Works by Rühl, Ralph

Results: 65

9-Cis-13,14-dihydroretinoic acid, a new endogenous mammalian ligand of retinoid X receptor and the active ligand of a potential new vitamin A category: vitamin A5.

Published in:

Nutrition Reviews, 2018, v. 76, p. 929, doi. 10.1093/nutrit/nuy057

By:

Rühl, Ralph;
Krężel, Wojciech;
Lera, Angel R de

Publication type:

Article

9-Cis-13,14-dihydroretinoic acid, a new endogenous mammalian ligand of retinoid X receptor and the active ligand of a potential new vitamin A category: vitamin A5.

Published in:

Nutrition Reviews, 2018, v. 76, n. 12, p. 929, doi. 10.1093/nutrit/nuy057

By:

Rühl, Ralph;
Krężel, Wojciech;
Lera, Angel R de

Publication type:

Article

Carotenoid metabolites, their tissue and blood concentrations in humans and further bioactivity via retinoid receptor-mediated signalling.

Published in:

Nutrition Research Reviews, 2023, v. 36, n. 2, p. 498, doi. 10.1017/S095442242200021X

By:

Bohn, Torsten;
de Lera, Angel R.;
Landrier, Jean-Francois;
Rühl, Ralph

Publication type:

Article

Mechanistic aspects of carotenoid health benefits – where are we now?

Published in:

Nutrition Research Reviews, 2021, v. 34, n. 2, p. 276, doi. 10.1017/S0954422421000147

By:

Bohn, Torsten;
Bonet, M. Luisa;
Borel, Patrick;
Keijer, Jaap;
Landrier, Jean-Francois;
Milisav, Irina;
Ribot, Joan;
Riso, Patrizia;
Winklhofer-Roob, Brigitte;
Sharoni, Yoav;
Corte-Real, Joana;
van Helden, Yvonne;
Loizzo, Monica Rosa;
Poljšak, Borut;
Porrini, Marisa;
Roob, Johannes;
Trebše, Polonca;
Tundis, Rosa;
Wawrzyniak, Agata;
Rühl, Ralph

Publication type:

Article

Saturated and monounsaturated fatty acids in membranes are determined by the gene expression of their metabolizing enzymes SCD1 and ELOVL6 regulated by the intake of dietary fat.

Published in:

European Journal of Nutrition, 2020, v. 59, n. 6, p. 2759, doi. 10.1007/s00394-019-02121-2

By:

Weiss-Hersh, Kathrin;
Garcia, Ada L.;
Marosvölgyi, Tamás;
Szklenár, Mónika;
Decsi, Tamás;
Rühl, Ralph

Publication type:

Article

Poly(ADP) ribose polymerase-1 ablation alters eicosanoid and docosanoid signaling and metabolism in a murine model of contact hypersensitivity.

Published in:

Molecular Medicine Reports, 2015, v. 11, n. 4, p. 2861, doi. 10.3892/mmr.2014.3044

By:

KISS, BORBÁLA;
SZÁNTÓ, MAGDOLNA;
SZKLENÁR, MÓNIKA;
BRUNYÁNSZKI, ATTILA;
MAROSVÖLGYI, TAMÁS;
SÁROSI, ESZTER;
REMENYIK, ÉVA;
GERGELY, PÁL;
VIRÁG, LÁSZLÓ;
DECSI, TAMÁS;
RÜHL, RALPH;
BAI, PETER

Publication type:

Article

9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice.

Published in:

PLoS Genetics, 2015, v. 11, n. 6, p. 1, doi. 10.1371/journal.pgen.1005213

By:

Rühl, Ralph;
Krzyżosiak, Agnieszka;
Niewiadomska-Cimicka, Anna;
Rochel, Natacha;
Szeles, Lajos;
Vaz, Belén;
Wietrzych-Schindler, Marta;
Álvarez, Susana;
Szklenar, Monika;
Nagy, Laszlo;
de Lera, Angel R.;
Krężel, Wojciech

Publication type:

Article

LRAT Overexpression Diminishes Intracellular Levels of Biologically Active Retinoids and Reduces Retinoid Antitumor Efficacy in the Murine Melanoma B16F10 Cell Line.

