Works by Reddy, P. Hemachandra

Results: 122

Methods to Study Mitochondria: Techniques Used to Study the Effects of Age‐Related Diseases Including Alzheimer's.

Published in:

Current Protocols, 2023, v. 3, n. 1, p. 1, doi. 10.1002/cpz1.631

By:

Baig, Javaria;
Pradeepkiran, Jangampalli Adi;
Reddy, P. Hemachandra

Publication type:

Article

Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.

Published in:

Nature Genetics, 1998, v. 20, n. 2, p. 198, doi. 10.1038/2510

By:

Reddy, P. Hemachandra;
Williams, Maya;
Charles, Vinod;
Garrett, Lisa;
Pike-Buchanan, Lisa;
Whetsell, William O.;
Miller, Georgina;
Tagle, Danilo A.

Publication type:

Article

Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage.

Published in:

Journal of Cell Biology, 2012, v. 197, n. 4, p. 535, doi. 10.1083/jcb.201110034

By:

Kageyama, Yusuke;
Zhongyan Zhang;
Roda, Ricardo;
Fukaya, Masahiro;
Wakabayashi, Junko;
Wakabayashi, Nobunao;
Kensler, Thomas W.;
Reddy, P. Hemachandra;
Iijima, Miho;
Sesaki, Hiromi

Publication type:

Article

Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases.

Published in:

Cells (2073-4409), 2020, v. 9, n. 6, p. 1345, doi. 10.3390/cells9061345

By:

John, Albin;
Kubosumi, Aaron;
Reddy, P. Hemachandra

Publication type:

Article

Dynamics of Dynamin-Related Protein 1 in Alzheimer's Disease and Other Neurodegenerative Diseases.

Published in:

Cells (2073-4409), 2019, v. 8, n. 9, p. 961, doi. 10.3390/cells8090961

By:

Oliver, Darryll;
Reddy, P. Hemachandra

Publication type:

Article

Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer's Disease.

Published in:

Cells (2073-4409), 2019, v. 8, n. 5, p. 488, doi. 10.3390/cells8050488

By:

Reddy, P. Hemachandra;
Oliver, Darryll MA

Publication type:

Article

Structure Based Design and Molecular Docking Studies for Phosphorylated Tau Inhibitors in Alzheimer's Disease.

Published in:

Cells (2073-4409), 2019, v. 8, n. 3, p. 260, doi. 10.3390/cells8030260

By:

Pradeepkiran, Jangampalli Adi;
Reddy, P. Hemachandra

Publication type:

Article

CART Peptide Is a Potential Endogenous Antioxidant and Preferentially Localized in Mitochondria.

Published in:

PLoS ONE, 2012, v. 7, n. 1, p. 1, doi. 10.1371/journal.pone.0029343

By:

Mao, Peizhong;
Meshul, Charles K.;
Thuillier, Philippe;
Goldberg, Natalie R. S.;
Reddy, P. Hemachandra

Publication type:

Article

Advancing Cancer Immunotherapy: The Potential of mRNA Vaccines As a Promising Therapeutic Approach.

Published in:

Advanced Therapeutics, 2024, v. 7, n. 2, p. 1, doi. 10.1002/adtp.202300255

By:

Goyal, Falak;
Chattopadhyay, Anandini;
Navik, Umashanker;
Jain, Aklank;
Reddy, P. Hemachandra;
Bhatti, Gurjit Kaur;
Bhatti, Jasvinder Singh

Publication type:

Article

Amino acid transporter SLC38A5 is a tumor promoter and a novel therapeutic target for pancreatic cancer.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-43983-1

By:

Sniegowski, Tyler;
Rajasekaran, Devaraja;
Sennoune, Souad R.;
Sunitha, Sukumaran;
Chen, Fang;
Fokar, Mohamed;
Kshirsagar, Sudhir;
Reddy, P. Hemachandra;
Korac, Ksenija;
Mahmud Syed, Mosharaf;
Sharker, Tanima;
Ganapathy, Vadivel;
Bhutia, Yangzom D.

Publication type:

Article

partial reduction of Drp1 improves cognitive behavior and enhances mitophagy, autophagy and dendritic spines in a transgenic Tau mouse model of Alzheimer disease.

Published in:

Human Molecular Genetics, 2022, v. 31, n. 11, p. 1788, doi. 10.1093/hmg/ddab360

By:

Kandimalla, Ramesh;
Manczak, Maria;
Pradeepkiran, Jangampalli Adi;
Morton, Hallie;
Reddy, P Hemachandra

Publication type:

Article

Protective effects of a small-molecule inhibitor DDQ against tau-induced toxicities in a transgenic tau mouse model of Alzheimer's disease.

