Works matching AU Purcell, Shaun M.

Results: 39

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.

Published in:

Nature, 2009, v. 460, n. 7256, p. 748, doi. 10.1038/nature08185

By:

Purcell, Shaun M.;
Wray, Naomi R.;
Stone, Jennifer L.;
Visscher, Peter M.;
O'Donovan, Michael C.;
Sullivan, Patrick F.;
Sklar, Pamela;
Purcell (Leader), Shaun M.;
Ruderfer, Douglas M.;
McQuillin, Andrew;
Morris, Derek W.;
O’Dushlaine, Colm T.;
Corvin, Aiden;
Holmans, Peter A.;
O’Donovan, Michael C.;
Macgregor, Stuart;
Gurling, Hugh;
Blackwood, Douglas H. R.;
Craddock, Nick J.;
Gill, Michael

Publication type:

Article

Synthetic Associations Created by Rare Variants Do Not Explain Most GWAS Results.

Published in:

PLoS Biology, 2011, v. 9, n. 1, p. 1, doi. 10.1371/journal.pbio.1000579

By:

Wray, Naomi R.;
Purcell, Shaun M.;
Visscher, Peter M.

Publication type:

Article

Statistics for X‐chromosome associations.

Published in:

Genetic Epidemiology, 2018, v. 42, n. 6, p. 539, doi. 10.1002/gepi.22132

By:

Özbek, Umut;
Lin, Hui‐Min;
Lin, Yan;
Weeks, Daniel E.;
Chen, Wei;
Shaffer, John R.;
Purcell, Shaun M.;
Feingold, Eleanor

Publication type:

Article

Genome-wide association analysis of composite sleep health scores in 413,904 individuals.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-07514-0

By:

Goodman, Matthew O.;
Faquih, Tariq;
Paz, Valentina;
Nagarajan, Pavithra;
Lane, Jacqueline M.;
Spitzer, Brian;
Maher, Matthew;
Chung, Joon;
Cade, Brian E.;
Purcell, Shaun M.;
Zhu, Xiaofeng;
Noordam, Raymond;
Phillips, Andrew J. K.;
Kyle, Simon D.;
Spiegelhalder, Kai;
Weedon, Michael N.;
Lawlor, Deborah A.;
Rotter, Jerome I.;
Taylor, Kent D.;
Isasi, Carmen R.

Publication type:

Article

Second-generation PLINK: rising to the challenge of larger and richer datasets.

Published in:

GigaScience, 2015, v. 4, n. 1, p. 1, doi. 10.1186/s13742-015-0047-8

By:

Chang, Christopher C.;
Chow, Carson C.;
Tellier, Laurent C. A. M.;
Vattikuti, Shashaank;
Purcell, Shaun M.;
Lee, James J.

Publication type:

Article

Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep.

Published in:

PLoS Genetics, 2019, v. 15, n. 4, p. 1, doi. 10.1371/journal.pgen.1007739

By:

Lee, Jiwon;
Gleason, Kevin J.;
Gottlieb, Daniel J.;
Cade, Brian E.;
Purcell, Shaun M.;
Wang, Heming;
Saxena, Richa;
Redline, Susan;
Sofer, Tamar;
Below, Jennifer E.;
Cai, Jianwen;
Evans, Daniel S.;
Stone, Katie L.;
Tranah, Gregory J.;
Frazier-Wood, Alexis C.;
Gharib, Sina A.;
Hillman, David R.;
Lederer, David J.;
Loredo, Jose S.;
Mei, Hao

Publication type:

Article

Rare chromosomal deletions and duplications increase risk of schizophrenia.

