Works by ROZEN, Rima

Results: 61

Gene deletion and restriction fragment length polymorphisms at the human ornithine transcarbamylase locus.

Published in:

Nature, 1985, v. 313, n. 6005, p. 815, doi. 10.1038/313815a0

By:

Rozen, Rima;
Fox, Joyce;
Fenton, Wayne A.;
Horwich, Arthur L.;
Rosenberg, Leon E.

Publication type:

Article

Severe Methylenetetrahydrofolate Reductase Deficiency Clinical Clues to a Potentially Treatable Cause of Adult-Onset Hereditary Spastic Paraplegia.

Published in:

JAMA Neurology, 2014, v. 71, n. 7, p. 901, doi. 10.1001/jamaneurol.2014.116

By:

Lossos, Alexander;
Teltsh, Omri;
Milman, Tsipi;
Meiner, Vardiella;
Rozen, Rima;
Leclerc, Daniel;
Schwahn, Bernd C.;
Karp, Natalya;
Rosenblatt, David S.;
Watkins, David;
Shaag, Avraham;
Korman, Stanley H.;
Heyman, Samuel N.;
Gal, Aya;
Newman, J. P.;
Steiner-Birmanns, Bettina;
Abramsky, Oded;
Kohn, Yoav

Publication type:

Article

Risk of congenital heart defects is influenced by genetic variation in folate metabolism.

Published in:

Cardiology in the Young, 2013, v. 23, n. 1, p. 89, doi. 10.1017/S1047951112000431

By:

Christensen, Karen E.;
Zada, Yassamin Feroz;
Rohlicek, Charles V.;
Andelfinger, Gregor U.;
Michaud, Jacques L.;
Bigras, Jean-Luc;
Richter, Andrea;
Dubé, Marie-Pierre;
Rozen, Rima

Publication type:

Article

Design and rationale of a genetic cohort study on congenital cardiac disease: experiences from a multi-institutional platform in Quebec.

Published in:

Cardiology in the Young, 2011, v. 21, n. 6, p. 654, doi. 10.1017/S1047951111000813

By:

Dubé, Marie-Pierre;
Bigras, Jean-Luc;
Thibeault, Maryse;
Bureau, Nathalie;
Chetaille, Philippe;
Richter, Andrea;
Mercier, Jocelyne;
Bellavance, Marc;
Rohlicek, Charles;
Rozen, Rima;
Nemer, Mona;
Khairy, Paul;
Gendron, Roxanne;
Andelfinger, Gregor

Publication type:

Article

The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2022, v. 42, n. 12, p. 2333, doi. 10.1177/0271678X221122644

By:

Reagan, Alaina M;
Christensen, Karen E;
Graham, Leah C;
Bedwell, Amanda A;
Eldridge, Kierra;
Speedy, Rachael;
Figueiredo, Lucas L;
Persohn, Scott C;
Bottiglieri, Teodoro;
Nho, Kwangsik;
Sasner, Michael;
Territo, Paul R;
Rozen, Rima;
Howell, Gareth R

Publication type:

Article

Postnatal cerebellar defects in mice deficient in methylenetetrahydrofolate reductase

Published in:

International Journal of Developmental Neuroscience, 2005, v. 23, n. 5, p. 465, doi. 10.1016/j.ijdevneu.2005.05.007

By:

Chen, Zhoutao;
Schwahn, Bernd C.;
Wu, Qing;
He, Xinying;
Rozen, Rima

Publication type:

Article

Folate and Genetics.

Published in:

Journal of Food Science (Wiley-Blackwell), 2004, v. 69, n. 1, p. SNQ65, doi. 10.1111/j.1365-2621.2004.tb17890.x

By:

ROZEN, RIMA

Publication type:

Article

Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation.

