Works by RAJAMANI, SRIDHARAN

Results: 29

A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current.
Published in:
Journal of Physiology, 2015, v. 593, n. 6, p. 1429, doi. 10.1113/jphysiol.2014.279554
By:
- Yang, Pei‐Chi;
- Song, Yejia;
- Giles, Wayne R.;
- Horvath, Balazs;
- Chen‐Izu, Ye;
- Belardinelli, Luiz;
- Rajamani, Sridharan;
- Clancy, Colleen E.
Publication type:
Article
Deranged sodium to sudden death.
Published in:
Journal of Physiology, 2015, v. 593, n. 6, p. 1331, doi. 10.1113/jphysiol.2014.281204
By:
- Clancy, Colleen E.;
- Chen‐Izu, Ye;
- Bers, Donald M.;
- Belardinelli, Luiz;
- Boyden, Penelope A.;
- Csernoch, Laszlo;
- Despa, Sanda;
- Fermini, Bernard;
- Hool, Livia C.;
- Izu, Leighton;
- Kass, Robert S.;
- Lederer, W. Jonathan;
- Louch, William E.;
- Maack, Christoph;
- Matiazzi, Alicia;
- Qu, Zhilin;
- Rajamani, Sridharan;
- Rippinger, Crystal M.;
- Sejersted, Ole M.;
- O'Rourke, Brian
Publication type:
Article
Small Conductance Ca2 +-Activated K+ (SK) Channel mRNA Expression in Human Atrial and Ventricular Tissue: Comparison Between Donor, Atrial Fibrillation and Heart Failure Tissue.
Published in:
Frontiers in Physiology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphys.2021.650964
By:
- Darkow, Elisa;
- Nguyen, Thong T.;
- Stolina, Marina;
- Kari, Fabian A.;
- Schmidt, Constanze;
- Wiedmann, Felix;
- Baczkó, István;
- Kohl, Peter;
- Rajamani, Sridharan;
- Ravens, Ursula;
- Peyronnet, Rémi
Publication type:
Article
Coding variants in RPL3L and MYZAP increase risk of atrial fibrillation.
Published in:
Communications Biology, 2018, v. 1, n. 1, p. N.PAG, doi. 10.1038/s42003-018-0068-9
By:
- Thorolfsdottir, Rosa B.;
- Sveinbjornsson, Gardar;
- Sulem, Patrick;
- Nielsen, Jonas B.;
- Jonsson, Stefan;
- Halldorsson, Gisli H.;
- Melsted, Pall;
- Ivarsdottir, Erna V.;
- Davidsson, Olafur B.;
- Kristjansson, Ragnar P.;
- Thorleifsson, Gudmar;
- Helgadottir, Anna;
- Gretarsdottir, Solveig;
- Norddahl, Gudmundur;
- Rajamani, Sridharan;
- Torfason, Bjarni;
- Valgardsson, Atli S.;
- Sverrisson, Jon T.;
- Tragante, Vinicius;
- Holmen, Oddgeir L.
Publication type:
Article
Carbon monoxide effects on human ventricle action potential assessed by mathematical simulations.
Published in:
Frontiers in Physiology, 2013, v. 4, p. 1, doi. 10.3389/fphys.2013.00282
By:
- Trenor, Beatriz;
- Cardona, Karen;
- Saiz, Javier;
- Rajamani, Sridharan;
- Belardinelli, Luiz;
- Giles, Wayne R.
Publication type:
Article
Genetic basis for the origin of cardiac arrhythmias: Implications for therapy.
Published in:
Current Cardiology Reports, 2002, v. 4, n. 5, p. 411, doi. 10.1007/s11886-002-0041-5
By:
- Mbai, Mackenzi;
- Rajamani, Sridharan;
- Delisle, Brian;
- Anson, Blake;
- Anderson, Corey;
- Makielski, Jonathan;
- January, Craig
Publication type:
Article
Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 inmurine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes.
Published in:
Cardiovascular Research, 2017, v. 113, n. 7, p. 829, doi. 10.1093/cvr/cvx077
By:
- Portero, Vincent;
- Casini, Simona;
- Hoekstra, Maaike;
- Verkerk, Arie O.;
- Mengarelli, Isabella;
- Belardinelli, Luiz;
- Rajamani, Sridharan;
- Wilde, Arthur A. M.;
- Bezzina, Connie R.;
- Veldkamp, Marieke W.;
- Remme, Carol Ann
Publication type:
Article
The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.
Published in:
Cardiovascular Research, 2013, v. 99, n. 4, p. 600, doi. 10.1093/cvr/cvt145
By:
- Shryock, John C.;
- Song, Yejia;
- Rajamani, Sridharan;
- Antzelevitch, Charles;
- Belardinelli, Luiz
Publication type:
Article
A common co-morbidity modulates disease expression and treatment efficacy in inherited cardiac sodium channelopathy.
Published in:
European Heart Journal, 2018, v. 39, n. 31, p. 2898, doi. 10.1093/eurheartj/ehy247
By:
- Rivaud, Mathilde R;
- Jansen, John A;
