Works by RAJAMANI, SRIDHARAN

Results: 29

Ranolazine selectively blocks persistent current evoked by epilepsy-associated Naν1.1 mutations.

Published in:

2010

By:

Kahlig, Kristopher M;
Lepist, Irene;
Leung, Kwan;
Rajamani, Sridharan;
George, Alfred L

Publication type:

journal article

Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome.

Published in:

2005

By:

Eckhardt, Lee L;
Rajamani, Sridharan;
January, Craig T

Publication type:

journal article

Cardiotoxic effects of fenfluramine hydrochloride on isolated cardiac preparations and ventricular myocytes of guinea-pigs.

Published in:

British Journal of Pharmacology, 2000, v. 129, n. 5, p. 843, doi. 10.1038/sj.bjp.0703118

By:

Rajamani, Sridharan;
Studenik, Christian;
Lemmens-Gruber, Rosa;
Heistracher, Peter

Publication type:

Article

Antiepileptic activity of preferential inhibitors of persistent sodium current.

Published in:

Epilepsia (Series 4), 2014, v. 55, n. 8, p. 1274, doi. 10.1111/epi.12657

By:

Anderson, Lyndsey L.;
Thompson, Christopher H.;
Hawkins, Nicole A.;
Nath, Ravi D.;
Petersohn, Adam A.;
Rajamani, Sridharan;
Bush, William S.;
Frankel, Wayne N.;
Vanoye, Carlos G.;
Kearney, Jennifer A.;
George, Alfred L.

Publication type:

Article

Coding variants in RPL3L and MYZAP increase risk of atrial fibrillation.

Published in:

Communications Biology, 2018, v. 1, n. 1, p. N.PAG, doi. 10.1038/s42003-018-0068-9

By:

Thorolfsdottir, Rosa B.;
Sveinbjornsson, Gardar;
Sulem, Patrick;
Nielsen, Jonas B.;
Jonsson, Stefan;
Halldorsson, Gisli H.;
Melsted, Pall;
Ivarsdottir, Erna V.;
Davidsson, Olafur B.;
Kristjansson, Ragnar P.;
Thorleifsson, Gudmar;
Helgadottir, Anna;
Gretarsdottir, Solveig;
Norddahl, Gudmundur;
Rajamani, Sridharan;
Torfason, Bjarni;
Valgardsson, Atli S.;
Sverrisson, Jon T.;
Tragante, Vinicius;
Holmen, Oddgeir L.

Publication type:

Article

Genetic basis for the origin of cardiac arrhythmias: Implications for therapy.

Published in:

Current Cardiology Reports, 2002, v. 4, n. 5, p. 411, doi. 10.1007/s11886-002-0041-5

By:

Mbai, Mackenzi;
Rajamani, Sridharan;
Delisle, Brian;
Anson, Blake;
Anderson, Corey;
Makielski, Jonathan;
January, Craig

Publication type:

Article

Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 inmurine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes.

Published in:

Cardiovascular Research, 2017, v. 113, n. 7, p. 829, doi. 10.1093/cvr/cvx077

By:

Portero, Vincent;
Casini, Simona;
Hoekstra, Maaike;
Verkerk, Arie O.;
Mengarelli, Isabella;
Belardinelli, Luiz;
Rajamani, Sridharan;
Wilde, Arthur A. M.;
Bezzina, Connie R.;
Veldkamp, Marieke W.;
Remme, Carol Ann

Publication type:

Article

The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.

Published in:

Cardiovascular Research, 2013, v. 99, n. 4, p. 600, doi. 10.1093/cvr/cvt145

By:

Shryock, John C.;
Song, Yejia;
Rajamani, Sridharan;
Antzelevitch, Charles;
Belardinelli, Luiz

Publication type:

Article

Meta-Analysis of Mechano-Sensitive Ion Channels in Human Hearts: Chamber- and Disease-Preferential mRNA Expression.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 13, p. 10961, doi. 10.3390/ijms241310961

By:

Darkow, Elisa;
Yusuf, Dilmurat;
Rajamani, Sridharan;
Backofen, Rolf;
Kohl, Peter;
Ravens, Ursula;
Peyronnet, Rémi

Publication type:

Article

Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.

