Found: 13

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  • Reversal of siRNA-mediated gene silencing in vivo.

    Published in:
    Nature Biotechnology, 2018, v. 36, n. 6, p. 509, doi. 10.1038/nbt.4136
    By:
    • Zlatev, Ivan;
    • Castoreno, Adam;
    • Brown, Christopher R;
    • Qin, June;
    • Waldron, Scott;
    • Schlegel, Mark K;
    • Degaonkar, Rohan;
    • Shulga-Morskaya, Svetlana;
    • Xu, Huilei;
    • Gupta, Swati;
    • Matsuda, Shigeo;
    • Akinc, Akin;
    • Rajeev, Kallanthottathil G;
    • Manoharan, Muthiah;
    • Maier, Martin A;
    • Jadhav, Vasant
    Publication type:
    Article

  • Rational design of cationic lipids for siRNA delivery.

    Published in:
    Nature Biotechnology, 2010, v. 28, n. 2, p. 172, doi. 10.1038/nbt.1602
    By:
    • Semple, Sean C.;
    • Akinc, Akin;
    • Chen, Jianxin;
    • Sandhu, Ammen P.;
    • Mui, Barbara L.;
    • Cho, Connie K.;
    • Sah, Dinah W. Y.;
    • Stebbing, Derrick;
    • Crosley, Erin J.;
    • Yaworski, Ed;
    • Hafez, Ismail M.;
    • Dorkin, J. Robert;
    • Qin, June;
    • Lam, Kieu;
    • Rajeev, Kallanthottathil G.;
    • Wong, Kim F.;
    • Jeffs, Lloyd B.;
    • Nechev, Lubomir;
    • Eisenhardt, Merete L.;
    • Jayaraman, Muthusamy
    Publication type:
    Article

  • An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia.

    Published in:
    Nature Medicine, 2015, v. 21, n. 5, p. 492, doi. 10.1038/nm.3847
    By:
    • Sehgal, Alfica;
    • Barros, Scott;
    • Ivanciu, Lacramioara;
    • Cooley, Brian;
    • Qin, June;
    • Racie, Tim;
    • Hettinger, Julia;
    • Carioto, Mary;
    • Jiang, Yongfeng;
    • Brodsky, Josh;
    • Prabhala, Harsha;
    • Zhang, Xuemei;
    • Attarwala, Husain;
    • Hutabarat, Renta;
    • Foster, Don;
    • Milstein, Stuart;
    • Charisse, Klaus;
    • Kuchimanchi, Satya;
    • Maier, Martin A;
    • Nechev, Lubo
    Publication type:
    Article

  • Unique Gene-Silencing and Structural Properties of 2′-Fluoro-Modified siRNAs.

    Published in:
    Angewandte Chemie, 2011, v. 123, n. 10, p. 2332, doi. 10.1002/ange.201006519
    By:
    • Manoharan, Muthiah;
    • Akinc, Akin;
    • Pandey, Rajendra K.;
    • Qin, June;
    • Hadwiger, Philipp;
    • John, Matthias;
    • Mills, Kathy;
    • Charisse, Klaus;
    • Maier, Martin A.;
    • Nechev, Lubomir;
    • Greene, Emily M.;
    • Pallan, Pradeep S.;
    • Rozners, Eriks;
    • Rajeev, Kallanthottathil G.;
    • Egli, Martin
    Publication type:
    Article

  • Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics.

    Published in:
    Molecular Therapy, 2013, v. 21, n. 8, p. 1570, doi. 10.1038/mt.2013.124
    By:
    • Maier, Martin A;
    • Jayaraman, Muthusamy;
    • Matsuda, Shigeo;
    • Liu, Ju;
    • Barros, Scott;
    • Querbes, William;
    • Tam, Ying K;
    • Ansell, Steven M;
    • Kumar, Varun;
    • Qin, June;
    • Zhang, Xuemei;
    • Wang, Qianfan;
    • Panesar, Sue;
    • Hutabarat, Renta;
    • Carioto, Mary;
    • Hettinger, Julia;
    • Kandasamy, Pachamuthu;
    • Butler, David;
    • Rajeev, Kallanthottathil G;
    • Pang, Bo
    Publication type:
    Article

  • Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells.

    Published in:
    Molecular Therapy, 2011, v. 19, n. 12, p. 2186, doi. 10.1038/mt.2011.190
    By:
    • Basha, Genc;
    • Novobrantseva, Tatiana I;
    • Rosin, Nicole;
    • Tam, Yuen Yi C;
    • Hafez, Ismail M;
    • Wong, Matthew K;
    • Sugo, Tsukasa;
    • Ruda, Vera M;
    • Qin, June;
    • Klebanov, Boris;
    • Ciufolini, Marco;
    • Akinc, Akin;
    • Tam, Ying K;
    • Hope, Michael J;
    • Cullis, Pieter R
    Publication type:
    Article

  • Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms.

