Works by Radolf, Justin D.

Results: 61

Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes.

Published in:

Nature Reviews Microbiology, 2012, v. 10, n. 2, p. 87, doi. 10.1038/nrmicro2714

By:

Radolf, Justin D.;
Caimano, Melissa J.;
Stevenson, Brian;
Hu, Linden T.

Publication type:

Article

Use of Epivolve phage display to generate a monoclonal antibody with opsonic activity directed against a subdominant epitope on extracellular loop 4 of Treponema pallidum BamA (TP0326).

Published in:

Frontiers in Immunology, 2023, p. 01, doi. 10.3389/fimmu.2023.1222267

By:

Ferguson, Mary R.;
Delgado, Kristina N.;
McBride, Shannon;
Orbe, Isabel C.;
La Vake, Carson J.;
Caimano, Melissa J.;
Mendez, Qiana;
Moraes, Trevor F.;
Schryvers, Anthony B.;
Moody, M. Anthony;
Radolf, Justin D.;
Weiner, Michael P.;
Hawley, Kelly L.

Publication type:

Article

Disease-Specific Diagnosis of Coinfecting Tickborne Zoonoses: Babesiosis, Human Granulocytic Ehrlichiosis, and Lyme Disease.

Published in:

Clinical Infectious Diseases, 2002, v. 34, n. 9, p. 1184

By:

Krause, Peter J.;
McKay, Kathleen;
Sikand, Vijay K.;
Lentz, Ronald;
Lepore, Timothy;
Closter, Linda;
Christianson, Diane;
Telford, Sam R.;
Persing, David;
Radolf, Justin D.;
Spielman, Andrew

Publication type:

Article

The RpoS Gatekeeper in Borrelia burgdorferi : An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity.

Published in:

Frontiers in Microbiology, 2019, p. 1, doi. 10.3389/fmicb.2019.01923

By:

Caimano, Melissa J.;
Groshong, Ashley M.;
Belperron, Alexia;
Mao, Jialing;
Hawley, Kelly L.;
Luthra, Amit;
Graham, Danielle E.;
Earnhart, Christopher G.;
Marconi, Richard T.;
Bockenstedt, Linda K.;
Blevins, Jon S.;
Radolf, Justin D.

Publication type:

Article

Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle.

Published in:

Molecular Microbiology, 2007, v. 65, n. 5, p. 1193, doi. 10.1111/j.1365-2958.2007.05860.x

By:

Caimano, Melissa J.;
Iyer, Radha;
Eggers, Christian H.;
Gonzalez, Cynthia;
Morton, Elizabeth A.;
Gilbert, Michael A.;
Schwartz, Ira;
Radolf, Justin D.

Publication type:

Article

The general transition metal (Tro) and Zn<sup>2+</sup> (Znu) transporters in Treponema pallidum: analysis of metal specificities and expression profiles.

Published in:

Molecular Microbiology, 2007, v. 65, n. 1, p. 137, doi. 10.1111/j.1365-2958.2007.05771.x

By:

Desrosiers, Daniel C.;
Yong Cheng Sun;
Zaidi, Akbar A.;
Eggers, Christian H.;
Cox, David L.;
Radolf, Justin D.

Publication type:

Article

The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks.

Published in:

Molecular Microbiology, 2007, v. 63, n. 3, p. 694, doi. 10.1111/j.1365-2958.2006.05550.x

By:

Xin Li;
Utpal Pal;
Ramamoorthi, Nandhini;
Xianzhong Liu;
Desrosiers, Daniel C.;
Eggers, Christian H.;
Anderson, John F.;
Radolf, Justin D.;
Fikrig, Erol

Publication type:

Article

Sigma factor selectivity in Borrelia burgdorferi: RpoS recognition of the ospE/ospF/elp promoters is dependent on the sequence of the −10 region.

Published in:

Molecular Microbiology, 2006, v. 59, n. 6, p. 1859, doi. 10.1111/j.1365-2958.2006.05066.x

By:

Eggers, Christian H.;
Caimano, Melissa J.;
Radolf, Justin D.

Publication type:

Article

A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host.

Published in:

Molecular Microbiology, 2003, v. 48, n. 3, p. 753, doi. 10.1046/j.1365-2958.2003.03452.x

By:

Purser, Joye E.;
Lawrenz, Matthew B.;
Caimano, Melissa J.;
Howell, Jerrilyn K.;
Radolf, Justin D.;
Norris, Steven J.

Publication type:

Article

Adaptation of the Lyme disease spirochaete to the mammalian host environment results in enhanced glycosaminoglycan and host cell binding.

