Works by Rakyan, Vardhman K.

Results: 31

The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans.

Published in:

Genome Biology, 2015, v. 16, n. 1, p. 1, doi. 10.1186/s13059-015-0748-4

By:

Lowe, Robert;
Overhoff, Marita G.;
Ramagopalan, Sreeram V.;
Garbe, James C.;
Koh, James;
Stampfer, Martha R.;
Beach, David H.;
Rakyan, Vardhman K.;
Bishop, Cleo L.

Publication type:

Article

Inactive or moderately active human promoters are enriched for inter-individual epialleles.

Published in:

Genome Biology, 2013, v. 14, n. 5, p. 1, doi. 10.1186/gb-2013-14-5-r43

By:

Gemma, Carolina;
Ramagopalan, Sreeram V.;
Down, Thomas A.;
Beyan, Huriya;
Hawa, Mohammed I.;
Holland, Michelle L.;
Hurd, Paul J.;
Giovannoni, Gavin;
Leslie, R. David;
Ebers, George C.;
Rakyan, Vardhman K.

Publication type:

Article

Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development.

Published in:

BMC Genomics, 2015, v. 16, n. 1, p. 1, doi. 10.1186/s12864-015-1506-4

By:

Lowe, Robert;
Gemma, Carolina;
Rakyan, Vardhman K.;
Holland, Michelle L.

Publication type:

Article

Ribosomal DNA copy number is associated with body mass in humans and other mammals.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49397-5

By:

Law, Pui Pik;
Mikheeva, Liudmila A.;
Rodriguez-Algarra, Francisco;
Asenius, Fredrika;
Gregori, Maria;
Seaborne, Robert A. E.;
Yildizoglu, Selin;
Miller, James R. C.;
Tummala, Hemanth;
Mesnage, Robin;
Antoniou, Michael N.;
Li, Weilong;
Tan, Qihua;
Hillman, Sara L.;
Rakyan, Vardhman K.;
Williams, David J.;
Holland, Michelle L.

Publication type:

Article

Author Correction: The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans.

Published in:

2024

By:

Lowe, Robert;
Overhoff, Marita G.;
Ramagopalan, Sreeram V.;
Garbe, James C.;
Koh, James;
Stampfer, Martha R.;
Beach, David H.;
Rakyan, Vardhman K.;
Bishop, Cleo L.

Publication type:

Correction Notice

Correlation of an epigenetic mitotic clock with cancer risk.

Published in:

Genome Biology, 2016, v. 17, p. 1, doi. 10.1186/s13059-016-1064-3

By:

Zhen Yang;
Andrew Wong;
Diana Kuh;
Paul, Dirk S.;
Rakyan, Vardhman K.;
Leslie, R. David;
Zheng, Shijie C.;
Widschwendter, Martin;
Beck, Stephan;
Teschendorff, Andrew E.

Publication type:

Article

DNA methylation profiling of human chromosomes 6, 20 and 22.

Published in:

Nature Genetics, 2006, v. 38, n. 12, p. 1378, doi. 10.1038/ng1909

By:

Eckhardt, Florian;
Lewin, Joern;
Cortese, Rene;
Rakyan, Vardhman K.;
Attwood, John;
Burger, Matthias;
Burton, John;
Cox, Tony V.;
Davies, Rob;
Down, Thomas A.;
Haefliger, Carolina;
Horton, Roger;
Howe, Kevin;
Jackson, David K.;
Kunde, Jan;
Koenig, Christoph;
Liddle, Jennifer;
Niblett, David;
Otto, Thomas;
Pettett, Roger

Publication type:

Article

The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations.

Published in:

PLoS Genetics, 2020, v. 16, n. 10, p. 1, doi. 10.1371/journal.pgen.1009035

By:

Åsenius, Fredrika;
Gorrie-Stone, Tyler J.;
Brew, Ama;
Panchbhaya, Yasmin;
Williamson, Elizabeth;
Schalkwyk, Leonard C.;
Rakyan, Vardhman K.;
Holland, Michelle L.;
Marzi, Sarah J.;
Williams, David J.

Publication type:

Article

Transgenerational inheritance of non-genetically determined phenotypes.

Published in:

Biochemical Society Transactions, 2013, v. 41, n. 3, p. 769, doi. 10.1042/BST20130043

By:

Holland, Michelle L.;
Rakyan, Vardhman K.

Publication type:

Article

DNA Methylation Profiling of the Human Major Histocompatibility Complex: A Pilot Study for the Human Epigenome Project.

Published in:

PLoS Biology, 2004, v. 2, n. 12, p. 2170, doi. 10.1371/journal.pbio.0020405

By:

Rakyan, Vardhman K.;
Hildmann, Thomas;
Novik, Karen L.;
Lewin, Jörn;
Tost, Jörg;
Cox, Antony V.;
Andrews, T. Dan;
Howe, Kevin L.;
Otto, Thomas;
Olek, Alexander;
Fischer, Judith;
Gut, Ivo G.;
Berlin, Kurt;
Beck, Stephan

Publication type:

Article

DNA Methylation Profiling of the Human Major Histocompatibility Complex: A Pilot Study for the Human Epigenome Project.

