Works by Rehwinkel, Jan

Results: 36

PNP inhibitors selectively kill cancer cells lacking SAMHD1.

Published in:

Molecular & Cellular Oncology, 2020, v. 7, n. 6, p. 1, doi. 10.1080/23723556.2020.1804308

By:

Davenne, Tamara;
Rehwinkel, Jan

Publication type:

Article

SAMHD1-dependent retroviral control and escape in mice.

Published in:

EMBO Journal, 2013, v. 32, n. 18, p. 2454, doi. 10.1038/emboj.2013.163

By:

Rehwinkel, Jan;
Maelfait, Jonathan;
Bridgeman, Anne;
Rigby, Rachel;
Hayward, Bruce;
Liberatore, Rachel A;
Bieniasz, Paul D;
Towers, Greg J;
Moita, Luis F;
Crow, Yanick J;
Bonthron, David T;
Reis e Sousa, Caetano

Publication type:

Article

A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay.

Published in:

EMBO Journal, 2007, v. 26, n. 6, p. 1591, doi. 10.1038/sj.emboj.7601588

By:

Behm-Ansmant, Isabelle;
Gatfield, David;
Rehwinkel, Jan;
Hilgers, Valérie;
Izaurralde, Elisa

Publication type:

Article

The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importina.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 10, p. 1001, doi. 10.1038/nsmb833

By:

Jínek, Martin;
Rehwinkel, Jan;
Lazarus, Brooke D;
Izaurralde, Elisa;
Hanover, John A;
Conti, Elena

Publication type:

Article

Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 6, p. 558, doi. 10.1038/nsmb759

By:

Rehwinkel, Jan;
Herold, Andrea;
Gari, Kerstin;
Köcher, Thomas;
Rode, Michaela;
Ciccarelli, Francesca L.;
Wilm, Matthias;
Izaurralde, Elisa

Publication type:

Article

The RNA sensor MDA5 detects SARS-CoV-2 infection.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-92940-3

By:

Sampaio, Natalia G.;
Chauveau, Lise;
Hertzog, Jonny;
Bridgeman, Anne;
Fowler, Gerissa;
Moonen, Jurgen P.;
Dupont, Maeva;
Russell, Rebecca A.;
Noerenberg, Marko;
Rehwinkel, Jan

Publication type:

Article

Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS.

Published in:

EMBO Journal, 2022, v. 41, n. 14, p. 1, doi. 10.15252/embj.2021109217

By:

Hertzog, Jonny;
Zhou, Wen;
Fowler, Gerissa;
Rigby, Rachel E;
Bridgeman, Anne;
Blest, Henry TW;
Cursi, Chiara;
Chauveau, Lise;
Davenne, Tamara;
Warner, Benjamin E;
Kinchington, Paul R;
Kranzusch, Philip J;
Rehwinkel, Jan

Publication type:

Article

SAMHD1‐mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination.

Published in:

EMBO Journal, 2020, v. 39, n. 15, p. 1, doi. 10.15252/embj.2019102931

By:

Husain, Afzal;
Xu, Jianliang;
Fujii, Hodaka;
Nakata, Mikiyo;
Kobayashi, Maki;
Wang, Ji‐Yang;
Rehwinkel, Jan;
Honjo, Tasuku;
Begum, Nasim A

Publication type:

Article

Sensing of viral and endogenous RNA by ZBP1/ DAI induces necroptosis.

Published in:

EMBO Journal, 2017, v. 36, n. 17, p. 2529, doi. 10.15252/embj.201796476

By:

Maelfait, Jonathan;
Liverpool, Layal;
Bridgeman, Anne;
Ragan, Katherine B;
Upton, Jason W;
Rehwinkel, Jan

Publication type:

Article

A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.

Published in:

EMBO Journal, 2017, v. 36, n. 5, p. 604, doi. 10.15252/embj.201696025

By:

Mlcochova, Petra;
Sutherland, Katherine A;
Watters, Sarah A;
Bertoli, Cosetta;
Bruin, Rob AM;
Rehwinkel, Jan;
Neil, Stuart J;
Lenzi, Gina M;
Kim, Baek;
Khwaja, Asim;
Gage, Matthew C;
Georgiou, Christiana;
Chittka, Alexandra;
Yona, Simon;
Noursadeghi, Mahdad;
Towers, Greg J;
Gupta, Ravindra K

Publication type:

Article

B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis.

