Works by Raynaud, Florence

Results: 35

Exposing 24-hour cycles in bile acids of male humans.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-53673-9

By:

Bello, Adesola T.;
Sarafian, Magali H.;
Wimborne, Elizabeth A.;
Middleton, Benita;
Revell, Victoria L.;
Raynaud, Florence I.;
Chowdhury, Namrata R.;
van der Veen, Daan R.;
Skene, Debra J.;
Swann, Jonathan R.

Publication type:

Article

Assessing histone demethylase inhibitors in cells: lessons learned.

Published in:

Epigenetics & Chromatin, 2017, v. 10, p. 1, doi. 10.1186/s13072-017-0116-6

By:

Hatch, Stephanie B.;
Yapp, Clarence;
Montenegro, Raquel C.;
Savitsky, Pavel;
Gamble, Vicki;
Tumber, Anthony;
Ruda, Gian Filippo;
Bavetsias, Vassilios;
Fedorov, Oleg;
Atrash, Butrus;
Raynaud, Florence;
Lanigan, Rachel;
Carmichael, LeAnne;
Tomlin, Kathy;
Burke, Rosemary;
Westaway, Susan M.;
Brown, Jack A.;
Prinjha, Rab K.;
Martinez, Elisabeth D.;
Oppermann, Udo

Publication type:

Article

A phase I/II study of a 72-h continuous infusion of etoposide in advanced soft tissue sarcoma.

Published in:

Sarcoma, 1997, v. 1, n. 3/4, p. 149, doi. 10.1080/13577149778236

By:

Crawley, Charles R;
Judson, Ian R.;
Verrill, Mark;
Hill, Catherine;
Raynaud, Florence I.

Publication type:

Article

Corrigendum: Drugging the PI3 kinome.

Published in:

2006

By:

Workman, Paul;
Clarke, Paul A;
Guillard, Sandrine;
Raynaud, Florence I

Publication type:

Correction Notice

Drugging the PI3 kinome.

Published in:

Nature Biotechnology, 2006, v. 24, n. 7, p. 794, doi. 10.1038/nbt0706-794

By:

Workman, Paul;
Clarke, Paul A.;
Guillard, Sandrine;
Raynaud, Florence I.

Publication type:

Article

FGF7--FGFR2 autocrine signaling increases growth and chemoresistance of fusion-positive rhabdomyosarcomas.

Published in:

Molecular Oncology, 2022, v. 16, n. 6, p. 1272, doi. 10.1002/1878-0261.13145

By:

Milton, Christopher I.;
Selfe, Joanna;
Aladowicz, Ewa;
Man, Stella Y. K.;
Bernauer, Carolina;
Missiaglia, Edoardo;
Walters, Zoë S.;
Gatz, Susanne A.;
Kelsey, Anna;
Generali, Melanie;
Box, Gary;
Valenti, Melanie;
de Haven-Brandon, Alexis;
Galiwango, David;
Hayes, Angela;
Clarke, Matthew;
Izquierdo, Elisa;
Gonzalez De Castro, David;
Raynaud, Florence I.;
Kirkin, Vladimir

Publication type:

Article

A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity.

Published in:

2020

By:

Kostaras, Eleftherios;
Kaserer, Teresa;
Lazaro, Glorianne;
Heuss, Sara Farrah;
Hussain, Aasia;
Casado, Pedro;
Hayes, Angela;
Yandim, Cihangir;
Palaskas, Nicolaos;
Yu, Yi;
Schwartz, Brian;
Raynaud, Florence;
Chung, Yuen-Li;
Cutillas, Pedro R.;
Vivanco, Igor

Publication type:

journal article

Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy.

