Works by Renslo, Adam R.

Results: 32

Expanding automated multiconformer ligand modeling to macrocycles and fragments.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.103797

By:

Flowers, Jessica;
Echols, Nathaniel;
Correy, Galen J.;
Jaishankar, Priyadarshini;
Togo, Takaya;
Renslo, Adam R.;
van den Bedem, Henry;
Fraser, James S.;
Wankowicz, Stephanie A.

Publication type:

Article

Ferronostics: Measuring Tumoral Ferrous Iron with PET to Predict Sensitivity to Iron-Targeted Cancer Therapies.

Published in:

Journal of Nuclear Medicine, 2020, v. 61, n. 12, p. 1, doi. 10.2967/jnumed.120.252460

By:

Ning Zhao;
Yangjie Huang;
Yung-hua Wang;
Muir, Ryan K.;
Ying-Chu Chen;
Junnian Wei;
Hooshdaran, Nima;
Viswanath, Pavithra;
Youngho Seo;
Ruggero, Davide;
Renslo, Adam R.;
Evans, Michael J.

Publication type:

Article

From Tethered to Freestanding Stabilizers of 14‐3‐3 Protein‐Protein Interactions through Fragment Linking.

Published in:

Angewandte Chemie, 2023, v. 135, n. 37, p. 1, doi. 10.1002/ange.202308004

By:

Visser, Emira J.;
Jaishankar, Priyadarshini;
Sijbesma, Eline;
Pennings, Marloes A. M.;
Vandenboorn, Edmee M. F.;
Guillory, Xavier;
Neitz, R. Jeffrey;
Morrow, John;
Dutta, Shubhankar;
Renslo, Adam R.;
Brunsveld, Luc;
Arkin, Michelle R.;
Ottmann, Christian

Publication type:

Article

Pyrvinium Pamoate and Structural Analogs Are Early Macrofilaricide Leads.

Published in:

Pharmaceuticals (14248247), 2022, v. 15, n. 2, p. 189, doi. 10.3390/ph15020189

By:

Gunderson, Emma L.;
Bryant, Clifford;
Bulman, Christina A.;
Fischer, Chelsea;
Luo, Mona;
Vogel, Ian;
Lim, Kee-Chong;
Jawahar, Shabnam;
Tricoche, Nancy;
Voronin, Denis;
Corbo, Christopher;
Ayiseh, Rene B.;
Manfo, Faustin P. T.;
Mbah, Glory E.;
Cho-Ngwa, Fidelis;
Beerntsen, Brenda;
Renslo, Adam R.;
Lustigman, Sara;
Sakanari, Judy A.

Publication type:

Article

Mutation of the conserved Asp‐Asp pair impairs the structure, function, and inhibition of CTX‐M Class A β‐lactamase.

Published in:

FEBS Letters, 2021, v. 595, n. 24, p. 2981, doi. 10.1002/1873-3468.14215

By:

Kemp, M. Trent;
Nichols, Derek A.;
Zhang, Xiujun;
Defrees, Kyle;
Na, Insung;
Renslo, Adam R.;
Chen, Yu

Publication type:

Article

Imaging-Selected Host Responses in the Context of Infections.

Published in:

Journal of Infectious Diseases, 2023, p. S302, doi. 10.1093/infdis/jiad313

By:

Foss, Catherine A;
Renslo, Adam R

Publication type:

Article

A zebrafish screen reveals Reninangiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.69795

By:

Kim, Gha- Hyun J.;
Han Mo;
Liu, Harrison;
Zhihao Wu;
Chen, Steven;
Jiashun Zheng;
Xiang Zhao;
Nucum, Daryl;
Shortland, James;
Longping Peng;
Elepano, Mannuel;
Tang, Benjamin;
Olson, Steven;
Paras, Nick;
Hao Li;
Renslo, Adam R.;
Arkin, Michelle R.;
Bo Huang;
Bingwei Lu;
Sirota, Marina

Publication type:

Article

From Tethered to Freestanding Stabilizers of 14‐3‐3 Protein‐Protein Interactions through Fragment Linking.

