Works by Rizo, Josep

Results: 74

Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer.

Published in:

PLoS Biology, 2008, v. 6, n. 3, p. e50, doi. 10.1371/journal.pbio.0060050

By:

Maojun Yang;
Bing Li;
Chyong-Jy Liu;
Tomchick, Diana R;
Machius, Mischa;
Rizo, Josep;
Hongtao Yu;
Xuelian Luo

Publication type:

Article

Structural Basis for a Munc13-1 Homodimer to Munc13-1/RIM Heterodimer Switch.

Published in:

PLoS Biology, 2006, v. 4, n. 7, p. e192, doi. 10.1371/journal.pbio.0040192

By:

Lu, Jun;
Machius, Mischa;
Dulubova, Irina;
Han Dai;
Südhof, Thomas C.;
Tomchick, Diana R.;
Rizo, Josep

Publication type:

Article

Endocytosis of Synaptotagmin 1 Is Mediated by a Novel, Tryptophan-Containing Motif.

Published in:

Traffic, 2003, v. 4, n. 7, p. 468, doi. 10.1034/j.1600-0854.2003.00101.x

By:

Jarousse, Nadine;
Wilson, Joshua D.;
Arac, Demet;
Rizo, Josep;
Kelly, Regis B.

Publication type:

Article

An unusual C2‐domain in the active‐zone protein piccolo: implications for Ca2+ regulation of neurotransmitter release.

Published in:

EMBO Journal, 2001, v. 20, n. 7, p. 1605, doi. 10.1093/emboj/20.7.1605

By:

Gerber, Stefan H.;
Garcia, Jesus;
Rizo, Josep;
Südhof, Thomas C.

Publication type:

Article

An unusual C2-domain in the active-zone protein piccolo: implications for Ca2+ regulation of neurotransmitter release.

Published in:

EMBO Journal, 2001, v. 20, n. 7, p. 1605, doi. 10.1093/emboj/20.7.1605

By:

Gerber, Stefan H.;
Garcia, Jesus;
Rizo, Josep;
Südhof, Thomas C.

Publication type:

Article

A conformational switch in syntaxin during exocytosis: role of munc18.

Published in:

EMBO Journal, 1999, v. 18, n. 16, p. 4372, doi. 10.1093/emboj/18.16.4372

By:

Dulubova, Irina;
Sugita, Shuzo;
Hill, Sandra;
Hosaka, Masahiro;
Fernandez, Imma;
Südhof, Thomas C.;
Rizo, Josep

Publication type:

Article

Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain?

Published in:

EMBO Journal, 1998, v. 17, n. 14, p. 3921, doi. 10.1093/emboj/17.14.3921

By:

Ubach, Josep;
Xiangyang Zhang;
Xuguang Shao;
Südhof, Thomas C.;
Rizo, Josep

Publication type:

Article

Evaluation of the tert-butyl group as a probe for NMR studies of macromolecular complexes.

Published in:

Journal of Biomolecular NMR, 2021, v. 75, n. 8/9, p. 347, doi. 10.1007/s10858-021-00380-y

By:

Voleti, Rashmi;
Bali, Sofia;
Guerrero, Jaime;
Smothers, Jared;
Springhower, Charis;
Acosta, Gerardo A.;
Brewer, Kyle D.;
Albericio, Fernando;
Rizo, Josep

Publication type:

Article

Sequence-specific assignment of methyl groups from the neuronal SNARE complex using lanthanide-induced pseudocontact shifts.

Published in:

Journal of Biomolecular NMR, 2016, v. 66, n. 4, p. 281, doi. 10.1007/s10858-016-0078-1

By:

Pan, Yun-Zu;
Quade, Bradley;
Brewer, Kyle;
Szabo, Monika;
Swarbrick, James;
Graham, Bim;
Rizo, Josep

Publication type:

Article

Enlightening molecular mechanisms through study of protein interactions.

Published in:

Journal of Molecular Cell Biology, 2012, v. 4, n. 5, p. 270, doi. 10.1093/jmcb/mjs036

By:

Rizo, Josep;
Rosen, Michael K.;
Gardner, Kevin H.

Publication type:

Article

Dual Modes of Munc18-1/SNARE Interactions Are Coupled by Functionally Critical Binding to Syntaxin-1 N Terminus.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 45, p. 12147, doi. 10.1523/JNEUROSCI.3655-07.2007

By:

Khvotchev, Mikhail;
Dulubova, Irina;
Jianyuan Sun;
Han Dai;
Rizo, Josep;
Südhof, Thomas C.

