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Paroxysmal nocturnal hemoglobinuria: pathophysiology, natural history and treatment options in the era of biological agents.
Published in:
Biologics: Targets & Therapy, 2008, v. 2, n. 2, p. 205
By:
- Risitano, Antonio M.;
- Rotoli, Bruno
Publication type:
Article
The long‐acting anti‐C5 ravulizumab results in C3 binding to PNH red cells similar to its parental molecule eculizumab.
Published in:
British Journal of Haematology, 2023, v. 201, n. 1, p. e1, doi. 10.1111/bjh.18662
By:
- Sica, Michela;
- Barone, Federica;
- Nannelli, Caterina;
- Ricci, Patrizia;
- Marano, Luana;
- De Angioletti, Maria;
- Di Bona, Eros;
- Risitano, Antonio M.;
- Notaro, Rosario
Publication type:
Article
Pharmacokinetic and pharmacodynamic effects of ravulizumab and eculizumab on complement component 5 in adults with paroxysmal nocturnal haemoglobinuria: results of two phase 3 randomised, multicentre studies.
Published in:
British Journal of Haematology, 2020, v. 191, n. 3, p. 476, doi. 10.1111/bjh.16711
By:
- Peffault de Latour, Régis;
- Brodsky, Robert A.;
- Ortiz, Stephan;
- Risitano, Antonio M.;
- Jang, Jun H.;
- Hillmen, Peter;
- Kulagin, Alexander D.;
- Kulasekararaj, Austin G.;
- Rottinghaus, Scott T.;
- Aguzzi, Rasha;
- Gao, Xiang;
- Wells, Richard A.;
- Szer, Jeff
Publication type:
Article
Therapeutic outcomes using subcutaneous low dose alemtuzumab for acquired bone marrow failure conditions.
Published in:
British Journal of Haematology, 2018, v. 183, n. 1, p. 133, doi. 10.1111/bjh.14907
By:
- Thota, Swapna;
- Patel, Bhumika J.;
- Sadaps, Meena;
- Balasubramanian, Suresh;
- Sanikommu, Srinivasa;
- Hirsch, Cassandra;
- Marotta, Serena;
- Sekeres, Mikkael A.;
- Risitano, Antonio M.;
- Maciejewski, Jaroslaw P.
Publication type:
Article
Advances in understanding the pathogenesis of acquired aplastic anaemia.
Published in:
British Journal of Haematology, 2018, v. 182, n. 6, p. 758, doi. 10.1111/bjh.15443
By:
- Luzzatto, Lucio;
- Risitano, Antonio M.
Publication type:
Article
Transplant results in adults with Fanconi anaemia.
Published in:
British Journal of Haematology, 2018, v. 180, n. 1, p. 100, doi. 10.1111/bjh.15006
By:
- Bierings, Marc;
- Bonfim, Carmem;
- Peffault De Latour, Regis;
- Aljurf, Mahmoud;
- Mehta, Parinda A.;
- Knol, Cora;
- Boulad, Farid;
- Tbakhi, Abdelghani;
- Esquirol, Albert;
- McQuaker, Grant;
- Sucak, Gulsan A.;
- Othman, Tarek B.;
- Halkes, Constantijn J. M.;
- Carpenter, Ben;
- Niederwieser, Dietger;
- Zecca, Marco;
- Kröger, Nicolaus;
- Michallet, Mauricette;
- Risitano, Antonio M.;
- Ehninger, Gerhard
Publication type:
Article
Similar outcome of upfront-unrelated and matched sibling stem cell transplantation in idiopathic paediatric aplastic anaemia. A study on behalf of the UK Paediatric BMT Working Party, Paediatric Diseases Working Party and Severe Aplastic Anaemia Working Party of EBMT
Published in:
British Journal of Haematology, 2015, v. 171, n. 4, p. 585, doi. 10.1111/bjh.13614
By:
- Dufour, Carlo;
- Veys, Paul;
- Carraro, Elisa;
- Bhatnagar, Neha;
- Pillon, Marta;
- Wynn, Rob;
- Gibson, Brenda;
- Vora, Ajay J.;
- Steward, Colin G.;
- Ewins, Anna M.;
- Hough, Rachael E.;
- Fuente, Josu;
- Velangi, Mark;
- Amrolia, Persis J.;
- Skinner, Roderick;
- Bacigalupo, Andrea;
- Risitano, Antonio M.;
- Socie, Gerard;
- Peffault de Latour, Regis;
- Passweg, Jakob
Publication type:
Article
Long-term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria.