    Published in:
    Molecular Therapy, 2010, v. 18, n. 7, p. 1357, doi. 10.1038/mt.2010.85
    By:
    • Akinc, Akin;
    • Querbes, William;
    • De, Soma;
    • Qin, June;
    • Frank-Kamenetsky, Maria;
    • Jayaprakash, K. Narayanannair;
    • Jayaraman, Muthusamy;
    • Rajeev, Kallanthottathil G;
    • Cantley, William L.;
    • Dorkin, J. Robert;
    • Butler, James S.;
    • Qin, LiuLiang;
    • Racie, Timothy;
    • Sprague, Andrew;
    • Fava, Eugenio;
    • Zeigerer, Anja;
    • Hope, Michael J.;
    • Zerial, Marino;
    • Sah, Dinah W. Y.;
    • Fitzgerald, Kevin
    Publication type:
    Article

  • Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver.

    Published in:
    Molecular Therapy, 2009, v. 17, n. 5, p. 872, doi. 10.1038/mt.2009.36
    By:
    • Akinc, Akin;
    • Goldberg, Michael;
    • Qin, June;
    • Dorkin, J. Robert;
    • Gamba-Vitalo, Christina;
    • Maier, Martin;
    • Jayaprakash, K. Narayanannair;
    • Jayaraman, Muthusamy;
    • Rajeev, Kallanthottathil G.;
    • Manoharan, Muthiah;
    • Koteliansky, Victor;
    • Röhl, Ingo;
    • Leshchiner, Elizaveta S.;
    • Langer, Robert;
    • Anderson, Daniel G.
    Publication type:
    Article

  • Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates.

    Published in:
    Nucleic Acids Research, 2024, v. 52, n. 10, p. 5423, doi. 10.1093/nar/gkae350
    By:
    • Yu, Mikyung;
    • Qin, June;
    • Liu, Xiumin;
    • Ramsden, Diane;
    • Williams, Brian;
    • Zlatev, Ivan;
    • Guenther, Dale;
    • Matsuda, Shigeo;
    • Tymon, Roxanne;
    • Darcy, Justin;
    • Wong, Catrina;
    • Tsung, Jamie;
    • Zawaneh, Peter;
    • Chong, Saeho;
    • Theile, Christopher S;
    • Taneja, Nathan;
    • Rogers, Arlin;
    • Liu, Ju;
    • Castellanos-Rizaldos, Elena;
    • Bond, Sarah
    Publication type:
    Article

  • siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′-F-NMC NTPs.

    Published in:
    Nucleic Acids Research, 2021, v. 49, n. 5, p. 2435, doi. 10.1093/nar/gkab050
    By:
    • Akabane-Nakata, Masaaki;
    • Erande, Namrata D;
    • Kumar, Pawan;
    • Degaonkar, Rohan;
    • Gilbert, Jason A;
    • Qin, June;
    • Mendez, Martha;
    • Woods, Lauren Blair;
    • Jiang, Yongfeng;
    • Janas, Maja M;
    • O'Flaherty, Derek K;
    • Zlatev, Ivan;
    • Schlegel, Mark K;
    • Matsuda, Shigeo;
    • Egli, Martin;
    • Manoharan, Muthiah
    Publication type:
    Article

  • Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates.

    Published in:
    Nucleic Acids Research, 2020, v. 48, n. 21, p. 11827, doi. 10.1093/nar/gkaa670
    By:
    • Brown, Christopher R;
    • Gupta, Swati;
    • Qin, June;
    • Racie, Timothy;
    • He, Guo;
    • Lentini, Scott;
    • Malone, Ryan;
    • Yu, Mikyung;
    • Matsuda, Shigeo;
    • Shulga-Morskaya, Svetlana;
    • Nair, Anil V;
    • Theile, Christopher S;
    • Schmidt, Karyn;
    • Shahraz, Azar;
    • Goel, Varun;
    • Parmar, Rubina G;
    • Zlatev, Ivan;
    • Schlegel, Mark K;
    • Nair, Jayaprakash K;
    • Jayaraman, Muthusamy
    Publication type:
    Article

  • Reactivity of Resident Immunocytes in Normal and Prepsoriatic Skin Using an Ex Vivo Skin-Explant Model System.

    Published in:
    Archives of Pathology & Laboratory Medicine, 2003, v. 127, n. 3, p. 289, doi. 10.5858/2003-127-0289-roriin
    By:
    • Curry, Jonathan L.;
    • Jian-Zhong Qin, June;
    • Robinson, Brian J.;
    • Nickoloff, Brian J.
    Publication type:
    Article

  • Unique Gene-Silencing and Structural Properties of 2′-Fluoro-Modified siRNAs.

    Published in:
    Angewandte Chemie International Edition, 2011, v. 50, n. 10, p. 2284, doi. 10.1002/anie.201006519
    By:
    • Manoharan, Muthiah;
    • Akinc, Akin;
    • Pandey, Rajendra K.;
    • Qin, June;
    • Hadwiger, Philipp;
    • John, Matthias;
    • Mills, Kathy;
    • Charisse, Klaus;
    • Maier, Martin A.;
    • Nechev, Lubomir;
    • Greene, Emily M.;
    • Pallan, Pradeep S.;
    • Rozners, Eriks;
    • Rajeev, Kallanthottathil G.;
    • Egli, Martin
    Publication type:
    Article