Publication type:

Article

Impact of a micellar environment on the conformations of two cyclic pentapeptides.

Published in:

Biopolymers, 1992, v. 32, n. 12, p. 1741, doi. 10.1002/bip.360321215

By:

Bruch, Martha D.;
Rizo, Josep;
Gierasch, Lila M.

Publication type:

Article

Cyclic pentapeptides as models for reverse turns: Determination of the equilibrium distribution between type I and type II conformations of Pro-Asn and Pro-Ala β-turns.

Published in:

Biopolymers, 1990, v. 29, n. 1, p. 263, doi. 10.1002/bip.360290130

By:

Stradley, Sarah J.;
Rizo, Josep;
Bruch, Martha D.;
Stroup, Adam N.;
Gierasch, Lila M.

Publication type:

Article

Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming.

Published in:

Journal of Cell Biology, 2009, v. 184, n. 5, p. 751, doi. 10.1083/jcb.200812026

By:

Deák, Ferenc;
Xu, Yi;
Chang, Wen-Pin;
Dulubova, Irina;
Khvotchev, Mikhail;
Liu, Xinran;
Südhof, Thomas C.;
Rizo, Josep

Publication type:

Article

Control of neurotransmitter release by two distinct membrane- binding faces of the Munc13- 1 C1C2B region.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.72030

By:

Camacho, Marcial;
Quade, Bradley;
Trimbuch, Thorsten;
Xu, Junjie;
Sari, Levent;
Rizo, Josep;
Rosenmund, Christian

Publication type:

Article

Molecular machinery turns full circle: Two proteins called Sec17 and Sec18 may have a larger role in membrane fusion than is commonly assumed in textbook models.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.70298

By:

RIZO, JOSEP;
JACZYNSKA, KLAUDIA;
STEPIEN, KAROLINA P.

Publication type:

Article

Re‐examining how Munc13‐1 facilitates opening of syntaxin‐1.

Published in:

Protein Science: A Publication of the Protein Society, 2020, v. 29, n. 6, p. 1440, doi. 10.1002/pro.3844

By:

Magdziarek, Magdalena;
Bolembach, Agnieszka A.;
Stepien, Karolina P.;
Quade, Bradley;
Liu, Xiaoxia;
Rizo, Josep

Publication type:

Article

Mechanism of neurotransmitter release coming into focus.

Published in:

Protein Science: A Publication of the Protein Society, 2018, v. 27, n. 8, p. 1364, doi. 10.1002/pro.3445

By:

Rizo, Josep

Publication type:

Article

Calcium Binding to PICK 1 Is Essential for the Intracellular Retention of AMPA Receptors Underlying Long-Term Depression.

Published in:

Journal of Neuroscience, 2010, v. 30, n. 49, p. 16437, doi. 10.1523/JNEUROSCI.4478-10.2010

By:

Citri, Ami;
Bhattacharyya, Samarjit;
Ma, Cong;
Morishita, Wade;
Scarlett Fang;
Rizo, Josep;
Malenka, Robert C.

Publication type:

Article

Calcium Binding to PICK1 Is Essential for the Intracellular Retention of AMPA Receptors Underlying Long-Term Depression.

Published in:

Journal of Neuroscience, 2010, v. 30, n. 48, p. 16437, doi. 10.1523/JNEUROSCI.4478-10.2010

By:

Citri, Ami;
Bhattacharyya, Samarjit;
Ma, Cong;
Morishita, Wade;
Fang, Scarlett;
Rizo, Josep;
Malenka, Robert C.

Publication type:

Article

Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming.

Published in:

Nature Communications, 2017, v. 8, n. 5, p. 15293, doi. 10.1038/ncomms15293

By:

Camacho, Marcial;
Basu, Jayeeta;
Trimbuch, Thorsten;
Chang, Shuwen;
Pulido-Lozano, Cristina;
Chang, Shwu-Shin;
Duluvova, Irina;
Abo-Rady, Masin;
Rizo, Josep;
Rosenmund, Christian

Publication type:

Article

Bimodal-hybrid heterocyclic amine targeting oxidative pathways and copper mis-regulation in Alzheimer's disease.

Published in:

Metallomics, 2014, v. 6, n. 11, p. 2072, doi. 10.1039/c4mt00161c

By:

Gonzalez, Paulina;
da Costa, Viviana C. P.;
Hyde, Kimberly;
Wu, Qiong;
Annunziata, Onofrio;
Rizo, Josep;
Akkaraju, Giridhar;
Green, Kayla N.

Publication type:

Article

SNARE function revisited.

