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Lynch syndrome-associated and sporadic microsatellite unstable colorectal cancers: different patterns of clonal evolution yield highly similar tumours.
Published in:
Human Molecular Genetics, 2024, v. 33, n. 21, p. 1858, doi. 10.1093/hmg/ddae124
By:
- Martin, Samantha;
- Katainen, Riku;
- Taira, Aurora;
- Välimäki, Niko;
- Ristimäki, Ari;
- Seppälä, Toni;
- Renkonen-Sinisalo, Laura;
- Lepistö, Anna;
- Tahkola, Kyösti;
- Mattila, Anne;
- Koskensalo, Selja;
- Mecklin, Jukka-Pekka;
- Rajamäki, Kristiina;
- Palin, Kimmo;
- Aaltonen, Lauri A
Publication type:
Article
Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report.
Published in:
Hereditary Cancer in Clinical Practice, 2019, v. 17, n. 1, p. N.PAG, doi. 10.1186/s13053-019-0127-3
By:
- Dominguez-Valentin, Mev;
- Seppälä, Toni T.;
- Sampson, Julian R.;
- Macrae, Finlay;
- Winship, Ingrid;
- Evans, D. Gareth;
- Scott, Rodney J.;
- Burn, John;
- Möslein, Gabriela;
- Bernstein, Inge;
- Pylvänäinen, Kirsi;
- Renkonen-Sinisalo, Laura;
- Lepistö, Anna;
- Lindblom, Annika;
- Plazzer, John-Paul;
- Tjandra, Douglas;
- Thomas, Huw;
- Green, Kate;
- Lalloo, Fiona;
- Crosbie, Emma J.
Publication type:
Article
Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report.
Published in:
Hereditary Cancer in Clinical Practice, 2019, v. 17, n. 1, p. N.PAG, doi. 10.1186/s13053-019-0106-8
By:
- Seppälä, Toni T.;
- Ahadova, Aysel;
- Dominguez-Valentin, Mev;
- Macrae, Finlay;
- Evans, D. Gareth;
- Therkildsen, Christina;
- Sampson, Julian;
- Scott, Rodney;
- Burn, John;
- Möslein, Gabriela;
- Bernstein, Inge;
- Holinski-Feder, Elke;
- Pylvänäinen, Kirsi;
- Renkonen-Sinisalo, Laura;
- Lepistö, Anna;
- Lautrup, Charlotte Kvist;
- Lindblom, Annika;
- Plazzer, John-Paul;
- Winship, Ingrid;
- Tjandra, Douglas
Publication type:
Article
Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report.
Published in:
Hereditary Cancer in Clinical Practice, 2017, p. 1, doi. 10.1186/s13053-017-0078-5
By:
- Seppälä, Toni;
- Pylvänäinen, Kirsi;
- Gareth Evans, Dafydd;
- Järvinen, Heikki;
- Renkonen-Sinisalo, Laura;
- Bernstein, Inge;
- Holinski-Feder, Elke;
- Sala, Paola;
- Lindblom, Annika;
- Macrae, Finlay;
- Blanco, Ignacio;
- Sijmons, Rolf;
- Jeffries, Jacqueline;
- Vasen, Hans;
- Burn, John;
- Nakken, Sigve;
- Hovig, Eivind;
- Rødland, Einar Andreas;
- Tharmaratnam, Kukatharmini;
- de Vos tot Nederveen Cappel, Wouter H.
Publication type:
Article
Distinct Mutational Profile of Lynch Syndrome Colorectal Cancers Diagnosed under Regular Colonoscopy Surveillance.
Published in:
Journal of Clinical Medicine, 2021, v. 10, n. 11, p. 2458, doi. 10.3390/jcm10112458
By:
- Ahadova, Aysel;
- Pfuderer, Pauline Luise;
- Ahtiainen, Maarit;
- Ballhausen, Alexej;
- Bohaumilitzky, Lena;
- Kösegi, Svenja;
- Müller, Nico;
- Tang, Yee Lin;
- Kosmalla, Kosima;
- Witt, Johannes;
- Endris, Volker;
- Stenzinger, Albrecht;
- von Knebel Doeberitz, Magnus;
- Bläker, Hendrik;
- Renkonen-Sinisalo, Laura;
- Lepistö, Anna;
- Böhm, Jan;
- Mecklin, Jukka-Pekka;
- Seppälä, Toni T.;
- Kloor, Matthias
Publication type:
Article
No evidence of EMAST in whole genome sequencing data from 248 colorectal cancers.