Published in:

Molecular Microbiology, 2003, v. 47, n. 5, p. 1433, doi. 10.1046/j.1365-2958.2003.03388.x

By:

Parveen, Nikhat;
Caimano, Melissa;
Radolf, Justin D.;
Leong, John M.

Publication type:

Article

Identification of loci critical for replication and compatibility of a Borrelia burgdorferi cp32 plasmid and use of a cp32-based shuttle vector for the expression of fluorescent reporters in the Lyme disease spirochaete.

Published in:

Molecular Microbiology, 2002, v. 43, n. 2, p. 281, doi. 10.1046/j.1365-2958.2002.02758.x

By:

Eggers, Christian H;
Caimano, Melissa J;
Clawson, Michael L;
Miller, William G;
Samuels, D. Scott;
Radolf, Justin D

Publication type:

Article

Evidence for in vivo but not in vitro expression of a Borrelia burgdorferi outer surface protein F (OspF) homologue.

Published in:

Molecular Microbiology, 1995, v. 18, n. 3, p. 507, doi. 10.1111/j.1365-2958.1995.mmi_18030507.x

By:

Akins, Darrin R.;
Porcella, Stephen F.;
Popova, Taissia G.;
Shevchenko, Dmitriy;
Baker, Scott I.;
Li, Minyue;
Norgard, Michael V.;
Radolf, Justin D.

Publication type:

Article

Treponema pallidum and the quest for outer membrane proteins.

Published in:

Molecular Microbiology, 1995, v. 16, n. 6, p. 1067, doi. 10.1111/j.1365-2958.1995.tb02332.x

By:

Radolf, Justin D.

Publication type:

Article

Treponema pallidum in gel microdroplets: a novel strategy for investigation of treponemal molecular architecture.

Published in:

Molecular Microbiology, 1995, v. 15, n. 6, p. 1151, doi. 10.1111/j.1365-2958.1995.tb02288.x

By:

Cox, David L.;
Akins, Darrin R.;
Porcella, Stephen F.;
Norgard, Michael V.;
Radolf, Justin D.

Publication type:

Article

Immune Evasion and Recognition of the Syphilis Spirochete in Blood and Skin of Secondary Syphilis Patients: Two Immunologically Distinct Compartments.

Published in:

PLoS Neglected Tropical Diseases, 2012, v. 6, n. 7, p. 1, doi. 10.1371/journal.pntd.0001717

By:

Cruz, Adriana R.;
Ramirez, Lady G.;
Zuluaga, Ana V.;
Pillay, Allan;
Abreu, Christine;
Valencia, Carlos A.;
La Vake, Carson;
Cervantes, Jorge L.;
Dunham-Ems, Star;
Cartun, Richard;
Mavilio, Domenico;
Radolf, Justin D.;
Salazar, Juan C.

Publication type:

Article

Immune Evasion and Recognition of the Syphilis Spirochete in Blood and Skin of Secondary Syphilis Patients: Two Immunologically Distinct Compartments.

Published in:

PLoS Neglected Tropical Diseases, 2012, v. 6, n. 7, p. 1, doi. 10.1371/journal.pntd.0001717

By:

Cruz, Adriana R.;
Ramirez, Lady G.;
Zuluaga, Ana V.;
Pillay, Allan;
Abreu, Christine;
Valencia, Carlos A.;
Vake, Carson La;
Cervantes, Jorge L.;
Dunham-Ems, Star;
Cartun, Richard;
Mavilio, Domenico;
Radolf, Justin D.;
Salazar, Juan C.

Publication type:

Article

T-Cell Responses to Treponema pallidum Proteins in Blood and Skin to Advance Syphilis Vaccine Design: Learning From Nature.

Published in:

Journal of Infectious Diseases, 2024, v. 230, n. 2, p. 275, doi. 10.1093/infdis/jiae246

By:

Salazar, Juan C;
Radolf, Justin D

Publication type:

Article

Consensus computational network analysis for identifying candidate outer membrane proteins from Borrelia spirochetes.

Published in:

BMC Microbiology, 2016, v. 16, p. 1, doi. 10.1186/s12866-016-0762-z

By:

Kenedy, Melisha R.;
Scott II, Edgar J.;
Shrestha, Binu;
Anand, Arvind;
Iqbal, Henna;
Radolf, Justin D.;
Dyer, David W.;
Akins, Darrin R.

Publication type:

Article

Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation.

Published in:

BMC Immunology, 2021, v. 22, n. 1, p. 1, doi. 10.1186/s12865-021-00418-8

By:

Benjamin, Sarah J.;
Hawley, Kelly L.;
Vera-Licona, Paola;
La Vake, Carson J.;
Cervantes, Jorge L.;
Ruan, Yijun;
Radolf, Justin D.;
Salazar, Juan C.

