Works by Race, Paul R.

Results: 32

Interrogation of an Enzyme Library Reveals the Catalytic Plasticity of Naturally Evolved [4+2] Cyclases.

Published in:

ChemBioChem, 2023, v. 24, n. 14, p. 1, doi. 10.1002/cbic.202300382

By:

Zorn, Katja;
Back, Catherine R.;
Barringer, Rob;
Chadimová, Veronika;
Manzo‐Ruiz, Monserrat;
Mbatha, Sbusisiwe Z.;
Mobarec, Juan‐Carlos;
Williams, Sam E.;
van der Kamp, Marc W.;
Race, Paul R.;
Willis, Christine L.;
Hayes, Martin A.

Publication type:

Article

Fine Tuning of Antibiotic Activity by a Tailoring Hydroxylase in a Trans‐AT Polyketide Synthase Pathway.

Published in:

ChemBioChem, 2018, v. 19, n. 8, p. 836, doi. 10.1002/cbic.201800036

By:

Mohammad, Hadi H.;
Connolly, Jack A.;
Song, Zhongshu;
Hothersall, Joanne;
Race, Paul R.;
Willis, Christine L.;
Simpson, Thomas J.;
Winn, Peter J.;
Thomas, Christopher M.

Publication type:

Article

Structure and Function of the α‐Hydroxylation Bimodule of the Mupirocin Polyketide Synthase.

Published in:

Angewandte Chemie, 2023, v. 135, n. 47, p. 1, doi. 10.1002/ange.202312514

By:

Winter, Ashley J.;
Khanizeman, R. Nisha;
Barker‐Mountford, Abigail M. C.;
Devine, Andrew J.;
Wang, Luoyi;
Song, Zhongshu;
Davies, Jonathan A.;
Race, Paul R.;
Williams, Christopher;
Simpson, Thomas J.;
Willis, Christine L.;
Crump, Matthew P.

Publication type:

Article

The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis.

Published in:

Angewandte Chemie, 2023, v. 135, n. 3, p. 1, doi. 10.1002/ange.202213053

By:

Devine, Andrew J.;
Parnell, Alice E.;
Back, Catherine R.;
Lees, Nicholas R.;
Johns, Samuel T.;
Zulkepli, Ainul Z.;
Barringer, Rob;
Zorn, Katja;
Stach, James E. M.;
Crump, Matthew P.;
Hayes, Martin A.;
van der Kamp, Marc W.;
Race, Paul R.;
Willis, Christine L.

Publication type:

Article

Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic Mupirocin.

Published in:

Angewandte Chemie, 2022, v. 134, n. 50, p. 1, doi. 10.1002/ange.202212393

By:

Winter, Ashley J.;
Rowe, Matthew T.;
Weir, Angus N. M.;
Akter, Nahida;
Mbatha, Sbusisiwe Z.;
Walker, Paul D.;
Williams, Christopher;
Song, Zhongshu;
Race, Paul R.;
Willis, Christine L.;
Crump, Matthew P.

Publication type:

Article

Control of β‐Branching in Kalimantacin Biosynthesis: Application of <sup>13</sup>C NMR to Polyketide Programming.

Published in:

Angewandte Chemie, 2019, v. 131, n. 36, p. 12576, doi. 10.1002/ange.201905482

By:

Walker, Paul D.;
Williams, Christopher;
Weir, Angus N. M.;
Wang, Luoyi;
Crosby, John;
Race, Paul R.;
Simpson, Thomas J.;
Willis, Christine L.;
Crump, Matthew P.

Publication type:

Article

An Esterase‐like Lyase Catalyzes Acetate Elimination in Spirotetronate/Spirotetramate Biosynthesis.

Published in:

Angewandte Chemie, 2019, v. 131, n. 8, p. 2327, doi. 10.1002/ange.201812105

By:

Lees, Nicholas R.;
Han, Li‐Chen;
Byrne, Matthew J.;
Davies, Jonathan A.;
Parnell, Alice E.;
Moreland, Pollyanna E. J.;
Stach, James E. M.;
van der Kamp, Marc W.;
Willis, Christine L.;
Race, Paul R.

Publication type:

Article

Studies of recombinant TWA1 reveal constitutive dimerization.

Published in:

Bioscience Reports, 2017, v. 37, n. 1, p. 1, doi. 10.1042/BSR20160401

By:

Francis, Ore;
Baker, Genevieve E.;
Race, Paul R.;
Adams, Josephine C.

