Xi;
    • Robers, Matthew B.;
    • Machleidt, Thomas;
    • Wilkinson, Jennifer
    Publication type:
    Article

  • Cellular LanthaScreen and β-Lactamase Reporter Assays for High-Throughput Screening of JAK2 Inhibitors.

    Published in:
    Assay & Drug Development Technologies, 2008, v. 6, n. 4, p. 519, doi. 10.1089/adt.2008.144
    By:
    • Matthew B. Robers;
    • Thomas Machleidt;
    • Coby B. Carlson;
    • Kun Bi
    Publication type:
    Article

  • tracerDB: a crowdsourced fluorescent tracer database for target engagement analysis.

    Published in:
    Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49896-5
    By:
    • Dopfer, Johannes;
    • Vasta, James D.;
    • Müller, Susanne;
    • Knapp, Stefan;
    • Robers, Matthew B.;
    • Schwalm, Martin P.
    Publication type:
    Article

  • Quantifying CDK inhibitor selectivity in live cells.

    Published in:
    Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16559-0
    By:
    • Wells, Carrow I.;
    • Vasta, James D.;
    • Corona, Cesear R.;
    • Wilkinson, Jennifer;
    • Zimprich, Chad A.;
    • Ingold, Morgan R.;
    • Pickett, Julie E.;
    • Drewry, David H.;
    • Pugh, Kathryn M.;
    • Schwinn, Marie K.;
    • Hwang, Byounghoon (Brian);
    • Zegzouti, Hicham;
    • Huber, Kilian V. M.;
    • Cong, Mei;
    • Meisenheimer, Poncho L.;
    • Willson, Timothy M.;
    • Robers, Matthew B.
    Publication type:
    Article