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The molecular approach to diagnosis in lung cancer.
Published in:
British Journal of Hospital Medicine (17508460), 2015, v. 76, n. 5, p. C74, doi. 10.12968/hmed.2015.76.5.C74
By:
- Moore, David A.;
- Le Quesne, John PC
Publication type:
Article
SOX9 has distinct roles in the formation and progression of different non‐small cell lung cancer histotypes.
Published in:
Journal of Pathology, 2021, v. 255, n. 1, p. 16, doi. 10.1002/path.5733
By:
- Bao, Jie;
- Närhi, Katja;
- Teodòsio, Ana;
- Hemmes, Annabrita;
- Linnavirta, Nora M;
- Mäyränpää, Mikko I;
- Salmenkivi, Kaisa;
- Le Quesne, John;
- Verschuren, Emmy W
Publication type:
Article
The path to a better biomarker: application of a risk management framework for the implementation of PD-L1 and TILs as immunooncology biomarkers in breast cancer clinical trials and daily practice.
Published in:
Journal of Pathology, 2020, v. 250, n. 5, p. 667, doi. 10.1002/path.5406
By:
- Gonzalez-Ericsson, Paula I.;
- Stovgaard, Elisabeth S.;
- Sua, Luz F.;
- Reisenbichler, Emily;
- Kos, Zuzana;
- Carter, Jodi M.;
- Michiels, Stefan;
- Le Quesne, John;
- Nielsen, Torsten O.;
- Lnkholm, Anne-Vibeke;
- Fox, Stephen B.;
- Adam, Julien;
- Bartlett, John MS;
- Rimm, David L.;
- Quinn, Cecily;
- Peeters, Dieter;
- Dieci, Maria V.;
- Vincent-Salomon, Anne;
- Cree, Ian;
- Hida, Akira I.
Publication type:
Article
The path to a better biomarker: application of a risk management framework for the implementation of PD‐L1 and TILs as immuno‐oncology biomarkers in breast cancer clinical trials and daily practice.
Published in:
Journal of Pathology, 2020, v. 250, n. 4, p. 667, doi. 10.1002/path.5406
By:
- Gonzalez‐Ericsson, Paula I;
- Stovgaard, Elisabeth S;
- Sua, Luz F;
- Reisenbichler, Emily;
- Kos, Zuzana;
- Carter, Jodi M;
- Michiels, Stefan;
- Le Quesne, John;
- Nielsen, Torsten O;
- Lænkholm, Anne‐Vibeke;
- Fox, Stephen B;
- Adam, Julien;
- Bartlett, John MS;
- Rimm, David L;
- Quinn, Cecily;
- Peeters, Dieter;
- Dieci, Maria V;
- Vincent‐Salomon, Anne;
- Cree, Ian;
- Hida, Akira I
Publication type:
Article
Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells.
Published in:
eLife, 2018, p. 1, doi. 10.7554/eLife.30224
By:
- Kolluri, Krishna Kalyan;
- Alifrangis, Constantine;
- Kumar, Neelam;
- Ishii, Yuki;
- Price, Stacey;
- Michaut, Magali;
- Williams, Steven;
- Barthorpe, Syd;
- Lightfoot, Howard;
- Busacca, Sara;
- Sharkey, Annabel;
- Zhenqiang Yuan;
- Sage, Elizabeth K.;
- Vallath, Sabarinath;
- Le Quesne, John;
- Tice, David A.;
- Alrifai, Doraid;
- von Karstedt, Sylvia;
- Montinaro, Antonella;
- Guppy, Naomi
Publication type:
Article
eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes.
Published in:
Nucleic Acids Research, 2018, v. 46, n. 6, p. 3075, doi. 10.1093/nar/gky108
By:
- Waldron, Joseph A;
- Raza, Farheen;
- Le Quesne, John
Publication type:
Article
The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24661-0
By:
- Ghaddar, Nour;
- Wang, Shuo;
- Woodvine, Bethany;
- Krishnamoorthy, Jothilatha;
- van Hoef, Vincent;
- Darini, Cedric;
- Kazimierczak, Urszula;
- Ah-son, Nicolas;
- Popper, Helmuth;
- Johnson, Myriam;
- Officer, Leah;
- Teodósio, Ana;
- Broggini, Massimo;
- Mann, Koren K.;
- Hatzoglou, Maria;
- Topisirovic, Ivan;
- Larsson, Ola;
- Le Quesne, John;
- Koromilas, Antonis E.
Publication type:
Article
Author Correction: Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment.