Published in:

Molecular Human Reproduction, 2024, v. 30, n. 4, p. 1, doi. 10.1093/molehr/gaae008

By:

Rebolledo, Edgar Martínez Duncker;
Chan, Donovan;
Christensen, Karen E;
Reagan, Alaina M;
Howell, Gareth R;
Rozen, Rima;
Trasler, Jacquetta

Publication type:

Article

Quantitative proteomics reveals differentially expressed proteins in murine preneoplastic intestine in a model of intestinal tumorigenesis induced by low dietary folate and MTHFR deficiency.

Published in:

Proteomics, 2014, v. 14, n. 21/22, p. 2558, doi. 10.1002/pmic.201400280

By:

Leclerc, Daniel;
Dejgaard, Kurt;
Mazur, Alexander;
Deng, Liyuan;
Wu, Qing;
Nilsson, Tommy;
Rozen, Rima

Publication type:

Article

Vasculopathic and thrombophilic risk factors for spontaneous preterm birth.

Published in:

International Journal of Epidemiology, 2009, v. 38, n. 3, p. 715, doi. 10.1093/ije/dyp167

By:

Michael S Kramer;
Susan R Kahn;
Rima Rozen;
Rhobert Evans;
Robert W Platt;
Moy Fong Chen;
Lise Goulet;
Louise Séguin;
Clément Dassa;
John Lydon;
Helen McNamara;
Mourad Dahhou;
Jacques Genest

Publication type:

Article

Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.

Published in:

Human Molecular Genetics, 2001, v. 10, n. 5, p. 433, doi. 10.1093/hmg/10.5.433

By:

Chen, Zhoutao;
Karaplis, Andrew C.;
Ackerman, Susan L.;
Pogribny, Igor P.;
Melnyk, Stepan;
Lussier-Cacan, Suzanne;
Chen, Moy Fong;
Pai, Aditya;
John, Simon W.M.;
Smith, Richard S.;
Bottiglieri, Teodoro;
Bagley, Pamela;
Selhub, Jacob;
Rudnicki, Michael A.;
James, S. Jill;
Rozen, Rima

Publication type:

Article

Homocysteine modulates the effect of simvastatin on expression of ApoA-I and NF-κB/iNOS.

Published in:

Cardiovascular Research, 2008, v. 80, n. 1, p. 151, doi. 10.1093/cvr/cvn157

By:

Mikael, Leonie G.;
Rozen, Rima

Publication type:

Article

Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency.

Published in:

Journal of Cellular Biochemistry, 2008, v. 105, n. 2, p. 467, doi. 10.1002/jcb.21847

By:

Roy, Marc;
Leclerc, Daniel;
Wu, Qing;
Gupta, Sapna;
Kruger, Warren D.;
Rozen, Rima

Publication type:

Article

ApcMin/+ mouse model of colon cancer: Gene expression profiling in tumors.

Published in:

Journal of Cellular Biochemistry, 2004, v. 93, n. 6, p. 1242, doi. 10.1002/jcb.20236

By:

Daniel Leclerc;
Liyuan Deng;
Jacquetta Trasler;
Rima Rozen

Publication type:

Article

Socio-economic disparities in preterm birth: causal pathways and mechanisms.

Published in:

Paediatric & Perinatal Epidemiology, 2001, v. 15, p. 104, doi. 10.1046/j.1365-3016.2001.00012.x

By:

Kramer, Michael S.;
Goulet, Lise;
Lydon, John;
Séguin, Louise;
McNamara, Helen;
Dassa, Clément;
Platt, Robert W.;
Fong Chen, Moy;
Gauthier, Henriette;
Genest, Jacques;
Kahn, Susan;
Libman, Michael;
Rozen, Rima;
Masse, André;
Miner, Louise;
Asselin, Guylaine;
Benjamin, Alice;
Klein, Julia;
Koren, Gideon

Publication type:

Article

Plasma homocysteine concentration changes after renal transplantation in children.