Published in:

2018

By:

Bossu, Alexandre;
Houtman, Marien J. C.;
Meijborg, Veronique M. F.;
Varkevisser, Rosanne;
Beekman, Henriette D. M.;
Dunnink, Albert;
de Bakker, Jacques M. T.;
Mollova, Nevena;
Rajamani, Sridharan;
Belardinelli, Luiz;
van der Heyden, Marcel A. G.;
Vos, Marc A.

Publication type:

journal article

The novel late Na+ current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations.

Published in:

2016

By:

Rajamani, Sridharan;
Liu, Gongxin;
El ‐ Bizri, Nesrine;
Guo, Donglin;
Li, Cindy;
Chen, Xiao ‐ Liang;
Kahlig, Kristopher M;
Mollova, Nevena;
Elzein, Elfatih;
Zablocki, Jeff;
Belardinelli, Luiz;
El-Bizri, Nesrine;
Chen, Xiao-Liang

Publication type:

journal article

Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone.

Published in:

Cardiovascular Research, 2008, v. 77, n. 3, p. 481, doi. 10.1093/cvr/cvm069

By:

Lin Wu;
Rajamani, Sridharan;
Shryock, John C.;
Hong Li;
Ruskin, Jeremy;
Antzelevitch, Charles;
Belardinelli, Luiz

Publication type:

Article

The anti-malarial drug halofantrine and its metabolite N-desbutylhalofantrine block HERG potassium channels.

Published in:

Cardiovascular Research, 2002, v. 55, n. 4, p. 799, doi. 10.1016/S0008-6363(02)00448-0

By:

Mbai, Mackenzi;
Rajamani, Sridharan;
January, Craig T

Publication type:

Article

Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice.

Published in:

2020

By:

Rivaud, Mathilde R;
Marchal, Gerard A;
Wolswinkel, Rianne;
Jansen, John A;
van der Made, Ingeborg;
Beekman, Leander;
Ruiz-Villalba, Adrián;
Baartscheer, Antonius;
Rajamani, Sridharan;
Belardinelli, Luiz;
Veen, Toon A B van;
Basso, Cristina;
Thiene, Gaetano;
Creemers, Esther E;
Bezzina, Connie R;
Remme, Carol Ann;
van Veen, Toon A B

Publication type:

journal article

Sodium channel block by ranolazine in an experimental model of stretch-related atrial fibrillation: prolongation of interatrial conduction time and increase in post-repolarization refractoriness.

Published in:

EP: Europace, 2013, v. 15, n. 5, p. 761, doi. 10.1093/europace/eus399

By:

Milberg, Peter;
Frommeyer, Gerrit;
Ghezelbash, Shokoufeh;
Rajamani, Sridharan;
Osada, Nani;
Razvan, Radu;
Belardinelli, Luiz;
Breithardt, Günter;
Eckardt, Lars

Publication type:

Article

The Selective Cardiac Late Sodium Current Inhibitor GS-458967 Suppresses Autonomically Triggered Atrial Fibrillation in an Intact Porcine Model.

Published in:

Journal of Cardiovascular Electrophysiology, 2015, v. 26, n. 12, p. 1364, doi. 10.1111/jce.12824

By:

CARNEIRO, JULIANA SARAN;
BENTO, AFONSO S. ALVES;
BACIC, DANILO;
NEARING, BRUCE D.;
RAJAMANI, SRIDHARAN;
BELARDINELLI, LUIZ;
VERRIER, RICHARD L.

Publication type:

Article

Combined Actions of Ivabradine and Ranolazine Reduce Ventricular Rate During Atrial Fibrillation.

Published in:

Journal of Cardiovascular Electrophysiology, 2015, v. 26, n. 3, p. 329, doi. 10.1111/jce.12569

By:

VERRIER, RICHARD L.;
SILVA, ANA F.G.;
BONATTI, RODOLFO;
BATATINHA, JULIO A.P.;
NEARING, BRUCE D.;
LIU, GONGXIN;
RAJAMANI, SRIDHARAN;
ZENG, DEWAN;
BELARDINELLI, LUIZ

Publication type:

Article

Carbon monoxide effects on human ventricle action potential assessed by mathematical simulations.