Publication type:

Article

SAXS reveals highly flexible interdomain linkers of tandem acyl carrier protein–thioesterase domains from a fungal nonreducing polyketide synthase.

Published in:

FEBS Letters, 2021, v. 595, n. 1, p. 133, doi. 10.1002/1873-3468.13954

By:

Bunnak, Waraporn;
Winter, Ashley J.;
Lazarus, Colin M.;
Crump, Matthew P.;
Race, Paul R.;
Wattana‐Amorn, Pakorn

Publication type:

Article

Derivation of a Precise and Consistent Timeline for Antibiotic Development.

Published in:

Antibiotics (2079-6382), 2022, v. 11, n. 9, p. 1237, doi. 10.3390/antibiotics11091237

By:

Stennett, Henry L.;
Back, Catherine R.;
Race, Paul R.

Publication type:

Article

The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products.

Published in:

Antibiotics (2079-6382), 2020, v. 9, n. 8, p. 509, doi. 10.3390/antibiotics9080509

By:

Williams, Sam E.;
Stennett, Henry L.;
Back, Catherine R.;
Tiwari, Kavita;
Ojeda Gomez, Jorge;
Challand, Martin R.;
Hendry, Katharine R.;
Spencer, James;
Essex-Lopresti, Angela E.;
Willis, Christine L.;
Curnow, Paul;
Race, Paul R.

Publication type:

Article

NITROREDUCTASE: A PRODRUG-ACTIVATING ENZYME FOR CANCER GENE THERAPY.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2004, v. 31, n. 11, p. 811, doi. 10.1111/j.1440-1681.2004.04085.x

By:

Searle, Peter F.;
Ming-Jen Chen;
Longqin Hu;
Race, Paul R.;
Lovering, Andrew L.;
Grove, Jane I.;
Guise, Chris;
Jaberipour, Mansooreh;
James, Nicholas D.;
Mautner, Vivien;
Young, Lawrence S.;
Kerr, David J.;
Mountain, Andrew;
White, Scott A.;
Hyde, Eva I.

Publication type:

Article

Structure and Function of the α‐Hydroxylation Bimodule of the Mupirocin Polyketide Synthase.

Published in:

Angewandte Chemie International Edition, 2023, v. 62, n. 47, p. 1, doi. 10.1002/anie.202312514

By:

Winter, Ashley J.;
Khanizeman, R. Nisha;
Barker‐Mountford, Abigail M. C.;
Devine, Andrew J.;
Wang, Luoyi;
Song, Zhongshu;
Davies, Jonathan A.;
Race, Paul R.;
Williams, Christopher;
Simpson, Thomas J.;
Willis, Christine L.;
Crump, Matthew P.

Publication type:

Article

The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis.

Published in:

Angewandte Chemie International Edition, 2023, v. 62, n. 3, p. 1, doi. 10.1002/anie.202213053

By:

Devine, Andrew J.;
Parnell, Alice E.;
Back, Catherine R.;
Lees, Nicholas R.;
Johns, Samuel T.;
Zulkepli, Ainul Z.;
Barringer, Rob;
Zorn, Katja;
Stach, James E. M.;
Crump, Matthew P.;
Hayes, Martin A.;
van der Kamp, Marc W.;
Race, Paul R.;
Willis, Christine L.

Publication type:

Article

Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic Mupirocin.

Published in:

Angewandte Chemie International Edition, 2022, v. 61, n. 50, p. 1, doi. 10.1002/anie.202212393

By:

Winter, Ashley J.;
Rowe, Matthew T.;
Weir, Angus N. M.;
Akter, Nahida;
Mbatha, Sbusisiwe Z.;
Walker, Paul D.;
Williams, Christopher;
Song, Zhongshu;
Race, Paul R.;
Willis, Christine L.;
Crump, Matthew P.

Publication type:

Article

Control of β‐Branching in Kalimantacin Biosynthesis: Application of <sup>13</sup>C NMR to Polyketide Programming.

Published in:

Angewandte Chemie International Edition, 2019, v. 58, n. 36, p. 12446, doi. 10.1002/anie.201905482

By:

Walker, Paul D.;
Williams, Christopher;
Weir, Angus N. M.;
Wang, Luoyi;
Crosby, John;
Race, Paul R.;
Simpson, Thomas J.;
Willis, Christine L.;
Crump, Matthew P.