Published in:
Genes, Chromosomes & Cancer, 2021, v. 60, n. 7, p. 463, doi. 10.1002/gcc.22941
By:
- Kondelin, Johanna;
- Martin, Samantha;
- Katainen, Riku;
- Renkonen‐Sinisalo, Laura;
- Lepistö, Anna;
- Koskensalo, Selja;
- Böhm, Jan;
- Mecklin, Jukka‐Pekka;
- Cajuso, Tatiana;
- Hänninen, Ulrika A.;
- Välimäki, Niko;
- Ravantti, Janne;
- Rajamäki, Kristiina;
- Palin, Kimmo;
- Aaltonen, Lauri A.
Publication type:
Article
Is there a need for neoadjuvant short-course radiotherapy in T3 rectal cancer with positive lymph node involvement? A single-center retrospective cohort study.
Published in:
World Journal of Surgical Oncology, 2019, v. 17, n. 1, p. N.PAG, doi. 10.1186/s12957-019-1670-0
By:
- Räsänen, Minna;
- Renkonen-Sinisalo, Laura;
- Mustonen, Harri;
- Lepistö, Anna
Publication type:
Article
Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11770-0
By:
- Cajuso, Tatiana;
- Sulo, Päivi;
- Tanskanen, Tomas;
- Katainen, Riku;
- Taira, Aurora;
- Hänninen, Ulrika A.;
- Kondelin, Johanna;
- Forsström, Linda;
- Välimäki, Niko;
- Aavikko, Mervi;
- Kaasinen, Eevi;
- Ristimäki, Ari;
- Koskensalo, Selja;
- Lepistö, Anna;
- Renkonen-Sinisalo, Laura;
- Seppälä, Toni;
- Kuopio, Teijo;
- Böhm, Jan;
- Mecklin, Jukka-Pekka;
- Kilpivaara, Outi
Publication type:
Article
Low anterior resection combined with a covering stoma in the treatment of rectal cancer reduces the risk of permanent anastomotic failure.
Published in:
International Journal of Colorectal Disease, 2015, v. 30, n. 10, p. 1323, doi. 10.1007/s00384-015-2291-x
By:
- Carpelan-Holmström, Monika;
- Renkonen-Sinisalo, Laura;
- Räsänen, Minna;
- Lepistö, Anna
Publication type:
Article
Pattern of rectal cancer recurrence after curative surgery.
Published in:
International Journal of Colorectal Disease, 2015, v. 30, n. 6, p. 775, doi. 10.1007/s00384-015-2182-1
By:
- Räsänen, Minna;
- Carpelan-Holmström, Monika;
- Mustonen, Harri;
- Renkonen-Sinisalo, Laura;
- Lepistö, Anna
Publication type:
Article
Surveillance for endometrial cancer in hereditary nonpolyposis colorectal cancer syndrome.
Published in:
International Journal of Cancer, 2007, v. 120, n. 4, p. 821, doi. 10.1002/ijc.22446
By:
- Renkonen-Sinisalo, Laura;
- Bützow, Ralf;
- Leminen, Arto;
- Lehtovirta, Pentti;
- Mecklin, Jukka-Pekka;
- Järvinen, Heikki J.
Publication type:
Article
Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers.
Published in:
British Journal of Cancer, 2019, v. 120, n. 9, p. 922, doi. 10.1038/s41416-019-0427-4
By:
- Hänninen, Ulrika A.;
- Wirta, Erkki-Ville;
- Katainen, Riku;
- Tanskanen, Tomas;
- Hamberg, Jiri;
- Taipale, Minna;
- Böhm, Jan;
- Renkonen-Sinisalo, Laura;
- Lepistö, Anna;
- Forsström, Linda M.;
- Pitkänen, Esa;
- Palin, Kimmo;
- Seppälä, Toni T.;
- Mäkinen, Netta;
- Mecklin, Jukka-Pekka;
- Aaltonen, Lauri A.
Publication type:
Article
Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers.
Published in:
2019
By:
- Hänninen, Ulrika A;
- Wirta, Erkki-Ville;
- Katainen, Riku;
- Tanskanen, Tomas;
- Hamberg, Jiri;
- Taipale, Minna;
- Böhm, Jan;
- Renkonen-Sinisalo, Laura;
- Lepistö, Anna;
- Forsström, Linda M;
- Pitkänen, Esa;
- Palin, Kimmo;
- Seppälä, Toni T;
- Mäkinen, Netta;
- Mecklin, Jukka-Pekka;
- Aaltonen, Lauri A
Publication type:
journal article
Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer.