Published in:

2018

By:

Bénard, Alan;
Sakwa, Imme;
Schierloh, Pablo;
Colom, André;
Mercier, Ingrid;
Tailleux, Ludovic;
Jouneau, Luc;
Boudinot, Pierre;
Al-Saati, Talal;
Lang, Roland;
Rehwinkel, Jan;
Loxton, Andre G.;
Kaufmann, Stefan H. E.;
Anton-Leberre, Véronique;
O'Garra, Anne;
Sasiain, Maria Del Carmen;
Gicquel, Brigitte;
Fillatreau, Simon;
Neyrolles, Olivier;
Hudrisier, Denis

Publication type:

journal article

Human ZBP1 induces cell death‐independent inflammatory signaling via RIPK3 and RIPK1.

Published in:

EMBO Reports, 2022, v. 23, n. 12, p. 1, doi. 10.15252/embr.202255839

By:

Peng, Ruoshi;
Wang, Chris Kedong;
Wang‐Kan, Xuan;
Idorn, Manja;
Kjær, Majken;
Zhou, Felix Y;
Fiil, Berthe Katrine;
Timmermann, Frederik;
Orozco, Susana L;
McCarthy, Julia;
Leung, Carol S;
Lu, Xin;
Bagola, Katrin;
Rehwinkel, Jan;
Oberst, Andrew;
Maelfait, Jonathan;
Paludan, Søren R;
Gyrd‐Hansen, Mads

Publication type:

Article

Inclusion of cGAMP within virus‐like particle vaccines enhances their immunogenicity.

Published in:

EMBO Reports, 2021, v. 22, n. 8, p. 1, doi. 10.15252/embr.202152447

By:

Chauveau, Lise;
Bridgeman, Anne;
Tan, Tiong K;
Beveridge, Ryan;
Frost, Joe N;
Rijal, Pramila;
Pedroza‐Pacheco, Isabela;
Partridge, Thomas;
Gilbert‐Jaramillo, Javier;
Knight, Michael L;
Liu, Xu;
Russell, Rebecca A;
Borrow, Persephone;
Drakesmith, Hal;
Townsend, Alain R;
Rehwinkel, Jan

Publication type:

Article

Regulation and inhibition of the DNA sensor cGAS.

Published in:

EMBO Reports, 2020, v. 21, n. 12, p. 1, doi. 10.15252/embr.202051345

By:

Hertzog, Jonny;
Rehwinkel, Jan

Publication type:

Article

RNA sensing: the more RIG-I the merrier?

Published in:

EMBO Reports, 2013, v. 14, n. 9, p. 751, doi. 10.1038/embor.2013.120

By:

Rehwinkel, Jan

Publication type:

Article

Is anti-viral defence the evolutionary origin of mRNA turnover? (Comment on DOI.

Published in:

BioEssays, 2016, v. 38, n. 9, p. 817, doi. 10.1002/bies.201600140

By:

Rehwinkel, Jan

Publication type:

Article

Keeping your armour intact: How HIV-1 evades detection by the innate immune system.

Published in:

BioEssays, 2014, v. 36, n. 7, p. 649, doi. 10.1002/bies.201400019

By:

Maelfait, Jonathan;
Seiradake, Elena;
Rehwinkel, Jan

Publication type:

Article

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates.

Published in:

Nature, 2014, v. 514, n. 7522, p. 372, doi. 10.1038/nature13590

By:

Goubau, Delphine;
Schlee, Martin;
Deddouche, Safia;
Rehwinkel, Jan;
Pruijssers, Andrea J.;
Iskarpatyoti, Jason A.;
Zillinger, Thomas;
Goldeck, Marion;
Schuberth, Christine;
Barchet, Winfried;
Ludwig, Janos;
Hartmann, Gunther;
Van der Veen, Annemarthe G.;
Reis e Sousa, Caetano;
Fujimura, Tsutomu;
Dermody, Terence S.

Publication type:

Article

Mouse knockout models for HIV-1 restriction factors.

Published in:

Cellular & Molecular Life Sciences, 2014, v. 71, n. 19, p. 3749, doi. 10.1007/s00018-014-1646-8

By:

Rehwinkel, Jan

Publication type:

Article

Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.

