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Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma.
- Published in:
- Life Science Alliance, 2023, v. 6, n. 4, p. 1, doi. 10.26508/lsa.202201756
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- Publication type:
- Article
A global view of the aspiring physician-scientist.
- Published in:
- 2022
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- Publication type:
- Interview
Publisher Correction: Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation.
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- 2022
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- Publication type:
- Correction Notice
Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation.
- Published in:
- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-021-03968-4
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- Publication type:
- Article
Harveian Oration 2020: Elucidation of molecular oxygen sensing mechanisms in human cells: implications for medicine.
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- Clinical Medicine, 2022, v. 22, n. 1, p. 23, doi. 10.7861/clinmed.ed.22.1.harv
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- Publication type:
- Article
Corrigendum: Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.
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- Human Molecular Genetics, 2021, v. 30, n. 9, p. 844, doi. 10.1093/hmg/ddab037
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- Publication type:
- Article
Erratum. Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion. Diabetes 2015;64:733-745.
- Published in:
- 2021
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- Publication type:
- Correction Notice
Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control.
- Published in:
- 2020
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- Publication type:
- journal article
Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors.
- Published in:
- ChemMedChem, 2020, v. 15, n. 3, p. 270, doi. 10.1002/cmdc.201900557
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- Publication type:
- Article
Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4.
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- Science Signaling, 2020, v. 13, n. 615, p. 1, doi. 10.1126/scisignal.aba1302
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- Publication type:
- Article
Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin.
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- EMBO Reports, 2019, v. 20, n. 1, p. N.PAG, doi. 10.15252/embr.201846401
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- Publication type:
- Article
PHD2 inactivation in Type I cells drives HIF‐2α‐dependent multilineage hyperplasia and the formation of paraganglioma‐like carotid bodies.
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- Journal of Physiology, 2018, v. 596, n. 18, p. 4393, doi. 10.1113/JP275996
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- Publication type:
- Article
Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.
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- PLoS Genetics, 2017, v. 13, n. 7, p. 1, doi. 10.1371/journal.pgen.1006872
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- Publication type:
- Article
Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters.
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- EMBO Reports, 2016, v. 17, n. 10, p. 1410, doi. 10.15252/embr.201642198
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- Publication type:
- Article
Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer.
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- Nature Communications, 2016, v. 7, n. 10, p. 13183, doi. 10.1038/ncomms13183
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- Publication type:
- Article
Pathways for Oxygen Regulation and Homeostasis: The 2016 Albert Lasker Basic Medical Research Award.
- Published in:
- 2016
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- Publication type:
- journal article
On the pivotal role of PPARa in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.
- Published in:
- FASEB Journal, 2016, v. 30, n. 8, p. 2684, doi. 10.1096/fj.201500094R
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- Publication type:
- Article
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
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- Nature Communications, 2016, v. 7, n. 8, p. 12673, doi. 10.1038/ncomms12673
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- Publication type:
- Article
Clinical iron deficiency disturbs normal human responses to hypoxia.
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- 2016
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- Publication type:
- journal article
Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathway.
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- Journal of Physiology, 2016, v. 594, n. 5, p. 1179, doi. 10.1113/JP271050
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- Publication type:
- Article
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.
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- PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0132004
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- Publication type:
- Article
Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion.
- Published in:
- Diabetes, 2015, v. 64, n. 3, p. 733, doi. 10.2337/db14-0233
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- Publication type:
- Article
Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2.
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- EMBO Reports, 2014, v. 15, n. 1, p. 70, doi. 10.1002/embr.201337642
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- Publication type:
- Article
Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.
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- Journal of Physiology, 2013, v. 591, n. 14, p. 3565, doi. 10.1113/jphysiol.2012.247254
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- Publication type:
- Article
Dynamic regulatory network controlling T<sub>H</sub>17 cell differentiation.
- Published in:
- Nature, 2013, v. 496, n. 7446, p. 461, doi. 10.1038/nature11981
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- Publication type:
- Article
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer.
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- Journal of Physiology, 2013, v. 591, n. 8, p. 2027, doi. 10.1113/jphysiol.2013.251470
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- Publication type:
- Article
Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice.
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- Journal of Physiology, 2012, v. 590, n. 16, p. 4079, doi. 10.1113/jphysiol.2012.232884
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- Publication type:
- Article
Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors.