Publication type:

Article

An Esterase‐like Lyase Catalyzes Acetate Elimination in Spirotetronate/Spirotetramate Biosynthesis.

Published in:

Angewandte Chemie International Edition, 2019, v. 58, n. 8, p. 2305, doi. 10.1002/anie.201812105

By:

Lees, Nicholas R.;
Han, Li‐Chen;
Byrne, Matthew J.;
Davies, Jonathan A.;
Parnell, Alice E.;
Moreland, Pollyanna E. J.;
Stach, James E. M.;
van der Kamp, Marc W.;
Willis, Christine L.;
Race, Paul R.

Publication type:

Article

Domain shuffling of a highly mutable ligand‐binding fold drives adhesin generation across the bacterial kingdom.

Published in:

Proteins, 2023, v. 91, n. 8, p. 1007, doi. 10.1002/prot.26487

By:

Barringer, Rob;
Parnell, Alice E.;
Lafita, Aleix;
Monzon, Vivian;
Back, Catherine R.;
Madej, Mariusz;
Potempa, Jan;
Nobbs, Angela H.;
Burston, Steven G.;
Bateman, Alex;
Race, Paul R.

Publication type:

Article

Rücktitelbild: Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics (Angew. Chem. 14/2017).

Published in:

Angewandte Chemie, 2017, v. 129, n. 14, p. 4126, doi. 10.1002/ange.201702123

By:

Gao, Shu ‐ Shan;
Wang, Luoyi;
Song, Zhongshu;
Hothersall, Joanne;
Stevens, Elton R.;
Connolly, Jack;
Winn, Peter J.;
Cox, Russell J.;
Crump, Matthew P.;
Race, Paul R.;
Thomas, Christopher M.;
Simpson, Thomas J.;
Willis, Christine L.

Publication type:

Article

Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics.

Published in:

Angewandte Chemie, 2017, v. 129, n. 14, p. 3988, doi. 10.1002/ange.201611590

By:

Gao, Shu ‐ Shan;
Wang, Luoyi;
Song, Zhongshu;
Hothersall, Joanne;
Stevens, Elton R.;
Connolly, Jack;
Winn, Peter J.;
Cox, Russell J.;
Crump, Matthew P.;
Race, Paul R.;
Thomas, Christopher M.;
Simpson, Thomas J.;
Willis, Christine L.

Publication type:

Article

Molecular basis of hyper-thermostability in the thermophilic archaeal aldolase MfnB.

Published in:

Extremophiles, 2024, v. 28, n. 3, p. 1, doi. 10.1007/s00792-024-01359-x

By:

Maddock, Rosie M. A.;
Marsh, Carl O.;
Johns, Samuel T.;
Rooms, Lynden D.;
Duke, Phillip W.;
van der Kamp, Marc W.;
Stach, James E. M.;
Race, Paul R.

Publication type:

Article

Enzyme‐catalysed polymer cross‐linking: Biocatalytic tools for chemical biology, materials science and beyond.

Published in:

Biopolymers, 2020, v. 111, n. 9, p. 1, doi. 10.1002/bip.23390

By:

Maddock, Rosie M. A.;
Pollard, Gregory J.;
Moreau, Nicolette G.;
Perry, Justin J.;
Race, Paul R.

Publication type:

Article

Structure and mechanism of a dehydratase/decarboxylase enzyme couple involved in polyketide β-methyl branch incorporation.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-71850-w

By:

Nair, Asha V.;
Robson, Alice;
Ackrill, Thomas D.;
Till, Marisa;
Byrne, Matthew J.;
Back, Catherine R.;
Tiwari, Kavita;
Davies, Jonathan A.;
Willis, Christine L.;
Race, Paul R.

Publication type:

Article

Solution structure of the major (Spy0128) and minor (Spy0125 and Spy0130) pili subunits from Streptococcus pyogenes.

Published in:

European Biophysics Journal, 2010, v. 39, n. 3, p. 469, doi. 10.1007/s00249-009-0432-2

By:

Solovyova, Alexandra S.;
Pointon, Jonathan A.;
Race, Paul R.;
Smith, Wendy D.;
Kehoe, Michael A.;
Banfield, Mark J.

Publication type:

Article

Crystal Structures of Cif from Bacterial Pathogens Photorhabdus luminescens and Burkholderia pseudomallei.