Published in:

Skin Pharmacology & Physiology, 2015, v. 28, n. 4, p. 205, doi. 10.1159/000368806

By:

amann, Philipp M.;
Czaja, Katharina;
Bazhin, alexandr V.;
Rühl, Ralph;
Eichmüller, Stefan B.;
Merk, Hans F.;
Baron, Jens M.

Publication type:

Article

Increased FADS2-Derived n-6 PUFAs and Reduced n-3 PUFAs in Plasma of Atopic Dermatitis Patients.

Published in:

Skin Pharmacology & Physiology, 2014, v. 27, n. 5, p. 242, doi. 10.1159/000358290

By:

Mihály, Johanna;
Marosvölgyi, Tamás;
Szegedi, andrea;
Köröskényi, Krisztina;
Lucas, Renata;
Törőcsik, Dániel;
Garcia, ada L.;
Decsi, Tamás;
Rühl, Ralph

Publication type:

Article

Plasma Levels of Bioactive Vitamin D and A5 Ligands Positively Correlate with Clinical Atopic Dermatitis Markers.

Published in:

Dermatology (10188665), 2022, v. 238, n. 6, p. 1076, doi. 10.1159/000524343

By:

Lucas, Renata;
Szklenar, Monika;
Mihály, Johanna;
Szegedi, Andrea;
Töröcsik, Daniel;
Rühl, Ralph

Publication type:

Article

Topical Vitamin D Receptor Antagonist/Partial-Agonist Treatment Induces Epidermal Hyperproliferation via RARγ Signaling Pathways.

Published in:

Dermatology (10188665), 2021, v. 237, n. 2, p. 197, doi. 10.1159/000508334

By:

Lucas, Renata;
Mihály, Johanna;
Gericke, Janine;
de Lera, Angel R.;
Alvarez, Susana;
Veleczki, Zsuzsanna;
Törőcsik, Dániel;
Rühl, Ralph

Publication type:

Article

Reduced Retinoid Signaling in the Skin after Systemic Retinoid-X Receptor Ligand Treatment in Mice with Potential Relevance for Skin Disorders.

Published in:

Dermatology (10188665), 2013, v. 225, n. 4, p. 304, doi. 10.1159/000345496

By:

Mihály, Johanna;
Gericke, Janine;
Aydemir, Gamze;
Weiss, Kathrin;
Carlsen, Harald;
Blomhoff, Rune;
Garcia, Javier;
Rühl, Ralph

Publication type:

Article

Downregulation of STRA6 Expression in Epidermal Keratinocytes Leads to Hyperproliferation-Associated Differentiation in Both In Vitro and In Vivo Skin Models.

Published in:

Journal of Investigative Dermatology, 2014, v. 134, n. 6, p. 1579, doi. 10.1038/jid.2013.507

By:

Skazik, Claudia;
Amann, Philipp M;
Heise, Ruth;
Marquardt, Yvonne;
Czaja, Katharina;
Kim, Arianna;
Rühl, Ralph;
Kurschat, Peter;
Merk, Hans F;
Bickers, David R;
Baron, Jens M

Publication type:

Article

PPARγ-Mediated and Arachidonic Acid-Dependent Signaling Is Involved in Differentiation and Lipid Production of Human Sebocytes.

Published in:

Journal of Investigative Dermatology, 2014, v. 134, n. 4, p. 910, doi. 10.1038/jid.2013.413

By:

Dozsa, Aniko;
Dezso, Balazs;
Toth, Balazs I;
Bacsi, Attila;
Poliska, Szilard;
Camera, Emanuela;
Picardo, Mauro;
Zouboulis, Christos C;
Bíró, Tamás;
Schmitz, Gerd;
Liebisch, Gerhard;
Rühl, Ralph;
Remenyik, Eva;
Nagy, Laszlo

Publication type:

Article

Eicosanoids and Docosanoids in Plasma and Aorta of Healthy and Atherosclerotic Rabbits.