Published in:

2017

By:

Faisal, Amir;
Mak, Grace W Y;
Gurden, Mark D;
Xavier, Cristina P R;
Anderhub, Simon J;
Innocenti, Paolo;
Westwood, Isaac M;
Naud, Sébastien;
Hayes, Angela;
Box, Gary;
Valenti, Melanie R;
De Haven Brandon, Alexis K;
O'Fee, Lisa;
Schmitt, Jessica;
Woodward, Hannah L;
Burke, Rosemary;
vanMontfort, Rob L M;
Blagg, Julian;
Raynaud, Florence I;
Eccles, Suzanne A

Publication type:

journal article

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.

Published in:

Angewandte Chemie, 2019, v. 131, n. 2, p. 525, doi. 10.1002/ange.201810179

By:

Vazquez‐Rodriguez, Saleta;
Wright, Miranda;
Rogers, Catherine M.;
Cribbs, Adam P.;
Velupillai, Srikannathasan;
Philpott, Martin;
Lee, Henry;
Dunford, James E.;
Huber, Kilian V. M.;
Robers, Matthew B.;
Vasta, James D.;
Thezenas, Marie‐Laetitia;
Bonham, Sarah;
Kessler, Benedikt;
Bennett, James;
Fedorov, Oleg;
Raynaud, Florence;
Donovan, Adam;
Blagg, Julian;
Bavetsias, Vassilios

Publication type:

Article

Assessing cognitive toxicity in early phase trials ‐ What are we missing?

Published in:

Psycho-Oncology, 2022, v. 31, n. 3, p. 405, doi. 10.1002/pon.5834

By:

Stapleton, Sarah E.;
Darlington, Anne‐Sophie;
Minchom, Anna;
Pal, Abhijit;
Raynaud, Florence;
Wiseman, Theresa

Publication type:

Article

Peritumoral Delivery of Docetaxel‐TIPS Microparticles for Prostate Cancer Adjuvant Therapy.

Published in:

Advanced Therapeutics, 2021, v. 4, n. 2, p. 1, doi. 10.1002/adtp.202000179

By:

Paliashvili, Ketevan;
Popov, Alexander;
Kalber, Tammy L.;
Patrick, P. Stephen;
Hayes, Angela;
Henley, Alan;
Raynaud, Florence I.;
Ahmed, Hashim U.;
Day, Richard M.

Publication type:

Article

Synthesis of a benzoxazinthione derivative of tanaproget and pharmacological evaluation for PET imaging of PR expression.

Published in:

EJNMMI Radiopharmacy & Chemistry, 2019, v. 4, n. 1, p. 1, doi. 10.1186/s41181-018-0054-z

By:

Allott, Louis;
Miranda, Cecilia;
Hayes, Angela;
Raynaud, Florence;
Cawthorne, Christopher;
Smith, Graham

Publication type:

Article

Intracellular Metabolomics Identifies Efflux Transporter Inhibitors in a Routine Caco-2 Cell Permeability Assay—Biological Implications.

Published in:

Cells (2073-4409), 2022, v. 11, n. 20, p. 3286, doi. 10.3390/cells11203286

By:

Naseem, Afia;
Pal, Akos;
Gowan, Sharon;
Asad, Yasmin;
Donovan, Adam;
Temesszentandrási-Ambrus, Csilla;
Kis, Emese;
Gaborik, Zsuzsanna;
Bhalay, Gurdip;
Raynaud, Florence

Publication type:

Article

Correction to: An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.

Published in:

2018

By:

Banerji, Udai;
Sain, Nivedita;
Sharp, Swee Y.;
Valenti, Melanie;
Asad, Yasmin;
Ruddle, Ruth;
Raynaud, Florence;
Walton, Michael;
Eccles, Suzanne A.;
Judson, Ian;
Jackman, Ann L.;
Workman, Paul

Publication type:

Correction Notice

Correction to: An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.

Published in:

2018

By:

Banerji, Udai;
Sain, Nivedita;
Sharp, Swee Y;
Valenti, Melanie;
Asad, Yasmin;
Ruddle, Ruth;
Raynaud, Florence;
Walton, Michael;
Eccles, Suzanne A;
Judson, Ian;
Jackman, Ann L;
Workman, Paul

Publication type:

corrected article

An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.