Published in:

Pediatric Nephrology, 2002, v. 17, n. 7, p. 520, doi. 10.1007/s00467-002-0868-4

By:

Merouani, Aicha;
Delvin, Edgar E.;
Genest, Jacques;
Rozen, Rima;
Lambert, Marie

Publication type:

Article

Plasma homocysteine concentration in children with chronic renal failure.

Published in:

Pediatric Nephrology, 2001, v. 16, n. 10, p. 805, doi. 10.1007/s004670100648

By:

Merouani, A.;
Lambert, Marie;
Delvin, Edgar E.;
Genest Jr., Jacques;
Robitaille, Pierre;
Rozen, Rima

Publication type:

Article

Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of Apo AI and IFN-γ in spleen and placenta, and through reduction of methylation potential.

Published in:

Molecular Nutrition & Food Research, 2013, v. 57, n. 4, p. 661, doi. 10.1002/mnfr.201200152

By:

Mikael, Leonie G.;
Pancer, Jill;
Jiang, Xinyin;
Wu, Qing;
Caudill, Marie;
Rozen, Rima

Publication type:

Article

Differential gene expression and methylation in the retinoid/ PPARA pathway and of tumor suppressors may modify intestinal tumorigenesis induced by low folate in mice.

Published in:

Molecular Nutrition & Food Research, 2013, v. 57, n. 4, p. 686, doi. 10.1002/mnfr.201200212

By:

Leclerc, Daniel;
Cao, Yuanhang;
Deng, Liyuan;
Mikael, Leonie G.;
Wu, Qing;
Rozen, Rima

Publication type:

Article

Complete deficiency of methylenetetrahydrofolate reductase in mice is associated with impaired retinal function and variable mortality, hematological profiles, and reproductive outcomes.

Published in:

Journal of Inherited Metabolic Disease, 2011, v. 34, n. 1, p. 147, doi. 10.1007/s10545-010-9127-1

By:

Lawrance, Andrea;
Racine, Julie;
Deng, Liyuan;
Wang, Xiaoling;
Lachapelle, Pierre;
Rozen, Rima

Publication type:

Article

The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects.

Published in:

Human Mutation, 2009, v. 30, n. 2, p. 212, doi. 10.1002/humu.20830

By:

Christensen, Karen E.;
Rohlicek, Charles V.;
Andelfinger, Gregor U.;
Michaud, Jacques;
Bigras, Jean-Luc;
Richter, Andrea;
MacKenzie, Robert E.;
Rozen, Rima

Publication type:

Article

Characterization of mutations in severe methylenetetrahydrofolate reductase deficiency reveals an FAD‐responsive mutationCommunicated by Jan P. Kraus.

Published in:

Human Mutation, 2003, v. 21, n. 5, p. 509, doi. 10.1002/humu.10193

By:

Sahar Sibani;
Daniel Leclerc;
Ilan S. Weisberg;
Erin O'Ferrall;
David Watkins;
Carmen Artigas;
David S. Rosenblatt;
Rima Rozen

Publication type:

Article

The thermolabile variant 677C→T can further reduce activity when expressed in CIS with severe mutations for human methylenetetrahydrofolate reductase.

Published in:

Human Mutation, 2000, v. 16, n. 2, p. 132, doi. 10.1002/1098-1004(200008)16:2<132::AID-HUMU5>3.0.CO;2-T

By:

Goyette, Philippe;
Rozen, Rima

Publication type:

Article

Characterization of six novel mutations in the methylenetetrahydrofolate reductase (MTHFR) gene in patients with homocystinuria.

Published in:

Human Mutation, 2000, v. 15, n. 3, p. 280, doi. 10.1002/(SICI)1098-1004(200003)15:3<280::AID-HUMU9>3.0.CO;2-I

By:

Sibani, Sahar;
Christensen, Benedicte;
O'Ferrall, Erin;
Saadi, Irfan;
Hiou-Tim, François;
Rosenblatt, David S.;
Rozen, Rima

Publication type:

Article

In vitro and in vivo correlations for I65T and M1V mutations at the phenylalanine hydroxylase locus.