Published in:

Life Science Alliance, 2023, v. 6, n. 1, p. 1, doi. 10.26508/lsa.202201449

By:

Moll, Tobias;
Odon, Valerie;
Harvey, Calum;
Collins, Mark O.;
Peden, Andrew;
Franklin, John;
Graves, Emily;
Marshall, Jack N. G.;
dos Santos Souza, Cleide;
Sai Zhang;
Castelli, Lydia;
Hautbergue, Guillaume;
Azzouz, Mimoun;
Gordon, David;
Krogan, Nevan;
Ferraiuolo, Laura;
Snyder, Michael P.;
Shaw, Pamela J.;
Rehwinkel, Jan;
Cooper-Knock, Johnathan

Publication type:

Article

The interferon-inducible GTPase MxB promotes capsid disassembly and genome release of herpesviruses.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.76804

By:

Serrero, Manutea C.;
Girault, Virginie;
Weigang, Sebastian;
Greco, Todd M.;
Ramos-Nascimento, Ana;
Anderson, Fenja;
Piras, Antonio;
Martinez, Ana Hickford;
Hertzog, Jonny;
Binz, Anne;
Pohlmann, Anja;
Prank, Ute;
Rehwinkel, Jan;
Bauerfeind, Rudolf;
Cristea, Ileana M.;
Pichlmair, Andreas;
Kochs, Georg;
Sodeik, Beate

Publication type:

Article

Aicardi-Goutières syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity.

Published in:

Human Molecular Genetics, 2009, v. 18, n. R2, p. R130, doi. 10.1093/hmg/ddp293

By:

Crow, Yanick J.;
Rehwinkel, Jan

Publication type:

Article

Exposing Viruses: RNA Patterns Sensed by RIG-I-like Receptors.

Published in:

Journal of Clinical Immunology, 2010, v. 30, n. 4, p. 491, doi. 10.1007/s10875-010-9384-7

By:

Rehwinkel, Jan

Publication type:

Article

RIG-I Plays a Dominant Role in the Induction of Transcriptional Changes in Zika Virus-Infected Cells, which Protect from Virus-Induced Cell Death.

Published in:

Cells (2073-4409), 2020, v. 9, n. 6, p. 1476, doi. 10.3390/cells9061476

By:

Schilling, Mirjam;
Bridgeman, Anne;
Gray, Nicki;
Hertzog, Jonny;
Hublitz, Philip;
Kohl, Alain;
Rehwinkel, Jan

Publication type:

Article

Hypoxia Regulates Endogenous Double-Stranded RNA Production via Reduced Mitochondrial DNA Transcription.

Published in:

Frontiers in Oncology, 2021, v. 11, p. 1, doi. 10.3389/fonc.2021.779739

By:

Arnaiz, Esther;
Miar, Ana;
Dias Junior, Antonio Gregorio;
Prasad, Naveen;
Schulze, Ulrike;
Waithe, Dominic;
Nathan, James A.;
Rehwinkel, Jan;
Harris, Adrian L.

Publication type:

Article

mRNA quality control: An ancient machinery recognizes and degrades mRNAs with nonsense codons

Published in:

FEBS Letters, 2007, v. 581, n. 15, p. 2845, doi. 10.1016/j.febslet.2007.05.027

By:

Behm-Ansmant, Isabelle;
Kashima, Isao;
Rehwinkel, Jan;
Saulière, Jérôme;
Wittkopp, Nadine;
Izaurralde, Elisa

Publication type:

Article

SAMHD1-dependent retroviral control and escape in mice.

Published in:

2013

By:

Rehwinkel, Jan;
Maelfait, Jonathan;
Rigby, Rachel;
Bridgeman, Anne;
Sousa, Caetano Reis e

Publication type:

Abstract

Genome-Wide Analysis of mRNAs Regulated by Drosha and Argonaute Proteins in Drosophila melanogaster.

Published in:

Molecular & Cellular Biology, 2006, v. 26, n. 8, p. 8, doi. 10.1128/MCB.26.8.2965-2975.2006

By:

Rehwinkel, Jan;
Natalin, Pavel;
Stark, Alexander;
Brennecke, Julius;
Cohen, Stephen M.;
Izaurralde, Elisa

Publication type:

Article

Innate immunology in COVID-19--a living review. Part I: viral entry, sensing and evasion.