Published in:

Nature Structural Biology, 2003, v. 10, n. 6, p. 417, doi. 10.1038/nsb0603-417

By:

Rizo, Josep

Publication type:

Article

A protein sequence that can encode native structure by disfavoring alternate conformations.

Published in:

Nature Structural Biology, 2002, v. 9, n. 5, p. 381

By:

Wigley, W. Christian;
Corboy, Michael J.;
Cutler, Todd D.;
Thibodeau, Patrick H.;
Oldan, Jorge;
Lee, Min Goo;
Rizo, Josep;
Hunt, John F.;
Thomas, Philip J.

Publication type:

Article

Vam3p structure reveals conserved and divergent properties of syntaxins.

Published in:

Nature Structural Biology, 2001, v. 8, n. 3, p. 258, doi. 10.1038/85012

By:

Dulubova, Irina;
Yamaguchi, Tomohiro;
Wang, Yun;
Südhof, Thomas C.;
Rizo, Josep

Publication type:

Article

Mechanics of membrane fusion.

Published in:

Nature Structural Biology, 1998, v. 5, n. 10, p. 839, doi. 10.1038/2280

By:

Rizo, Josep;
Südhof, Thomas C.

Publication type:

Article

Structural insights for selective disruption of Beclin 1 binding to Bcl-2.

Published in:

Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-05467-w

By:

Pan, Yun-Zu;
Liang, Qiren;
Tomchick, Diana R.;
De Brabander, Jef K.;
Rizo, Josep

Publication type:

Article

Snares and munc18 in synaptic vesicle fusion.

Published in:

Nature Reviews Neuroscience, 2002, v. 3, n. 8, p. 641, doi. 10.1038/nrn898

By:

Rizo, Josep;
Südhof, Thomas C.

Publication type:

Article

Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations.

Published in:

FEBS Open Bio, 2025, v. 15, n. 5, p. 699, doi. 10.1002/2211-5463.13966

By:

Rizo, Josep;
Jaczynska, Klaudia;
Rosenmund, Christian

Publication type:

Article

An open chat with... Josep Rizo.

Published in:

FEBS Open Bio, 2024, v. 14, n. 1, p. 8, doi. 10.1002/2211-5463.13746

By:

Tsagakis, Ioannis;
Rizo, Josep

Publication type:

Article

Analysis of tripartite Synaptotagmin‐1‐SNARE‐complexin‐1 complexes in solution.

Published in:

FEBS Open Bio, 2023, v. 13, n. 1, p. 26, doi. 10.1002/2211-5463.13503

By:

Jaczynska, Klaudia;
Esquivies, Luis;
Pfuetzner, Richard A.;
Alten, Baris;
Brewer, Kyle D.;
Zhou, Qiangjun;
Kavalali, Ege T.;
Brunger, Axel T.;
Rizo, Josep

Publication type:

Article

On the difficulties of characterizing weak protein interactions that are critical for neurotransmitter release.

Published in:

FEBS Open Bio, 2022, v. 12, n. 11, p. 1912, doi. 10.1002/2211-5463.13473

By:

Rizo, Josep;
David, Guillaume;
Fealey, Michael E.;
Jaczynska, Klaudia

Publication type:

Article

The beginning and the end of SNARE‐induced membrane fusion.

Published in:

FEBS Open Bio, 2022, v. 12, n. 11, p. 1958, doi. 10.1002/2211-5463.13447

By:

Mion, Delphine;
Bunel, Louis;
Heo, Paul;
Pincet, Frédéric;
Rizo, Josep

Publication type:

Article

Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion.

Published in:

EMBO Journal, 2006, v. 25, n. 12, p. 2856, doi. 10.1038/sj.emboj.7601165

By:

Deák, Ferenc;
Ok-Ho Shin;
Jiong Tang;
Hanson, Phyllis;
Ubach, Josep;
Jahn, Reinhard;
Rizo, Josep;
Kavalali, Ege T.;
Südhof, Thomas C.

Publication type:

Article

Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release.

Published in:

EMBO Journal, 2006, v. 25, n. 10, p. 2039, doi. 10.1038/sj.emboj.7601103

By:

Pang, Zhiping P.;
Jianyuan Sun;
Rizo, Josep;
Maximov, Anton;
Südhof, Thomas C.

Publication type:

Article

A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

Published in:

EMBO Journal, 2005, v. 24, n. 16, p. 2839, doi. 10.1038/sj.emboj.7600753

By:

Dulubova, Irina;
Xuelin Lou;
Jun Lu;
Huryeva, Iryna;
Alam, Amer;
Schneggenburger, Ralf;
Südhof, Thomas C;
Rizo, Josep

Publication type:

Article

Conformation-specific binding of p31comet antagonizes the function of Mad2 in the spindle checkpoint.