Published in:

Angewandte Chemie International Edition, 2023, v. 62, n. 37, p. 1, doi. 10.1002/anie.202308004

By:

Visser, Emira J.;
Jaishankar, Priyadarshini;
Sijbesma, Eline;
Pennings, Marloes A. M.;
Vandenboorn, Edmee M. F.;
Guillory, Xavier;
Neitz, R. Jeffrey;
Morrow, John;
Dutta, Shubhankar;
Renslo, Adam R.;
Brunsveld, Luc;
Arkin, Michelle R.;
Ottmann, Christian

Publication type:

Article

Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads.

Published in:

PLoS Neglected Tropical Diseases, 2011, v. 5, n. 5, p. 1, doi. 10.1371/journal.pntd.0001023

By:

Ang, Kenny K. H.;
Ratnam, Joseline;
Gut, Jiri;
Legac, Jennifer;
Hansell, Elizabeth;
Mackey, Zachary B.;
Skrzypczynska, Katarzyna M.;
Debnath, Anjan;
Engel, Juan C.;
Rosenthal, Philip J.;
McKerrow, James H.;
Arkin, Michelle R.;
Renslo, Adam R.

Publication type:

Article

Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads.

Published in:

PLoS Neglected Tropical Diseases, 2011, v. 5, n. 5, p. 1, doi. 10.1371/journal.pntd.0001023

By:

Ang, Kenny K. H.;
Ratnam, Joseline;
Gut, Jiri;
Legac, Jennifer;
Hansell, Elizabeth;
Mackey, Zachary B.;
Skrzypczynska, Katarzyna M.;
Debnath, Anjan;
Engel, Juan C.;
Rosenthal, Philip J.;
McKerrow, James H.;
Arkin, Michelle R.;
Renslo, Adam R.

Publication type:

Article

Identification of Small Molecule Lead Compounds for Visceral Leishmaniasis Using a Novel Ex Vivo Splenic Explant Model System.

Published in:

PLoS Neglected Tropical Diseases, 2011, v. 5, n. 2, p. 1, doi. 10.1371/journal.pntd.0000962

By:

Osorio, Yaneth;
Travi, Bruno L.;
Renslo, Adam R.;
Peniche, Alex G.;
Melby, Peter C.

Publication type:

Article

Identification of Small Molecule Lead Compounds for Visceral Leishmaniasis Using a Novel Ex Vivo Splenic Explant Model System.

Published in:

PLoS Neglected Tropical Diseases, 2011, v. 5, n. 2, p. 1, doi. 10.1371/journal.pntd.0000962

By:

Travi, Yaneth Osorio1,2¤, Bruno L.;
Renslo, Adam R.;
Peniche, Alex G.;
Melby, Peter C.

Publication type:

Article

Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening.

Published in:

PLoS Neglected Tropical Diseases, 2009, v. 3, n. 7, p. 1, doi. 10.1371/journal.pntd.0000478

By:

Abdulla, Maha-Hamadien;
Ruelas, Debbie S.;
Wolff, Brian;
Snedecor, June;
Lim, Kee-Chong;
Xu, Fengyun;
Renslo, Adam R.;
Williams, Janice;
McKerrow, James H.;
Caffrey, Conor R.

Publication type:

Article

Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening.

Published in:

PLoS Neglected Tropical Diseases, 2009, v. 3, n. 7, p. 1, doi. 10.1371/journal.pntd.0000478

By:

Abdulla, Maha-Hamadien;
Ruelas, Debbie S.;
Wolff, Brian;
Snedecor, June;
Lim, Kee-Chong;
Xu, Fengyun;
Renslo, Adam R.;
Williams, Janice;
McKerrow, James H.;
Caffrey, Conor R.

Publication type:

Article

Structure-Activity Studies of Bis- O-Arylglycolamides: Inhibitors of the Integrated Stress Response.

Published in:

ChemMedChem, 2016, v. 11, n. 8, p. 870, doi. 10.1002/cmdc.201500483

By:

Hearn, Brian R.;
Jaishankar, Priyadarshini;
Sidrauski, Carmela;
Tsai, Jordan C.;
Vedantham, Punitha;
Fontaine, Shaun D.;
Walter, Peter;
Renslo, Adam R.

Publication type:

Article

Drug Delivery to the Malaria Parasite Using an Arterolane-Like Scaffold.

