Works by Ravikumar, Brinda

Results: 16

Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer's disease model.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-82658-7

By:

Duan, Lishu;
Hu, Mufeng;
Tamm, Joseph A.;
Grinberg, Yelena Y.;
Shen, Fang;
Chai, Yating;
Xi, Hualin;
Gibilisco, Lauren;
Ravikumar, Brinda;
Gautam, Vivek;
Karran, Eric;
Townsend, Matthew;
Talanian, Robert V.

Publication type:

Article

Plasma membrane contributes to the formation of pre-autophagosomal structures.

Published in:

2010

By:

Ravikumar, Brinda;
Moreau, Kevin;
Jahreiss, Luca;
Puri, Claudia;
Rubinsztein, David C.

Publication type:

Correction Notice

Plasma membrane contributes to the formation of pre-autophagosomal structures.

Published in:

Nature Cell Biology, 2010, v. 12, n. 8, p. 747, doi. 10.1038/ncb2078

By:

Ravikumar, Brinda;
Moreau, Kevin;
Jahreiss, Luca;
Puri, Claudia;
Rubinsztein, David C.

Publication type:

Article

Dynein mutations impair autophagic clearance of aggregate-prone proteins.

Published in:

Nature Genetics, 2005, v. 37, n. 7, p. 771, doi. 10.1038/ng1591

By:

Ravikumar, Brinda;
Acevedo-Arozena, Abraham;
Imarisio, Sara;
Berger, Zdenek;
Vacher, Coralie;
O'Kane, Cahir J.;
Brown, Steve D. M.;
Rubinsztein, David C.

Publication type:

Article

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.

Published in:

Nature Genetics, 2004, v. 36, n. 6, p. 585, doi. 10.1038/ng1362

By:

Ravikumar, Brinda;
Vacher, Coralie;
Berger, Zdenek;
Davies, Janet E.;
Luo, Shouqing;
Oroz, Lourdes G.;
Scaravilli, Francesco;
Easton, Douglas F.;
Duden, Rainer;
O'Kane, Cahir J.;
Rubinsztein, David C.

Publication type:

Article

Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D.

Published in:

Journal of Cell Biology, 2012, v. 196, n. 4, p. 483, doi. 10.1083/jcb.201110114

By:

Moreau, Kevin;
Ravikumar, Brinda;
Puri, Claudia;
Rubinsztein, David C.

Publication type:

Article

α-Synuclein impairs macroautophagy: implications for Parkinson's disease.

Published in:

Journal of Cell Biology, 2010, v. 190, n. 6, p. 1023, doi. 10.1083/jcb.201003122

By:

Winslow, Ashley R.;
Chen, Chien-Wen;
Corrochano, Silvia;
Acevedo-Arozena, Abraham;
Gordon, David E.;
Peden, Andrew A.;
Lichtenberg, Maike;
Menzies, Fiona M.;
Ravikumar, Brinda;
Imarisio, Sara;
Brown, Steve;
O'Kane, Cahir J.;
Rubinsztein, David C.

Publication type:

Article

Palmitoylation of huntingtin by HIP14is essential for its trafficking and function.

Published in:

Nature Neuroscience, 2006, v. 9, n. 6, p. 824, doi. 10.1038/nn1702

By:

Yanai, Anat;
Kun Huang;
Rujun Kang;
Singaraja, Roshni R.;
Arstikaitis, Pamela;
Lu Gan;
Orban, Paul C.;
Mullard, Asher;
Cowan, Catherine M.;
Raymond, Lynn A.;
Drisdel, Renaldo C.;
Green, William N.;
Ravikumar, Brinda;
Rubinsztein, David C.;
El-Husseini, Alaa;
Hayden, Michael R.

Publication type:

Article

Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy.

Published in:

Nature Communications, 2015, v. 6, n. 8, p. 8045, doi. 10.1038/ncomms9045

By:

Moreau, Kevin;
Ghislat, Ghita;
Hochfeld, Warren;
Renna, Maurizio;
Zavodszky, Eszter;
Runwal, Gautam;
Puri, Claudia;
Lee, Shirley;
Siddiqi, Farah;
Menzies, Fiona M.;
Ravikumar, Brinda;
Rubinsztein, David C.