Published in:
British Journal of Haematology, 2013, v. 162, n. 1, p. 62, doi. 10.1111/bjh.12347
By:
- Hillmen, Peter;
- Muus, Petra;
- Röth, Alexander;
- Elebute, Modupe O.;
- Risitano, Antonio M.;
- Schrezenmeier, Hubert;
- Szer, Jeffrey;
- Browne, Paul;
- Maciejewski, Jaroslaw P.;
- Schubert, Jörg;
- Urbano‐Ispizua, Alvaro;
- Castro, Carlos;
- Socié, Gérard;
- Brodsky, Robert A.
Publication type:
Article
Complement inhibition in medicine: Hematology and beyond; complement inhibition in hematology: PNH and beyond.
Published in:
American Journal of Hematology, 2023, v. 98, p. S3, doi. 10.1002/ajh.26912
By:
- Peffault de Latour, Régis;
- Risitano, Antonio M.
Publication type:
Article
Upfront unrelated donor hematopoietic stem cell transplantation in patients with idiopathic aplastic anemia: A retrospective study of the Severe Aplastic Anemia Working Party of European Bone Marrow Transplantation.
Published in:
American Journal of Hematology, 2022, v. 97, n. 1, p. E1, doi. 10.1002/ajh.26354
By:
- Petit, Audrey Françoise;
- Kulasekararaj, Austin G.;
- Eikema, Dirk‐Jan;
- Maschan, Alexey;
- Adjaoud, Dalila;
- Kulagin, Alexander;
- Grassi, Anna;
- Fagioli, Franca;
- Griskevicius, Laimonas;
- Snowden, John A.;
- Johansson, Jan‐Erik J.;
- Dalle, Jean‐Hugues;
- Byrne, Jenny;
- Risitano, Antonio M.;
- Peffault de Latour, Régis;
- Dufour, Carlo
Publication type:
Article
The role of ponatinib in adult BCR-ABL1 positive acute lymphoblastic leukemia after allogeneic transplantation: a real-life retrospective multicenter study.
Published in:
2021
By:
- Leotta, Salvatore;
- Markovic, Uros;
- Pirosa, Maria Cristina;
- Stella, Stefania;
- Tringali, Stefania;
- Martino, Massimo;
- Specchia, Giorgina;
- Carluccio, Paola;
- Risitano, Antonio M.;
- Grimaldi, Francesco;
- Vigna, Ernesto;
- Palmieri, Fausto;
- Palmieri, Raffaele;
- Annunziata, Mario;
- Pisapia, Giovanni;
- Palazzo, Giulia;
- Milone, Giulio Antonio;
- Pelle, Angelo Curto;
- Scalise, Luca;
- Di Giorgio, Mary Ann
Publication type:
journal article
Use of eltrombopag in aplastic anemia in Europe.
Published in:
2019
By:
- Ecsedi, Matyas;
- Drexler, Beatrice;
- Passweg, Jakob;
- Patriarca, Andrea;
- Bruno, Benedetto;
- Onofrillo, Daniela;
- Lanino, Edoardo;
- Dufour, Carlo;
- Pulanic, Drazen;
- Serventi-Seiwerth, Ranka;
- Garnier, Alice;
- Ljungman, Per;
- Bonifazi, Francesca;
- Giammarco, Sabrina;
- Tournilhac, Olivier;
- Lengline, Étienne;
- de Latour, Régis Peffault;
- Pioltelli, Pietro;
- Rovó, Alicia;
- Risitano, Antonio M.
Publication type:
journal article
New Challenges to Developing Animal Models for Human Immune-Mediated Marrow Failure.
Published in:
Clinical Medicine & Research, 2005, v. 3, n. 2, p. 63, doi. 10.3121/cmr.3.2.63
By:
- Risitano, Antonio M.
Publication type:
Article
Endothelial complications after hematopoietic stem cell transplantation.
Published in:
Drugs & Cell Therapies in Hematology, 2015, n. 4, p. 197
By:
- Pagliuca, Simona;
- Marotta, Serena;
- Risitano, Antonio M.
Publication type:
Article
Anti-complement Treatment for Paroxysmal Nocturnal Hemoglobinuria: Time for Proximal Complement Inhibition? A Position Paper From the SAAWP of the EBMT.
Published in:
Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.01157
By:
- Risitano, Antonio M.;
- Marotta, Serena;
- Ricci, Patrizia;
- Marano, Luana;
- Frieri, Camilla;
- Cacace, Fabiana;
- Sica, Michela;
- Kulasekararaj, Austin;
- Calado, Rodrigo T.;
- Scheinberg, Phillip;
- Notaro, Rosario;
- Peffault de Latour, Regis
Publication type:
Article
The complement alternative pathway in paroxysmal nocturnal hemoglobinuria: From a pathogenic mechanism to a therapeutic target.
Published in:
Immunological Reviews, 2023, v. 313, n. 1, p. 262, doi. 10.1111/imr.13137
By:
- Risitano, Antonio M.;
- Frieri, Camilla;
- Urciuoli, Eleonora;
- Marano, Luana
Publication type:
Article
Aplastic anemia: immunosuppressive therapy in 2010.