Publication type:

Article

Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks.

Published in:

2009

By:

Dunham-Ems, Star M.;
Caimano, Melissa J.;
Pal, Utpal;
Wolgemuth, Charles W.;
Eggers, Christian H.;
Balic, Anamaria;
Radolf, Justin D.

Publication type:

journal article

Bull's eye (Book).

Published in:

2004

By:

Radolf, Justin D.

Publication type:

Book Review

A suite of PCR-LwCas13a assays for detection and genotyping of Treponema pallidum in clinical samples.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32250-y

By:

Chen, Wentao;
Luo, Hao;
Zeng, Lihong;
Pan, Yuying;
Parr, Jonathan B.;
Jiang, Yinbo;
Cunningham, Clark H.;
Hawley, Kelly L.;
Radolf, Justin D.;
Ke, Wujian;
Ou, Jiangli;
Yang, Jianjiang;
Yang, Bin;
Zheng, Heping

Publication type:

Article

Prominent Osseous and Unusual Dermatologic Manifestations of Early Syphilis in Two Patients with Discordant Serological Statuses for Human Immunodeficiency Virus Infection.

Published in:

Clinical Infectious Diseases, 1996, v. 23, n. 3, p. 462

By:

Rademacher, Steven E.;
Radolf, Justin D.

Publication type:

Article

Secondary Syphilis in Cali, Colombia: New Concepts in Disease Pathogenesis.

Published in:

PLoS Neglected Tropical Diseases, 2010, v. 4, n. 5, p. 1, doi. 10.1371/journal.pntd.0000690

By:

Cruz, Adriana R.;
Pillay, Allan;
Zuluaga, Ana V.;
Ramirez, Lady G.;
Duque, Jorge E.;
Aristizabal, Gloria E.;
Fiel-Gan, Mary D.;
Jaramillo, Roberto;
Trujillo, Rodolfo;
Valencia, Carlos;
Jagodzinski, Linda;
Cox, David L.;
Radolf, Justin D.;
Salazar, Juan C.

Publication type:

Article

Secondary Syphilis in Cali, Colombia: New Concepts in Disease Pathogenesis.

Published in:

PLoS Neglected Tropical Diseases, 2010, v. 4, n. 5, p. 1, doi. 10.1371/journal.pntd.0000690

By:

Cruz, Adriana R.;
Pillay, Allan;
Zuluaga, Ana V.;
Ramirez, Lady G.;
Duque, Jorge E.;
Aristizabal, Gloria E.;
Fiel-Gan, Mary D.;
Jaramillo, Roberto;
Trujillo, Rodolfo;
Valencia, Carlos;
Jagodzinski, Linda;
Cox, David L.;
Radolf, Justin D.;
Salazar, Juan C.

Publication type:

Article

Editorial Commentary: Xenodiagnosis for Posttreatment Lyme Disease Syndrome: Resolving the Conundrum or Adding to It?

Published in:

2014

By:

Bockenstedt, Linda K.;
Radolf, Justin D.

Publication type:

Opinion

HrpA, an RNA Helicase Involved in RNA Processing, Is Required for Mouse Infectivity and Tick Transmission of the Lyme Disease Spirochete.

Published in:

PLoS Pathogens, 2013, v. 9, n. 12, p. 1, doi. 10.1371/journal.ppat.1003841

By:

Salman-Dilgimen, Aydan;
Hardy, Pierre-Olivier;
Radolf, Justin D.;
Caimano, Melissa J.;
Chaconas, George

Publication type:

Article

Borrelia burgdorferi Requires the Alternative Sigma Factor RpoS for Dissemination within the Vector during Tick-to-Mammal Transmission.

Published in:

PLoS Pathogens, 2012, v. 8, n. 2, p. 1, doi. 10.1371/journal.ppat.1002532

By:

Dunham-Ems, Star M.;
Caimano, Melissa J.;
Eggers, Christian H.;
Radolf, Justin D.

Publication type:

Article

Borrelia burgdorferi Requires Glycerol for Maximum Fitness During The Tick Phase of the Enzootic Cycle.

Published in:

PLoS Pathogens, 2011, v. 7, n. 7, p. 1, doi. 10.1371/journal.ppat.1002102

By:

Pappas, Christopher J.;
Iyer, Radha;
Petzke, Mary M.;
Caimano, Melissa J.;
Radolf, Justin D.;
Schwartz, Ira

Publication type:

Article

CD14 Signaling Restrains Chronic Inflammation through Induction of p38-MAPK/SOCS-Dependent Tolerance.

