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Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics.
- Published in:
- eLife, 2016, p. 1, doi. 10.7554/eLife.12977
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- Publication type:
- Article
Tuning protein autoinhibition by domain destabilization.
- Published in:
- Nature Structural & Molecular Biology, 2011, v. 18, n. 5, p. 550, doi. 10.1038/nsmb.2039
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- Publication type:
- Article
Azidohomoalanine: A Conformationally Sensitive IR Probe of Protein Folding, Protein Structure, and Electrostatics.
- Published in:
- Angewandte Chemie, 2010, v. 122, n. 41, p. 7635, doi. 10.1002/ange.201003325
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- Publication type:
- Article
The islet tissue plasminogen activator/plasmin system is upregulated with human islet amyloid polypeptide aggregation and protects beta cells from aggregation-induced toxicity.
- Published in:
- Diabetologia, 2024, v. 67, n. 9, p. 1897, doi. 10.1007/s00125-024-06161-0
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- Publication type:
- Article
Islet amyloid polypeptide aggregation exerts cytotoxic and proinflammatory effects on the islet vasculature in mice.
- Published in:
- Diabetologia, 2022, v. 65, n. 10, p. 1687, doi. 10.1007/s00125-022-05756-9
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- Publication type:
- Article
Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised mouse islets in vitro.
- Published in:
- Diabetologia, 2020, v. 63, n. 11, p. 2385, doi. 10.1007/s00125-020-05232-2
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- Publication type:
- Article
Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology.
- Published in:
- Journal of Diabetes Research, 2015, p. 1, doi. 10.1155/2016/2798269
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- Publication type:
- Article
General Amyloid Inhibitors? A Critical Examination of the Inhibition of IAPP Amyloid Formation by Inositol Stereoisomers.
- Published in:
- PLoS ONE, 2014, v. 9, n. 9, p. 1, doi. 10.1371/journal.pone.0104023
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- Publication type:
- Article
Analysis of electrostatic interactions in the denatured state ensemble of the N-terminal domain of L9 under native conditions.
- Published in:
- Proteins, 2011, v. 79, n. 12, p. 3500, doi. 10.1002/prot.23145
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- Publication type:
- Article
A protein dissection study demonstrates that two specific hydrophobic clusters play a key role in stabilizing the core structure of the molten globule state of human α-lactalbumin.
- Published in:
- Proteins, 2001, v. 42, n. 2, p. 237, doi. 10.1002/1097-0134(20010201)42:2<237::AID-PROT110>3.0.CO;2-B
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- Publication type:
- Article
Solution structure of a peptide model of a region important for the folding of α-lactalbumin provides evidence for the formation of nonnative structure in the denatured state.
- Published in:
- Proteins, 2000, v. 38, n. 2, p. 189, doi. 10.1002/(SICI)1097-0134(20000201)38:2<189::AID-PROT7>3.0.CO;2-F
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- Publication type:
- Article
NMR Studies of Methanogens: What Good Is a Cyclic Pyrophosphate?a.
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- Annals of the New York Academy of Sciences, 1987, v. 508, n. 1, p. 16, doi. 10.1111/j.1749-6632.1987.tb32891.x
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- Publication type:
- Article
Local control of peptide conformation: Stabilization of cis proline peptide bonds by aromatic proline interactions.
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- Biopolymers, 1998, v. 45, n. 5, p. 381, doi. 10.1002/(SICI)1097-0282(19980415)45:5<381::AID-BIP6>3.0.CO;2-H
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- Publication type:
- Article
The triphenylmethane dye brilliant blue G is only moderately effective at inhibiting amyloid formation by human amylin or at disaggregating amylin amyloid fibrils, but interferes with amyloid assays; Implications for inhibitor design.
- Published in:
- PLoS ONE, 2019, v. 14, n. 8, p. 1, doi. 10.1371/journal.pone.0219130
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- Publication type:
- Article
Thermodynamic genetics of the folding of the B1 immunoglobulin-binding domain from streptococcal protein G.
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- Proteins, 1995, v. 21, n. 1, p. 11, doi. 10.1002/prot.340210103
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- Publication type:
- Article
RAGE binds preamyloid IAPP intermediates and mediates pancreatic β cell proteotoxicity.
- Published in:
- 2018
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- Publication type:
- journal article
Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology.
- Published in:
- Disease Markers, 2015, p. 1, doi. 10.1155/2016/2798269
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- Publication type:
- Article
Conformational analysis of peptide fragments derived from the peripheral subunit-binding domain from the pyruvate dehydrogenase multienzyme complex of Bacillus stearothermophilus: Evidence for nonrandom structure in the unfolded state.
- Published in:
- Biopolymers, 1999, v. 49, n. 1, p. 29, doi. 10.1002/(SICI)1097-0282(199901)49:1<29::AID-BIP4>3.0.CO;2-7
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- Publication type:
- Article
Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity.
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- FEBS Letters, 2013, v. 587, n. 8, p. 1106, doi. 10.1016/j.febslet.2013.01.046
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- Publication type:
- Article
Phosphorus-31 magnetic resonance imaging of hydroxyapatite: A model for bone imaging.
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- Magnetic Resonance in Medicine, 1992, v. 25, n. 1, p. 1, doi. 10.1002/mrm.1910250102
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- Publication type:
- Article
Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry.
