Works by Rephaeli, Ada

Results: 23

Formaldehyde-releasing prodrugs specifically affect cancer cells by depletion of intracellular glutathione and augmentation of reactive oxygen species.

Published in:

Cancer Chemotherapy & Pharmacology, 2008, v. 62, n. 3, p. 471, doi. 10.1007/s00280-007-0627-0

By:

Levovich, Inesa;
Nudelman, Abraham;
Berkovitch, Gili;
Swift, Lonnie P.;
Cutts, Suzanne M.;
Phillips, Don R.;
Rephaeli, Ada

Publication type:

Article

The cardio-protecting agent and topoisomerase II catalytic inhibitor sobuzoxane enhances doxorubicin-DNA adduct mediated cytotoxicity.

Published in:

Cancer Chemotherapy & Pharmacology, 2008, v. 61, n. 5, p. 739, doi. 10.1007/s00280-007-0528-2

By:

Swift, Lonnie P.;
Cutts, Suzanne M.;
Nudelman, Abraham;
Levovich, Inessa;
Rephaeli, Ada;
Phillips, Don R.

Publication type:

Article

Multifunctional 5-aminolevulinic acid prodrugs activating diverse cell-death pathways.

Published in:

Investigational New Drugs, 2012, v. 30, n. 3, p. 1028, doi. 10.1007/s10637-011-9669-6

By:

Berkovitch-Luria, Gili;
Weitman, Michal;
Nudelman, Abraham;
Rephaeli, Ada;
Malik, Zvi

Publication type:

Article

The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity.

Published in:

Investigational New Drugs, 2012, v. 30, n. 1, p. 130, doi. 10.1007/s10637-010-9542-z

By:

Tarasenko, Nataly;
Kessler-Icekson, Gania;
Boer, Pnina;
Inbal, Aida;
Schlesinger, Hadassa;
Phillips, Don;
Cutts, Suzanne;
Nudelman, Abraham;
Rephaeli, Ada

Publication type:

Article

The selectivty and anti-metastatic activity of oral bioavailable butyric acid prodrugs.

Published in:

Investigational New Drugs, 2006, v. 24, n. 5, p. 383, doi. 10.1007/s10637-006-6213-1

By:

Ada Rephaeli;
Michal Entin-Meer;
Dikla Angel;
Nataly Tarasenko;
Tal Gruss-Fischer;
Irena Bruachman;
Don Phillips;
Suzanne Cutts;
Daphne Haas-Kogan;
Abraham Nudelman

Publication type:

Article

Histone deacetylase inhibitors: the anticancer, antimetastatic and antiangiogenic activities of AN-7 are superior to those of the clinically tested AN-9 (Pivanex).

Published in:

Clinical & Experimental Metastasis, 2008, v. 25, n. 7, p. 703, doi. 10.1007/s10585-008-9179-x

By:

Tarasenko, Nataly;
Nudelman, Abraham;
Tarasenko, Igor;
Entin-Meer, Michal;
Hass-Kogan, Daphne;
Inbal, Aida;
Rephaeli, Ada

Publication type:

Article

In vivo and in vitro antitumor activity of butyroyloxymethyl-diethyl phosphate (AN-7), a histone deacetylase inhibitor, in human prostate cancer.

Published in:

International Journal of Cancer, 2005, v. 116, n. 2, p. 226, doi. 10.1002/ijc.21030

By:

Rephaeli, Ada;
Blank-Porat, Diana;
Tarasenko, Nataly;
Entin-Meer, Michal;
Levovich, Inesa;
Cutts, Suzanne M.;
Phillips, Don R.;
Malik, Zvi;
Nudelman, Abraham

Publication type:

Article

The Power and Potential of Doxorubicin-DNA Adducts.

Published in:

IUBMB Life, 2005, v. 57, n. 2, p. 73, doi. 10.1080/15216540500079093

By:

Cutts, Suzanne;
Nudelman, Abraham;
Rephaeli, Ada;
Phillips, Don R.

Publication type:

Article

An evaluation of the interaction of pixantrone with formaldehyde-releasing drugs in cancer cells.

Published in:

Cancer Chemotherapy & Pharmacology, 2022, v. 89, n. 6, p. 773, doi. 10.1007/s00280-022-04435-1

By:

Mansour, Oula C.;
Nudelman, Abraham;
Rephaeli, Ada;
Phillips, Don R.;
Cutts, Suzanne M.;
Evison, Benny J.

Publication type:

Article

The hydroxyl epimer of doxorubicin controls the rate of formation of cytotoxic anthracycline-DNA adducts.

Published in:

Cancer Chemotherapy & Pharmacology, 2013, v. 71, n. 3, p. 809, doi. 10.1007/s00280-012-2049-x

By:

Forrest, Robert;
Swift, Lonnie;
Evison, Benny;
Rephaeli, Ada;
Nudelman, Abraham;
Phillips, Don;
Cutts, Suzanne

Publication type:

Article

Comparison of the anticancer properties of a novel valproic acid prodrug to leading histone deacetylase inhibitors.

Published in:

Journal of Cellular Biochemistry, 2018, v. 119, n. 4, p. 3417, doi. 10.1002/jcb.26512

By:

Tarasenko, Nataly;
Chekroun‐Setti, Hanna;
Nudelman, Abraham;
Rephaeli, Ada

Publication type:

Article

Prodrugs of butyric acid from bench to bedside: Synthetic design, mechanisms of action, and clinical applications.

Published in:

Drug Development Research, 2000, v. 50, n. 3/4, p. 379, doi. 10.1002/1098-2299(200007/08)50:3/4<379::AID-DDR20>3.0.CO;2-8

By:

Rephaeli, Ada;
Zhuk, Regina;
Nudelman, Abraham

Publication type:

Article

Comparison between the effect of butyric acid and its prodrug pivaloyloxymethylbutyrate on histones hyperacetylation in an HL-60 leukemic cell line.