- Postema, Pieter G;
- Nannenberg, Eline A;
- Mizusawa, Yuka;
- van der Nagel, Roel;
- Wolswinkel, Rianne;
- van der Made, Ingeborg;
- Marchal, Gerard A;
- Rajamani, Sridharan
Publication type:
Article
In silico assessment of drug safety in human heart applied to late sodium current blockers.
Published in:
Channels (19336950), 2013, v. 7, n. 4, p. 249, doi. 10.4161/chan.24905
By:
- Trenor, Beatriz;
- Gomis-Tena, Julio;
- Cardona, Karen;
- Romero, Lucia;
- Rajamani, Sridharan;
- Belardinelli, Luiz;
- Giles, Wayne R;
- Saiz, Javier
Publication type:
Article
Ranolazine block of human Nav1.4 sodium channels and paramyotonia congenita mutants.
Published in:
Channels (19336950), 2011, v. 5, n. 2, p. 161, doi. 10.4161/chan.5.2.14851
By:
- El-Bizri, Nesrine;
- Kahlig, Kristopher M.;
- Shyrock, John C.;
- George, Jr., Alfred L.;
- Belardinelli, Luiz;
- Rajamani, Sridharan
Publication type:
Article
The Selective Cardiac Late Sodium Current Inhibitor GS-458967 Suppresses Autonomically Triggered Atrial Fibrillation in an Intact Porcine Model.
Published in:
Journal of Cardiovascular Electrophysiology, 2015, v. 26, n. 12, p. 1364, doi. 10.1111/jce.12824
By:
- CARNEIRO, JULIANA SARAN;
- BENTO, AFONSO S. ALVES;
- BACIC, DANILO;
- NEARING, BRUCE D.;
- RAJAMANI, SRIDHARAN;
- BELARDINELLI, LUIZ;
- VERRIER, RICHARD L.
Publication type:
Article
Combined Actions of Ivabradine and Ranolazine Reduce Ventricular Rate During Atrial Fibrillation.
Published in:
Journal of Cardiovascular Electrophysiology, 2015, v. 26, n. 3, p. 329, doi. 10.1111/jce.12569
By:
- VERRIER, RICHARD L.;
- SILVA, ANA F.G.;
- BONATTI, RODOLFO;
- BATATINHA, JULIO A.P.;
- NEARING, BRUCE D.;
- LIU, GONGXIN;
- RAJAMANI, SRIDHARAN;
- ZENG, DEWAN;
- BELARDINELLI, LUIZ
Publication type:
Article
Phytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death in mice.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-96936-x
By:
- Ge, Hongfei;
- Liu, Gongxin;
- Yamawaki, Tracy M.;
- Tao, Caroline;
- Alexander, Shawn T.;
- Ly, Kimberly;
- Fordstrom, Preston;
- Shkumatov, Artem A.;
- Li, Chi-Ming;
- Rajamani, Sridharan;
- Zhou, Mingyue;
- Ason, Brandon
Publication type:
Article
Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice.
Published in:
2020
By:
- Rivaud, Mathilde R;
- Marchal, Gerard A;
- Wolswinkel, Rianne;
- Jansen, John A;
- van der Made, Ingeborg;
- Beekman, Leander;
- Ruiz-Villalba, Adrián;
- Baartscheer, Antonius;
- Rajamani, Sridharan;
- Belardinelli, Luiz;
- Veen, Toon A B van;
- Basso, Cristina;
- Thiene, Gaetano;
- Creemers, Esther E;
- Bezzina, Connie R;
- Remme, Carol Ann;
- van Veen, Toon A B
Publication type:
journal article
Sodium channel block by ranolazine in an experimental model of stretch-related atrial fibrillation: prolongation of interatrial conduction time and increase in post-repolarization refractoriness.
Published in:
EP: Europace, 2013, v. 15, n. 5, p. 761, doi. 10.1093/europace/eus399
By:
- Milberg, Peter;
- Frommeyer, Gerrit;
- Ghezelbash, Shokoufeh;
- Rajamani, Sridharan;
- Osada, Nani;
- Razvan, Radu;
- Belardinelli, Luiz;
- Breithardt, Günter;
- Eckardt, Lars
Publication type:
Article
Meta-Analysis of Mechano-Sensitive Ion Channels in Human Hearts: Chamber- and Disease-Preferential mRNA Expression.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 13, p. 10961, doi. 10.3390/ijms241310961
By:
- Darkow, Elisa;
- Yusuf, Dilmurat;
- Rajamani, Sridharan;
- Backofen, Rolf;
- Kohl, Peter;
- Ravens, Ursula;
- Peyronnet, Rémi
Publication type:
Article
Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.
Published in:
2018
By:
- Bossu, Alexandre;
- Houtman, Marien J. C.;
- Meijborg, Veronique M. F.;
- Varkevisser, Rosanne;
- Beekman, Henriette D. M.;
- Dunnink, Albert;
- de Bakker, Jacques M. T.;
- Mollova, Nevena;
- Rajamani, Sridharan;
- Belardinelli, Luiz;