Published in:

Cancer Chemotherapy & Pharmacology, 2008, v. 62, n. 5, p. 769, doi. 10.1007/s00280-007-0662-x

By:

Banerji, Udai;
Sain, Nivedita;
Sharp, Swee Y.;
Valenti, Melanie;
Asad, Yasmin;
Ruddle, Ruth;
Raynaud, Florence;
Walton, Michael;
Eccles, Suzanne A.;
Judson, Ian;
Jackman, Ann L.;
Workman, Paul

Publication type:

Article

Identification of biliary metabolites of ifosfamide using <sup>31</sup>P magnetic resonance spectroscopy and mass spectrometry.

Published in:

Cancer Chemotherapy & Pharmacology, 2005, v. 56, n. 4, p. 409, doi. 10.1007/s00280-005-1023-2

By:

Payne, Geoffrey S.;
Dzik-Jurasz, Andrzej S. K.;
Mancini, Laura;
Nutley, Bernard;
Raynaud, Florence;
Leach, Martin O.

Publication type:

Article

ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma.

Published in:

Communications Biology, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42003-019-0420-8

By:

Carvalho, Diana;
Taylor, Kathryn R.;
Olaciregui, Nagore Gene;
Molinari, Valeria;
Clarke, Matthew;
Mackay, Alan;
Ruddle, Ruth;
Henley, Alan;
Valenti, Melanie;
Hayes, Angela;
Brandon, Alexis De Haven;
Eccles, Suzanne A.;
Raynaud, Florence;
Boudhar, Aicha;
Monje, Michelle;
Popov, Sergey;
Moore, Andrew S.;
Mora, Jaume;
Cruz, Ofelia;
Vinci, Mara

Publication type:

Article

Application of Meso Scale Technology for the Measurement of Phosphoproteins in Human Tumor Xenografts.

Published in:

Assay & Drug Development Technologies, 2007, v. 5, n. 3, p. 391, doi. 10.1089/adt.2006.044

By:

Sharon M. Gowan;
Anthea Hardcastle;
Albert E. Hallsworth;
Melanie R. Valenti;
Lisa-Jane K. Hunter;
Alexis K. de Haven Brandon;
Michelle D. Garrett;
Florence Raynaud;
Paul Workman;
Wynne Aherne;
Suzanne A. Eccles

Publication type:

Article

Metabolomic changes of the multi (-AGC-) kinase inhibitor AT13148 in cells, mice and patients are associated with NOS regulation.

Published in:

Metabolomics, 2020, v. 16, n. 4, p. 1, doi. 10.1007/s11306-020-01676-0

By:

Pal, Akos;
Asad, Yasmin;
Ruddle, Ruth;
Henley, Alan T.;
Swales, Karen;
Decordova, Shaun;
Eccles, Suzanne A.;
Collins, Ian;
Garrett, Michelle D.;
De Bono, Johann;
Banerji, Udai;
Raynaud, Florence I.

Publication type:

Article

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.

Published in:

Angewandte Chemie International Edition, 2019, v. 58, n. 2, p. 515, doi. 10.1002/anie.201810179

By:

Vazquez‐Rodriguez, Saleta;
Wright, Miranda;
Rogers, Catherine M.;
Cribbs, Adam P.;
Velupillai, Srikannathasan;
Philpott, Martin;
Lee, Henry;
Dunford, James E.;
Huber, Kilian V. M.;
Robers, Matthew B.;
Vasta, James D.;
Thezenas, Marie‐Laetitia;
Bonham, Sarah;
Kessler, Benedikt;
Bennett, James;
Fedorov, Oleg;
Raynaud, Florence;
Donovan, Adam;
Blagg, Julian;
Bavetsias, Vassilios

Publication type:

Article

De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy.