Published in:

Frontiers in Physiology, 2013, v. 4, p. 1, doi. 10.3389/fphys.2013.00282

By:

Trenor, Beatriz;
Cardona, Karen;
Saiz, Javier;
Rajamani, Sridharan;
Belardinelli, Luiz;
Giles, Wayne R.

Publication type:

Article

A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current.

Published in:

Journal of Physiology, 2015, v. 593, n. 6, p. 1429, doi. 10.1113/jphysiol.2014.279554

By:

Yang, Pei‐Chi;
Song, Yejia;
Giles, Wayne R.;
Horvath, Balazs;
Chen‐Izu, Ye;
Belardinelli, Luiz;
Rajamani, Sridharan;
Clancy, Colleen E.

Publication type:

Article

Deranged sodium to sudden death.

Published in:

Journal of Physiology, 2015, v. 593, n. 6, p. 1331, doi. 10.1113/jphysiol.2014.281204

By:

Clancy, Colleen E.;
Chen‐Izu, Ye;
Bers, Donald M.;
Belardinelli, Luiz;
Boyden, Penelope A.;
Csernoch, Laszlo;
Despa, Sanda;
Fermini, Bernard;
Hool, Livia C.;
Izu, Leighton;
Kass, Robert S.;
Lederer, W. Jonathan;
Louch, William E.;
Maack, Christoph;
Matiazzi, Alicia;
Qu, Zhilin;
Rajamani, Sridharan;
Rippinger, Crystal M.;
Sejersted, Ole M.;
O'Rourke, Brian

Publication type:

Article

Blockade of Na+ Channels in Pancreatic α-Cells Has Antidiabetic Effects.

Published in:

Diabetes, 2014, v. 63, n. 10, p. 3545, doi. 10.2337/db13-1562

By:

Dhalla, Arvinder K.;
Ming Yang;
Yun Ning;
Kahlig, Kristopher M.;
Krause, Michael;
Rajamani, Sridharan;
Belardinelli, Luiz

Publication type:

Article

Blockade of Na+ Channels in Pancreatic [alpha]-Cells Has Antidiabetic Effects.

Published in:

2014

By:

Dhalla, Arvinder K;
Yang, Ming;
Ning, Yun;
Kahlig, Kristopher M;
Krause, Michael;
Rajamani, Sridharan;
Belardinelli, Luiz

Publication type:

Journal Article

Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure.

Published in:

PLoS ONE, 2012, v. 7, n. 3, p. 1, doi. 10.1371/journal.pone.0032659

By:

Trenor, Beatriz;
Cardona, Karen;
Gomez, Juan F.;
Rajamani, Sridharan;
Ferrero, Jose M.;
Belardinelli, Luiz;
Saiz, Javier

Publication type:

Article

Phytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death in mice.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-96936-x

By:

Ge, Hongfei;
Liu, Gongxin;
Yamawaki, Tracy M.;
Tao, Caroline;
Alexander, Shawn T.;
Ly, Kimberly;
Fordstrom, Preston;
Shkumatov, Artem A.;
Li, Chi-Ming;
Rajamani, Sridharan;
Zhou, Mingyue;
Ason, Brandon

Publication type:

Article

Small Conductance Ca2 +-Activated K+ (SK) Channel mRNA Expression in Human Atrial and Ventricular Tissue: Comparison Between Donor, Atrial Fibrillation and Heart Failure Tissue.

Published in:

Frontiers in Physiology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphys.2021.650964

By:

Darkow, Elisa;
Nguyen, Thong T.;
Stolina, Marina;
Kari, Fabian A.;
Schmidt, Constanze;
Wiedmann, Felix;
Baczkó, István;
Kohl, Peter;
Rajamani, Sridharan;
Ravens, Ursula;
Peyronnet, Rémi

Publication type:

Article

A common co-morbidity modulates disease expression and treatment efficacy in inherited cardiac sodium channelopathy.