Published in:
2021
By:
- Zhang, Min;
- Luo, Jin-Li;
- Sun, Qianqian;
- Harber, James;
- Dawson, Alan G.;
- Nakas, Apostolos;
- Busacca, Sara;
- Sharkey, Annabel J.;
- Waller, David;
- Sheaff, Michael T.;
- Richards, Cathy;
- Wells-Jordan, Peter;
- Gaba, Aarti;
- Poile, Charlotte;
- Baitei, Essa Y.;
- Bzura, Aleksandra;
- Dzialo, Joanna;
- Jama, Maymun;
- Le Quesne, John;
- Bajaj, Amrita
Publication type:
Correction Notice
Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-21798-w
By:
- Zhang, Min;
- Luo, Jin-Li;
- Sun, Qianqian;
- Harber, James;
- Dawson, Alan G.;
- Nakas, Apostolos;
- Busacca, Sara;
- Sharkey, Annabel J.;
- Waller, David;
- Sheaff, Michael T.;
- Richards, Cathy;
- Wells-Jordan, Peter;
- Gaba, Aarti;
- Poile, Charlotte;
- Baitei, Essa Y.;
- Bzura, Aleksandra;
- Dzialo, Joanna;
- Jama, Maymun;
- Le Quesne, John;
- Bajaj, Amrita
Publication type:
Article
UTRly malignant: mRNA stability and the invasive phenotype in breast cancer UTRly malignant: mRNA stability and the invasive phenotype in breast cancer.
Published in:
Journal of Pathology, 2013, v. 230, n. 2, p. 129, doi. 10.1002/path.4175
By:
- Le Quesne, John
Publication type:
Article
Biological and prognostic associations of miR-205 and let-7b in breast cancer revealed by in situ hybridization analysis of micro-RNA expression in arrays of archival tumour tissue.
Published in:
Journal of Pathology, 2012, v. 227, n. 3, p. 306, doi. 10.1002/path.3983
By:
- Quesne, John Le;
- Jones, Julia;
- Warren, Joanna;
- Dawson, Sarah-Jane;
- Ali, H Raza;
- Bardwell, Helen;
- Blows, Fiona;
- Pharoah, Paul;
- Caldas, Carlos
Publication type:
Article
Dysregulation of protein synthesis and disease.
Published in:
Journal of Pathology, 2010, v. 220, n. 2, p. 140, doi. 10.1002/path.2627
By:
- Le Quesne, John PC;
- Spriggs, Keith A;
- Bushell, Martin;
- Willis, Anne E
Publication type:
Article
Reduced Protumorigenic Tumor-Associated Macrophages With Statin Use in Premalignant Human Lung Adenocarcinoma.
Published in:
JNCI Cancer Spectrum, 2020, v. 4, n. 2, p. 1, doi. 10.1093/jncics/pkz101
By:
- Dujaily, Esraa Al;
- Baena, Juvenal;
- Das, Madhumita;
- Sereno, Marco;
- Smith, Claire;
- Kamata, Tamihiro;
- Officer, Leah;
- Pritchard, Catrin;
- Quesne, John Le
Publication type:
Article
Characterisation of microRNA expression in post-natal mouse mammary gland development.
Published in:
BMC Genomics, 2009, v. 10, p. 548, doi. 10.1186/1471-2164-10-548
By:
- Avril-Sassen, Stefanie;
- Goldstein, Leonard D.;
- Stingl, John;
- Blenkiron, Cherie;
- Le Quesne, John;
- Spiteri, Inmaculada;
- Karagavriilidou, Konstantina;
- Watson, Christine J.;
- Tavaré, Simon;
- Miska, Eric A.;
- Caldas, Carlos
Publication type:
Article
C-Myc 5′ untranslated region contains an internal ribosome entry segment.
Published in:
Oncogene, 1998, v. 16, n. 3, p. 423, doi. 10.1038/sj.onc.1201763
By:
- Stoneley, Mark;
- Paulin, Fiona EM;
- Quesne, John PC Le;
- Chappell, Stephen A;
- Willis, Anne E
Publication type:
Article
IL-4 receptor dependent expansion of lung CD169<sup>+</sup> macrophages in microfilaria-driven inflammation.
Published in:
PLoS Neglected Tropical Diseases, 2019, v. 13, n. 8, p. 1, doi. 10.1371/journal.pntd.0007691
By:
- Fercoq, Frédéric;
- Remion, Estelle;
- Frohberger, Stefan J.;
- Vallarino-Lhermitte, Nathaly;
- Hoerauf, Achim;
- Le Quesne, John;
- Landmann, Frédéric;
- Hübner, Marc P.;
- Carlin, Leo M.;
- Martin, Coralie
Publication type:
Article
Inclusion of multiple high‐risk histopathological criteria improves the prediction of adjuvant chemotherapy efficacy in lung adenocarcinoma.
Published in:
Histopathology, 2021, v. 78, n. 6, p. 838, doi. 10.1111/his.14301
By:
- Sereno, Marco;
- He, Zhangyi;
- Smith, Claire R;
- Baena, Juvenal;
- Das, Madhumita;
- Hastings, Robert K;
- Rake, Grace;
- Fennell, Dean A;
- Nakas, Apostolos;
- Moore, David A;
- Le Quesne, John
Publication type:
Article
The ERBB network facilitates KRAS-driven lung tumorigenesis.