Published in:

Journal of Vascular Research, 2013, v. 50, n. 5, p. 372, doi. 10.1159/000350865

By:

Szklenar, Monika;
Kalkowski, Janine;
Stangl, Verena;
Lorenz, Mario;
Rühl, Ralph

Publication type:

Article

Method to determine 4-oxo-retinoic acids, retinoic acids and retinol in serum and cell extracts by liquid chromatography/diode-array detection atmospheric pressure chemical ionisation tandem mass spectrometry.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2006, v. 20, n. 16, p. 2497, doi. 10.1002/rcm.2621

By:

Rühl, Ralph

Publication type:

Article

Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans.

Published in:

Molecular Nutrition & Food Research, 2017, v. 61, n. 6, p. n/a, doi. 10.1002/mnfr.201600685

By:

Bohn, Torsten;
Desmarchelier, Charles;
Dragsted, Lars O.;
Nielsen, Charlotte S.;
Stahl, Wilhelm;
Rühl, Ralph;
Keijer, Jaap;
Borel, Patrick

Publication type:

Article

Lycopene supplementation restores vitamin A deficiency in mice and possesses thereby partial pro-vitamin A activity transmitted via RAR signaling.

Published in:

Molecular Nutrition & Food Research, 2016, v. 60, n. 11, p. 2413, doi. 10.1002/mnfr.201600031

By:

Aydemir, Gamze;
Kasiri, Yasamin;
Bartók, Emöke‐Márta;
Birta, Eszter;
Fröhlich, Kati;
Böhm, Volker;
Mihaly, Johanna;
Rühl, Ralph

Publication type:

Article

Lycopene-derived bioactive retinoic acid receptors/retinoid- X receptors-activating metabolites may be relevant for lycopene's anti-cancer potential.

Published in:

Molecular Nutrition & Food Research, 2013, v. 57, n. 5, p. 739, doi. 10.1002/mnfr.201200548

By:

Aydemir, Gamze;
Kasiri, Yasamin;
Birta, Eszter;
Béke, Gabriella;
Garcia, Ada L.;
Bartók, Emőke‐Márta;
Rühl, Ralph

Publication type:

Article

Lycopene induces retinoic acid receptor transcriptional activation in mice.

Published in:

Molecular Nutrition & Food Research, 2012, v. 56, n. 5, p. 702, doi. 10.1002/mnfr.201100681

By:

Aydemir, Gamze;
Carlsen, Harald;
Blomhoff, Rune;
Rühl, Ralph

Publication type:

Article

Role of vitamin A elimination or supplementation diets during postnatal development on the allergic sensitisation in mice.

Published in:

Molecular Nutrition & Food Research, 2007, v. 51, n. 9, p. 1173, doi. 10.1002/mnfr.200600277

By:

Rühl, Ralph;
Hänel, Andrej;
Garcia, Ada L.;
Dahten, Anja;
Herz, Udo;
Schweigert, Florian J.;
Worm, Margitta

Publication type:

Article

β-Carotene in the human body: metabolic bioactivation pathways - from digestion to tissue distribution and excretion.

Published in:

2019

By:

Bohn, Torsten;
Desmarchelier, Charles;
El, Sedef N.;
Keijer, Jaap;
van Schothorst, Evert;
Rühl, Ralph;
Borel, Patrick

Publication type:

journal article

Effects of dietary retinoids and carotenoids on immune development.

Published in:

Proceedings of the Nutrition Society, 2007, v. 66, n. 3, p. 458, doi. 10.1017/S002966510600509X

By:

Rühl, Ralph

Publication type:

Article

Inhibition of IgE-Production by Peroxisome Proliferator-Activated Receptor Ligands.

Published in:

Journal of Investigative Dermatology, 2003, v. 121, n. 4, p. 757, doi. 10.1046/j.1523-1747.2003.12493.x

By:

Rühl, Ralph;
Dahten, Anja;
Schweigert, Florian J.;
Herz, Udo;
Worm, Margitta

Publication type:

Article

Retinoid Signaling by all-trans Retinoic Acid and all-trans Retinoyl-β-D-Glucuronide Is Attenuated by Simultaneous Exposure of Human Keratinocytes to Retinol.