Published in:

Nature, 2008, v. 455, n. 7210, p. 237, doi. 10.1038/nature07239

By:

Stone, Jennifer L.;
O’Donovan, Michael C.;
Gurling, Hugh;
Kirov, George K.;
Blackwood, Douglas H. R.;
Corvin, Aiden;
Craddock, Nick J.;
Gill, Michael;
Hultman, Christina M.;
Lichtenstein, Paul;
McQuillin, Andrew;
Pato, Carlos N.;
Ruderfer, Douglas M.;
Owen, Michael J.;
St Clair, David;
Sullivan, Patrick F.;
Sklar, Pamela;
Purcell (Leader), Shaun M.;
Korn, Joshua;
Macgregor, Stuart

Publication type:

Article

No evidence for rare recessive and compound heterozygous disruptive variants in schizophrenia.

Published in:

European Journal of Human Genetics, 2015, v. 23, n. 4, p. 555, doi. 10.1038/ejhg.2014.228

By:

Ruderfer, Douglas M;
Lim, Elaine T;
Genovese, Giulio;
Moran, Jennifer L;
Hultman, Christina M;
Sullivan, Patrick F;
McCarroll, Steven A;
Holmans, Peter;
Sklar, Pamela;
Purcell, Shaun M

Publication type:

Article

Mosaic copy number variation in schizophrenia.

Published in:

European Journal of Human Genetics, 2013, v. 21, n. 9, p. 1007, doi. 10.1038/ejhg.2012.287

By:

Ruderfer, Douglas M;
Chambert, Kim;
Moran, Jennifer;
Talkowski, Michael;
Chen, Elizabeth S;
Gigek, Carolina;
Gusella, James F;
Blackwood, Douglas H;
Corvin, Aiden;
Gurling, Hugh M;
Hultman, Christina M;
Kirov, George;
Magnusson, Patrick;
O'Donovan, Michael C;
Owen, Michael J;
Pato, Carlos;
St Clair, David;
Sullivan, Patrick F;
Purcell, Shaun M;
Sklar, Pamela

Publication type:

Article

Exome sequencing and the genetic basis of complex traits.

Published in:

Nature Genetics, 2012, v. 44, n. 6, p. 623, doi. 10.1038/ng.2303

By:

Kiezun, Adam;
Garimella, Kiran;
Do, Ron;
Stitziel, Nathan O;
Neale, Benjamin M;
McLaren, Paul J;
Gupta, Namrata;
Sklar, Pamela;
Sullivan, Patrick F;
Moran, Jennifer L;
Hultman, Christina M;
Lichtenstein, Paul;
Magnusson, Patrik;
Lehner, Thomas;
Shugart, Yin Yao;
Price, Alkes L;
de Bakker, Paul I W;
Purcell, Shaun M;
Sunyaev, Shamil R

Publication type:

Article

Extremely low-coverage sequencing and imputation increases power for genome-wide association studies.

Published in:

Nature Genetics, 2012, v. 44, n. 6, p. 631, doi. 10.1038/ng.2283

By:

Pasaniuc, Bogdan;
Rohland, Nadin;
McLaren, Paul J;
Garimella, Kiran;
Zaitlen, Noah;
Li, Heng;
Gupta, Namrata;
Neale, Benjamin M;
Daly, Mark J;
Sklar, Pamela;
Sullivan, Patrick F;
Bergen, Sarah;
Moran, Jennifer L;
Hultman, Christina M;
Lichtenstein, Paul;
Magnusson, Patrik;
Purcell, Shaun M;
Haas, David W;
Liang, Liming;
Sunyaev, Shamil

Publication type:

Article

Testing for an Unusual Distribution of Rare Variants.

Published in:

PLoS Genetics, 2011, v. 7, n. 3, p. 1, doi. 10.1371/journal.pgen.1001322

By:

Neale, Benjamin M.;
Rivas, Manuel A.;
Voight, Benjamin F.;
Altshuler, David;
Devlin, Bernie;
Orho-Melander, Marju;
Kathiresan, Sekar;
Purcell, Shaun M.;
Roeder, Kathryn;
Daly, Mark J.

Publication type:

Article

Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions.