Published in:

PLoS Biology, 2004, v. 2, n. 11, p. 1, doi. 10.1371/journal.pbio.0020405

By:

Rakyan, Vardhman K;
Hildmann, Thomas;
Novik, Karen L;
Lewin, Jörn;
Tost, Jörg;
Cox, Antony V;
Andrews, T. Dan;
Howe, Kevin L;
Otto, Thomas;
Olek, Alexander;
Fischer, Judith;
Gut, Ivo G;
Berlin, Kurt;
Beck, Stephan

Publication type:

Article

Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states.

Published in:

Genome Biology, 2022, v. 23, n. 1, p. 1, doi. 10.1186/s13059-022-02617-x

By:

Rodriguez-Algarra, Francisco;
Seaborne, Robert A. E.;
Danson, Amy F.;
Yildizoglu, Selin;
Yoshikawa, Harunori;
Law, Pui Pik;
Ahmad, Zakaryya;
Maudsley, Victoria A.;
Brew, Ama;
Holmes, Nadine;
Ochôa, Mateus;
Hodgkinson, Alan;
Marzi, Sarah J.;
Pradeepa, Madapura M.;
Loose, Matthew;
Holland, Michelle L.;
Rakyan, Vardhman K.

Publication type:

Article

A donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation.

Published in:

Genome Medicine, 2015, v. 7, p. 1, doi. 10.1186/s13073-015-0246-z

By:

Paul, Dirk S.;
Jones, Allison;
Sellar, Rob S.;
Mayor, Neema P.;
Feber, Andrew;
Webster, Amy P.;
Afonso, Neuza;
Sergeant, Ruhena;
Szydlo, Richard M.;
Apperley, Jane F.;
Widschwendter, Martin;
Mackinnon, Stephen;
Marsh, Steven G. E.;
Madrigal, J. Alejandro;
Rakyan, Vardhman K.;
Peggs, Karl S.;
Beck, Stephan

Publication type:

Article

Epigenome-wide association studies for common human diseases.

Published in:

Nature Reviews Genetics, 2011, v. 12, n. 8, p. 529, doi. 10.1038/nrg3000

By:

Rakyan, Vardhman K.;
Down, Thomas A.;
Balding, David J.;
Beck, Stephan

Publication type:

Article

Marmal-aid - a database for Infinium HumanMethylation450.

Published in:

BMC Bioinformatics, 2013, v. 14, n. 1, p. 1, doi. 10.1186/1471-2105-14-359

By:

Lowe, Robert;
Rakyan, Vardhman K.

Publication type:

Article

The human blood DNA methylome displays a highly distinctive profile compared with other somatic tissues.

Published in:

Epigenetics, 2015, v. 10, n. 4, p. 274, doi. 10.1080/15592294.2014.1003744

By:

Lowe, Robert;
Slodkowicz, Greg;
Goldman, Nick;
Rakyan, Vardhman K

Publication type:

Article

Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates.

Published in:

Epigenetics, 2015, v. 10, n. 1, p. 50, doi. 10.4161/15592294.2014.989741

By:

Hillman, Sara L;
Finer, Sarah;
Smart, Melissa C;
Mathews, Chris;
Lowe, Robert;
Rakyan, Vardhman K;
Hitman, Graham A;
Williams, David J

Publication type:

Article

The promise and challenges of blood spot methylomics.

Published in:

Epigenetics, 2013, v. 8, n. 8, p. 775, doi. 10.4161/epi.25357

By:

Ramagopalan, Sreeram V.;
Rakyan, Vardhman K.

Publication type:

Article

Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies.

Published in:

Epigenetics, 2013, v. 8, n. 4, p. 1, doi. 10.4161/epi.24362

By:

Lowe, Robert;
Gemma, Carolina;
Beyan, Huriya;
Hawa, Mohammed I.;
Bazeos, Alexandra;
Leslie, R. David;
Montpetit, Alexandre;
Rakyan, Vardhman K.;
Ramagopalan, Sreeram V.

Publication type:

Article

The hunt for the epiallele.

Published in:

Environmental & Molecular Mutagenesis, 2011, v. 52, n. 1, p. 1, doi. 10.1002/em.20590

By:

Finer, Sarah;
Holland, Michelle L.;
Nanty, Lisa;
Rakyan, Vardhman K.

Publication type:

Article

Maternal gestational diabetes is associated with genome-wide DNA methylation variation in placenta and cord blood of exposed offspring.

Published in:

Human Molecular Genetics, 2015, v. 24, n. 11, p. 3021, doi. 10.1093/hmg/ddv013

By:

Finer, Sarah;
Mathews, Chris;
Lowe, Rob;
Smart, Melissa;
Hillman, Sara;
Lin Foo;
Sinha, Ajay;
Williams, David;
Rakyan, Vardhman K.;
Hitman, Graham A.

Publication type:

Article

Genome Wide Analysis of Acute Myeloid Leukemia Reveal Leukemia Specific Methylome and Subtype Specific Hypomethylation of Repeats.