Published in:

Journal of Investigative Dermatology, 1999, v. 112, n. 2, p. 157, doi. 10.1046/j.1523-1747.1999.00496.x

By:

Zouboulis, Christos C.;
Seltmann, Holger;
Sass, Jörn Oliver;
Rühl, Ralph;
Plum, Claudia;
Hettmannsperger, Uwe;
Blume-Peytavi, Ulrike;
Nau, Heinz;
Orfanos, Constantin E.

Publication type:

Article

Effects of all-trans-retinoic acid and all-trans-retinoyl glucuronide in two in vitro systems of distinct biological complexity.

Published in:

Archives of Toxicology, 2001, v. 75, n. 8, p. 497, doi. 10.1007/s002040100257

By:

Rühl, Ralph;
Sass, Jörn;
Nau, Heinz;
Klug, Stephan

Publication type:

Article

All-trans-retinoic acid and all-trans-retinoyl-β-d-glucuronide alter the development of axolotl embryos (Ambystoma mexicanum) in vitro.

Published in:

Archives of Toxicology, 2000, v. 74, n. 3, p. 173

By:

Krätke, Renate;
Rühl, Ralph;
Kirschbaum, Frank;
Nau, Heinz

Publication type:

Article

Embryonic Subcellular Distribution of 13-cis- and All-trans-Retinoic Acid Indicates Differential Cytosolic/Nuclear Localization.

Published in:

Toxicological Sciences, 2001, v. 63, n. 1, p. 82, doi. 10.1093/toxsci/63.1.82

By:

Rühl, Ralph;
Plum, Claudia;
Elmazar, Mohamed M. A.;
Nau, Heinz

Publication type:

Article

Retinol Saturase Knock-Out Mice are Characterized by Impaired Clearance of Apoptotic Cells and Develop Mild Autoimmunity.

Published in:

Biomolecules (2218-273X), 2019, v. 9, n. 11, p. 737, doi. 10.3390/biom9110737

By:

Sarang, Zsolt;
Sághy, Tibor;
Budai, Zsófia;
Ujlaky-Nagy, László;
Bedekovics, Judit;
Beke, Lívia;
Méhes, Gábor;
Nagy, Gábor;
Rühl, Ralph;
Moise, Alexander R.;
Palczewski, Krzysztof;
Szondy, Zsuzsa

Publication type:

Article

Estimated Dietary Intakes of Vitamin A5.

Published in:

Nutrients, 2024, v. 16, n. 23, p. 4004, doi. 10.3390/nu16234004

By:

Bohn, Torsten;
Despotovic, Marta;
Vahid, Farhad;
Rühl, Ralph

Publication type:

Article

Vitamin A5/X, a New Food to Lipid Hormone Concept for a Nutritional Ligand to Control RXR-Mediated Signaling.

Published in:

Nutrients, 2021, v. 13, n. 3, p. 925, doi. 10.3390/nu13030925

By:

Krężel, Wojciech;
Rivas, Aurea;
Szklenar, Monika;
Ciancia, Marion;
Alvarez, Rosana;
de Lera, Angel R.;
Rühl, Ralph;
Canas, Jose Atilio

Publication type:

Article

Apo-14´-Carotenoic Acid Is a Novel Endogenous and Bioactive Apo-Carotenoid.

Published in:

Nutrients, 2019, v. 11, n. 9, p. 2084, doi. 10.3390/nu11092084

By:

Aydemir, Gamze;
Domínguez, Marta;
de Lera, Angel R.;
Mihaly, Johanna;
Törőcsik, Dániel;
Rühl, Ralph

Publication type:

Article

Reduced Carotenoid and Retinoid Concentrations and Altered Lycopene Isomer Ratio in Plasma of Atopic Dermatitis Patients.

Published in:

Nutrients, 2018, v. 10, n. 10, p. 1390, doi. 10.3390/nu10101390

By:

Lucas, Renata;
Mihály, Johanna;
Lowe, Gordon M.;
Graham, Daniel L.;
Szklenar, Monika;
Szegedi, Andrea;
Töröcsik, Daniel;
Rühl, Ralph

Publication type:

Article

An Endogenous Mammalian Retinoid X Receptor Ligand, At Last!

Published in:

ChemMedChem, 2016, v. 11, n. 10, p. 1027, doi. 10.1002/cmdc.201600105

By:

de Lera, Ángel R.;
Krezel, Wojciech;
Rühl, Ralph

Publication type:

Article

Reduced retinoids and retinoid receptors' expression in pancreatic cancer: A link to patient survival.

Published in:

Molecular Carcinogenesis, 2015, v. 54, n. 9, p. 870, doi. 10.1002/mc.22158

By:

Bleul, Tim;
Rühl, Ralph;
Bulashevska, Svetlana;
Karakhanova, Svetlana;
Werner, Jens;
Bazhin, Alexandr V.

Publication type:

Article

Carotenoids and their metabolites are naturally occurring activators of gene expression via the pregnane X receptor.

Published in:

European Journal of Nutrition, 2004, v. 43, n. 6, p. 336, doi. 10.1007/s00394-004-0475-1

By:

Rühl, Ralph;
Sczech, Ronny;
Landes, Nico;
Pfluger, Paul;
Kluth, Dirk;
Schweigert, Florian

Publication type:

Article

Reduced adiponectin expression after high‐fat diet is associated with selective up‐regulation of ALDH1A1 and further retinoic acid receptor signaling in adipose tissue.

Published in:

FASEB Journal, 2017, v. 31, n. 1, p. 203, doi. 10.1096/fj.201600263rr

By:

Landrier, Jean‐Francois;
Kasiri, Elnaz;
Karkeni, Esma;
Mihály, Johanna;
Béke, Gabriella;
Weiss, Kathrin;
Lucas, Renata;
Aydemir, Gamze;
Salles, Jérome;
Walrand, Stéphane;
Lera, Angel R.;
Rühl, Ralph

Publication type:

Article

Reduced adiponectin expression after high-fat diet is associated with selective up-regulation of ALDH1A1 and further retinoic acid receptor signaling in adipose tissue.

Published in:

FASEB Journal, 2017, v. 31, n. 1, p. 203, doi. 10.1096/fj.201600263RR

By:

Landrier, Jean-Francois;
Kasiri, Elnaz;
Karkeni, Esma;
Mihály, Johanna;
Béke, Gabriella;
Weiss, Kathrin;
Lucas, Renata;
Aydemir, Gamze;
Salles, Jérome;
Walrand, Stéphane;
de Lera, Angel R.;
Rühl, Ralph

Publication type:

Article

Lipid metabolite levels of prostaglandin D<sub>2</sub> and eicosapentaenoic acid recovered from bronchoalveolar lavage fluid correlate with lung function of chronic obstructive pulmonary disease patients and controls.

Published in:

Electrophoresis, 2009, v. 30, n. 7, p. 1228, doi. 10.1002/elps.200800722

By:

Csanky, Ezster;
Rühl, Ralph;
Scholtz, Beata;
Vasko, Attila;
Takacs, Laszlo;
Hempel, William M.

Publication type:

Article

Vitamin A-Deficient Diet Accelerated Atherogenesis in Apolipoprotein E<sup>−/−</sup> Mice and Dietary β-Carotene Prevents This Consequence.

Published in:

BioMed Research International, 2015, v. 2015, p. 1, doi. 10.1155/2015/758723

By:

Relevy, Noa Zolberg;
Harats, Dror;
Harari, Ayelet;
Ben-Amotz, Ami;
Bitzur, Rafael;
Rühl, Ralph;
Shaish, Aviv

Publication type:

Article

Transcriptomic and lipidomic profiling of eicosanoid/docosanoid signalling in affected and non‐affected skin of human atopic dermatitis patients.

Published in:

Experimental Dermatology, 2019, v. 28, n. 2, p. 177, doi. 10.1111/exd.13867

By:

Töröcsik, Daniel;
Szegedi, Andrea;
Lucas, Renata;
Weise, Christin;
Worm, Margitta;
Gericke, Janine;
Mihaly, Johanna;
Rühl, Ralph

Publication type:

Article

Sebocytes differentially express and secrete adipokines.