Published in:

European Heart Journal, 2018, v. 39, n. 31, p. 2898, doi. 10.1093/eurheartj/ehy247

By:

Rivaud, Mathilde R;
Jansen, John A;
Postema, Pieter G;
Nannenberg, Eline A;
Mizusawa, Yuka;
van der Nagel, Roel;
Wolswinkel, Rianne;
van der Made, Ingeborg;
Marchal, Gerard A;
Rajamani, Sridharan

Publication type:

Article

Sequence variants with large effects on cardiac electrophysiology and disease.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12682-9

By:

Norland, Kristjan;
Sveinbjornsson, Gardar;
Thorolfsdottir, Rosa B.;
Davidsson, Olafur B.;
Tragante, Vinicius;
Rajamani, Sridharan;
Helgadottir, Anna;
Gretarsdottir, Solveig;
van Setten, Jessica;
Asselbergs, Folkert W.;
Sverrisson, Jon Th.;
Stephensen, Sigurdur S.;
Oskarsson, Gylfi;
Sigurdsson, Emil L.;
Andersen, Karl;
Danielsen, Ragnar;
Thorgeirsson, Gudmundur;
Thorsteinsdottir, Unnur;
Arnar, David O.;
Sulem, Patrick

Publication type:

Article

In silico assessment of drug safety in human heart applied to late sodium current blockers.

Published in:

Channels (19336950), 2013, v. 7, n. 4, p. 249, doi. 10.4161/chan.24905

By:

Trenor, Beatriz;
Gomis-Tena, Julio;
Cardona, Karen;
Romero, Lucia;
Rajamani, Sridharan;
Belardinelli, Luiz;
Giles, Wayne R;
Saiz, Javier

Publication type:

Article

Ranolazine block of human Nav1.4 sodium channels and paramyotonia congenita mutants.

Published in:

Channels (19336950), 2011, v. 5, n. 2, p. 161, doi. 10.4161/chan.5.2.14851

By:

El-Bizri, Nesrine;
Kahlig, Kristopher M.;
Shyrock, John C.;
George, Jr., Alfred L.;
Belardinelli, Luiz;
Rajamani, Sridharan

Publication type:

Article

Works by RAJAMANI, SRIDHARAN

Ranolazine selectively blocks persistent current evoked by epilepsy-associated Naν1.1 mutations.

Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome.

Cardiotoxic effects of fenfluramine hydrochloride on isolated cardiac preparations and ventricular myocytes of guinea-pigs.

Antiepileptic activity of preferential inhibitors of persistent sodium current.

Coding variants in RPL3L and MYZAP increase risk of atrial fibrillation.

Genetic basis for the origin of cardiac arrhythmias: Implications for therapy.

Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 inmurine Scn5a-1798insD<sup>+/-</sup> and human SCN5A-1795insD<sup>+/-</sup> iPSC-derived cardiomyocytes.

The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.

Meta-Analysis of Mechano-Sensitive Ion Channels in Human Hearts: Chamber- and Disease-Preferential mRNA Expression.

Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.

The novel late Na<sup>+</sup> current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations.

Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone.

The anti-malarial drug halofantrine and its metabolite N-desbutylhalofantrine block HERG potassium channels.

Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice.

Sodium channel block by ranolazine in an experimental model of stretch-related atrial fibrillation: prolongation of interatrial conduction time and increase in post-repolarization refractoriness.

The Selective Cardiac Late Sodium Current Inhibitor GS-458967 Suppresses Autonomically Triggered Atrial Fibrillation in an Intact Porcine Model.

Combined Actions of Ivabradine and Ranolazine Reduce Ventricular Rate During Atrial Fibrillation.

Carbon monoxide effects on human ventricle action potential assessed by mathematical simulations.

A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na<sup>+</sup> current.

Deranged sodium to sudden death.

Blockade of Na<sup>+</sup> Channels in Pancreatic α-Cells Has Antidiabetic Effects.

Blockade of Na+ Channels in Pancreatic [alpha]-Cells Has Antidiabetic Effects.

Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure.

Phytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death in mice.

Small Conductance Ca<sup>2 +</sup>-Activated K<sup>+</sup> (SK) Channel mRNA Expression in Human Atrial and Ventricular Tissue: Comparison Between Donor, Atrial Fibrillation and Heart Failure Tissue.

A common co-morbidity modulates disease expression and treatment efficacy in inherited cardiac sodium channelopathy.

Sequence variants with large effects on cardiac electrophysiology and disease.

In silico assessment of drug safety in human heart applied to late sodium current blockers.

Ranolazine block of human Na<sub>v</sub>1.4 sodium channels and paramyotonia congenita mutants.