Published in:
International Journal of Cancer, 2014, v. 135, n. 3, p. 611, doi. 10.1002/ijc.28705
By:
- Cajuso, Tatiana;
- Hänninen, Ulrika A.;
- Kondelin, Johanna;
- Gylfe, Alexandra E.;
- Tanskanen, Tomas;
- Katainen, Riku;
- Pitkänen, Esa;
- Ristolainen, Heikki;
- Kaasinen, Eevi;
- Taipale, Minna;
- Taipale, Jussi;
- Böhm, Jan;
- Renkonen‐Sinisalo, Laura;
- Mecklin, Jukka‐Pekka;
- Järvinen, Heikki;
- Tuupanen, Sari;
- Kilpivaara, Outi;
- Vahteristo, Pia
Publication type:
Article
Distinct molecular profiles in Lynch syndrome-associated and sporadic ovarian carcinomas.
Published in:
International Journal of Cancer, 2013, v. 133, n. 11, p. 2596, doi. 10.1002/ijc.28287
By:
- Niskakoski, Anni;
- Kaur, Sippy;
- Renkonen‐Sinisalo, Laura;
- Lassus, Heini;
- Järvinen, Heikki J.;
- Mecklin, Jukka‐Pekka;
- Bützow, Ralf;
- Peltomäki, Päivi
Publication type:
Article
3′-UTR poly(T/U) repeat of EWSR1 is altered in microsatellite unstable colorectal cancer with nearly perfect sensitivity.
Published in:
Familial Cancer, 2015, v. 14, n. 3, p. 449, doi. 10.1007/s10689-015-9804-1
By:
- Kondelin, Johanna;
- Tuupanen, Sari;
- Gylfe, Alexandra;
- Aavikko, Mervi;
- Renkonen-Sinisalo, Laura;
- Järvinen, Heikki;
- Böhm, Jan;
- Mecklin, Jukka-Pekka;
- Andersen, Claus;
- Vahteristo, Pia;
- Pitkänen, Esa;
- Aaltonen, Lauri
Publication type:
Article
Utility of computed tomographic colonography in surveillance for hereditary nonpolyposis colorectal cancer syndrome.
Published in:
Familial Cancer, 2007, v. 6, n. 1, p. 135, doi. 10.1007/s10689-007-9116-1
By:
- Laura Renkonen-Sinisalo;
- Arto Kivisaari;
- Leena Kivisaari;
- Seppo Sarna;
- Heikki Järvinen
Publication type:
Article
Eleven Candidate Susceptibility Genes for Common Familial Colorectal Cancer.
Published in:
PLoS Genetics, 2013, v. 9, n. 10, p. 1, doi. 10.1371/journal.pgen.1003876
By:
- Gylfe, Alexandra E.;
- Katainen, Riku;
- Kondelin, Johanna;
- Tanskanen, Tomas;
- Cajuso, Tatiana;
- Hänninen, Ulrika;
- Taipale, Jussi;
- Taipale, Minna;
- Renkonen-Sinisalo, Laura;
- Järvinen, Heikki;
- Mecklin, Jukka-Pekka;
- Kilpivaara, Outi;
- Pitkänen, Esa;
- Vahteristo, Pia;
- Tuupanen, Sari;
- Karhu, Auli;
- Aaltonen, Lauri A.
Publication type:
Article
Desmoid tumor patients carry an elevated risk of familial adenomatous polyposis.
Published in:
Journal of Surgical Oncology, 2016, v. 113, n. 2, p. 209, doi. 10.1002/jso.24117
By:
- Koskenvuo, Laura;
- Peltomäki, Päivi;
- Renkonen‐Sinisalo, Laura;
- Gylling, Annette;
- Nieminen, Taina T.;
- Ristimäki, Ari;
- Lepistö, Anna
Publication type:
Article
DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas.
Published in:
Clinical Epigenetics, 2015, v. 7, n. 1, p. 1, doi. 10.1186/s13148-015-0102-4
By:
- Valo, Satu;
- Kaur, Sippy;
- Ristimäki, Ari;
- Renkonen-Sinisalo, Laura;
- Järvinen, Heikki;
- Mecklin, Jukka-Pekka;
- Nyström, Minna;
- Peltomäki, Päivi
Publication type:
Article

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