Published in:

Autophagy, 2020, v. 16, n. 6, p. 1044, doi. 10.1080/15548627.2019.1659608

By:

Andrejeva, Gabriela;
Gowan, Sharon;
Lin, Gigin;
Wong Te Fong, Anne-Christine LF;
Shamsaei, Elham;
Parkes, Harry G.;
Mui, James;
Raynaud, Florence I.;
Asad, Yasmin;
Vizcay-Barrena, Gema;
Nikitorowicz-Buniak, Joanna;
Valenti, Melanie;
Howell, Louise;
Fleck, Roland A.;
Martin, Lesley-Ann;
Kirkin, Vladimir;
Leach, Martin O.;
Chung, Yuen-Li

Publication type:

Article

Development and validation of a liquid chromatography/tandem mass spectrometry method for the determination of the novel anticancer agent 17-DMAG in human plasma.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2006, v. 20, n. 19, p. 2845, doi. 10.1002/rcm.2668

By:

Moreno-Farre, Javier;
Asad, Yasmin;
Pacey, Simon;
Workman, Paul;
Raynaud, Florence I.

Publication type:

Article

Overexpression of Bcl.

Published in:

International Journal of Cancer, 2002, v. 97, n. 6, p. 858, doi. 10.1002/ijc.10132

By:

Rogers, Paul M.;
Beale, Philip J.;
Al-Moundhri, Mansour;
Boxall, Frances;
Patterson, Lisa;
Valenti, Melanie;
Raynaud, Florence;
Hobbs, Steve;
Johnston, Stephen;
Kelland, Lloyd R.

Publication type:

Article

Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma.

Published in:

Cell Cycle, 2009, v. 8, n. 3, p. 443, doi. 10.4161/cc.8.3.7643

By:

Guillard, Sandrine;
Clarke, Paul A.;
Poele, Robert te;
Mohri, Zahra;
Bjerke, Lynn;
Valenti, Melanie;
Raynaud, Florence;
Eccles, Suzanne A.;
Workman, Paul

Publication type:

Article

A Phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma.

Published in:

Investigational New Drugs, 2012, v. 30, n. 1, p. 341, doi. 10.1007/s10637-010-9493-4

By:

Pacey, Simon;
Gore, Martin;
Chao, David;
Banerji, Udai;
Larkin, James;
Sarker, Sarah;
Owen, Karen;
Asad, Yasmin;
Raynaud, Florence;
Walton, Mike;
Judson, Ian;
Workman, Paul;
Eisen, Tim

Publication type:

Article

Effect of acute total sleep deprivation on plasma melatonin, cortisol and metabolite rhythms in females.

Published in:

European Journal of Neuroscience, 2020, v. 51, n. 1, p. 366, doi. 10.1111/ejn.14411

By:

Honma, Aya;
Revell, Victoria L.;
Gunn, Pippa J.;
Davies, Sarah K.;
Middleton, Benita;
Raynaud, Florence I.;
Skene, Debra J.

Publication type:

Article

Synthesis and Evaluation of a 2,11-Cembranoid-Inspired Library.

Published in:

Chemistry - A European Journal, 2016, v. 22, n. 16, p. 5657, doi. 10.1002/chem.201505093

By:

Welford, Amanda J;
Caldwell, John J.;
Liu, Manjuan;
Richards, Meirion;
Brown, Nathan;
Lomas, Cara;
Tizzard, Graham J.;
Pitak, Mateusz B.;
Coles, Simon J.;
Eccles, Suzanne A.;
Raynaud, Florence I.;
Collins, Ian

Publication type:

Article

Investigation of metabolites for estimating blood deposition time.

