Found: 4

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  • Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor.

    Published in:
    Biopharmaceutics & Drug Disposition, 2014, v. 35, n. 4, p. 237, doi. 10.1002/bdd.1889
    By:
    • Basavapathruni, Aravind;
    • Olhava, Edward J.;
    • Daigle, Scott R.;
    • Therkelsen, Carly A.;
    • Jin, Lei;
    • Boriack‐Sjodin, P. Ann;
    • Allain, Christina J.;
    • Klaus, Christine R.;
    • Raimondi, Alejandra;
    • Scott, Margaret Porter;
    • Dovletoglou, Angelos;
    • Richon, Victoria M.;
    • Pollock, Roy M.;
    • Copeland, Robert A.;
    • Moyer, Mikel P.;
    • Chesworth, Richard;
    • Pearson, Paul G.;
    • Waters, Nigel J.
    Publication type:
    Article

  • Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas.

    Published in:
    PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0111840
    By:
    • Knutson, Sarah K.;
    • Warholic, Natalie M.;
    • Johnston, L. Danielle;
    • Klaus, Christine R.;
    • Wigle, Tim J.;
    • Iwanowicz, Dorothy;
    • Littlefield, Bruce A.;
    • Porter-Scott, Margaret;
    • Smith, Jesse J.;
    • Moyer, Mikel P.;
    • Copeland, Robert A.;
    • Pollock, Roy M.;
    • Kuntz, Kevin W.;
    • Raimondi, Alejandra;
    • Keilhack, Heike
    Publication type:
    Article

  • A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.

    Published in:
    Nature Chemical Biology, 2015, v. 11, n. 6, p. 432, doi. 10.1038/nchembio.1810
    By:
    • Chan-Penebre, Elayne;
    • Kuplast, Kristy G;
    • Majer, Christina R;
    • Boriack-Sjodin, P Ann;
    • Wigle, Tim J;
    • Johnston, L Danielle;
    • Rioux, Nathalie;
    • Munchhof, Michael J;
    • Jin, Lei;
    • Jacques, Suzanne L;
    • West, Kip A;
    • Lingaraj, Trupti;
    • Stickland, Kimberly;
    • Ribich, Scott A;
    • Raimondi, Alejandra;
    • Scott, Margaret Porter;
    • Waters, Nigel J;
    • Pollock, Roy M;
    • Smith, Jesse J;
    • Barbash, Olena
    Publication type:
    Article

  • A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.

    Published in:
    Nature Chemical Biology, 2012, v. 8, n. 11, p. 890, doi. 10.1038/nchembio.1084
    By:
    • Knutson, Sarah K;
    • Wigle, Tim J;
    • Warholic, Natalie M;
    • Sneeringer, Christopher J;
    • Allain, Christina J;
    • Klaus, Christine R;
    • Sacks, Joelle D;
    • Raimondi, Alejandra;
    • Majer, Christina R;
    • Song, Jeffrey;
    • Scott, Margaret Porter;
    • Jin, Lei;
    • Smith, Jesse J;
    • Olhava, Edward J;
    • Chesworth, Richard;
    • Moyer, Mikel P;
    • Richon, Victoria M;
    • Copeland, Robert A;
    • Keilhack, Heike;
    • Pollock, Roy M
    Publication type:
    Article