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Pharmacological inhibition of focal segmental glomerulosclerosis-related, gain of function mutants of TRPC6 channels by semi-synthetic derivatives of larixol.
- Published in:
- 2017
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- Publication type:
- journal article
Eine intrinsische Hydrophobieskala für Aminosäuren und ihre Anwendung auf fluorierte Verbindungen.
- Published in:
- Angewandte Chemie, 2019, v. 131, n. 24, p. 8300, doi. 10.1002/ange.201813954
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- Publication type:
- Article
Chemoselective and Bioorthogonal Ligation Reactions. Concepts and Applications. 2 Bände Herausgegeben von W. Russ Algar, Philip Dawson und Igor L. Medintz.
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- Angewandte Chemie, 2018, v. 130, n. 1, p. 38, doi. 10.1002/ange.201710401
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- Publication type:
- Article
Proteintemplat-gesteuerte Fragmentligationen - von der molekularen Erkennung zur Wirkstofffindung.
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- Angewandte Chemie, 2017, v. 129, n. 26, p. 7464, doi. 10.1002/ange.201610372
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- Publication type:
- Article
Proteintemplat-gesteuerte Bildung eines Inhibitors des Koagulationsfaktors Xa durch eine Amidierung ohne Hintergrundreaktion.
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- Angewandte Chemie, 2017, v. 129, n. 13, p. 3772, doi. 10.1002/ange.201611547
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- Publication type:
- Article
Eintopfsynthese ungeschützter anomerer Glykosylthiole in Wasser für Glykan-Ligationen mit hochfunktionalisierten Zuckern.
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- Angewandte Chemie, 2016, v. 128, n. 50, p. 15736, doi. 10.1002/ange.201607228
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- Publication type:
- Article
Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling.
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- Magnetic Resonance, 2021, v. 2, n. 1, p. 355, doi. 10.5194/mr-2-355-2021
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- Publication type:
- Article
Peptide-Heterocycle Chimera: New Classes of More Drug-Like Peptidomimetics by Ligations of Peptide-Bis(electrophiles) with Various Bis(nucleophiles).
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- European Journal of Organic Chemistry, 2011, v. 2011, n. 4, p. 730, doi. 10.1002/ejoc.201001206
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- Publication type:
- Article
Benzoylphosphonate-Based Photoactive Phosphopeptide Mimetics for Modulation of Protein Tyrosine Phosphatases and Highly Specific Labeling of SH2 Domains.
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- Angewandte Chemie International Edition, 2012, v. 51, n. 37, p. 9441, doi. 10.1002/anie.201201475
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- Publication type:
- Article
Cyclative Cleavage through Dipolar Cycloaddition: Polymer-Bound Azidopeptidylphosphoranes Deliver Locked cis-Triazolylcyclopeptides as Privileged Protein Binders.
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- Angewandte Chemie International Edition, 2010, v. 49, n. 31, p. 5378, doi. 10.1002/anie.200904980
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- Publication type:
- Article
Selective Identification of Cooperatively Binding Fragments in a High-Throughput Ligation Assay Enables Development of a Picomolar Caspase-3 Inhibitor.
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- Angewandte Chemie International Edition, 2009, v. 48, n. 34, p. 6346, doi. 10.1002/anie.200901647
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- Publication type:
- Article
Metal-Free, Regioselective Triazole Ligations that Deliver Locked cis Peptide Mimetics.
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- Angewandte Chemie International Edition, 2009, v. 48, n. 27, p. 5042, doi. 10.1002/anie.200806390
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- Publication type:
- Article
Sensitized Detection of Inhibitory Fragments and Iterative Development of Non-Peptidic Protease Inhibitors by Dynamic Ligation Screening.
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- Angewandte Chemie International Edition, 2008, v. 47, n. 17, p. 3275, doi. 10.1002/anie.200704594
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- Publication type:
- Article
Multivalent Design of Apoptosis-Inducing Bid-BH3 Peptide-Oligosaccharides Boosts the Intracellular Activity at Identical Overall Peptide Concentrations.
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- Chemistry - A European Journal, 2012, v. 18, n. 52, p. 16708, doi. 10.1002/chem.201202276
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- Publication type:
- Article
Chemoenzymatic Synthesis of a Glycolipid Library and Elucidation of the Antigenic Epitope for Construction of a Vaccine Against Lyme Disease.
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- Chemistry - A European Journal, 2010, v. 16, n. 11, p. 3536, doi. 10.1002/chem.200902205
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- Publication type:
- Article
Incorporation of Amino Acids with Long-Chain Terminal Olefins into Proteins.
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- Molecules, 2016, v. 21, n. 3, p. 287, doi. 10.3390/molecules21030287
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- Publication type:
- Article
Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments.
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- Nature Communications, 2016, v. 7, n. 9, p. 12761, doi. 10.1038/ncomms12761
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- Publication type:
- Article
Catalytic activation of pre-substrates via dynamic fragment assembly on protein templates.