Published in:

PLoS Pathogens, 2009, v. 5, n. 12, p. 1, doi. 10.1371/journal.ppat.1000687

By:

Sahay, Bikash;
Patsey, Rebeca L.;
Eggers, Christian H.;
Salazar, Juan C.;
Radolf, Justin D.;
Sellati, Timothy J.

Publication type:

Article

Activation of Human Monocytes by Live Borrelia burgdorferi Generates TLR2-Dependent and -Independent Responses Which Include Induction of IFN-β.

Published in:

PLoS Pathogens, 2009, v. 5, n. 5, p. 1, doi. 10.1371/journal.ppat.1000444

By:

Salazar, Juan C.;
Duhnam-Ems, Star;
La Vake, Carson;
Cruz, Adriana R.;
Moore, Meagan W.;
Caimano, Melissa J.;
Velez-Climent, Leonor;
Shupe, Jonathan;
Krueger, Winfried;
Radolf, Justin D.

Publication type:

Article

A TFIIH-Associated Mediator Head Is a Basal Factor of Small Nuclear Spliced Leader RNA Gene Transcription in Early-Diverged Trypanosomes.

Published in:

Molecular & Cellular Biology, 2010, v. 30, n. 23, p. 5502, doi. 10.1128/MCB.00966-10

By:

Ju Huck Lee;
Gang Cai;
Panigrahi, Aswini K.;
Dunham-Ems, Star;
Nguyen, Tu N.;
Radolf, Justin D.;
Asturias, Francisco J.;
Günzl, Arthur

Publication type:

Article

Stage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host adaptation.

Published in:

Molecular Microbiology, 2015, v. 95, n. 3, p. 509, doi. 10.1111/mmi.12882

By:

Iyer, Radha;
Caimano, Melissa J.;
Luthra, Amit;
Axline, David;
Corona, Arianna;
Iacobas, Dumitru A.;
Radolf, Justin D.;
Schwartz, Ira

Publication type:

Article

The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host.

Published in:

Molecular Microbiology, 2011, v. 82, n. 3, p. 679, doi. 10.1111/j.1365-2958.2011.07845.x

By:

Eggers, Christian H.;
Caimano, Melissa J.;
Malizia, Robert A.;
Kariu, Toru;
Cusack, Brian;
Desrosiers, Daniel C.;
Hazlett, Karsten R. O.;
Claiborne, Al;
Pal, Utpal;
Radolf, Justin D.

Publication type:

Article

TP0326, a Treponema pallidum β-.

Published in:

Molecular Microbiology, 2011, v. 80, n. 6, p. 1496, doi. 10.1111/j.1365-2958.2011.07662.x

By:

Desrosiers, Daniel C.;
Anand, Arvind;
Luthra, Amit;
Dunham-Ems, Star M.;
LeDoyt, Morgan;
Cummings, Michael A. D.;
Eshghi, Azad;
Cameron, Caroline E.;
Cruz, Adriana R.;
Salazar, Juan C.;
Caimano, Melissa J.;
Radolf, Justin D.

Publication type:

Article

Identification of residues within ligand-binding domain 1 (LBD1) of the Borrelia burgdorferi OspC protein required for function in the mammalian environment.

Published in:

Molecular Microbiology, 2010, v. 76, n. 2, p. 393, doi. 10.1111/j.1365-2958.2010.07103.x

By:

Earnhart, Christopher G.;
LeBlanc, DeLacy V.;
Alix, Katie E.;
Desrosiers, Daniel C.;
Radolf, Justin D.;
Marconi, Richard T.

Publication type:

Article

Who is the BosR around here anyway?

Published in:

Molecular Microbiology, 2009, v. 74, n. 6, p. 1295, doi. 10.1111/j.1365-2958.2009.06971.x

By:

Samuels, D. Scott;
Radolf, Justin D.

Publication type:

Article

Treponema pallidum, the stealth pathogen, changes, but how?

Published in:

Molecular Microbiology, 2009, v. 72, n. 5, p. 1081, doi. 10.1111/j.1365-2958.2009.06711.x

By:

Radolf, Justin D.;
Desrosiers, Daniel C.

Publication type:

Article

The long strange trip of Borrelia burgdorferi outer-surface protein C.

Published in:

Molecular Microbiology, 2008, v. 69, n. 1, p. 1, doi. 10.1111/j.1365-2958.2008.06226.x

By:

Radolf, Justin D.;
Caimano, Melissa J.

Publication type:

Article

Discrimination of bacterial lipoproteins by Toll-like receptor 6.