Published in:
Science Translational Medicine, 2018, v. 10, n. 446, p. 1, doi. 10.1126/scitranslmed.aao2565
By:
- Kruspig, Björn;
- Monteverde, Tiziana;
- Neidler, Sarah;
- Hock, Andreas;
- Kerr, Emma;
- Nixon, Colin;
- Clark, William;
- Hedley, Ann;
- Laing, Sarah;
- Coffelt, Seth B.;
- Le Quesne, John;
- Dick, Craig;
- Vousden, Karen;
- Martins, Carla P.;
- Murphy, Daniel J.
Publication type:
Article
Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-86834-7
By:
- Busacca, Sara;
- Zhang, Qi;
- Sharkey, Annabel;
- Dawson, Alan G.;
- Moore, David A.;
- Waller, David A.;
- Nakas, Apostolos;
- Jones, Carolyn;
- Cain, Kelvin;
- Luo, Jin-li;
- Salcedo, Adriana;
- Salaroglio, Iris Chiara;
- Riganti, Chiara;
- Le Quesne, John;
- John, Tom;
- Boutros, Paul C.;
- Zhang, Shu-Dong;
- Fennell, Dean A.
Publication type:
Article
Repositioning PARP inhibitors for SARS-CoV-2 infection(COVID-19); a new multi-pronged therapy for acute respiratory distress syndrome?
Published in:
2020
By:
- Curtin, Nicola;
- Bányai, Krisztián;
- Thaventhiran, James;
- Le Quesne, John;
- Helyes, Zsuzsanna;
- Bai, Péter
Publication type:
journal article
Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence.
Published in:
Biochemical Society Transactions, 2015, v. 43, n. 6, p. 1227, doi. 10.1042/BST20150163
By:
- Raza, Farheen;
- Waldron, Joseph Alexander;
- Le Quesne, John
Publication type:
Article
Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study.
Published in:
PLoS Biology, 2014, v. 12, n. 7, p. 1, doi. 10.1371/journal.pbio.1001906
By:
- Jamal-Hanjani, Mariam;
- Hackshaw, Alan;
- Ngai, Yenting;
- Shaw, Jacqueline;
- Dive, Caroline;
- Quezada, Sergio;
- Middleton, Gary;
- de Bruin, Elza;
- Le Quesne, John;
- Shafi, Seema;
- Falzon, Mary;
- Horswell, Stuart;
- Blackhall, Fiona;
- Khan, Iftekhar;
- Janes, Sam;
- Nicolson, Marianne;
- Lawrence, David;
- Forster, Martin;
- Fennell, Dean;
- Lee, Siow-Ming
Publication type:
Article
eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation.
Published in:
Nucleic Acids Research, 2023, v. 51, n. 4, p. 1859, doi. 10.1093/nar/gkad030
By:
- Schmidt, Tobias;
- Dabrowska, Adrianna;
- Waldron, Joseph A;
- Hodge, Kelly;
- Koulouras, Grigorios;
- Gabrielsen, Mads;
- Munro, June;
- Tack, David C;
- Harris, Gemma;
- McGhee, Ewan;
- Scott, David;
- Carlin, Leo M;
- Huang, Danny;
- Le Quesne, John;
- Zanivan, Sara;
- Wilczynska, Ania;
- Bushell, Martin
Publication type:
Article
Publisher Correction: Genomic instability in mutant p53 cancer cells upon entotic engulfment.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06026-2
By:
- Mackay, Hannah L.;
- Moore, David;
- Hall, Callum;
- Birkbak, Nicolai J.;
- Jamal-Hanjani, Mariam;
- Karim, Saadia A.;
- Phatak, Vinaya M.;
- Piñon, Lucia;
- Morton, Jennifer P.;
- Swanton, Charles;
- Le Quesne, John;
- Muller, Patricia A. J.
Publication type:
Article
BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05790-5
By:
- Lazarus, Kyren A.;
- Hadi, Fazal;
- Zambon, Elisabetta;
- Bach, Karsten;
- Santolla, Maria-Francesca;
- Watson, Julie K.;
- Correia, Lucia L.;
- Das, Madhumita;
- Ugur, Rosemary;
- Pensa, Sara;
- Becker, Lukas;
- Campos, Lia S.;
- Ladds, Graham;
- Liu, Pentao;
- Evan, Gerard I.;
- McCaughan, Frank M.;
- Le Quesne, John;
- Lee, Joo-Hyeon;
- Calado, Dinis;
- Khaled, Walid T.