Published in:

Human Mutation, 1992, v. 1, n. 2, p. 147, doi. 10.1002/humu.1380010210

By:

John, Simon W. M.;
Scriver, Charles R.;
Laframboise, Rachel;
Rozen, Rima

Publication type:

Article

Folic Acid and Methyltetrahydrofolate Supplementation in the Mthfr 677C>T Mouse Model with Hepatic Steatosis.

Published in:

Nutrients, 2025, v. 17, n. 1, p. 82, doi. 10.3390/nu17010082

By:

Christensen, Karen E.;
Faquette, Marie-Lou;
Leclerc, Daniel;
Keser, Vafa;
Luan, Yan;
Bennett-Firmin, Jeanna L.;
Malysheva, Olga V.;
Reagan, Alaina M.;
Howell, Gareth R.;
Caudill, Marie A.;
Bottiglieri, Teodoro;
Rozen, Rima

Publication type:

Article

Moderate Folic Acid Supplementation in Pregnant Mice Results in Altered Sex-Specific Gene Expression in Brain of Young Mice and Embryos.

Published in:

Nutrients, 2022, v. 14, n. 5, p. N.PAG, doi. 10.3390/nu14051051

By:

Luan, Yan;
Cosín-Tomás, Marta;
Leclerc, Daniel;
Malysheva, Olga V.;
Caudill, Marie A.;
Rozen, Rima

Publication type:

Article

Mild Choline Deficiency and MTHFD1 Synthetase Deficiency Interact to Increase Incidence of Developmental Delays and Defects in Mice.

Published in:

Nutrients, 2022, v. 14, n. 1, p. 127, doi. 10.3390/nu14010127

By:

Christensen, Karen E.;
Malysheva, Olga V.;
Carlin, Stephanie;
Matias, Fernando;
MacFarlane, Amanda J.;
Jacobs, René L.;
Caudill, Marie A.;
Rozen, Rima

Publication type:

Article

Moderate Folic Acid Supplementation in Pregnant Mice Results in Behavioral Alterations in Offspring with Sex-Specific Changes in Methyl Metabolism.

Published in:

Nutrients, 2020, v. 12, n. 6, p. 1716, doi. 10.3390/nu12061716

By:

Cosín-Tomás, Marta;
Luan, Yan;
Leclerc, Daniel;
Malysheva, Olga V.;
Lauzon, Nidia;
Bahous, Renata H.;
Christensen, Karen E.;
Caudill, Marie A.;
Rozen, Rima

Publication type:

Article

Mapping and sequencing the human genome. Prepared by the Committee on Mapping and Sequencing the Human Genome, board of basic biology, commission on life sciences, National Research Council. X + 116 pp. Washington, D.C. National Academy Press: 1988, $14.95

Published in:

American Journal of Human Biology, 1989, v. 1, n. 4, p. 496, doi. 10.1002/ajhb.1310010415

By:

Rozen, Rima

Publication type:

Article

Mapping our genes. Genome projects: How big, how fast? office of technology assessment, Congress of the United States. 218 pp. Baltimore: Johns Hopkins Press. 1988, $10.00.

Published in:

American Journal of Human Biology, 1989, v. 1, n. 4, p. 496, doi. 10.1002/ajhb.1310010416

By:

Rozen, Rima

Publication type:

Article

Transient neonatal cystinuria.

Published in:

2005

By:

Boutros, Marylise;
Vicanek, Caroline;
Rozen, Rima;
Goodyer, Paul

Publication type:

journal article

SLC7A9 mutations in all three cystinuria subtypes.

Published in:

Kidney International, 2002, v. 62, n. 5, p. 1550, doi. 10.1046/j.1523-1755.2002.00602.x

By:

Leclerc, Daniel;
Boutros, Marylise;
Suh, Daniel;
Wu, Qing;
Palacin, Manuel;
Ellis, James R.;
Goodyer, Paul;
Rozen, Rima

Publication type:

Article

Cystinuria subtype and the risk of nephrolithiasis.