- van der Heyden, Marcel A. G.;
- Vos, Marc A.
Publication type:
journal article
The novel late Na+ current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations.
Published in:
2016
By:
- Rajamani, Sridharan;
- Liu, Gongxin;
- El ‐ Bizri, Nesrine;
- Guo, Donglin;
- Li, Cindy;
- Chen, Xiao ‐ Liang;
- Kahlig, Kristopher M;
- Mollova, Nevena;
- Elzein, Elfatih;
- Zablocki, Jeff;
- Belardinelli, Luiz;
- El-Bizri, Nesrine;
- Chen, Xiao-Liang
Publication type:
journal article
Ranolazine selectively blocks persistent current evoked by epilepsy-associated Naν1.1 mutations.
Published in:
2010
By:
- Kahlig, Kristopher M;
- Lepist, Irene;
- Leung, Kwan;
- Rajamani, Sridharan;
- George, Alfred L
Publication type:
journal article
Sequence variants with large effects on cardiac electrophysiology and disease.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12682-9
By:
- Norland, Kristjan;
- Sveinbjornsson, Gardar;
- Thorolfsdottir, Rosa B.;
- Davidsson, Olafur B.;
- Tragante, Vinicius;
- Rajamani, Sridharan;
- Helgadottir, Anna;
- Gretarsdottir, Solveig;
- van Setten, Jessica;
- Asselbergs, Folkert W.;
- Sverrisson, Jon Th.;
- Stephensen, Sigurdur S.;
- Oskarsson, Gylfi;
- Sigurdsson, Emil L.;
- Andersen, Karl;
- Danielsen, Ragnar;
- Thorgeirsson, Gudmundur;
- Thorsteinsdottir, Unnur;
- Arnar, David O.;
- Sulem, Patrick
Publication type:
Article
Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome.
Published in:
2005
By:
- Eckhardt, Lee L;
- Rajamani, Sridharan;
- January, Craig T
Publication type:
journal article
Cardiotoxic effects of fenfluramine hydrochloride on isolated cardiac preparations and ventricular myocytes of guinea-pigs.
Published in:
British Journal of Pharmacology, 2000, v. 129, n. 5, p. 843, doi. 10.1038/sj.bjp.0703118
By:
- Rajamani, Sridharan;
- Studenik, Christian;
- Lemmens-Gruber, Rosa;
- Heistracher, Peter
Publication type:
Article
Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone.
Published in:
Cardiovascular Research, 2008, v. 77, n. 3, p. 481, doi. 10.1093/cvr/cvm069
By:
- Lin Wu;
- Rajamani, Sridharan;
- Shryock, John C.;
- Hong Li;
- Ruskin, Jeremy;
- Antzelevitch, Charles;
- Belardinelli, Luiz
Publication type:
Article
The anti-malarial drug halofantrine and its metabolite N-desbutylhalofantrine block HERG potassium channels.
Published in:
Cardiovascular Research, 2002, v. 55, n. 4, p. 799, doi. 10.1016/S0008-6363(02)00448-0
By:
- Mbai, Mackenzi;
- Rajamani, Sridharan;
- January, Craig T
Publication type:
Article
Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure.
Published in:
PLoS ONE, 2012, v. 7, n. 3, p. 1, doi. 10.1371/journal.pone.0032659
By:
- Trenor, Beatriz;
- Cardona, Karen;
- Gomez, Juan F.;
- Rajamani, Sridharan;
- Ferrero, Jose M.;
- Belardinelli, Luiz;
- Saiz, Javier
Publication type:
Article
Blockade of Na+ Channels in Pancreatic [alpha]-Cells Has Antidiabetic Effects.
Published in:
2014
By:
- Dhalla, Arvinder K;
- Yang, Ming;
- Ning, Yun;
- Kahlig, Kristopher M;
- Krause, Michael;
- Rajamani, Sridharan;
- Belardinelli, Luiz
Publication type:
Journal Article
Blockade of Na+ Channels in Pancreatic α-Cells Has Antidiabetic Effects.
Published in:
Diabetes, 2014, v. 63, n. 10, p. 3545, doi. 10.2337/db13-1562
By:
- Dhalla, Arvinder K.;
- Ming Yang;
- Yun Ning;
- Kahlig, Kristopher M.;
- Krause, Michael;
- Rajamani, Sridharan;
- Belardinelli, Luiz
Publication type:
Article
Antiepileptic activity of preferential inhibitors of persistent sodium current.
Published in:
Epilepsia (Series 4), 2014, v. 55, n. 8, p. 1274, doi. 10.1111/epi.12657
By:
- Anderson, Lyndsey L.;
- Thompson, Christopher H.;
- Hawkins, Nicole A.;
- Nath, Ravi D.;
- Petersohn, Adam A.;
- Rajamani, Sridharan;
- Bush, William S.;
- Frankel, Wayne N.;
- Vanoye, Carlos G.;
- Kearney, Jennifer A.;
- George, Alfred L.
Publication type:
Article