Published in:

International Immunology, 2001, v. 13, n. 7, p. 933, doi. 10.1093/intimm/13.7.933

By:

Takeuchi, Osamu;
Kawai, Taro;
Mühlradt, Peter F.;
Morr, Michael;
Radolf, Justin D.;
Zychlinsky, Arturo;
Takeda, Kiyoshi;
Akira, Shizuo

Publication type:

Article

Treponema pallidum TroA is a periplasmic zinc-binding protein with a helical backbone.

Published in:

Nature Structural Biology, 1999, v. 6, n. 7, p. 628

By:

Lee, Yong-Hwan;
Deka, Ranjit K.;
Norgard, Michael V.;
Radolf, Justin D.;
Hasemann, Charles A.

Publication type:

Article

Immunodominant extracellular loops of Treponema pallidum FadL outer membrane proteins elicit antibodies with opsonic and growth-inhibitory activities.

Published in:

PLoS Pathogens, 2024, v. 20, n. 12, p. 1, doi. 10.1371/journal.ppat.1012443

By:

Delgado, Kristina N.;
Caimano, Melissa J.;
Orbe, Isabel C.;
Vicente, Crystal F.;
La Vake, Carson J.;
Grassmann, André A.;
Moody, M. Anthony;
Radolf, Justin D.;
Hawley, Kelly L.

Publication type:

Article

Analysis of Treponema pallidum Strains From China Using Improved Methods for Whole-Genome Sequencing From Primary Syphilis Chancres.

Published in:

2021

By:

Chen, Wentao;
Šmajs, David;
Hu, Yongfei;
Ke, Wujian;
Pospíšilová, Petra;
Hawley, Kelly L;
Caimano, Melissa J;
Radolf, Justin D;
Sena, Arlene;
Tucker, Joseph D;
Yang, Bin;
Juliano, Jonathan J;
Zheng, Heping;
Parr, Jonathan B

Publication type:

journal article

A systematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: rethinking the significance of serological non-responsiveness and the serofast state after therapy.

Published in:

2015

By:

Seña, Arlene C.;
Xiao-Hui Zhang;
Li, Trudy;
He-Ping Zheng;
Bin Yang;
Li-Gang Yang;
Salazar, Juan C.;
Cohen, Myron S.;
Moody, M. Anthony;
Radolf, Justin D.;
Tucker, Joseph D.;
Zhang, Xiao-Hui;
Zheng, He-Ping;
Yang, Bin;
Yang, Li-Gang

Publication type:

journal article

IFNγ Enhances CD64-Potentiated Phagocytosis of Treponema pallidum Opsonized with Human Syphilitic Serum by Human Macrophages.

Published in:

Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.01227

By:

Hawley, Kelly L.;
Cruz, Adriana R.;
Benjamin, Sarah J.;
La Vake, Carson J.;
Cervantes, Jorge L.;
LeDoyt, Morgan;
Ramirez, Lady G.;
Mandich, Daniza;
Fiel-Gan, Mary;
Caimano, Melissa J.;
Radolf, Justin D.;
Salazar, Juan C.

Publication type:

Article

MyD88 Deficiency Markedly Worsens Tissue Inflammation and Bacterial Clearance in Mice Infected with <i>Treponema pallidum</i>, the Agent of Syphilis.

Published in:

PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0071388

By:

Silver, Adam C.;
Dunne, Dana W.;
Zeiss, Caroline J.;
Bockenstedt, Linda K.;
Radolf, Justin D.;
Salazar, Juan C.;
Fikrig, Erol

Publication type:

Article

Pulling the Trigger on Lyme Arthritis.

Published in:

Journal of Infectious Diseases, 2013, v. 207, n. 6, p. 877, doi. 10.1093/infdis/jis931

By:

Radolf, Justin D.

Publication type:

Article

Pulling the trigger on lyme arthritis.

Published in:

2013

By:

Radolf, Justin D

Publication type:

Editorial

Serodiagnosis of Syphilis in the Recombinant Era: Reversal of Fortune.

Published in:

2011

By:

Hoover, Karen W.;
Radolf, Justin D.

Publication type:

Opinion

Anti-Tumor Necrosis Factor-α Activation of Borrelia burgdorferi Spirochetes in Antibiotic-Treated Murine Lyme Borreliosis: An Unproven Conclusion.

Published in:

2007

By:

Wormser, Gary P.;
Barthold, Stephen W.;
Shapiro, Eugene D.;
Dattwyler, Raymond J.;
Bakken, Johan S.;
Steere, Allen C.;
Bockenstedt, Linda K.;
Radolf, Justin D.

Publication type:

Letter