Published in:

International Journal of Cancer, 1994, v. 56, n. 6, p. 906, doi. 10.1002/ijc.2910560625

By:

Aviram, Adina;
Zimrah, Yael;
Shaklai, Mali;
Nudelman, Abraham;
Rephaeli, Ada

Publication type:

Article

Derivatives of butyric acid as potential anti-neoplastic agents.

Published in:

International Journal of Cancer, 1991, v. 49, n. 1, p. 66, doi. 10.1002/ijc.2910490113

By:

Rephaeli, Ada;
Rabizadeh, Ester;
Aviram, Adina;
Shaklai, Mati;
Ruse, Margaretta;
Nudelman, Abraham

Publication type:

Article

Effect of Histone Deacetylase Inhibitor, Butyroyloxymethyl-Diethyl Phosphate (AN-7), on Corneal Neovascularization in a Mouse Model.

Published in:

2017

By:

Schaap-Fogler, Michal;
Bahar, Irit;
Rephaeli, Ada;
Dahbash, Mor;
Nudelman, Abraham;
Livny, Eitan;
Barliya, Tilda;
Nisgav, Yael;
Livnat, Tami

Publication type:

journal article

The Histone Deacetylase Inhibitor AN7, Attenuates Choroidal Neovascularization in a Mouse Model.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 3, p. 714, doi. 10.3390/ijms20030714

By:

Dahbash, Mor;
Sella, Ruti;
Megiddo-Barnir, Elinor;
Nisgav, Yael;
Tarasenko, Nataly;
Weinberger, Dov;
Rephaeli, Ada;
Livnat, Tami

Publication type:

Article

Proliferation-associated changes of Ca<sup>2+</sup> transport in myeloid leukemic cell lines.

Published in:

Journal of Cellular Physiology, 1990, v. 143, n. 1, p. 154, doi. 10.1002/jcp.1041430121

By:

Rephaeli, Ada;
Aviram, Adina;
Rabizadeh, Ester;
Shaklai, Mati

Publication type:

Article

Valproic Acid Prodrug Affects Selective Markers, Augments Doxorubicin Anticancer Activity and Attenuates Its Toxicity in a Murine Model of Aggressive Breast Cancer.

Published in:

Pharmaceuticals (14248247), 2021, v. 14, n. 12, p. 1244, doi. 10.3390/ph14121244

By:

Tarasenko, Nataly;
Wilner, Harel Josef;
Nudelman, Abraham;
Kessler-Icekson, Gania;
Rephaeli, Ada

Publication type:

Article

The Therapeutic Potential of AN-7, a Novel Histone Deacetylase Inhibitor, for Treatment of Mycosis Fungoides/Sezary Syndrome Alone or with Doxorubicin.

Published in:

PLoS ONE, 2016, v. 11, n. 1, p. 1, doi. 10.1371/journal.pone.0146115

By:

Moyal, Lilach;
Feldbaum, Nataly;
Goldfeiz, Neta;
Rephaeli, Ada;
Nudelman, Abraham;
Weitman, Michal;
Tarasenko, Nataly;
Gorovitz, Batia;
Maron, Leah;
Yehezkel, Shiran;
Amitay-Laish, Iris;
Lubin, Ido;
Hodak, Emmilia

Publication type:

Article

Disparate Impact of Butyroyloxymethyl Diethylphosphate (AN-7), a Histone Deacetylase Inhibitor, and Doxorubicin in Mice Bearing a Mammary Tumor.

Published in:

PLoS ONE, 2012, v. 7, n. 2, p. 1, doi. 10.1371/journal.pone.0031393

By:

Tarasenko, Nataly;
Cutts, Suzanne M.;
Phillips, Don R.;
Inbal, Aida;
Nudelman, Abraham;
Kessler-Icekson, Gania;
Rephaeli, Ada

Publication type:

Article

AN-7, a butyric acid prodrug, sensitizes cutaneous T-cell lymphoma cell lines to doxorubicin via inhibition of DNA double strand breaks repair.

Published in:

Investigational New Drugs, 2018, v. 36, n. 1, p. 1, doi. 10.1007/s10637-017-0500-x

By:

Moyal, Lilach;
Goldfeiz, Neta;
Gorovitz, Batia;
Rephaeli, Ada;
Tal, Efrat;
Tarasenko, Nataly;
Nudelman, Abraham;
Ziv, Yael;
Hodak, Emmilia

Publication type:

Article

Effects of histone deacetylase inhibitory prodrugs on epigenetic changes and DNA damage response in tumor and heart of glioblastoma xenograft.

Published in:

Investigational New Drugs, 2017, v. 35, n. 4, p. 412, doi. 10.1007/s10637-017-0448-x

By:

Tarasenko, Nataly;
Nudelman, Abraham;
Rozic, Gabriela;
Cutts, Suzanne;
Rephaeli, Ada

Publication type:

Article

Mode of interaction between butyroyloxymethyl-diethyl phosphate (AN-7) and doxorubicin in MCF-7 and resistant MCF-7/Dx cell lines.

Published in:

Journal of Cancer Research & Clinical Oncology, 2006, v. 132, n. 10, p. 673, doi. 10.1007/s00432-006-0116-6

By:

Engel, Dikla;
Nudelman, Abraham;
Levovich, Inesa;
Gruss-Fischer, Tal;
Entin-Meer, Michal;
Phillips, Don;
Cutts, Suzanne;
Rephaeli, Ada

Publication type:

Article