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An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia.
Published in:
Nature Medicine, 2015, v. 21, n. 5, p. 492, doi. 10.1038/nm.3847
By:
- Sehgal, Alfica;
- Barros, Scott;
- Ivanciu, Lacramioara;
- Cooley, Brian;
- Qin, June;
- Racie, Tim;
- Hettinger, Julia;
- Carioto, Mary;
- Jiang, Yongfeng;
- Brodsky, Josh;
- Prabhala, Harsha;
- Zhang, Xuemei;
- Attarwala, Husain;
- Hutabarat, Renta;
- Foster, Don;
- Milstein, Stuart;
- Charisse, Klaus;
- Kuchimanchi, Satya;
- Maier, Martin A;
- Nechev, Lubo
Publication type:
Article
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight.
Published in:
Nature Nanotechnology, 2014, v. 9, n. 8, p. 648, doi. 10.1038/nnano.2014.84
By:
- Dahlman, James E.;
- Barnes, Carmen;
- Khan, Omar F.;
- Thiriot, Aude;
- Jhunjunwala, Siddharth;
- Shaw, Taylor E.;
- Xing, Yiping;
- Sager, Hendrik B.;
- Sahay, Gaurav;
- Speciner, Lauren;
- Bader, Andrew;
- Bogorad, Roman L.;
- Yin, Hao;
- Racie, Tim;
- Dong, Yizhou;
- Jiang, Shan;
- Seedorf, Danielle;
- Dave, Apeksha;
- Singh Sandhu, Kamaljeet;
- Webber, Matthew J.
Publication type:
Article
Harnessing a Physiologic Mechanism for siRNA Delivery With Mimetic Lipoprotein Particles.
Published in:
Molecular Therapy, 2012, v. 20, n. 8, p. 1582, doi. 10.1038/mt.2012.33
By:
- Nakayama, Tomoko;
- Butler, James S;
- Sehgal, Alfica;
- Severgnini, Mariano;
- Racie, Tim;
- Sharman, Jennifer;
- Ding, Feng;
- Morskaya, Svetlana Shulga;
- Brodsky, Joshua;
- Tchangov, Lubomir;
- Kosovrasti, Verbena;
- Meys, Mike;
- Nechev, Lubomir;
- Wang, Gang;
- Peng, Chang Geng;
- Fang, Yupang;
- Maier, Martin;
- Rajeev, Kallanthottathil G;
- Li, Robert;
- Hettinger, Julia
Publication type:
Article
RNAi‐mediated reduction of hepatic Tmprss6 diminishes anemia and secondary iron overload in a splenectomized mouse model of β‐thalassemia intermedia.
Published in:
American Journal of Hematology, 2018, v. 93, n. 6, p. 745, doi. 10.1002/ajh.25079
By:
- Schmidt, Paul J.;
- Liu, Kaifeng;
- Visner, Gary;
- Fitzgerald, Kevin;
- Fishman, Shannon;
- Racie, Tim;
- Hettinger, Julia L.;
- Butler, James S.;
- Fleming, Mark D.
Publication type:
Article
Combination therapy with a T mprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of β-thalassemia intermedia.
Published in:
American Journal of Hematology, 2015, v. 90, n. 4, p. 310, doi. 10.1002/ajh.23934
By:
- Schmidt, Paul J.;
- Racie, Tim;
- Westerman, Mark;
- Fitzgerald, Kevin;
- Butler, James S.;
- Fleming, Mark D.
Publication type:
Article
Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing.
Published in:
Nucleic Acids Research, 2021, v. 49, n. 18, p. 10250, doi. 10.1093/nar/gkab724
By:
- Jahns, Hartmut;
- Degaonkar, Rohan;
- Podbevsek, Peter;
- Gupta, Swati;
- Bisbe, Anna;
- Aluri, Krishna;
- Szeto, John;
- Kumar, Pawan;
- LeBlanc, Sarah;
- Racie, Tim;
- Brown, Christopher R;
- Castoreno, Adam;
- Guenther, Dale C;
- Jadhav, Vasant;
- Maier, Martin A;
- Plavec, Janez;
- Egli, Martin;
- Manoharan, Muthiah;
- Zlatev, Ivan
Publication type:
Article

Found: 6

An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia.

In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight.

Harnessing a Physiologic Mechanism for siRNA Delivery With Mimetic Lipoprotein Particles.

RNAi‐mediated reduction of hepatic Tmprss6 diminishes anemia and secondary iron overload in a splenectomized mouse model of β‐thalassemia intermedia.

Combination therapy with a T mprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of β-thalassemia intermedia.

Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing.