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Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor.
Published in:
Nature, 2015, v. 518, n. 7538, p. 240, doi. 10.1038/nature13948
By:
- Juric, Dejan;
- Castel, Pau;
- Griffith, Malachi;
- Griffith, Obi L.;
- Won, Helen H.;
- Ellis, Haley;
- Ebbesen, Saya H.;
- Ainscough, Benjamin J.;
- Ramu, Avinash;
- Iyer, Gopa;
- Shah, Ronak H.;
- Huynh, Tiffany;
- Mino-Kenudson, Mari;
- Sgroi, Dennis;
- Isakoff, Steven;
- Thabet, Ashraf;
- Elamine, Leila;
- Solit, David B.;
- Lowe, Scott W.;
- Quadt, Cornelia
Publication type:
Article
A Phase 1b/2 Study of Alpelisib in Combination with Cetuximab in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.
Published in:
Targeted Oncology, 2023, v. 18, n. 6, p. 853, doi. 10.1007/s11523-023-00997-z
By:
- Razak, Albiruni R. Abdul;
- Wang, Hung-Ming;
- Chang, Jang-Yang;
- Ahn, Myung-Ju;
- Munster, Pamela;
- Blumenschein Jr, George;
- Solomon, Benjamin;
- Lim, Darren Wan-Teck;
- Hong, Ruey-Long;
- Pfister, David;
- Saba, Nabil F.;
- Lee, Se-Hoon;
- van Herpen, Carla;
- Quadt, Cornelia;
- Bootle, Douglas;
- Blumenstein, Lars;
- Demanse, David;
- Delord, Jean-Pierre
Publication type:
Article
Phase I study of alpelisib (BYL719), an α‐specific PI3K inhibitor, in Japanese patients with advanced solid tumors.
Published in:
Cancer Science, 2019, v. 110, n. 3, p. 1021, doi. 10.1111/cas.13923
By:
- Ando, Yuichi;
- Iwasa, Satoru;
- Takahashi, Shunji;
- Saka, Hideo;
- Kakizume, Tomoyuki;
- Natsume, Kazuto;
- Suenaga, Naoko;
- Quadt, Cornelia;
- Yamada, Yasuhide
Publication type:
Article
Phase I dose-escalation study of buparlisib ( BKM120), an oral pan-class I PI3K inhibitor, in Japanese patients with advanced solid tumors.
Published in:
Cancer Science, 2014, v. 105, n. 3, p. 347, doi. 10.1111/cas.12350
By:
- Ando, Yuichi;
- Inada‐Inoue, Megumi;
- Mitsuma, Ayako;
- Yoshino, Takayuki;
- Ohtsu, Atsushi;
- Suenaga, Naoko;
- Sato, Masahiko;
- Kakizume, Tomoyuki;
- Robson, Matthew;
- Quadt, Cornelia;
- Doi, Toshihiko
Publication type:
Article
Overcoming Phosphatidylinositol 3-Kinase PI3K) Activation in Breast Cancer: Emerging PI3K Inhibitors.
Published in:
Journal of OncoPathology, 2015, v. 3, n. 1, p. 27, doi. 10.13032/tjop.2052-5931.100107
By:
- Massacesi, Cristian;
- di Tomaso, Emmanuelle;
- Urban, Patrick;
- Germa, Caroline;
- Fretault, Nathalie;
- Bharani-Dharan, Bharani;
- Tavorath, Ranjana;
- Quadt, Cornelia;
- Coughlin, Christina;
- Hirawat, Samit
Publication type:
Article
A risk analysis of alpelisib-induced hyperglycemia in patients with advanced solid tumors and breast cancer.
Published in:
Breast Cancer Research, 2024, v. 26, n. 1, p. 1, doi. 10.1186/s13058-024-01773-1
By:
- Rodón, Jordi;
- Demanse, David;
- Rugo, Hope S.;
- Burris, Howard A.;
- Simó, Rafael;
- Farooki, Azeez;
- Wellons, Melissa F.;
- André, Fabrice;
- Hu, Huilin;
- Vuina, Dragica;
- Quadt, Cornelia;
- Juric, Dejan
Publication type:
Article
A phase I study of single-agent BEZ235 special delivery system sachet in Japanese patients with advanced solid tumors.
Published in:
2019
By:
- Toyoda, Masanori;
- Watanabe, Koichiro;
- Amagasaki, Taro;
- Natsume, Kazuto;
- Takeuchi, Hiromi;
- Quadt, Cornelia;
- Shirao, Kuniaki;
- Minami, Hironobu
Publication type:
journal article
Phase 1/1b dose escalation and expansion study of BEZ235, a dual PI3K/mTOR inhibitor, in patients with advanced solid tumors including patients with advanced breast cancer.
Published in:
2018
By:
- Rodon, Jordi;
- Pérez-Fidalgo, Alejandro;
- Krop, Ian E.;
- Burris, Howard;
- Guerrero-Zotano, Angel;
- Britten, Carolyn D.;
- Becerra, Carlos;
- Schellens, Jan;
- Richards, Donald A.;
- Schuler, Martin;
- Abu-Khalaf, Maysa;
- Johnson, Faye M.;
- Ranson, Malcolm;
- Edenfield, Jeff;
- Silva, Antonio P.;
- Hackl, Wolfgang;
- Quadt, Cornelia;
- Demanse, David;
- Duval, Vincent;
- Baselga, Jose
Publication type:
journal article
T-cell activation and B-cell depletion in chimpanzees treated with a bispecific anti-CD19/anti-CD3 single-chain antibody construct.
Published in:
Cancer Immunology, Immunotherapy, 2006, v. 55, n. 5, p. 503, doi. 10.1007/s00262-005-0001-1
By:
- Schlereth, Bernd;
- Quadt, Cornelia;
- Dreier, Torsten;
- Kufer, Peter;
- Lorenczewski, Grit;
- Prang, Nadja;
- Brandl, Christian;
- Lippold, Sandra;
- Cobb, Kathy;
- Brasky, Kathleen;
- Leo, Eugen;
- Bargou, Ralf;
- Murthy, Krishna;
- Baeuerle, Patrick
Publication type:
Article
mTORC1 Inhibition Is Required for Sensitivity to PI3K p110α Inhibitors in PIK3CA-Mutant Breast Cancer.
Published in:
Science Translational Medicine, 2013, v. 5, n. 196, p. 1, doi. 10.1126/scitranslmed.3005747
By:
- Elkabets, Moshe;
- Vora, Sadhna;
- Juric, Dejan;
- Morse, Natasha;
- Mino-Kenudson, Mari;
- Muranen, Taru;
- Tao, Jessica;
- Campos, Ana Bosch;
- Rodon, Jordi;
- Ibrahim, Yasir H.;
- Serra, Violeta;
- Rodrik-Outmezguine, Vanessa;
- Hazra, Saswati;
- Singh, Sharat;
- Kim, Phillip;
- Quadt, Cornelia;
- Manway Liu;
- Huang, Alan;
- Rosen, Neal;
- Engelman, Jeffrey A.
Publication type:
Article
Synergistic action of the novel HSP90 inhibitor NVP-AUY922 with histone deacetylase inhibitors, melphalan, or doxorubicin in multiple myeloma.
Published in:
European Journal of Haematology, 2010, v. 84, n. 4, p. 337, doi. 10.1111/j.1600-0609.2009.01403.x
By:
- Kaiser, Martin;
- Lamottke, Britta;
- Mieth, Maren;
- Jensen, Michael R.;
- Quadt, Cornelia;
- Garcia-Echeverria, Carlos;
- Atadja, Peter;
- Heider, Ulrike;
- von Metzler, Ivana;
- Türkmen, Seval;
- Sezer, Orhan
Publication type:
Article
<sup>89</sup>Zr-Bevacizumab PET of Early Antiangiogenic Tumor Response to Treatment with HSP90 Inhibitor NVP-AUY922.
Published in:
Journal of Nuclear Medicine, 2010, v. 51, n. 5, p. 761, doi. 10.2967/jnumed.109.071043
By:
- Nagengast, Wouter B.;
- de Korte, Maarten A.;
- Munnink, Thijs H. Oude;
- Timmer-Bosscha, Hetty;
- den Dunnen, Wifred F.;
- Hollema, Harry;
- de Jong, Johan R.;
- Jensen, Michael R.;
- Quadt, Cornelia;
- Garcia-Echeverria, Carlos;
- van Dongen, Guus A. M. S.;
- Hooge, Marjolijn N. Lub-de;
- Schröder, Carolien P.;
- de Vries, Elisabeth G. E.
Publication type:
Article
Population pharmacokinetics and pharmacodynamics of BYL719, a phosphoinositide 3-kinase antagonist, in adult patients with advanced solid malignancies.
Published in:
British Journal of Clinical Pharmacology, 2014, v. 78, n. 3, p. 543, doi. 10.1111/bcp.12378
By:
- De Buck, Stefan S.;
- Jakab, Annamaria;
- Boehm, Markus;
- Bootle, Douglas;
- Juric, Dejan;
- Quadt, Cornelia;
- Goggin, Timothy K.
Publication type:
Article
Anti-myeloma activity of the novel 2-aminothienopyrimidine Hsp90 inhibitor NVP-BEP800.
Published in:
British Journal of Haematology, 2009, v. 147, n. 3, p. 319, doi. 10.1111/j.1365-2141.2009.07852.x
By:
- Stühmer, Thorsten;
- Chatterjee, Manik;
- Grella, Evelyn;
- Seggewiss, Ruth;
- Langer, Christian;
- Müller, Sabine;
- Schoepfer, Joseph;
- Garcia-Echeverria, Carlos;
- Quadt, Cornelia;
- Jensen, Michael R.;
- Einsele, Hermann;
- Bargou, Ralf C.
Publication type:
Article
PI3K inhibitors as new cancer therapeutics: implications for clinical trial design.
Published in:
OncoTargets & Therapy, 2016, v. 9, p. 203, doi. 10.2147/OTT.S89967
By:
- Massacesi, Cristian;
- Di Tomaso, Emmanuelle;
- Urban, Patrick;
- Germa, Caroline;
- Quadt, Cornelia;
- Trandafir, Lucia;
- Aimone, Paola;
- Fretault, Nathalie;
- Dharan, Bharani;
- Tavorath, Ranjana;
- Hirawat, Samit
Publication type:
Article

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