Published in:

PLoS ONE, 2012, v. 7, n. 3, p. 1, doi. 10.1371/journal.pone.0033213

By:

Saied, Marwa H.;
Marzec, Jacek;
Khalid, Sabah;
Smith, Paul;
Down, Thomas A.;
Rakyan, Vardhman K.;
Molloy, Gael;
Raghavan, Manoj;
Debernardi, Silvana;
Young, Bryan D.

Publication type:

Article

Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus.

Published in:

PLoS ONE, 2010, v. 5, n. 11, p. 1, doi. 10.1371/journal.pone.0014040

By:

Bell, Christopher G.;
Finer, Sarah;
Lindgren, Cecilia M.;
Wilson, Gareth A.;
Rakyan, Vardhman K.;
Teschendorff, Andrew E.;
Akan, Pelin;
Stupka, Elia;
Down, Thomas A.;
Prokopenko, Inga;
Morison, Ian M.;
Mill, Jonathan;
Pidsley, Ruth;
Deloukas, Panos;
Frayling, Timothy M.;
Hattersley, Andrew T.;
McCarthy, Mark I.;
Beck, Stephan;
Hitman, Graham A.

Publication type:

Article

Early life diet conditions the molecular response to post-weaning protein restriction in the mouse.

Published in:

BMC Biology, 2018, v. 16, n. 1, p. 1, doi. 10.1186/s12915-018-0516-5

By:

Danson, Amy F.;
Marzi, Sarah J.;
Lowe, Robert;
Holland, Michelle L.;
Rakyan, Vardhman K.

Publication type:

Article

Identification of Type 1 Diabetes-Associated DNA Methylation Variable Positions That Precede Disease Diagnosis.

Published in:

PLoS Genetics, 2011, v. 7, n. 9, p. 1, doi. 10.1371/journal.pgen.1002300

By:

Rakyan, Vardhman K.;
Beyan, Huriya;
Down, Thomas A.;
Hawa, Mohammed I.;
Maslau, Siarhei;
Aden, Deeqo;
Daunay, Antoine;
Busato, Florence;
Mein, Charles A.;
Manfras, Burkhard;
Dias, Kerith-Rae M.;
Bell, Christopher G.;
Tost, Jörg;
Boehm, Bernhard O.;
Beck, Stephan;
Leslie, R. David

Publication type:

Article

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci.

Published in:

eLife, 2018, p. 1, doi. 10.7554/eLife.31977

By:

Thurner, Matthias;
van de Bunt, Martijn;
Torres, Jason M.;
Mahajan, Anubha;
Nylander, Vibe;
Bennett, Amanda J.;
Gaulton, Kyle J.;
Barrett, Amy;
Burrows, Carla;
Bell, Christopher G.;
Lowe, Robert;
Beck, Stephan;
Rakyan, Vardhman K.;
Gloyn, Anna L.;
McCarthy, Mark I.

Publication type:

Article

From genome to epigenome.

Published in:

Human Molecular Genetics, 2005, v. 14, n. suppl_1, p. R3, doi. 10.1093/hmg/ddi110

By:

Murrell, Adele;
Rakyan, Vardhman K.;
Beck, Stephan

Publication type:

Article

Correcting for cell-type composition bias in epigenome-wide association studies.

Published in:

Genome Medicine, 2014, v. 6, n. 3, p. 1, doi. 10.1186/gm540

By:

Lowe, Robert;
Rakyan, Vardhman K.

Publication type:

Article

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis.

Published in:

Nature Biotechnology, 2008, v. 26, n. 7, p. 779, doi. 10.1038/nbt1414

By:

Down, Thomas A;
Rakyan, Vardhman K;
Turner, Daniel J;
Flicek, Paul;
Li, Heng;
Kulesha, Eugene;
Gräf, Stefan;
Johnson, Nathan;
Herrero, Javier;
Tomazou, Eleni M;
Thorne, Natalie P;
Bäckdahl, Liselotte;
Herberth, Marlis;
Howe, Kevin L;
Jackson, David K;
Miretti, Marcos M;
Marioni, John C;
Birney, Ewan;
Hubbard, Tim J P;
Durbin, Richard

Publication type:

Article

Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species.

Published in:

Genome Biology, 2018, v. 19, p. 1, doi. 10.1186/s13059-018-1397-1

By:

Lowe, Robert;
Barton, Carl;
Jenkins, Christopher A.;
Ernst, Christina;
Forman, Oliver;
Fernandez-Twinn, Denise S.;
Bock, Christoph;
Rossiter, Stephen J.;
Faulkes, Chris G.;
Ozanne, Susan E.;
Walter, Lutz;
Odom, Duncan T.;
Mellersh, Cathryn;
Rakyan, Vardhman K.

Publication type:

Article

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus.

Published in:

BMC Medical Genomics, 2010, v. 3, p. 33, doi. 10.1186/1755-8794-3-33

By:

Bell, Christopher G.;
Teschendorff, Andrew E.;
Rakyan, Vardhman K.;
Maxwell, Alexander P.;
Beck, Stephan;
Savage, David A.

Publication type:

Article