Published in:

PLoS Genetics, 2009, v. 5, n. 6, p. 1, doi. 10.1371/journal.pgen.1000534

By:

Raychaudhuri, Soumya;
Plenge, Robert M.;
Rossin, Elizabeth J.;
Ng, Aylwin C. Y.;
Purcell, Shaun M.;
Sklar, Pamela;
Scolnick, Edward M.;
Xavier, Ramnik J.;
Altshuler, David;
Daly, Mark J.

Publication type:

Article

Modifiers and Subtype-Specific Analyses in Whole-Genome Association Studies: A Likelihood Framework.

Published in:

Human Heredity, 2011, v. 72, n. 1, p. 10, doi. 10.1159/000327158

By:

Lee, Phil H.;
Bergen, Sarah E.;
Perlis, Roy H.;
Sullivan, Patrick F.;
Sklar, Pamela;
Smoller, Jordan W.;
Purcell, Shaun M.

Publication type:

Article

Exome Sequencing of Familial Bipolar Disorder.

Published in:

2016

By:

Goes, Fernando S.;
Pirooznia, Mehdi;
Parla, Jennifer S.;
Kramer, Melissa;
Ghiban, Elena;
Mavruk, Senem;
Yun-Ching Chen;
Monson, Eric T.;
Willour, Virginia L.;
Karchin, Rachel;
Flickinger, Matthew;
Locke, Adam E.;
Levy, Shawn E.;
Scott, Laura J.;
Boehnke, Michael;
Stahl, Eli;
Moran, Jennifer L.;
Hultman, Christina M.;
Landén, Mikael;
Purcell, Shaun M.

Publication type:

journal article

Common Variants on Xq28 Conferring Risk of Schizophrenia in Han Chinese.

Published in:

2014

By:

Wong, Emily H.M.;
So, Hon-Cheong;
Li, Miaoxin;
Wang, Quang;
Butler, Amy W.;
Paul, Basil;
Wu, Hei-Man;
Hui, Tomy C.K.;
Choi, Siu-Chung;
So, Man-Ting;
Garcia-Barcelo, Maria-Mercè;
McAlonan, Grainne M.;
Chen, Eric Y.H.;
Cheung, Eric F.C.;
Chan, Raymond C.K.;
Purcell, Shaun M.;
Cherny, Stacey S.;
Chen, Ronald R.L.;
Li, Tao;
Sham, Pak-Chung

Publication type:

Journal Article

Common Variants on Xq28 Conferring Risk of Schizophrenia in Han Chinese.

Published in:

Schizophrenia Bulletin, 2014, v. 40, n. 4, p. 777, doi. 10.1093/schbul/sbt104

By:

Wong, Emily H.M.;
So, Hon-Cheong;
Li, Miaoxin;
Wang, Quang;
Butler, Amy W.;
Paul, Basil;
Wu, Hei-Man;
Hui, Tomy C.K.;
Choi, Siu-Chung;
So, Man-Ting;
Garcia-Barcelo, Maria-Mercè;
McAlonan, Grainne M.;
Chen, Eric Y.H.;
Cheung, Eric F.C.;
Chan, Raymond C.K.;
Purcell, Shaun M.;
Cherny, Stacey S.;
Chen, Ronald R.L.;
Li, Tao;
Sham, Pak-Chung

Publication type:

Article

A framework for the interpretation of de novo mutation in human disease.

Published in:

Nature Genetics, 2014, v. 46, n. 9, p. 944, doi. 10.1038/ng.3050

By:

Samocha, Kaitlin E;
Robinson, Elise B;
Sanders, Stephan J;
Stevens, Christine;
Sabo, Aniko;
McGrath, Lauren M;
Kosmicki, Jack A;
Rehnström, Karola;
Mallick, Swapan;
Kirby, Andrew;
Wall, Dennis P;
MacArthur, Daniel G;
Gabriel, Stacey B;
DePristo, Mark;
Purcell, Shaun M;
Palotie, Aarno;
Boerwinkle, Eric;
Buxbaum, Joseph D;
Cook, Edwin H;
Gibbs, Richard A

Publication type:

Article

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.