Published in:

ChemMedChem, 2015, v. 10, n. 1, p. 47, doi. 10.1002/cmdc.201402362

By:

Fontaine, Shaun D.;
Spangler, Benjamin;
Gut, Jiri;
Lauterwasser, Erica M. W.;
Rosenthal, Philip J.;
Renslo, Adam R.

Publication type:

Article

Tailoring Small Molecules for an Allosteric Site on Procaspase-6.

Published in:

ChemMedChem, 2014, v. 9, n. 1, p. 73, doi. 10.1002/cmdc.201300424

By:

Murray, Jeremy;
Giannetti, Anthony M.;
Steffek, Micah;
Gibbons, Paul;
Hearn, Brian R.;
Cohen, Frederick;
Tam, Christine;
Pozniak, Christine;
Bravo, Brandon;
Lewcock, Joe;
Jaishankar, Priyadarshini;
Ly, Cuong Q.;
Zhao, Xianrui;
Tang, Yinyan;
Chugha, Preeti;
Arkin, Michelle R.;
Flygare, John;
Renslo, Adam R.

Publication type:

Article

Inside Cover: Tailoring Small Molecules for an Allosteric Site on Procaspase-6 (ChemMedChem 1/2014).

Published in:

ChemMedChem, 2014, v. 9, n. 1, p. 2, doi. 10.1002/cmdc.201390058

By:

Murray, Jeremy;
Giannetti, Anthony M.;
Steffek, Micah;
Gibbons, Paul;
Hearn, Brian R.;
Cohen, Frederick;
Tam, Christine;
Pozniak, Christine;
Bravo, Brandon;
Lewcock, Joe;
Jaishankar, Priyadarshini;
Ly, Cuong Q.;
Zhao, Xianrui;
Tang, Yinyan;
Chugha, Preeti;
Arkin, Michelle R.;
Flygare, John;
Renslo, Adam R.

Publication type:

Article

2-Aminothiazoles with Improved Pharmacotherapeutic Properties for Treatment of Prion Disease.

Published in:

ChemMedChem, 2013, v. 8, n. 5, p. 847, doi. 10.1002/cmdc.201300007

By:

Li, Zhe;
Silber, B. Michael;
Rao, Satish;
Gever, Joel R.;
Bryant, Clifford;
Gallardo‐Godoy, Alejandra;
Dolghih, Elena;
Widjaja, Kartika;
Elepano, Manuel;
Jacobson, Matthew P.;
Prusiner, Stanley B.;
Renslo, Adam R.

Publication type:

Article

A Fragmenting Hybrid Approach for Targeted Delivery of Multiple Therapeutic Agents to the Malaria Parasite.

Published in:

ChemMedChem, 2011, v. 6, n. 3, p. 415, doi. 10.1002/cmdc.201100002

By:

Mahajan, Sumit S.;
Deu, Edgar;
Lauterwasser, Erica M. W.;
Leyva, Melissa J.;
Ellman, Jonathan A.;
Bogyo, Matthew;
Renslo, Adam R.

Publication type:

Article

Inside Cover: A Fragmenting Hybrid Approach for Targeted Delivery of Multiple Therapeutic Agents to the Malaria Parasite (ChemMedChem 3/2011).

Published in:

ChemMedChem, 2011, v. 6, n. 3, p. 382, doi. 10.1002/cmdc.201190006

By:

Mahajan, Sumit S.;
Deu, Edgar;
Lauterwasser, Erica M. W.;
Leyva, Melissa J.;
Ellman, Jonathan A.;
Bogyo, Matthew;
Renslo, Adam R.

Publication type:

Article

Isolation of an Acid/Base Complex in Solution Puts the Brakes on Nitrogen Inversion.

Published in:

Angewandte Chemie International Edition, 2001, v. 40, n. 7, p. 1221, doi. 10.1002/1521-3773(20010401)40:7<1221::AID-ANIE1221>3.0.CO;2-N

By:

Wash, Paul L.;
Renslo, Adam R.;
Rebek, Jr., Julius

Publication type:

Article

Molecular Recognition with Introverted Functionality.

Published in:

Angewandte Chemie International Edition, 2000, v. 39, n. 18, p. 3281, doi. 10.1002/1521-3773(20000915)39:18<3281::AID-ANIE3281>3.0.CO;2-P

By:

Renslo, Adam R.;
Rebek, Jr., Julius

Publication type:

Article

Nanoscale Container Structures and Their Host - Guest Properties.