Published in:

Human Molecular Genetics, 2022, v. 31, n. 7, p. 1022, doi. 10.1093/hmg/ddab285

By:

Vijayan, Murali;
George, Mathew;
Bunquin, Lloyd E;
Bose, Chhanda;
Reddy, P Hemachandra

Publication type:

Article

Protective effects of mitophagy enhancers against amyloid beta-induced mitochondrial and synaptic toxicities in Alzheimer disease.

Published in:

Human Molecular Genetics, 2022, v. 31, n. 3, p. 423, doi. 10.1093/hmg/ddab262

By:

Kshirsagar, Sudhir;
Sawant, Neha;
Morton, Hallie;
Reddy, Arubala P;
Reddy, P Hemachandra

Publication type:

Article

Protective effects of a small molecule inhibitor ligand against hyperphosphorylated tau-induced mitochondrial and synaptic toxicities in Alzheimer disease.

Published in:

Human Molecular Genetics, 2022, v. 31, n. 2, p. 244, doi. 10.1093/hmg/ddab244

By:

Pradeepkiran, Jangampalli Adi;
Munikumar, Manne;
Reddy, Arubala P;
Reddy, P Hemachandra

Publication type:

Article

Selective serotonin reuptake inhibitor citalopram ameliorates cognitive decline and protects against amyloid beta-induced mitochondrial dynamics, biogenesis, autophagy, mitophagy and synaptic toxicities in a mouse model of Alzheimer's disease.

Published in:

Human Molecular Genetics, 2021, v. 30, n. 9, p. 789, doi. 10.1093/hmg/ddab091

By:

Reddy, Arubala P;
Sawant, Neha;
Morton, Hallie;
Kshirsagar, Sudhir;
Bunquin, Lloyd E;
Yin, Xiangling;
Reddy, P Hemachandra

Publication type:

Article

Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer's disease.

Published in:

Human Molecular Genetics, 2021, v. 30, n. 10, p. 847, doi. 10.1093/hmg/ddab054

By:

Reddy, Arubala P;
Yin, Xiangling;
Sawant, Neha;
Reddy, P Hemachandra

Publication type:

Article

Protective effects of BACE1 inhibitory ligand molecules against amyloid beta-induced synaptic and mitochondrial toxicities in Alzheimer's disease.

Published in:

Human Molecular Genetics, 2020, v. 29, n. 1, p. 49, doi. 10.1093/hmg/ddz227

By:

Pradeepkiran, Jangampalli Adi;
Reddy, Arubala P;
Yin, Xiangling;
Manczak, Maria;
Reddy, P Hemachandra

Publication type:

Article

Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity.

Published in:

Human Molecular Genetics, 2019, v. 28, n. 5, p. 875, doi. 10.1093/hmg/ddy399

By:

Manczak, Maria;
Kandimalla, Ramesh;
Yin, Xiangling;
Reddy, P Hemachandra

Publication type:

Article

Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity.

Published in:

Human Molecular Genetics, 2019, v. 28, n. 2, p. 177, doi. 10.1093/hmg/ddy335

By:

Manczak, Maria;
Kandimalla, Ramesh;
Yin, Xiangling;
Reddy, P Hemachandra

Publication type:

Article

Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.

Published in:

Human Molecular Genetics, 2018, v. 27, n. 14, p. 2502, doi. 10.1093/hmg/ddy154

By:

Reddy, P. Hemachandra;
XiangLing Yin;
Manczak, Maria;
Kumar, Subodh;
Pradeepkiran, Jangampalli Adi;
Vijayan, Murali;
Reddy, Arubala P.

Publication type:

Article

Identification of novel circulatory microRNA signatures linked to patients with ischemic stroke.

Published in:

Human Molecular Genetics, 2018, v. 27, n. 13, p. 2318, doi. 10.1093/hmg/ddy136

By:

Vijayan, Murali;
Kumar, Subodh;
Xiangling Yin;
Zafer, Dila;
Chanana, Vishal;
Cengiz, Pelin;
Reddy, P. Hemachandra

Publication type:

Article

Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease.

Published in:

Human Molecular Genetics, 2018, v. 27, n. 8, p. 1332, doi. 10.1093/hmg/ddy042

By:

Manczak, Maria;
Kandimalla, Ramesh;
Xiangling Yin;
Hemachandra Reddy, P.

Publication type:

Article

Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease.

Published in:

Human Molecular Genetics, 2018, v. 27, n. 1, p. 30, doi. 10.1093/hmg/ddx381

By:

Kandimalla, Ramesh;
Manczak, Maria;
Xiangling Yin;
Rui Wang;
Reddy, P. Hemachandra

Publication type:

Article

MicroRNA-455-3p as a potential peripheral biomarker for Alzheimer's disease.