Works by RAJAMANI, SRIDHARAN

A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na<sup>+</sup> current.

Deranged sodium to sudden death.

Small Conductance Ca<sup>2 +</sup>-Activated K<sup>+</sup> (SK) Channel mRNA Expression in Human Atrial and Ventricular Tissue: Comparison Between Donor, Atrial Fibrillation and Heart Failure Tissue.

Coding variants in RPL3L and MYZAP increase risk of atrial fibrillation.

Carbon monoxide effects on human ventricle action potential assessed by mathematical simulations.

Genetic basis for the origin of cardiac arrhythmias: Implications for therapy.

Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 inmurine Scn5a-1798insD<sup>+/-</sup> and human SCN5A-1795insD<sup>+/-</sup> iPSC-derived cardiomyocytes.

The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.

A common co-morbidity modulates disease expression and treatment efficacy in inherited cardiac sodium channelopathy.

In silico assessment of drug safety in human heart applied to late sodium current blockers.

Ranolazine block of human Na<sub>v</sub>1.4 sodium channels and paramyotonia congenita mutants.

The Selective Cardiac Late Sodium Current Inhibitor GS-458967 Suppresses Autonomically Triggered Atrial Fibrillation in an Intact Porcine Model.

Combined Actions of Ivabradine and Ranolazine Reduce Ventricular Rate During Atrial Fibrillation.

Phytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death in mice.

Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice.

Sodium channel block by ranolazine in an experimental model of stretch-related atrial fibrillation: prolongation of interatrial conduction time and increase in post-repolarization refractoriness.

Meta-Analysis of Mechano-Sensitive Ion Channels in Human Hearts: Chamber- and Disease-Preferential mRNA Expression.

Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.

The novel late Na<sup>+</sup> current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations.

Ranolazine selectively blocks persistent current evoked by epilepsy-associated Naν1.1 mutations.

Sequence variants with large effects on cardiac electrophysiology and disease.

Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome.

Cardiotoxic effects of fenfluramine hydrochloride on isolated cardiac preparations and ventricular myocytes of guinea-pigs.

Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone.

The anti-malarial drug halofantrine and its metabolite N-desbutylhalofantrine block HERG potassium channels.

Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure.

Blockade of Na+ Channels in Pancreatic [alpha]-Cells Has Antidiabetic Effects.

Blockade of Na<sup>+</sup> Channels in Pancreatic α-Cells Has Antidiabetic Effects.

Antiepileptic activity of preferential inhibitors of persistent sodium current.