Published in:
Pediatric Reports, 2011, v. 3, p. 14, doi. 10.4081/pr.2011.s2.e7
By:
- Risitano, Antonio M.;
- Perna, Fabiana
Publication type:
Article
CT-121: Phase 3 Study of the Efficacy and Safety of Iptacopan (LNP023), an Oral Factor B Inhibitor, in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Naïve to Complement Inhibitor Therapy.
Published in:
Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S450, doi. 10.1016/S2152-2650(21)01999-6
By:
- de Latour, Régis Peffault;
- Bing Han;
- Ueda, Yasutaka;
- Yu Cheng;
- Bermann, Georgina;
- Dahlke, Marion;
- Risitano, Antonio M.
Publication type:
Article
CT-118: PH3 Study of Efficacy and Safety of Iptacopan (LNP023), an Oral Complement Factor B Inhibitor, in Patients with Paroxysmal Nocturnal Hemoglobinuria and Residual Anemia Despite Anti-C5 Antibody Treatment.
Published in:
Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S449, doi. 10.1016/S2152-2650(21)01998-4
By:
- Risitano, Antonio M.;
- Kulasekararaj, Austin;
- De Castro, Carlos M.;
- Scheinberg, Phillip;
- Levitch, Rafael;
- Bermann, Georgina;
- Dahlke, Marion;
- de Latour, Régis Peffault
Publication type:
Article
Poster: CT-118: PH3 Study of Efficacy and Safety of Iptacopan (LNP023), an Oral Complement Factor B Inhibitor, in Patients with Paroxysmal Nocturnal Hemoglobinuria and Residual Anemia Despite Anti-C5 Antibody Treatment.
Published in:
Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S259, doi. 10.1016/S2152-2650(21)01635-9
By:
- Risitano, Antonio M.;
- Kulasekararaj, Austin;
- De Castro, Carlos M.;
- Scheinberg, Phillip;
- Levitch, Rafael;
- Bermann, Georgina;
- Dahlke, Marion;
- De Latour, Régis Peffault
Publication type:
Article
Valganciclovir as CMV reactivation prophylaxis in patients receiving alemtuzumab for marrow failure syndromes.
Published in:
2009
By:
- Risitano, Antonio M.;
- Serio, Bianca;
- Selleri, Carmine;
- Rotoli, Bruno
Publication type:
Letter
Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention.
Published in:
European Journal of Clinical Investigation, 2015, v. 45, n. 4, p. 423, doi. 10.1111/eci.12419
By:
- Mastellos, Dimitrios C.;
- Yancopoulou, Despina;
- Kokkinos, Petros;
- Huber‐Lang, Markus;
- Hajishengallis, George;
- Biglarnia, Ali R.;
- Lupu, Florea;
- Nilsson, Bo;
- Risitano, Antonio M.;
- Ricklin, Daniel;
- Lambris, John D.
Publication type:
Article
Toward complement inhibition 2.0: Next generation anticomplement agents for paroxysmal nocturnal hemoglobinuria.
Published in:
American Journal of Hematology, 2018, v. 93, n. 4, p. 564, doi. 10.1002/ajh.25016
By:
- Risitano, Antonio M.;
- Marotta, Serena
Publication type:
Article
Acute immune toxicity during anti-thymocyte globulin: That's CARPA!
Published in:
American Journal of Hematology, 2018, v. 93, n. 1, p. E22, doi. 10.1002/ajh.24945
By:
- Marotta, Serena;
- Ricci, Patrizia;
- Marano, Luana;
- Beneduce, Giuliana;
- Vitagliano, Orsola;
- De Gregorio, Fiorenza;
- Grimaldi, Francesco;
- Pane, Fabrizio;
- Risitano, Antonio M.
Publication type:
Article
Paroxysmal nocturnal hemoglobinuria in the era of complement inhibition.
Published in:
American Journal of Hematology, 2016, v. 91, p. 359, doi. 10.1002/ajh.24323
By:
- Risitano, Antonio M
Publication type:
Article
Paroxysmal nocturnal hemoglobinuria in the era of complement inhibition.
Published in:
American Journal of Hematology, 2016, v. 91, n. 4, p. 359, doi. 10.1002/ajh.24323
By:
- Risitano, Antonio M.
Publication type:
Article
Assessment of human antihuman antibodies to eculizumab after long-term treatment in patients with paroxysmal nocturnal hemoglobinuria.
Published in:
American Journal of Hematology, 2016, v. 91, n. 3, p. E16, doi. 10.1002/ajh.24280
By:
- Hillmen, Peter;
- Muus, Petra;
- Szer, Jeffrey;
- Hill, Anita;
- Höchsmann, Britta;
- Kulasekararaj, Austin;
- Risitano, Antonio M.;
- Van Den Neste, Eric;
- Liljeholm, Maria;
- Ebrahim, Kurt S.;
- Bedrosian, Camille L.;
- Gao, Xiang;
- Ames, Donna;
- Socié, Gérard
Publication type:
Article
Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes.