Publication type:
Article
Genomic instability in mutant p53 cancer cells upon entotic engulfment.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05368-1
By:
- Mackay, Hannah L.;
- Moore, David;
- Hall, Callum;
- Birkbak, Nicolai J.;
- Jamal-Hanjani, Mariam;
- Karim, Saadia A.;
- Phatak, Vinaya M.;
- Piñon, Lucia;
- Morton, Jennifer P.;
- Swanton, Charles;
- Le Quesne, John;
- Muller, Patricia A. J.
Publication type:
Article
Mapping the landscape of histomorphological cancer phenotypes using self-supervised learning on unannotated pathology slides.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-48666-7
By:
- Claudio Quiros, Adalberto;
- Coudray, Nicolas;
- Yeaton, Anna;
- Yang, Xinyu;
- Liu, Bojing;
- Le, Hortense;
- Chiriboga, Luis;
- Karimkhan, Afreen;
- Narula, Navneet;
- Moore, David A.;
- Park, Christopher Y.;
- Pass, Harvey;
- Moreira, Andre L.;
- Le Quesne, John;
- Tsirigos, Aristotelis;
- Yuan, Ke
Publication type:
Article
Visualization of exhaled breath metabolites reveals distinct diagnostic signatures for acute cardiorespiratory breathlessness.
Published in:
Science Translational Medicine, 2022, v. 14, n. 671, p. 1, doi. 10.1126/scitranslmed.abl5849
By:
- Ibrahim, Wadah;
- Wilde, Michael J.;
- Cordell, Rebecca L.;
- Richardson, Matthew;
- Salman, Dahlia;
- Free, Robert C.;
- Zhao, Bo;
- Singapuri, Amisha;
- Hargadon, Beverley;
- Gaillard, Erol A.;
- Suzuki, Toru;
- Ng, Leong L.;
- Coats, Tim;
- Thomas, Paul;
- Monks, Paul S.;
- Brightling, Christopher E.;
- Greening, Neil J.;
- Siddiqui, Salman;
- Munton, Rachel;
- Le Quesne, John
Publication type:
Article
mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity.
Published in:
Genome Biology, 2019, v. 20, n. 1, p. 1, doi. 10.1186/s13059-019-1901-2
By:
- Waldron, Joseph A.;
- Tack, David C.;
- Ritchey, Laura E.;
- Gillen, Sarah L.;
- Wilczynska, Ania;
- Turro, Ernest;
- Bevilacqua, Philip C.;
- Assmann, Sarah M.;
- Bushell, Martin;
- Le Quesne, John
Publication type:
Article
eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5′UTR.
Published in:
Genome Biology, 2019, v. 20, n. 1, p. N.PAG, doi. 10.1186/s13059-019-1857-2
By:
- Wilczynska, Ania;
- Gillen, Sarah L.;
- Schmidt, Tobias;
- Meijer, Hedda A.;
- Jukes-Jones, Rebekah;
- Langlais, Claudia;
- Kopra, Kari;
- Lu, Wei-Ting;
- Godfrey, Jack D.;
- Hawley, Benjamin R.;
- Hodge, Kelly;
- Zanivan, Sara;
- Cain, Kelvin;
- Le Quesne, John;
- Bushell, Martin
Publication type:
Article
Protein expression of S100A2 reveals it association with patient prognosis and immune infiltration profile in colorectal cancer.
Published in:
Journal of Cancer, 2023, v. 14, n. 10, p. 1837, doi. 10.7150/jca.83910
By:
- Hatthakarnkul, Phimmada;
- Ammar, Aula;
- Pennel, Kathryn A. F.;
- Officer-Jones, Leah;
- Cusumano, Silvia;
- Quinn, Jean A.;
- Mohemmed Matly, Amna Ahmed;
- Alexander, Peter G.;
- Hay, Jennifer;
- Andersen, Ditte;
- Lynch, Gerard;
- van Wyk, Hester C.;
- Maka, Noori;
- McMillan, Donald C.;
- Quesne, John Le;
- Thuwajit, Chanitra;
- Edwards, Joanne
Publication type:
Article
Microfilaria-dependent thoracic pathology associated with eosinophilic and fibrotic polyps in filaria-infected rodents.
Published in:
Parasites & Vectors, 2020, v. 13, n. 1, p. 1, doi. 10.1186/s13071-020-04428-0
By:
- Fercoq, Frédéric;
- Remion, Estelle;
- Vallarino-Lhermitte, Nathaly;
- Alonso, Joy;
- Raveendran, Lisy;
- Nixon, Colin;
- Le Quesne, John;
- Carlin, Leo M.;
- Martin, Coralie
Publication type:
Article
Micro-RNAs and breast cancer
Published in:
Molecular Oncology, 2010, v. 4, n. 3, p. 230, doi. 10.1016/j.molonc.2010.04.009
By:
- Le Quesne, John;
- Caldas, Carlos
Publication type:
Article

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