Published in:

Nature Genetics, 2013, v. 45, n. 9, p. 984, doi. 10.1038/ng.2711

By:

Lee, S Hong;
Ripke, Stephan;
Neale, Benjamin M;
Faraone, Stephen V;
Purcell, Shaun M;
Perlis, Roy H;
Mowry, Bryan J;
Thapar, Anita;
Goddard, Michael E;
Witte, John S;
Absher, Devin;
Agartz, Ingrid;
Akil, Huda;
Amin, Farooq;
Andreassen, Ole A;
Anjorin, Adebayo;
Anney, Richard;
Anttila, Verneri;
Arking, Dan E;
Asherson, Philip

Publication type:

Article

Statistical power and significance testing in large-scale genetic studies.

Published in:

Nature Reviews Genetics, 2014, v. 15, n. 5, p. 335, doi. 10.1038/nrg3706

By:

Sham, Pak C.;
Purcell, Shaun M.

Publication type:

Article

Pleiotropy in complex traits: challenges and strategies.

Published in:

Nature Reviews Genetics, 2013, v. 14, n. 7, p. 483, doi. 10.1038/nrg3461

By:

Solovieff, Nadia;
Cotsapas, Chris;
Lee, Phil H.;
Purcell, Shaun M.;
Smoller, Jordan W.

Publication type:

Article

The Genomic Psychiatry Cohort: Partners in Discovery.

Published in:

American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 2013, v. 162B, n. 4, p. 306, doi. 10.1002/ajmg.b.32160

By:

Pato, Michele T.;
Sobell, Janet L.;
Medeiros, Helena;
Abbott, Colony;
Sklar, Brooke M.;
Buckley, Peter F.;
Bromet, Evelyn J.;
Escamilla, Michael A.;
Fanous, Ayman H.;
Lehrer, Douglas S.;
Macciardi, Fabio;
Malaspina, Dolores;
McCarroll, Steve A.;
Marder, Stephen R.;
Moran, Jennifer;
Morley, Christopher P.;
Nicolini, Humberto;
Perkins, Diana O.;
Purcell, Shaun M.;
Rapaport, Mark H.

Publication type:

Article

Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses' Health Study II.

Published in:

BMC Psychiatry, 2009, v. 9, p. 1, doi. 10.1186/1471-244X-9-29

By:

Koenen, Karestan C.;
DeVivo, Immaculata;
Rich-Edwards, Janet;
Smoller, Jordan W.;
Wright, Rosalind J.;
Purcell, Shaun M.

Publication type:

Article

INRICH: interval-based enrichment analysis for genome-wide association studies.

Published in:

Bioinformatics, 2012, v. 28, n. 13, p. 1797, doi. 10.1093/bioinformatics/bts191

By:

Lee, Phil H.;
O'Dushlaine, Colm;
Thomas, Brett;
Purcell, Shaun M.

Publication type:

Article

A multivariate test of association.

Published in:

Bioinformatics, 2009, v. 25, n. 1, p. 132, doi. 10.1093/bioinformatics/btn563

By:

Ferreira, Manuel A. R.;
Purcell, Shaun M.

Publication type:

Article

Genetic Association Analysis of 300 Genes Identifies a Risk Haplotype in SLC18A2 for Post-traumatic Stress Disorder in Two Independent Samples.

Published in:

Neuropsychopharmacology, 2014, v. 39, n. 8, p. 1872, doi. 10.1038/npp.2014.34

By:

Solovieff, Nadia;
Roberts, Andrea L;
Ratanatharathorn, Andrew;
Haloosim, Michelle;
De Vivo, Immaculata;
King, Anthony P;
Liberzon, Israel;
Aiello, Allison;
Uddin, Monica;
Wildman, Derek E;
Galea, Sandro;
Smoller, Jordan W;
Purcell, Shaun M;
Koenen, Karestan C

Publication type:

Article

Causal Association Between Subtypes of Excessive Daytime Sleepiness and Risk of Cardiovascular Diseases.