- Published in:
- Angewandte Chemie, 2012, v. 124, n. 27, p. 6776, doi. 10.1002/ange.201202000
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- Publication type:
- Article
Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors.
- Published in:
- Angewandte Chemie International Edition, 2012, v. 51, n. 27, p. 6672, doi. 10.1002/anie.201202000
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- Publication type:
- Article
Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.
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- Nature Genetics, 2012, v. 44, n. 4, p. 420, doi. 10.1038/ng.2204
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- Publication type:
- Article
The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.
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- EMBO Reports, 2012, v. 13, n. 3, p. 251, doi. 10.1038/embor.2012.9
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- Publication type:
- Article
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
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- Nature Cell Biology, 2012, v. 14, n. 2, p. 201, doi. 10.1038/ncb2424
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- Publication type:
- Article
Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation.
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- FASEB Journal, 2011, v. 25, n. 6, p. 2001, doi. 10.1096/fj.10-177378
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- Publication type:
- Article
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
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- EMBO Reports, 2011, v. 12, n. 5, p. 463, doi. 10.1038/embor.2011.43
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- Publication type:
- Article
Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.
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- FEBS Journal, 2011, v. 278, n. 7, p. 1086, doi. 10.1111/j.1742-4658.2011.08022.x
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- Publication type:
- Article
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.
- Published in:
- 2011
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- Publication type:
- journal article
The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens.
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- EMBO Reports, 2011, v. 12, n. 1, p. 63, doi. 10.1038/embor.2010.170
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- Publication type:
- Article
Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia- Inducible Factor 1α (HIF-1α).
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- PLoS ONE, 2011, v. 6, n. 1, p. 1, doi. 10.1371/journal.pone.0016210
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- Publication type:
- Article
Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.
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- Human Molecular Genetics, 2010, v. 19, n. 19, p. 3844, doi. 10.1093/hmg/ddq305
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- Publication type:
- Article
PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nε-dimethyl lysine demethylase.
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- Human Molecular Genetics, 2010, v. 19, n. 2, p. 217, doi. 10.1093/hmg/ddp480
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- Publication type:
- Article
Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials.
- Published in:
- 2009
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- Publication type:
- journal article
Effects of Iron Supplementation and Depletion on Hypoxic Pulmonary Hypertension.
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- JAMA: Journal of the American Medical Association, 2009, v. 302, n. 13, p. 1444, doi. 10.1001/jama.2009.1404
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- Publication type:
- Article
FIH-Dependent Asparaginyl Hydroxylation of Ankyrin Repeat Domain-Containing Proteins.
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- Annals of the New York Academy of Sciences, 2009, v. 1177, n. 1, p. 9, doi. 10.1111/j.1749-6632.2009.05042.x
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- Publication type:
- Article
Angiogenesis: escape from hypoxia.
- Published in:
- Nature Medicine, 2009, v. 15, n. 5, p. 491, doi. 10.1038/nm0509-491
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- Publication type:
- Article
The increase in pulmonary arterial pressure caused by hypoxia depends on iron status.
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- Journal of Physiology, 2008, v. 586, n. 24, p. 5999, doi. 10.1113/jphysiol.2008.160960
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- Publication type:
- Article
Molecular mechanisms of carbonic anhydrase IX-mediated pH regulation under hypoxia.
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- BJU International, 2008, v. 101, p. 8, doi. 10.1111/j.1464-410X.2008.07642.x
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- Publication type:
- Article
The human side of hypoxia-inducible factor.
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- British Journal of Haematology, 2008, v. 141, n. 3, p. 325, doi. 10.1111/j.1365-2141.2008.07029.x
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- Publication type:
- Article
Cellular oxygen sensing in health and disease.
- Published in:
- Pediatric Nephrology, 2008, v. 23, n. 5, p. 681, doi. 10.1007/s00467-007-0632-x
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- Publication type:
- Article
HIF-1 and HIF-2: working alone or together in hypoxia?
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- Journal of Clinical Investigation, 2007, v. 117, n. 4, p. 862, doi. 10.1172/JCI31750
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- Publication type:
- Article
Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology.
- Published in:
- 2006
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- Publication type:
- journal article