Published in:

Human Molecular Genetics, 2017, v. 26, n. 19, p. 3808, doi. 10.1093/hmg/ddx267

By:

Kumar, Subodh;
Vijayan, Murali;
Reddy, P. Hemachandra

Publication type:

Article

Aqua-soluble DDQ reduces the levels of Drp1 and Aβ and inhibits abnormal interactions between Ab and Drp1 and protects Alzheimer's disease neurons from Aβ- and Drp1-induced mitochondrial and synaptic toxicities.

Published in:

Human Molecular Genetics, 2017, v. 26, n. 17, p. 3375, doi. 10.1093/hmg/ddx226

By:

Kuruva, Chandra Sekhar;
Manczak, Maria;
Xiangling Yin;
Ogunmokun, Gilbert;
Reddy, Arubala P.;
Reddy, P. Hemachandra

Publication type:

Article

Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer's disease.

Published in:

Human Molecular Genetics, 2017, v. 26, n. 8, p. 1483, doi. 10.1093/hmg/ddx052

By:

Reddy, P. Hemachandra;
Manczak, Maria;
Kandimalla, Ramesh

Publication type:

Article

Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.

Published in:

Human Molecular Genetics, 2016, v. 25, n. 23, p. 5148, doi. 10.1093/hmg/ddw330

By:

Manczak, Maria;
Kandimalla, Ramesh;
Fry, David;
Sesaki, Hiromi;
Hemachandra Reddy, P.

Publication type:

Article

Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.

Published in:

Human Molecular Genetics, 2016, v. 25, n. 22, p. 4881, doi. 10.1093/hmg/ddw312

By:

Kandimalla, Ramesh;
Manczak, Maria;
Fry, David;
Suneetha, Yeguvapalli;
Hiromi Sesaki;
Reddy, P. Hemachandra

Publication type:

Article

Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.

Published in:

Human Molecular Genetics, 2016, v. 25, n. 9, p. 1739, doi. 10.1093/hmg/ddw045

By:

Xiangling Yin;
Manczak, Maria;
Reddy, P. Hemachandra

Publication type:

Article

Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease.

Published in:

Human Molecular Genetics, 2015, v. 24, n. 25, p. 7308, doi. 10.1093/hmg/ddv429

By:

Manczak, Maria;
Reddy, P. Hemachandra

Publication type:

Article

How does dancing promote brain reconditioning in the elderly?

Published in:

Frontiers in Aging Neuroscience, 2013, v. 5, p. 1, doi. 10.3389/fnagi.2013.00004

By:

Foster, Philip P.;
Reddy, P. Hemachandra

Publication type:

Article

Cell-Free DNA As Peripheral Biomarker of Alzheimer's Disease.

Published in:

Aging & Disease, 2025, v. 16, n. 2, p. 787, doi. 10.14336/AD.2024.0329

By:

Khemka, Sachi;
Sehar, Ujala;
Manna, Pulak R.;
Kshirsagar, Sudhir;
Reddy, P. Hemachandra

Publication type:

Article

Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer's Disease.

Published in:

Aging & Disease, 2025, v. 16, n. 2, p. 658, doi. 10.14336/AD.2024.0286

By:

Pradeepkiran, Jangampalli Adi;
Baig, Javaria;
Islam, Md Ariful;
Kshirsagar, Sudhir;
Reddy, P. Hemachandra

Publication type:

Article

Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching.

Published in:

Neural Regeneration Research, 2025, v. 20, n. 9, p. 2624, doi. 10.4103/NRR.NRR-D-24-00157

By:

Pradeepkiran, Jangampalli Adi;
Rawat, Priyanka;
Reddy, Arubala P.;
Orlov, Erika;
Reddy, P. Hemachandra

Publication type:

Article

Human Alzheimer's postmortem raphe brain heterogeneity: Single cell RNAseq 10X genomics approach.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.065909

By:

Reddy, Arubala P.;
Peng, Joyce;
Mechref, Yahia;
Reddy, Hemachandra P

Publication type:

Article

Synaptosomal versus cytosolic microRNAs and synapse function in Alzheimer's disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.057307

By:

Kumar, Subodh;
Orlov, Erika;
Reddy, P. Hemachandra

Publication type:

Article

Lower Activation in Frontal Cortex and Posterior Cingulate Cortex Observed during Sex Determination Test in Early-Stage Dementia of the Alzheimer Type.

Published in:

Frontiers in Aging Neuroscience, 2017, v. 9, p. 1, doi. 10.3389/fnagi.2017.00156

By:

Rajmohan, Ravi;
Anderson, Ronald C.;
Dan Fang;
Meyer, Austin G.;
Laengvejkal, Pavis;
Julayanont, Parunyou;
Hannabas, Greg;
Linton, Kitten;
Culberson, John;
Khan, Hafiz;
De Toledo, John;
Reddy, P. Hemachandra;
O'Boyle, Michael W.