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- Nature Communications, 2014, v. 5, n. 11, p. 5170, doi. 10.1038/ncomms6170
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- Publication type:
- Article
A Critical Study on Acylating and Covalent Reversible Fragment Inhibitors of SARS‐CoV‐2 Main Protease Targeting the S1 Site with Pyridine.
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- ChemMedChem, 2023, v. 18, n. 9, p. 1, doi. 10.1002/cmdc.202200635
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- Publication type:
- Article
Biological Characterization, Mechanistic Investigation and Structure‐Activity Relationships of Chemically Stable TLR2 Antagonists.
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- ChemMedChem, 2020, v. 15, n. 14, p. 1364, doi. 10.1002/cmdc.202000060
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- Publication type:
- Article
Solid-Phase Supported Synthesis of the Branched Pentasaccharide Moiety That Occurs in Most Complex Type N-Glycan Chains.
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- Angewandte Chemie International Edition, 1998, v. 37, n. 9, p. 1241, doi. 10.1002/(SICI)1521-3773(19980518)37:9<1241::AID-ANIE1241>3.0.CO;2-6
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- Publication type:
- Article
Sulfation Pattern Dependent Iron(III) Mediated Interleukin‐8 Glycan Binding.
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- ChemBioChem, 2022, v. 23, n. 3, p. 1, doi. 10.1002/cbic.202100552
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- Publication type:
- Article
Corrigendum to: Off‐target inhibition by active site‐targeting SHP2 inhibitors.
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- FEBS Open Bio, 2019, v. 9, n. 12, p. 2174, doi. 10.1002/2211-5463.12754
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- Publication type:
- Article
Chemoselective and Bioorthogonal Ligation Reactions. Concepts and Applications. 2 Volumes Edited by W. Russ Algar, Philip Dawson, and Igor L. Medintz.
- Published in:
- Angewandte Chemie International Edition, 2018, v. 57, n. 1, p. 38, doi. 10.1002/anie.201710401
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- Publication type:
- Article
Protein-Templated Fragment Ligations-From Molecular Recognition to Drug Discovery.
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- Angewandte Chemie International Edition, 2017, v. 56, n. 26, p. 7358, doi. 10.1002/anie.201610372
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- Publication type:
- Article
Protein-Templated Formation of an Inhibitor of the Blood Coagulation Factor Xa through a Background-Free Amidation Reaction.
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- Angewandte Chemie International Edition, 2017, v. 56, n. 13, p. 3718, doi. 10.1002/anie.201611547
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- Publication type:
- Article
One-Pot Synthesis of Unprotected Anomeric Glycosyl Thiols in Water for Glycan Ligation Reactions with Highly Functionalized Sugars.
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- Angewandte Chemie International Edition, 2016, v. 55, n. 50, p. 15510, doi. 10.1002/anie.201607228
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- Publication type:
- Article
Fluorescent Mimetics of CMP-Neu5Ac Are Highly Potent, Cell-Permeable Polarization Probes of Eukaryotic and Bacterial Sialyltransferases and Inhibit Cellular Sialylation.
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- Angewandte Chemie International Edition, 2014, v. 53, n. 22, p. 5700, doi. 10.1002/anie.201400394
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- Publication type:
- Article
Propargyl Amides as Irreversible Inhibitors of Cysteine Proteases-A Lesson on the Biological Reactivity of Alkynes.
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- Angewandte Chemie International Edition, 2013, v. 52, n. 32, p. 8210, doi. 10.1002/anie.201303544
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- Publication type:
- Article
A Formylglycine‐Peptide for the Site‐Directed Identification of Phosphotyrosine‐Mimetic Fragments**.
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- Chemistry - A European Journal, 2022, v. 28, n. 57, p. 1, doi. 10.1002/chem.202201282
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- Publication type:
- Article
Reversible Vernetzung von hyperverzweigten Polymeren: eine Strategie zur kombinatorischen Dekorierung multivalenter Gerüste.
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- Angewandte Chemie, 2005, v. 117, n. 10, p. 1584, doi. 10.1002/ange.200460559
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- Publication type:
- Article
Organische Proteinchemie: Entdeckung von Wirkstoffen durch die chemische Modifizierung von Proteinen.
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- Angewandte Chemie, 2004, v. 116, n. 35, p. 4654, doi. 10.1002/ange.200460075
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- Publication type:
- Article
Ein Phosphoran als polymergebundenes Acylanionenäquivalent: Linkerreagentien für schonende und vielseitige C-C-Kupplungen ( Ein Teil dieser Arbeit wurde auf der ORCHEM 2002 in Bad Nauheim präsentiert. Wir bedanken uns für die großzügige Unterstützung durch Prof. G. Jung und Prof. M. E. Maier, Tübingen, den Strukturfonds der Universität Tübingen, das DFG-Projekt Reaktive Intermediate in polymeren Gelen (Ra 895/2), den Fonds der Chemischen Industrie, die Novabiochem AG (Läufelfingen, Schweiz) und die Personal Chemistry GmbH (Konstanz). Wir danken Andreas Petri, Bojan Bister und Daniel Bischoff für Unterstützung bei den Analysen. )
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- Angewandte Chemie, 2003, v. 115, n. 22, p. 2595, doi. 10.1002/ange.200351190
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- Publication type:
- Article
The structural investigation of glycosaminoglycan binding to CXCL12 displays distinct interaction sites.