Published in:

Kidney International, 1998, v. 54, n. 1, p. 56, doi. 10.1046/j.1523-1755.1998.00957.x

By:

Goodyear, Paul;
Saadi, Irfan;
Ong, Patricia;
Elkas, Gay;
Rozen, Rima

Publication type:

Article

Molecular genetics of cystinuria: Mutation analysis of SLC3A1 and evidence for another gene in the Type I (silent) phenotype.

Published in:

Kidney International, 1998, v. 54, n. 1, p. 48, doi. 10.1046/j.1523-1755.1998.00956.x

By:

Saadi, Irfan;
Xing-Zhen Chen;
Hediger, Matthias;
Ong, Patricia;
Pereira, Perpetual;
Goodyear, Paul;
Rozen, Rima

Publication type:

Article

Molecular genetics of cystinuria in French Canadians: identification of four novel mutations in type I patients.

Published in:

1996

By:

Horsford, Jonathan;
Saari, Irfan;
Raelson, John;
Goodyer, Paul R.;
Rozen, Rima;
Horsford, J;
Saadi, I;
Raelson, J;
Goodyer, P R;
Rozen, R

Publication type:

journal article

The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia.

Published in:

Nature Structural Biology, 1999, v. 6, n. 4, p. 359

By:

Guenther, Brian D.;
Sheppard, Christal A.;
Tran, Pamela;
Rozen, Rima;
Matthews, Rowena G.;
Ludwig, Martha L.

Publication type:

Article

Biochemistry and genetics of folate metabolism.

Published in:

2010

By:

Rozen, Rima

Publication type:

Abstract

Murine MTHFD1-synthetase deficiency, a model for the human MTHFD1 R653Q polymorphism, decreases growth of colorectal tumors.

Published in:

Molecular Carcinogenesis, 2017, v. 56, n. 3, p. 1030, doi. 10.1002/mc.22568

By:

Lévesque, Nancy;
ChristENsEN, KarEN E.;
Van Der Kraak, LaurEN;
Best, Ana F.;
DENg, Liyuan;
Caldwell, Don;
MacFarlane, Amanda J.;
Beauchemin, Nicole;
RozEN, Rima

Publication type:

Article

Reduced folate carrier 80A→G polymorphism, plasma folate, and risk of placental abruption.

Published in:

Human Genetics, 2008, v. 124, n. 2, p. 137, doi. 10.1007/s00439-008-0531-7

By:

Ananth, Cande V.;
Peltier, Morgan R.;
Moore, Dirk F.;
Kinzler, Wendy L.;
Leclerc, Daniel;
Rozen, Rima R.

Publication type:

Article

Folate Deficiency and/or the Genetic Variant Mthfr<sup>677C >T</sup> Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex‐Specific Manner.

Published in:

Molecular Nutrition & Food Research, 2024, v. 68, n. 5, p. 1, doi. 10.1002/mnfr.202300355

By:

Leclerc, Daniel;
Christensen, Karen E.;
Reagan, Alaina M.;
Keser, Vafa;
Luan, Yan;
Malysheva, Olga V.;
Wasek, Brandi;
Bottiglieri, Teodoro;
Caudill, Marie A.;
Howell, Gareth R.;
Rozen, Rima

Publication type:

Article

Moderate Folic Acid Supplementation in Pregnant Mice Results in Altered Methyl Metabolism and in Sex‐Specific Placental Transcription Changes.

Published in:

Molecular Nutrition & Food Research, 2021, v. 65, n. 14, p. 1, doi. 10.1002/mnfr.202100197

By:

Luan, Yan;
Leclerc, Daniel;
Cosín‐Tomás, Marta;
Malysheva, Olga V.;
Wasek, Brandi;
Bottiglieri, Teodoro;
Caudill, Marie A.;
Rozen, Rima

Publication type:

Article

Mild Methylenetetrahydrofolate Reductase Deficiency Alters Inflammatory and Lipid Pathways in Liver.