Published in:

EMBO Journal, 2004, v. 23, n. 15, p. 3133, doi. 10.1038/sj.emboj.7600322

By:

Guohong Xia;
Xuelian Luo;
Habu, Toshiyuki;
Rizo, Josep;
Matsumoto, Tomohiro;
Hongtao Yu

Publication type:

Article

How Tlg2p/syntaxin 16 'snares' Vps45.

Published in:

EMBO Journal, 2002, v. 21, n. 14, p. 3620, doi. 10.1093/emboj/cdf381

By:

Dulubova, Irina;
Vamaguchi, Tomohiro;
Yan Gao;
Sang-Won Min;
Huryeva, Iryna;
Südhof, Thomas C.;
Rizo, Josep

Publication type:

Article

Role of electrostatic and hydrophobic interactions in Ca(2+)-dependent phospholipid binding by the C(2)A-domain from synaptotagmin I.

Published in:

2002

By:

Gerber, Stefan H;
Rizo, Josep;
Südhof, Thomas C

Publication type:

journal article

Role of Electrostatic and Hydrophobic Interactions in Ca2+;-Dependent Phospholipid Binding by the C[sub2]A-Domain From Synaptotagmin 1.

Published in:

Diabetes, 2002, v. 51, p. S12, doi. 10.2337/diabetes.51.2007.S12

By:

Gerber, Stefan H.;
Rizo, Josep;
Südhof, Thomas C.

Publication type:

Article

Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 5, p. 542, doi. 10.1038/nsmb.2047

By:

Cong Ma;
Wei Li;
Yibin Xu;
Rizo, Josep

Publication type:

Article

Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 5, p. 568, doi. 10.1038/nsmb.1791

By:

Mingshan Xue;
Craig, Timothy K.;
Junjie Xu;
Chao, Hsiao-Tuan;
Rizo, Josep;
Rosenmund, Christian

Publication type:

Article

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 3, p. 280, doi. 10.1038/nsmb.1758

By:

Ok-Ho Shin;
Jun Lu;
Jeong-Seop Rhee;
Tomchick, Diana R.;
Pang, Zhiping P.;
Wojcik, Sonja M.;
Camacho-Perez, Marcial;
Brose, Nils;
Machius, Mischa;
Rizo, Josep;
Rosenmund, Christian;
Südhof, Thomas C.

Publication type:

Article

Synaptotagmin-SNARE coupling enlightened.

Published in:

2010

By:

Rizo, Josep

Publication type:

Opinion

The Janus-faced nature of the C2B domain is fundamental for synaptotagmin-1 function.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 11, p. 1160, doi. 10.1038/nsmb.1508

By:

Mingshan Xue;
Cong Ma;
Craig, Timothy K.;
Rosenmund, Christian;
Rizo, Josep

Publication type:

Article

Synaptic vesicle fusion.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 7, p. 665, doi. 10.1038/nsmb.1450

By:

Rizo, Josep;
Rosenmund, Christian

Publication type:

Article

How much can SNAREs flex their muscles?

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 10, p. 880, doi. 10.1038/nsmb1007-880

By:

Rizo, Josep;
Dai, Han

Publication type:

Article

Distinct domains of complexin I differentially regulate neurotransmitter release.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 10, p. 949, doi. 10.1038/nsmb1292

By:

Mingshan Xue;
Reim, Kerstin;
Xiaocheng Chen;
Hsiao-Tuan Chao;
Hui Deng;
Rizo, Josep;
Brose, Nils;
Rosenmund, Christian

Publication type:

Article

Close membrane-membrane proximity induced by Ca2+-dependent multivalent binding of synaptotagmin-1 to phospholipids.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 3, p. 209, doi. 10.1038/nsmb1056

By:

Araç, Demet;
Xiaocheng Chen;
Khant, Htet A.;
Ubach, Josep;
Ludtke, Steven J.;
Kikkawa, Masahide;
Johnson, Arthur E.;
Wah Chiu;
Südhof, Thomas C.;
Rizo, Josep

Publication type:

Article

A minimal domain responsible for Munc13 activity.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 11, p. 1017, doi. 10.1038/nsmb1001

By:

Basu, Jayeeta;
Nan Shen;
Dulubova, Irina;
Jun Lu;
Rong Guan;
Guryev, Oleg;
Grishin, Nick V.;
Rosenmund, Christian;
Rizo, Josep

Publication type:

Article