Published in:

International Journal of Legal Medicine, 2018, v. 132, n. 1, p. 25, doi. 10.1007/s00414-017-1638-y

By:

Lech, Karolina;
Liu, Fan;
Davies, Sarah K.;
Ackermann, Katrin;
Ang, Joo Ern;
Middleton, Benita;
Revell, Victoria L.;
Raynaud, Florence J.;
Hoveijn, Igor;
Hut, Roelof A.;
Skene, Debra J.;
Kayser, Manfred

Publication type:

Article

Erratum to: investigation of metabolites for estimating blood deposition time.

Published in:

2018

By:

Lech, Karolina;
Liu, Fan;
Davies, Sarah K.;
Ackermann, Katrin;
Ang, Joo Ern;
Middleton, Benita;
Revell, Victoria L.;
Raynaud, Florence I.;
Hoveijn, Igor;
Hut, Roelof A.;
Skene, Debra J.;
Kayser, Manfred

Publication type:

Erratum

Identification of Human Plasma Metabolites Exhibiting Time-of-Day Variation Using an Untargeted Liquid Chromatography-Mass Spectrometry Metabolomic Approach.

Published in:

Chronobiology International: The Journal of Biological & Medical Rhythm Research, 2012, v. 29, n. 7, p. 868, doi. 10.3109/07420528.2012.699122

By:

Ang, Joo Ern;
Revell, Victoria;
Mann, Anuska;
Mäntele, Simone;
Otway, Daniella T.;
Johnston, Jonathan D.;
Thumser, Alfred E.;
Skene, Debra J.;
Raynaud, Florence

Publication type:

Article

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.20722

By:

Clarke, Paul A.;
Ortiz-Ruiz, Maria-Jesus;
TePoele, Robert;
Adeniji-Popoola, Olajumoke;
Box, Gary;
Court, Will;
Czasch, Stephanie;
El Bawab, Samer;
Esdar, Christina;
Ewan, Ken;
Gowan, Sharon;
De Haven Brandon, Alexis;
Hewitt, Phillip;
Hobbs, Stephen M.;
Kaufmann, Wolfgang;
Mallinger, Aurélie;
Raynaud, Florence;
Roe, Toby;
Rohdich, Felix;
Schiemann, Kai

Publication type:

Article

Presence of human breast cancer xenograft changes the diurnal profile of amino acids in mice.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-04994-6

By:

Junior, Rubens Paula;
Sonehara, Nathália Martins;
Jardim-Perassi, Bruna Victorasso;
Pal, Akos;
Asad, Yasmin;
Almeida Chuffa, Luiz Gustavo;
Chammas, Roger;
Raynaud, Florence I.;
Zuccari, Debora A. P. C.

Publication type:

Article

WNK1 signalling regulates amino acid transport and mTORC1 activity to sustain acute myeloid leukaemia growth.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-59969-8

By:

Duan, Shunlei;
Agger, Karl;
Messling, Jan-Erik;
Nishimura, Koutarou;
Han, Xuerui;
Peña-Rømer, Isabel;
Shliaha, Pavel;
Damhofer, Helene;
Douglas, Max;
Kohli, Manas;
Pal, Akos;
Asad, Yasmin;
Van Dyke, Aaron;
Reilly, Raquel;
Köchl, Robert;
Tybulewicz, Victor L. J.;
Hendrickson, Ronald C.;
Raynaud, Florence I.;
Gallipoli, Paolo;
Poulogiannis, George

Publication type:

Article

Pyrido[3,4- d ]pyrimidin-4(3 H )-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution.

Published in:

Xenobiotica, 2017, v. 47, n. 9, p. 771, doi. 10.1080/00498254.2016.1230245

By:

Hayes, Angela;
Mok, N. Yi;
Liu, Manjuan;
Thai, Ching;
Henley, Alan T.;
Atrash, Butrus;
Lanigan, Rachel M.;
Sejberg, Jemmy;
Le Bihan, Yann-Vaï;
Bavetsias, Vassilios;
Blagg, Julian;
Raynaud, Florence I.

Publication type:

Article