Published in:

Journal of the American Heart Association, 2023, v. 12, n. 24, p. 1, doi. 10.1161/JAHA.122.030568

By:

Goodman, Matthew O.;
Dashti, Hassan S.;
Lane, Jacqueline M.;
Windred, Daniel P.;
Burns, Angus;
Jones, Samuel E.;
Sofer, Tamar;
Purcell, Shaun M.;
Xiaofeng Zhu;
Ollila, Hanna M.;
Kyle, Simon D.;
Spiegelhalder, Kai;
Peker, Yuksel;
Huang, Tianyi;
Cain, Sean W.;
Phillips, Andrew J. K.;
Saxena, Richa;
Rutter, Martin K.;
Redline, Susan;
Heming Wang

Publication type:

Article

Statistical Power and the Classical Twin Design.

Published in:

2020

By:

Sham, Pak C.;
Purcell, Shaun M.;
Cherny, Stacey S.;
Neale, Michael C.;
Neale, Benjamin M.;
Evans, David;
Medland, Sarah;
Gillespie, Nathan

Publication type:

journal article

Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.

Published in:

Genome Medicine, 2021, v. 13, n. 1, p. 1, doi. 10.1186/s13073-021-00917-8

By:

Cade, Brian E.;
Lee, Jiwon;
Sofer, Tamar;
Wang, Heming;
Zhang, Man;
Chen, Han;
Gharib, Sina A.;
Gottlieb, Daniel J.;
Guo, Xiuqing;
Lane, Jacqueline M.;
Liang, Jingjing;
Lin, Xihong;
Mei, Hao;
Patel, Sanjay R.;
Purcell, Shaun M.;
Saxena, Richa;
Shah, Neomi A.;
Evans, Daniel S.;
Hanis, Craig L.;
Hillman, David R.

Publication type:

Article

Objectively regular sleep patterns and mortality in a prospective cohort: The Multi‐Ethnic Study of Atherosclerosis.

Published in:

Journal of Sleep Research, 2024, v. 33, n. 1, p. 1, doi. 10.1111/jsr.14048

By:

Chung, Joon;
Goodman, Matthew O.;
Huang, Tianyi;
Castro‐Diehl, Cecilia;
Chen, Jarvis T.;
Sofer, Tamar;
Bertisch, Suzanne M.;
Purcell, Shaun M.;
Redline, Susan

Publication type:

Article

Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders.

Published in:

Genome Medicine, 2017, v. 9, p. 1, doi. 10.1186/s13073-017-0497-y

By:

Nguyen, Hoang T.;
Bryois, Julien;
Kim, April;
Dobbyn, Amanda;
Huckins, Laura M.;
Munoz-Manchado, Ana B.;
Ruderfer, Douglas M.;
Genovese, Giulio;
Fromer, Menachem;
Xinyi Xu;
Pinto, Dalila;
Linnarsson, Sten;
Verhage, Matthijs;
Smit, August B.;
Hjerling-Leffler, Jens;
Buxbaum, Joseph D.;
Hultman, Christina;
Sklar, Pamela;
Purcell, Shaun M.;
Lage, Kasper

Publication type:

Article

AI-Driven sleep staging from actigraphy and heart rate.

Published in:

PLoS ONE, 2023, v. 18, n. 5, p. 1, doi. 10.1371/journal.pone.0285703

By:

Song, Tzu-An;
Chowdhury, Samadrita Roy;
Malekzadeh, Masoud;
Harrison, Stephanie;
Hoge, Terri Blackwell;
Redline, Susan;
Stone, Katie L.;
Saxena, Richa;
Purcell, Shaun M.;
Dutta, Joyita

Publication type:

Article

mTADA is a framework for identifying risk genes from de novo mutations in multiple traits.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16487-z

By:

Nguyen, Tan-Hoang;
Dobbyn, Amanda;
Brown, Ruth C.;
Riley, Brien P.;
Buxbaum, Joseph D.;
Pinto, Dalila;
Purcell, Shaun M.;
Sullivan, Patrick F.;
He, Xin;
Stahl, Eli A.