Published in:
Journal of Hematology & Oncology, 2017, v. 10, p. 1, doi. 10.1186/s13045-017-0496-x
By:
- Sica, Michela;
- Rondelli, Tommaso;
- Ricci, Patrizia;
- De Angioletti, Maria;
- Risitano, Antonio M.;
- Notaro, Rosario
Publication type:
Article
From perpetual haemosiderinuria to possible iron overload: iron redistribution in paroxysmal nocturnal haemoglobinuria patients on eculizumab by magnetic resonance imaging.
Published in:
British Journal of Haematology, 2012, v. 158, n. 3, p. 415, doi. 10.1111/j.1365-2141.2012.09145.x
By:
- Risitano, Antonio M.;
- Imbriaco, Massimo;
- Marando, Ludovica;
- Seneca, Elisa;
- Soscia, Ernesto;
- Malcovati, Luca;
- Iori, Anna P.;
- Pane, Fabrizio;
- Notaro, Rosario;
- Matarazzo, Margherita
Publication type:
Article
Immunosuppressive therapies in the management of immune-mediated marrow failures in adults: where we stand and where we are going.
Published in:
British Journal of Haematology, 2011, v. 152, n. 2, p. 127, doi. 10.1111/j.1365-2141.2010.08439.x
By:
- Risitano, Antonio M.
Publication type:
Article
Should irradiated blood products be given routinely to all patients with aplastic anaemia undergoing immunosuppressive therapy with antithymocyte globulin (ATG)? A survey from the European Group for Blood and Marrow Transplantation Severe Aplastic Anaemia Working Party
Published in:
2010
By:
- Marsh, Judith;
- Socie, Gerard;
- Tichelli, Andre;
- Schrezenmeier, Hubert;
- Hochsmann, Britta;
- Risitano, Antonio M.;
- Fuehrer, Monika;
- Bekassy, Albert N.;
- Korthof, Elizabeth T.;
- Locasciulli, Anna;
- Ljungman, Per;
- Bacigalupo, Andrea;
- Camitta, Bruce;
- Young, Neal S.;
- Passweg, Jakob
Publication type:
Letter
The management of pregnancy in paroxysmal nocturnal haemoglobinuria on long term eculizumab.
Published in:
British Journal of Haematology, 2010, v. 149, n. 3, p. 446, doi. 10.1111/j.1365-2141.2010.08099.x
By:
- Kelly, Richard;
- Arnold, Louise;
- Richards, Stephen;
- Hill, Anita;
- Bomken, Charlotte;
- Hanley, John;
- Loughney, Andrew;
- Beauchamp, Jon;
- Khursigara, Gus;
- Rother, Russell P.;
- Chalmers, Elizabeth;
- Fyfe, Andrew;
- Fitzsimons, Edward;
- Nakamura, Ryotaro;
- Gaya, Anna;
- Risitano, Antonio M.;
- Schubert, Jörg;
- Norfolk, Derek;
- Simpson, Nigel;
- Hillmen, Peter
Publication type:
Article
Elevated circulating endothelial membrane microparticles in paroxysmal nocturnal haemoglobinuria.
Published in:
British Journal of Haematology, 2004, v. 125, n. 6, p. 804, doi. 10.1111/j.1365-2141.2004.04974.x
By:
- Simak, Jan;
- Holada, Karel;
- Risitano, Antonio M.;
- Zivny, Jan H.;
- Young, Neal S.;
- Vostal, Jaroslav G.
Publication type:
Article
Selective reduction of natural killer T cells in the bone marrow of aplastic anaemia.
Published in:
British Journal of Haematology, 2002, v. 119, n. 3, p. 803, doi. 10.1046/j.1365-2141.2002.03875.x
By:
- Zeng, Weihua;
- Maciejewski, Jaroslaw P.;
- Chen, Guibin;
- Risitano, Antonio M.;
- Kirby, Martha;
- Kajigaya, Sachiko;
- Young, Neal S.
Publication type:
Article
Paroxysmal Nocturnal Hemoglobinuria after Autologous Stem Cell Transplantation: Extinction of the Clone during Treatment with Eculizumab - Pathophysiological Implications of a Unique Clinical Case.
Published in:
Acta Haematologica, 2011, v. 126, n. 2, p. 103, doi. 10.1159/000327251
By:
- Pulini, Stefano;
- Marando, Ludovica;
- Natale, Annalisa;
- Pascariello, Caterina;
- Catinella, Virginia;
- Del Vecchio, Luigi;
- Risitano, Antonio M.;
- Fioritoni, Giuseppe
Publication type:
Article

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