Published in:

Angewandte Chemie International Edition, 2000, v. 39, n. 6, p. 1076, doi. 10.1002/(SICI)1521-3773(20000317)39:6<1076::AID-ANIE1076>3.0.CO;2-E

By:

Tucci, Fabio C.;
Renslo, Adam R.;
Rudkevich, Dmitry M.;
Rebek, Jr., Julius

Publication type:

Article

Predicting Binding to P-Glycoprotein by Flexible Receptor Docking.

Published in:

PLoS Computational Biology, 2011, v. 7, n. 6, p. 1, doi. 10.1371/journal.pcbi.1002083

By:

Dolghih, Elena;
Bryant, Clifford;
Renslo, Adam R.;
Jacobson, Matthew P.

Publication type:

Article

Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6.

Published in:

PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0050864

By:

Heise, Christopher E.;
Murray, Jeremy;
Augustyn, Katherine E.;
Bravo, Brandon;
Chugha, Preeti;
Cohen, Frederick;
Giannetti, Anthony M.;
Gibbons, Paul;
Hannoush, Rami N.;
Hearn, Brian R.;
Jaishankar, Priyadarshini;
Ly, Cuong Q.;
Shah, Kinjalkumar;
Stanger, Karen;
Steffek, Micah;
Yinyan Tang;
Xianrui Zhao;
Lewcock, Joseph W.;
Renslo, Adam R.;
Flygare, John

Publication type:

Article

cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool.

Published in:

eLife, 2017, p. 1, doi. 10.7554/eLife.29750

By:

Camarena, Vladimir;
Sant, David W.;
Huff, Tyler C.;
Mustafi, Sushmita;
Muir, Ryan K.;
Aron, Allegra T.;
Chang, Christopher J.;
Renslo, Adam R.;
Monje, Paula V.;
Gaofeng Wang

Publication type:

Article

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.11878

By:

Gallagher, Ciara M.;
Garri, Carolina;
Cain, Erica L.;
Kenny Kean-Hooi Ang;
Wilson, Christopher G.;
Chen, Steven;
Hearn, Brian R.;
Jaishankar, Priyadarshini;
Aranda-Diaz, Andres;
Arkin, Michelle R.;
Renslo, Adam R.;
Walter, Peter

Publication type:

Article

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.

Published in:

eLife, 2015, p. 1

By:

Sidrauski, Carmela;
Tsai, Jordan C.;
Mendez, Aaron S.;
Walter, Peter;
Kampmann, Martin;
Weissman, Jonathan S.;
Hearn, Brian R.;
Vedantham, Punitha;
Jaishankar, Priyadarshini;
Renslo, Adam R.;
Sokabe, Masaaki;
Fraser, Christopher S.;
Newton, Billy W.;
Verschueren, Erik;
Tang, Edward L.;
Johnson, Jeffrey R.;
Krogan, Nevan J.

Publication type:

Article

Systematic Exploration of Passive Permeability in Tetrapeptides with Hydrogen‐Bond‐Accepting Amino Acid Side Chains.

Published in:

ChemMedChem, 2022, v. 17, n. 16, p. 1, doi. 10.1002/cmdc.202200204

By:

Shimizu, Hiroki;
Renslo, Adam R.

Publication type:

Article

Drug discovery and development for neglected parasitic diseases.

Published in:

Nature Chemical Biology, 2006, v. 2, n. 12, p. 701, doi. 10.1038/nchembio837

By:

Renslo, Adam R.;
McKerrow, James H.

Publication type:

Article

High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations.

Published in:

Scientific Reports, 2015, p. 13891, doi. 10.1038/srep13891

By:

Mott, Bryan T.;
Eastman, Richard T.;
Guha, Rajarshi;
Sherlach, Katy S.;
Siriwardana, Amila;
Shinn, Paul;
McKnight, Crystal;
Michael, Sam;
Lacerda-Queiroz, Norinne;
Patel, Paresma R.;
Khine, Pwint;
Sun, Hongmao;
Kasbekar, Monica;
Aghdam, Nima;
Fontaine, Shaun D.;
Liu, Dongbo;
Mierzwa, Tim;
Mathews-Griner, Lesley A.;
Ferrer, Marc;
Renslo, Adam R.

Publication type:

Article