Publication type:

Article

The Genetic Structure of the Swedish Population.

Published in:

PLoS ONE, 2011, v. 6, n. 8, p. 1, doi. 10.1371/journal.pone.0022547

By:

Humphreys, Keith;
Grankvist, Alexander;
Leu, Monica;
Hall, Per;
Liu, Jianjun;
Ripatti, Samuli;
Rehnström, Karola;
Groop, Leif;
Klareskog, Lars;
Ding, Bo;
Grönberg, Henrik;
Xu, Jianfeng;
Pedersen, Nancy L.;
Lichtenstein, Paul;
Mattingsdal, Morten;
Andreassen, Ole A.;
O'Dushlaine, Colm;
Purcell, Shaun M.;
Sklar, Pamela;
Sullivan, Patrick F.

Publication type:

Article

A polygenic burden of rare disruptive mutations in schizophrenia.

Published in:

Nature, 2014, v. 506, n. 7487, p. 185, doi. 10.1038/nature12975

By:

Purcell, Shaun M.;
Moran, Jennifer L.;
Fromer, Menachem;
Ruderfer, Douglas;
Solovieff, Nadia;
Roussos, Panos;
O'Dushlaine, Colm;
Chambert, Kimberly;
Bergen, Sarah E.;
Kähler, Anna;
Duncan, Laramie;
Stahl, Eli;
Genovese, Giulio;
Fernández, Esperanza;
Collins, Mark O.;
Komiyama, Noboru H.;
Choudhary, Jyoti S.;
Magnusson, Patrik K. E.;
Banks, Eric;
Shakir, Khalid

Publication type:

Article

Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-05415-4

By:

Wang, Heming;
Kurniansyah, Nuzulul;
Cade, Brian E.;
Goodman, Matthew O.;
Chen, Han;
Gottlieb, Daniel J.;
Gharib, Sina A.;
Purcell, Shaun M.;
Lin, Xihong;
Saxena, Richa;
Zhu, Xiaofeng;
Durda, Peter;
Tracy, Russel;
Liu, Yongmei;
Taylor, Kent D.;
Johnson, W. Craig;
Gabriel, Stacey;
Smith, Joshua D.;
Aguet, François;
Ardlie, Kirstin

Publication type:

Article

Family-based genetic risk prediction of multifactorial disease.

Published in:

Genome Medicine, 2010, v. 2, n. 1, p. 1, doi. 10.1186/gm123

By:

Ruderfer, Douglas M.;
Korn, Joshua;
Purcell, Shaun M.

Publication type:

Article

Sleep Architecture, Obstructive Sleep Apnea, and Cognitive Function in Adults.

Published in:

JAMA Network Open, 2023, v. 6, n. 7, p. e2325152, doi. 10.1001/jamanetworkopen.2023.25152

By:

Pase, Matthew P.;
Harrison, Stephanie;
Misialek, Jeffrey R.;
Kline, Christopher E.;
Cavuoto, Marina;
Baril, Andree-Ann;
Yiallourou, Stephanie;
Bisson, Alycia;
Himali, Dibya;
Leng, Yue;
Yang, Qiong;
Seshadri, Sudha;
Beiser, Alexa;
Gottesman, Rebecca F.;
Redline, Susan;
Lopez, Oscar;
Lutsey, Pamela L.;
Yaffe, Kristine;
Stone, Katie L.;
Purcell, Shaun M.

Publication type:

Article

Sources of Variation in the Spectral Slope of the Sleep EEG.

Published in:

eNeuro, 2022, v. 9, n. 5, p. 1, doi. 10.1523/ENEURO.0094-22.2022

By:

Kozhemiako, Nataliia;
Mylonas, Dimitris;
Pan, Jen Q.;
Prerau, Michael J.;
Redline, Susan;
Purcell, Shaun M.

Publication type:

Article