Published in:

Molecular Nutrition & Food Research, 2019, v. 63, n. 3, p. N.PAG, doi. 10.1002/mnfr.201801001

By:

Leclerc, Daniel;
Christensen, Karen E.;
Cauvi, Olivia;
Yang, Ethan;
Fournelle, Frédéric;
Bahous, Renata H.;
Malysheva, Olga V.;
Deng, Liyuan;
Wu, Qing;
Zhou, Zili;
Gao, Zu‐Hua;
Chaurand, Pierre;
Caudill, Marie A.;
Rozen, Rima

Publication type:

Article

THE AUTHORS REPLY.

Published in:

American Journal of Epidemiology, 2009, v. 150, n. 3, p. 324

By:

Shaw, Gary M.;
Rozen, Rima;
Finnell, Richard H.;
Wasserman, Cathy R.;
Lammer, Edward J.

Publication type:

Article

Age Dependence of the Influence of Methylenetetrahydrofolate Reductase Genotype on Plasma Homocysteine Level.

Published in:

American Journal of Epidemiology, 2003, v. 158, n. 9, p. 871, doi. 10.1093/aje/kwg234

By:

Loretta D. Spotila;
Paul F. Jacques;
Peter B. Berger;
Karla V. Ballman;
R. Curtis Ellison;
Rima Rozen

Publication type:

Article

Homocysteine‐betaine interactions in a murine model of 5,10‐methylenetetrahydrofolate reductase deficiency.

Published in:

FASEB Journal, 2003, v. 17, n. 3, p. 1, doi. 10.1096/fj.02-0456fje

By:

Schwahn, Bernd C.;
Chen, Zhoutao;
Laryea, Maurice D.;
Wendel, Udo;
Lussier‐Cacan, Suzanne;
Genest, Jacques;
Mar, Mei‐Heng;
Zeisel, Steven H.;
Castro, Carmen;
Garrow, Timothy;
Rozen, Rima

Publication type:

Article

Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism.

Published in:

Biochemical Journal, 2014, v. 461, n. 2, p. 205, doi. 10.1042/BJ20131568

By:

JADAVJI, Nafisa M.;
BAHOUS, Renata H.;
DENG, Liyuan;
MALYSHEVA, Olga;
GRAND'MAISON, Marilyn;
BEDELL, Barry J.;
CAUDILL, Marie A.;
ROZEN, Rima

Publication type:

Article

High Dietary Folate in Mice Alters Immune Response and Reduces Survival after Malarial Infection.

Published in:

PLoS ONE, 2015, v. 10, n. 11, p. 1, doi. 10.1371/journal.pone.0143738

By:

Meadows, Danielle N.;
Bahous, Renata H.;
Best, Ana F.;
Rozen, Rima

Publication type:

Article

Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency.

Published in:

Molecular Neurobiology, 2019, v. 56, n. 6, p. 4175, doi. 10.1007/s12035-018-1375-3

By:

Bahous, Renata H.;
Cosín-Tomás, Marta;
Deng, Liyuan;
Leclerc, Daniel;
Malysheva, Olga;
Ho, Ming-Kai;
Pallàs, Mercè;
Kaliman, Perla;
Bedell, Barry J.;
Caudill, Marie A.;
Rozen, Rima

Publication type:

Article

Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms.

Published in:

Mammalian Genome, 2002, v. 13, n. 9, p. 483, doi. 10.1007/s00335-002-2167-6

By:

Tran, Pamela;
Leclerc, Daniel;
Chan, Manuel;
Pai, Aditya;
Hiou-Tim, Francois;
Wu, Qing;
Goyette, Philippe;
Artigas, Carmen;
Milos, Renate;
Rozen, Rima

Publication type:

Article