Publication type:

Article

White Matter Deterioration May Foreshadow Impairment of Emotional Valence Determination in Early-Stage Dementia of the Alzheimer Type.

Published in:

Frontiers in Aging Neuroscience, 2017, v. 11, p. 1, doi. 10.3389/fnagi.2017.00037

By:

Rajmohan, Ravi;
Anderson, Ronald C.;
Fang, Dan;
Meyer, Austin G.;
Laengvejkal, Pavis;
Julayanont, Parunyou;
Hannabas, Greg;
Linton, Kitten;
Culberson, John;
Khan, Hafiz M. R.;
De Toledo, John;
Reddy, P. Hemachandra;
O'Boyle, Michael

Publication type:

Article

68 and FX2149 Attenuate Mutant LRRK2-R1441C-Induced Neural Transport Impairment.

Published in:

Frontiers in Aging Neuroscience, 2017, v. 8, p. 1, doi. 10.3389/fnagi.2016.00337

By:

Thomas, Joseph M.;
Tianxia Li;
Wei Yang;
Fengtian Xue;
Fishman, Paul S.;
Smith, Wanli W.;
Reddy, P. Hemachandra;
Thomas, Bobby

Publication type:

Article

Impact of Exercise and Education in Adults of Lubbock, Texas: Implications for Better Lifestyle.

Published in:

Frontiers in Aging Neuroscience, 2016, p. 1, doi. 10.3389/fnagi.2016.00085

By:

Boles, Annette N.;
Khan, Hafiz;
Lenzmeier, Taylor A.;
Molinar-Lopez, Veronica A.;
Ament, James C.;
TeBrink, Kate L.;
Stonum, Kathleen;
Gonzales, Ruben M.;
Reddy, P. Hemachandra;
Xuemin Xu;
Swerdlow, Russell H.

Publication type:

Article

Garrison Institute on Aging--Lubbock Retired and Senior Volunteer Program (RSVP) Provides Services to South Plains, Texas.

Published in:

Frontiers in Aging Neuroscience, 2015, p. 1, doi. 10.3389/fnagi.2015.00215

By:

Blackmon, Joan;
Boles, Annette N.;
Reddy, P. Hemachandra

Publication type:

Article

Plasmalemmal VDAC-1 corroborated as amyloid Aß-receptor.

Published in:

2015

By:

Thinnes, Friedrich P.;
Reddy, P. Hemachandra;
Marin, Raquel

Publication type:

Opinion

Role of mitochondria in neurodegenerative diseases: mitochondria as a therapeutic target in Alzheimer's disease.

Published in:

2009

By:

Reddy PH;
Reddy, P Hemachandra

Publication type:

journal article

Abnormal mitochondrial structural and functional changes caused by amyloid beta in Alzheimer's disease

Published in:

2009

By:

Mao, Peizhong;
Manczak, Maria;
Shree, Divya;
Reddy, P. Hemachandra

Publication type:

Abstract

P4-169: Mitochondrially targeted antioxidant therapeutics in Alzheimer's disease

Published in:

2008

By:

Reddy, P. Hemachandra;
Manczak, Maria;
Zhao, Wei

Publication type:

Abstract

Counting on COVID-19 Vaccine: Insights into the Current Strategies, Progress and Future Challenges.

Published in:

Biomedicines, 2021, v. 9, n. 11, p. 1740, doi. 10.3390/biomedicines9111740

By:

Kandimalla, Ramesh;
Chakraborty, Pratik;
Vallamkondu, Jayalakshmi;
Chaudhary, Anupama;
Samanta, Sonalinandini;
Reddy, P. Hemachandra;
De Feo, Vincenzo;
Dewanjee, Saikat

Publication type:

Article

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 23, p. 5131, doi. 10.1093/hmg/dds360

By:

Manczak, Maria;
Reddy, P. Hemachandra

Publication type:

Article

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 13, p. 2973, doi. 10.1093/hmg/dds128

By:

Mao, Peizhong;
Manczak, Maria;
Calkins, Marcus J.;
Truong, Quang;
Reddy, Tejaswini P.;
Reddy, Arubala P.;
Shirendeb, Ulziibat;
Lo, Herng-Hsiang;
Rabinovitch, Peter S.;
Reddy, P. Hemachandra

Publication type:

Article

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 11, p. 2538, doi. 10.1093/hmg/dds072

By:

Manczak, Maria;
Reddy, P. Hemachandra

Publication type:

Article

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 2, p. 406, doi. 10.1093/hmg/ddr475

By:

Shirendeb, Ulziibat P.;
Calkins, Marcus J.;
Manczak, Maria;
Anekonda, Vishwanath;
Dufour, Brett;
McBride, Jodi L.;
Mao, Peizhong;
Reddy, P. Hemachandra

Publication type:

Article