Published in:

Experimental Dermatology, 2016, v. 25, n. 3, p. 194, doi. 10.1111/exd.12879

By:

Kovács, Dóra;
Lovászi, Marianna;
Póliska, Szilárd;
Oláh, Attila;
Bíró, Tamás;
Veres, Imre;
Zouboulis, Christos C.;
Ståhle, Mona;
Rühl, Ralph;
Remenyik, Éva;
Törőcsik, Dániel

Publication type:

Article

Knockdown of lecithin retinol acyltransferase increases all- trans retinoic acid levels and restores retinoid sensitivity in malignant melanoma cells.

Published in:

Experimental Dermatology, 2014, v. 23, n. 11, p. 832, doi. 10.1111/exd.12548

By:

Amann, Philipp M.;
Czaja, Katharina;
Bazhin, Alexandr V.;
Rühl, Ralph;
Skazik, Claudia;
Heise, Ruth;
Marquardt, Yvonne;
Eichmüller, Stefan B.;
Merk, Hans F.;
Baron, Jens M.

Publication type:

Article

Decreased retinoid concentration and retinoid signalling pathways in human atopic dermatitis.

Published in:

Experimental Dermatology, 2011, v. 20, n. 4, p. 326, doi. 10.1111/j.1600-0625.2010.01225.x

By:

Mihály, Johanna;
Gamlieli, Anat;
Worm, Margitta;
Rühl, Ralph

Publication type:

Article

9-cis β-carotene Inhibits Atherosclerosis Development in Female LDLR-/- Mice.

Published in:

Functional Foods in Health & Disease, 2015, v. 5, n. 2, p. 67, doi. 10.31989/ffhd.v5i2.172

By:

Zolberg Relevy, Noa;
Rühl, Ralph;
Harari, Ayelet;
Grosskopf, Itamar;
Barshack, Iris;
Ben-Amotz, Ami;
Nir, Uri;
Gottlieb, Hugo;
Kamari, Yehuda;
Harats, Dror;
Shaish, Aviv

Publication type:

Article

Retinoid Concentrations in the Mouse during Postnatal Development and after Maternal Vitamin A Supplementation.

Published in:

Annals of Nutrition & Metabolism, 2005, v. 49, n. 5, p. 333, doi. 10.1159/000087697

By:

García, Ada L.;
Rühl, Ralph;
Schweigert, Florian J.

Publication type:

Article

Allergen-Induced Dermatitis Causes Alterations in Cutaneous Retinoid-Mediated Signaling in Mice.

Published in:

PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0071244

By:

Gericke, Janine;
Ittensohn, Jan;
Mihály, Johanna;
Dubrac, Sandrine;
Rühl, Ralph

Publication type:

Article

Ratio of Pro-Resolving and Pro-Inflammatory Lipid Mediator Precursors as Potential Markers for Aggressive Periodontitis.

Published in:

PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0070838

By:

Zein Elabdeen, Hager R.;
Mustafa, Manal;
Szklenar, Monika;
Rühl, Ralph;
Ali, Raouf;
Bolstad, Anne Isine

Publication type:

Article

Regulation of Retinoid-Mediated Signaling Involved in Skin Homeostasis by RAR and RXR Agonists/Antagonists in Mouse Skin.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0062643

By:

Gericke, Janine;
Ittensohn, Jan;
Mihály, Johanna;
Álvarez, Susana;
Álvarez, Rosana;
Töröcsik, Dániel;
de Lera, Ángel R.;
Rühl, Ralph

Publication type:

Article

Defining a vitamin A5/X specific deficiency – vitamin A5/X as a critical dietary factor for mental health.

Published in:

International Journal for Vitamin & Nutrition Research, 2024, v. 94, n. 5-6, p. 443, doi. 10.1024/0300-9831/a000808

By:

Bánáti, Diána;
Hellman-Regen, Julian;
Mack, Isabelle;
Young, Hayley A.;
Benton, David;
Eggersdorfer, Manfred;
Rohn, Sascha;
Dulińska-Litewka, Joanna;
Krężel, Wojciech;
Rühl, Ralph

Publication type:

Article