Publication type:

Article

Broad proteomics analysis of seeding-induced aggregation of α-synuclein in M83 neurons reveals remodeling of proteostasis mechanisms that might contribute to Parkinson's disease pathogenesis.

Published in:

Molecular Brain, 2024, v. 17, n. 1, p. 1, doi. 10.1186/s13041-024-01099-1

By:

Lumpkin, Casey J.;
Patel, Hiral;
Potts, Gregory K.;
Chaurasia, Shilpi;
Gibilisco, Lauren;
Srivastava, Gyan P.;
Lee, Janice Y.;
Brown, Nathan J.;
Amarante, Patricia;
Williams, Jon D.;
Karran, Eric;
Townsend, Matthew;
Woods, Dori;
Ravikumar, Brinda

Publication type:

Article

IGF-1 receptor antagonism inhibits autophagy.

Published in:

Human Molecular Genetics, 2013, v. 22, n. 22, p. 4528, doi. 10.1093/hmg/ddt300

By:

Renna, Maurizio;
Bento, Carla F.;
Fleming, Angeleen;
Menzies, Fiona M.;
Siddiqi, Farah H.;
Ravikumar, Brinda;
Puri, Claudia;
Garcia-Arencibia, Moises;
Sadiq, Oana;
Corrochano, Silvia;
Carter, Sarah;
Brown, Steve D.M.;
Acevedo-Arozena, Abraham;
Rubinsztein, David C.

Publication type:

Article

P4‐670: DISCOVERING ALZHEIMER'S DISEASE NETWORKS IN ACCELERATING MEDICINES PARTNERSHIP – ALZHEIMER'S DISEASE DATASETS.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1588, doi. 10.1016/j.jalz.2019.09.036

By:

Srivastava, Gyan P.;
Ravikumar, Brinda;
Bi, Yingtao;
Mishra, Smriti;
Das, Amit;
Shah, Mohammad I.;
Kamaraj, Balu;
Bhattacharyya, Amitava;
Philip, Philge;
Devanarayan, Viswanath;
Bannon, Anthony W.;
Das, Sudeshna;
Xi, Simon;
Townsend, Matt

Publication type:

Article

Rapamycin pre-treatment protects against apoptosis.

Published in:

Human Molecular Genetics, 2006, v. 15, n. 7, p. 1209, doi. 10.1093/hmg/ddl036

By:

Ravikumar, Brinda;
Berger, Zdenek;
Vacher, Coralie;
O'Kane, Cahir J.;
Rubinsztein, David C.

Publication type:

Article

Rapamycin alleviates toxicity of different aggregate-prone proteins.

Published in:

Human Molecular Genetics, 2006, v. 15, n. 3, p. 433, doi. 10.1093/hmg/ddi458

By:

Berger, Zdenek;
Ravikumar, Brinda;
Menzies, Fiona M.;
Oroz, Lourdes Garcia;
Underwood, Benjamin R.;
Pangalos, Menelas N.;
Schmitt, Ina;
Wullner, Ullrich;
Evert, Bernd O.;
O'Kane, Cahir J.;
Rubinsztein, David C.

Publication type:

Article

Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy.

Published in:

Human Molecular Genetics, 2003, v. 12, n. 9, p. 985, doi. 10.1093/hmg/ddg109

By:

Ravikumar, Brinda;
Stewart, Abigail;
Kita, Hiroko;
Kato, Kikuya;
Duden, Rainer;
Rubinsztein, David C.

Publication type:

Article

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy.

Published in:

Human Molecular Genetics, 2002, v. 11, n. 9, p. 1107, doi. 10.1093/hmg/11.9.1107

By:

Ravikumar, Brinda;
Duden, Rainer;
Rubinsztein, David C.

Publication type:

Article