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Direct GPCR-EGFR interaction enables synergistic membrane-to-nucleus information transfer.
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- Cellular & Molecular Life Sciences, 2024, v. 81, n. 1, p. 1, doi. 10.1007/s00018-024-05281-5
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- Article
Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 2, p. 1358, doi. 10.3390/ijms25021358
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- Article
Application of Ligand- and Structure-Based Prediction Models for the Design of Alkylhydrazide-Based HDAC3 Inhibitors as Novel Anti-Cancer Compounds.
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- Pharmaceuticals (14248247), 2023, v. 16, n. 7, p. 968, doi. 10.3390/ph16070968
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- Article
Front Cover: Chemically Diverse S. mansoni HDAC8 Inhibitors Reduce Viability in Worm Larval and Adult Stages (ChemMedChem 3/2023).
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- ChemMedChem, 2023, v. 18, n. 3, p. 1, doi. 10.1002/cmdc.202300028
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- Article
Chemically Diverse S. mansoni HDAC8 Inhibitors Reduce Viability in Worm Larval and Adult Stages.
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- ChemMedChem, 2023, v. 18, n. 3, p. 1, doi. 10.1002/cmdc.202200510
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- Article
First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement**.
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- ChemBioChem, 2022, v. 23, n. 14, p. 1, doi. 10.1002/cbic.202200180
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- Article
Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 14, p. 7535, doi. 10.3390/ijms23147535
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- Article
Docking, Binding Free Energy Calculations and In Vitro Characterization of Pyrazine Linked 2-Aminobenzamides as Novel Class I Histone Deacetylase (HDAC) Inhibitors.
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- Molecules, 2022, v. 27, n. 8, p. N.PAG, doi. 10.3390/molecules27082526
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- Article
Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 1, p. 369, doi. 10.3390/ijms23010369
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- Article
Histone Deacetylase (HDAC) Inhibitors for the Treatment of Schistosomiasis.
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- Pharmaceuticals (14248247), 2022, v. 15, n. 1, p. 80, doi. 10.3390/ph15010080
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- Article
Structure-Based Design, Docking and Binding Free Energy Calculations of A366 Derivatives as Spindlin1 Inhibitors.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 11, p. 5910, doi. 10.3390/ijms22115910
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- Article
Exploring aromatic cage flexibility of the histone methyllysine reader protein Spindlin1 and its impact on binding mode prediction: an in silico study.
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- Journal of Computer-Aided Molecular Design, 2021, v. 35, n. 6, p. 695, doi. 10.1007/s10822-021-00391-9
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- Article
Strategies To Design Selective Histone Deacetylase Inhibitors.
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- ChemMedChem, 2021, v. 16, n. 9, p. 1336, doi. 10.1002/cmdc.202000934
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- Article
Binding Free Energy (BFE) Calculations and Quantitative Structure–Activity Relationship (QSAR) Analysis of Schistosoma mansoni Histone Deacetylase 8 (sm HDAC8) Inhibitors.
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- Molecules, 2021, v. 26, n. 9, p. 2584, doi. 10.3390/molecules26092584
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- Article
HaloTag‐Targeted Sirtuin‐Rearranging Ligand (SirReal) for the Development of Proteolysis‐Targeting Chimeras (PROTACs) against the Lysine Deacetylase Sirtuin 2 (Sirt2)**.
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- ChemBioChem, 2020, v. 21, n. 23, p. 3371, doi. 10.1002/cbic.202000351
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- Article
Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni.
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- PLoS Neglected Tropical Diseases, 2020, v. 14, n. 7, p. 1, doi. 10.1371/journal.pntd.0008332
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- Article
Preclinical Evaluation of Benzazepine-Based PET Radioligands (R)- and (S)-<sup>11</sup>C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and Tightrope Walk between GluN2B- and Sigma1 Receptor-Targeted PET Imaging.
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- Journal of Nuclear Medicine, 2019, v. 60, n. 12, p. 1, doi. 10.2967/jnumed.118.22105
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- Article
Preclinical Evaluation of Benzazepine-Based PET Radioligands (R)- and (S)-<sup>11</sup>C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and a Tightrope Walk Between GluN2B- and <sub>σ1</sub>-Receptor--Targeted PET Imaging.
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- Journal of Nuclear Medicine, 2019, v. 60, n. 8, p. 1167, doi. 10.2967/jnumed.118.221051
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- Article
Opening the Selectivity Pocket in the Human Lysine Deacetylase Sirtuin2 – New Opportunities, New Questions.
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- Chemical Record, 2018, v. 18, n. 12, p. 1701, doi. 10.1002/tcr.201800044
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- Article
Front Cover: Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis (ChemMedChem 15/2018).
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- ChemMedChem, 2018, v. 13, n. 15, p. 1488, doi. 10.1002/cmdc.201800494
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- Article
Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis.
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- ChemMedChem, 2018, v. 13, n. 15, p. 1517, doi. 10.1002/cmdc.201800238
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- Article
Pharmacogenetic Aspects of the Interaction of AT1 Receptor Antagonists With ATP-Binding Cassette Transporter ABCG2.
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- Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.00463
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- Article
A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.
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- Molecules, 2018, v. 23, n. 3, p. 566, doi. 10.3390/molecules23030566
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- Article
The Current State of NAD<sup>+</sup>-Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.
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- Medicinal Research Reviews, 2018, v. 38, n. 1, p. 147, doi. 10.1002/med.21436
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- Article
Design, Synthesis, Pharmacological Evaluation and Docking Studies of GluN2B-Selective NMDA Receptor Antagonists with a Benzo[7]annulen-7-amine Scaffold.
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- ChemMedChem, 2017, v. 12, n. 15, p. 1212, doi. 10.1002/cmdc.201700311
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- Article
Muscle Carnitine Palmitoyltransferase II Deficiency: A Review of Enzymatic Controversy and Clinical Features.
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- International Journal of Molecular Sciences, 2017, v. 18, n. 1, p. 82, doi. 10.3390/ijms18010082
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- Article
Identification and Structure-Activity Relationship Studies of Small-Molecule Inhibitors of the Methyllysine Reader Protein Spindlin1.
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- ChemMedChem, 2016, v. 11, n. 20, p. 2327, doi. 10.1002/cmdc.201600362
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- Article
Stereospecific capillary electrophoresis assays using pentapeptide substrates for the study of Aspergillus nidulans methionine sulfoxide reductase A and mutant enzymes.
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- Electrophoresis, 2016, v. 37, n. 14, p. 2083, doi. 10.1002/elps.201600181
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- Article
Analysis of the Resistance of Hepatitis C Virus NS5B Polymerase Inhibitors via Docking and Molecular Dynamics Simulation.
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- Molecular Informatics, 2015, v. 34, n. 2/3, p. 78, doi. 10.1002/minf.201400048
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- Article
Mind the Methyl: Methyllysine Binding Proteins in Epigenetic Regulation.
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- ChemMedChem, 2014, v. 9, n. 3, p. 466, doi. 10.1002/cmdc.201300422
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- Article
A Novel Non-phenolic Dibenzazecine Derivative with Nanomolar Affinities for Dopamine Receptors.
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- Chemistry & Biodiversity, 2011, v. 8, n. 3, p. 431, doi. 10.1002/cbdv.201000317
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Residues at the Indole- NH of LE300 Modulate Affinities and Selectivities for Dopamine Receptors.
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- Archiv der Pharmazie, 2011, v. 344, n. 1, p. 28, doi. 10.1002/ardp.201000121
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- Article