Published in:

Oxford Open Immunology, 2020, v. 1, n. 1, p. 1, doi. 10.1093/oxfimm/iqaa004

By:

Coveney, Clarissa;
Tellier, Michel;
Fangfang Lu;
Maleki-Toyserkani, Shayda;
Jones, Ruth;
Bart, Valentina M. T.;
Pring, Ellie;
Alrubayyi, Aljawharah;
Richter, Felix C.;
Scourfield, D. Oliver;
Rehwinkel, Jan;
Rodrigues, Patrícia R. S.;
Davies, Luke C.;
Gea-Mallorquí, Ester

Publication type:

Article

PYHIN proteins: center stage in DNA sensing.

Published in:

Nature Immunology, 2010, v. 11, n. 11, p. 984, doi. 10.1038/ni1110-984

By:

Goubau, Delphine;
Rehwinkel, Jan;
Reis e Sousa, Caetano

Publication type:

Article

Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype.

Published in:

Frontiers in Immunology, 2021, v. 11, p. N.PAG, doi. 10.3389/fimmu.2021.623430

By:

Fraser, Emily;
Denney, Laura;
Antanaviciute, Agne;
Blirando, Karl;
Vuppusetty, Chaitanya;
Zheng, Yuejuan;
Repapi, Emmanouela;
Iotchkova, Valentina;
Taylor, Stephen;
Ashley, Neil;
St Noble, Victoria;
Benamore, Rachel;
Hoyles, Rachel;
Clelland, Colin;
Rastrick, Joseph M. D.;
Hardman, Clare S.;
Alham, Nasullah K.;
Rigby, Rachel E.;
Simmons, Alison;
Rehwinkel, Jan

Publication type:

Article

Deoxyguanosine is a TLR7 agonist.

Published in:

European Journal of Immunology, 2020, v. 50, n. 1, p. 56, doi. 10.1002/eji.201948151

By:

Davenne, Tamara;
Bridgeman, Anne;
Rigby, Rachel E.;
Rehwinkel, Jan

Publication type:

Article

Infection with a Brazilian isolate of Zika virus generates RIG‐I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling.

Published in:

European Journal of Immunology, 2018, v. 48, n. 7, p. 1120, doi. 10.1002/eji.201847483

By:

Hertzog, Jonny;
Dias Junior, Antonio Gregorio;
Rigby, Rachel E.;
Donald, Claire L.;
Mayer, Alice;
Sezgin, Erdinc;
Song, Chaojun;
Jin, Boquan;
Hublitz, Philip;
Eggeling, Christian;
Kohl, Alain;
Rehwinkel, Jan

Publication type:

Article

Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses.

Published in:

European Journal of Immunology, 2015, v. 45, n. 12, p. 3386, doi. 10.1002/eji.201545794

By:

Goubau, Delphine;
der Veen, Annemarthe G.;
Chakravarty, Probir;
Lin, Rongtuan;
Rogers, Neil;
Rehwinkel, Jan;
Deddouche, Safia;
Rosewell, Ian;
Hiscott, John;
Reis e Sousa, Caetano

Publication type:

Article

Fractional response analysis reveals logarithmic cytokine responses in cellular populations.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24449-2

By:

Nienałtowski, Karol;
Rigby, Rachel E.;
Walczak, Jarosław;
Zakrzewska, Karolina E.;
Głów, Edyta;
Rehwinkel, Jan;
Komorowski, Michał

Publication type:

Article

Genome-Wide Identification of Alternative Splice Forms Down-Regulated by Nonsense-Mediated mRNA Decay in Drosophila.

Published in:

PLoS Genetics, 2009, v. 5, n. 6, p. 1, doi. 10.1371/journal.pgen.1000525

By:

Hansen, Kasper Daniel;
Lareau, Liana F.;
Blanchette, Marco;
Green, Richard E.;
Qi Meng;
Rehwinkel, Jan;
Gallusser, Fabian L.;
Izaurralde, Elisa;
Rio, Donald C.;
Dudoit, Sandrine;
Brenner, Steven E.

Publication type:

Article