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- Glycobiology, 2016, v. 26, n. 11, p. 1209, doi. 10.1093/glycob/cww059
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- Publication type:
- Article
The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation.
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- Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-07923-2
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- Publication type:
- Article
Cell‐Penetrating Peptide‐Bismuth Bicycles.
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- Angewandte Chemie International Edition, 2024, v. 63, n. 10, p. 1, doi. 10.1002/anie.202318615
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- Publication type:
- Article
Pentafluorophosphato‐Phenylalanines: Amphiphilic Phosphotyrosine Mimetics Displaying Fluorine‐Specific Protein Interactions.
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- Angewandte Chemie International Edition, 2022, v. 61, n. 25, p. 1, doi. 10.1002/anie.202203579
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- Publication type:
- Article
Peptide–Bismuth Bicycles: In Situ Access to Stable Constrained Peptides with Superior Bioactivity.
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- Angewandte Chemie International Edition, 2022, v. 61, n. 4, p. 1, doi. 10.1002/anie.202113857
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- Publication type:
- Article
Chemical Evolution of Antivirals Against Enterovirus D68 through Protein‐Templated Knoevenagel Reactions.
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- Angewandte Chemie International Edition, 2021, v. 60, n. 24, p. 13294, doi. 10.1002/anie.202102074
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- Publication type:
- Article
An Intrinsic Hydrophobicity Scale for Amino Acids and Its Application to Fluorinated Compounds.
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- Angewandte Chemie International Edition, 2019, v. 58, n. 24, p. 8216, doi. 10.1002/anie.201813954
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- Publication type:
- Article
Fluoreszente Mimetika von CMP-Neu5Ac sind hochaffine, zellgängige Polarisationssonden eukaryotischer und bakterieller Sialyltransferasen und inhibieren die zelluläre Sialylierung.
- Published in:
- Angewandte Chemie, 2014, v. 126, n. 22, p. 5808, doi. 10.1002/ange.201400394
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- Publication type:
- Article
Propargylamide als irreversible Inhibitoren von Cysteinproteasen - zur biologischen Reaktivität von Alkinen.
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- Angewandte Chemie, 2013, v. 125, n. 32, p. 8368, doi. 10.1002/ange.201303544
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- Publication type:
- Article
Benzoylphosphonat-basierte, photoaktive Phosphotyrosinpeptidmimetika zur funktionellen Modulierung von Proteintyrosinphosphatasen und hochspezifischen Markierung von SH2-Domänen.
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- Angewandte Chemie, 2012, v. 124, n. 37, p. 9577, doi. 10.1002/ange.201201475
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- Publication type:
- Article
Cyclisierende Abspaltungen über dipolare Cycloadditionen: Polymergebundene Azidopeptidylphosphorane liefern konformativ fixierte cis-Triazolylcyclopeptide als privilegierte Proteinbinder.
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- Angewandte Chemie, 2010, v. 122, n. 31, p. 5506, doi. 10.1002/ange.200904980
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- Publication type:
- Article
Handbook of Reagents for Organic Synthesis. Reagents for High-Throughput Solid-Phase and Solution-Phase Organic Synthesis. Herausgegeben von Peter Wipf.
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- Angewandte Chemie, 2006, v. 118, n. 9, p. 1371, doi. 10.1002/ange.200585319
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- Publication type:
- Article
Efficient access to peptidyl ketones and peptidyl diketones via C-alkylations and C-acylations of polymer-supported phosphorus ylides followed by hydrolytic and/or oxidative cleavage.
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- Biopolymers, 2010, v. 94, n. 2, p. 220, doi. 10.1002/bip.21378
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- Publication type:
- Article
Dual Action of Sulfated Hyaluronan on Angiogenic Processes in Relation to Vascular Endothelial Growth Factor-A.
- Published in:
- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-54211-0
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- Publication type:
- Article
Chemical Synthesis of a Glycolipid Library by a Solid-Phase Strategy Allows Elucidation of the Structural Specificity of Immunostimulation by RhamnolipidsEssential parts of this work were presented at Eurocombi 3 in Winchester (UK), July 18–21, 2005 as an oral contribution by J.B., who received a “Young Investigators Presentation Award”.
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- Chemistry - A European Journal, 2006, v. 12, n. 27, p. 7116, doi. 10.1002/chem.200600482
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- Publication type:
- Article
Cover Picture.
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- Chemistry - A European Journal, 2001, v. 7, n. 18, p. 3847, doi. 10.1002/1521-3765(20010917)7:18<3847::AID-CHEM3847>3.0.CO;2-2
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- Publication type:
- Article
Spatially Resolved Single Bead Analysis: Homogeneity, Diffusion, and Adsorption in Cross-Linked Polystyrene.
- Published in:
- Chemistry - A European Journal, 2001, v. 7, n. 18, p. 3884, doi. 10.1002/1521-3765(20010917)7:18<3884::AID-CHEM3884>3.0.CO;2-C
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- Publication type:
- Article