Published in:

PLoS ONE, 2009, v. 4, n. 5, p. 1, doi. 10.1371/journal.pone.0005582

By:

Crow, Allister;
Race, Paul R.;
Jubelin, Grégory;
Chavez, Carolina Varela;
Escoubas, Jean-Michel;
Oswald, Eric;
Banfield, Mark J.

Publication type:

Article

A Natural Diels‐Alder Biocatalyst Enables Efficient [4+2] Cycloaddition Under Harsh Reaction Conditions.

Published in:

ChemCatChem, 2019, v. 11, n. 20, p. 5027, doi. 10.1002/cctc.201901285

By:

Marsh, Carl O.;
Lees, Nicholas R.;
Han, Li‐Chen;
Byrne, Matthew J.;
Mbatha, Sbusisiwe Z.;
Maschio, Laurence;
Pagden‐Ratcliffe, Sebastian;
Duke, Phillip W.;
Stach, James E. M.;
Curnow, Paul;
Willis, Christine L.;
Race, Paul R.

Publication type:

Article

Back Cover: Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics (Angew. Chem. Int. Ed. 14/2017).

Published in:

Angewandte Chemie International Edition, 2017, v. 56, n. 14, p. 4066, doi. 10.1002/anie.201702123

By:

Gao, Shu-Shan;
Wang, Luoyi;
Song, Zhongshu;
Crump, Matthew P.;
Simpson, Thomas J.;
Willis, Christine L.;
Cox, Russell J.;
Hothersall, Joanne;
Stevens, Elton R.;
Connolly, Jack;
Winn, Peter J.;
Thomas, Christopher M.;
Race, Paul R.

Publication type:

Article

Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics.

Published in:

Angewandte Chemie International Edition, 2017, v. 56, n. 14, p. 3930, doi. 10.1002/anie.201611590

By:

Gao, Shu-Shan;
Wang, Luoyi;
Song, Zhongshu;
Crump, Matthew P.;
Simpson, Thomas J.;
Willis, Christine L.;
Cox, Russell J.;
Hothersall, Joanne;
Stevens, Elton R.;
Connolly, Jack;
Winn, Peter J.;
Thomas, Christopher M.;
Race, Paul R.

Publication type:

Article

Correction: Back et al. A New Micromonospora Strain with Antibiotic Activity Isolated from the Microbiome of a Mid-Atlantic Deep-Sea Sponge. Mar. Drugs 2021, 19 , 105.

Published in:

2023

By:

Back, Catherine R.;
Stennett, Henry L.;
Williams, Sam E.;
Wang, Luoyi;
Ojeda Gomez, Jorge;
Abdulle, Omar M.;
Duffy, Thomas;
Neal, Christopher;
Mantell, Judith;
Jepson, Mark A.;
Hendry, Katharine R.;
Powell, David;
Stach, James E. M.;
Essex-Lopresti, Angela E.;
Willis, Christine L.;
Curnow, Paul;
Race, Paul R.

Publication type:

Correction Notice

A New Micromonospora Strain with Antibiotic Activity Isolated from the Microbiome of a Mid-Atlantic Deep-Sea Sponge.

Published in:

Marine Drugs, 2021, v. 19, n. 2, p. 105, doi. 10.3390/md19020105

By:

Back, Catherine R.;
Stennett, Henry L.;
Williams, Sam E.;
Wang, Luoyi;
Ojeda Gomez, Jorge;
Abdulle, Omar M.;
Duffy, Thomas;
Neal, Christopher;
Mantell, Judith;
Jepson, Mark A.;
Hendry, Katharine R.;
Powell, David;
Stach, James E. M.;
Essex-Lopresti, Angela E.;
Willis, Christine L.;
Curnow, Paul;
Race, Paul R.;
Kurtboke, Ipek

Publication type:

Article

Integration of the Rac1- and actin-binding properties of Coronin-1C.

Published in:

Small GTPases, 2015, v. 6, n. 1, p. 41, doi. 10.4161/21541248.2014.992259

By:

Tilley, Frances C;
Williamson, Rosalind C;
Race, Paul R;
Rendall, Thomas C;
Bass, Mark D

Publication type:

Article

BrisSynBio: a BBSRC/EPSRC-funded Synthetic Biology Research Centre.

Published in:

Biochemical Society Transactions, 2016, v. 44, n. 3, p. 689, doi. 10.1042/BST20160004

By:

Sedgley, Kathleen R.;
Race, Paul R.;
Woolfson, Derek N.

Publication type:

Article