- Published in:
- Nature Chemistry, 2015, v. 7, n. 1, p. 73, doi. 10.1038/nchem.2129
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- Publication type:
- Article
Two-dimensional infrared spectroscopy reveals the complex behaviour of an amyloid fibril inhibitor.
- Published in:
- Nature Chemistry, 2012, v. 4, n. 5, p. 355, doi. 10.1038/nchem.1293
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- Publication type:
- Article
Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers.
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- Protein Science: A Publication of the Protein Society, 2012, v. 21, n. 3, p. 373, doi. 10.1002/pro.2023
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- Publication type:
- Article
Native like structure in the unfolded state of the villin headpiece helical subdomain, an ultrafast folding protein.
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- Protein Science: A Publication of the Protein Society, 2009, v. 18, n. 8, p. 1692, doi. 10.1002/pro.152
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- Publication type:
- Article
A comparative study of the α-subdomains of bovine and human α-lactalbumin reveals key differences that correlate with molten globule stability.
- Published in:
- Protein Science: A Publication of the Protein Society, 2005, v. 14, n. 1, p. 89, doi. 10.1110/ps.04977905
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- Publication type:
- Article
Low levels of asparagine deamidation can have a dramatic effect on aggregation of amyloidogenic peptides: Implications for the study of amyloid formation.
- Published in:
- Protein Science: A Publication of the Protein Society, 2002, v. 11, n. 2, p. 342, doi. 10.1110/ps.48702
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- Publication type:
- Article
The failure of simple empirical relationships to predict the viscosity of mixed aqueous solutions of guanidine hydrochloride and glucose has important implications for the study of protein folding.
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- Protein Science: A Publication of the Protein Society, 2000, v. 9, n. 8, p. 1601
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- Publication type:
- Article
Global analysis of the thermal and chemical denaturation of the N-terminal domain of the ribosomal protein L9 in H<sub>2</sub>O and D<sub>2</sub>O. Determination of the thermodynamic parameters, Δ H°, Δ S°, and Δ C°<sub>p</sub>, and evaluation of solvent isotope effects
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- Protein Science: A Publication of the Protein Society, 1998, v. 7, n. 11, p. 2405, doi. 10.1002/pro.5560071118
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- Publication type:
- Article
Amide proton exchange measurements as a probe of the stability and dynamics of the N-terminal domain of the ribosomal protein L9: Comparison with the intact protein
- Published in:
- Protein Science: A Publication of the Protein Society, 1998, v. 7, n. 9, p. 1994
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- Publication type:
- Article
Identification of the epitopes of calcitonin gene-related peptide (CGRP) for two anti-CGRP monoclonal antibodies by 2D NMR.
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- Protein Science: A Publication of the Protein Society, 1997, v. 6, n. 9, p. 1945, doi. 10.1002/pro.5560060915
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- Publication type:
- Article
Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction.
- Published in:
- Nature Chemical Biology, 2011, v. 7, n. 2, p. 113, doi. 10.1038/nchembio.501
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- Publication type:
- Article
The Fluorescent Amino Acid p-Cyanophenylalanine Provides an Intrinsic Probe of Amyloid Formation.
- Published in:
- ChemBioChem, 2008, v. 9, n. 9, p. 1372, doi. 10.1002/cbic.200800052
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- Publication type:
- Article
Evolutionary Adaptation and Amyloid Formation: Does the Reduced Amyloidogenicity and Cytotoxicity of Ursine Amylin Contribute to the Metabolic Adaption of Bears and Polar Bears?
- Published in:
- Israel Journal of Chemistry, 2017, v. 57, n. 7/8, p. 750, doi. 10.1002/ijch.201600081
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- Publication type:
- Article
Azidohomoalanine: A Conformationally Sensitive IR Probe of Protein Folding, Protein Structure, and Electrostatics.
- Published in:
- Angewandte Chemie International Edition, 2010, v. 49, n. 41, p. 7473, doi. 10.1002/anie.201003325
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- Publication type:
- Article
A critical assessment of the role of helical intermediates in amyloid formation by natively unfolded proteins and polypeptides.
- Published in:
- PEDS: Protein Engineering, Design & Selection, 2009, v. 22, n. 8, p. 453, doi. 10.1093/protein/gzp036
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- Publication type:
- Article
On the plasticity of amyloid formation: The impact of destabilizing small to large substitutions on islet amyloid polypeptide amyloid formation.
- Published in:
- Protein Science: A Publication of the Protein Society, 2023, v. 32, n. 2, p. 1, doi. 10.1002/pro.4539
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- Publication type:
- Article
Differential effects of serine side chain interactions in amyloid formation by islet amyloid polypeptide.
- Published in:
- Protein Science: A Publication of the Protein Society, 2020, v. 29, n. 2, p. 555, doi. 10.1002/pro.3782
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- Publication type:
- Article
The dye SYPRO orange binds to amylin amyloid fibrils but not pre-fibrillar intermediates.
- Published in:
- Protein Science: A Publication of the Protein Society, 2016, v. 25, n. 10, p. 1834, doi. 10.1002/pro.2992
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- Publication type:
- Article
Neprilysin Is Required for Angiotensin-(1-7)'s Ability to Enhance Insulin Secretion via Its Proteolytic Activity to Generate Angiotensin-(1-2).
- Published in:
- 2017
- By:
- Publication type:
- journal article