Works matching AU Pun, Frank W.

Results: 19

Utilizing AI for the Identification and Validation of Novel Therapeutic Targets and Repurposed Drugs for Endometriosis.

Published in:

Advanced Science, 2025, v. 12, n. 5, p. 1, doi. 10.1002/advs.202406565

By:

Liu, Bonnie Hei Man;
Lin, Yuezhen;
Long, Xi;
Hung, Sze Wan;
Gaponova, Anna;
Ren, Feng;
Zhavoronkov, Alex;
Pun, Frank W.;
Wang, Chi Chiu

Publication type:

Article

AI-Driven Drug Target Screening Platform Identified Oncogene CACNA2D1 Activated by Enhancer Infestation in Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4697, doi. 10.3390/ijms26104697

By:

Chung, Dittman Lai-Shun;
Leung, Geoffrey Ho Duen;
Liu, Songran;
Lok, Sarah Wing Yan;
Xin, Ying;
Xia, Yunfei;
Zhavoronkov, Alex;
Pun, Frank W.;
Ng, Wai-Tong;
Dai, Wei

Publication type:

Article

#296 : Identification and Validation of Two Novel Therapeutic Targets for Endometriosis with Artificial Intelligence (AI).

Published in:

2023

By:

Wang, Chi Chiu;
Pun, Frank W;
Liu, Bonnie Hei Man;
Lin, Yuezhen;
Ren, Feng;
Zhavoronkov, Alex

Publication type:

Abstract

Utilizing AI for the Identification and Validation of Novel Therapeutic Targets and Repurposed Drugs for Endometriosis.

Published in:

Advanced Science, 2025, v. 12, n. 5, p. 1, doi. 10.1002/advs.202406565

By:

Liu, Bonnie Hei Man;
Lin, Yuezhen;
Long, Xi;
Hung, Sze Wan;
Gaponova, Anna;
Ren, Feng;
Zhavoronkov, Alex;
Pun, Frank W.;
Wang, Chi Chiu

Publication type:

Article

Massive interstitial copy-neutral loss-ofheterozygosity as evidence for cancer being a disease of the DNA-damage response.

Published in:

BMC Medical Genomics, 2015, v. 8, n. 1, p. 1, doi. 10.1186/s12920-015-0104-2

By:

Yogesh Kumar;
Jianfeng Yang;
Taobo Hu;
Lei Chen;
Zhi Xu;
Lin Xu;
Xiao-Xia Hu;
Gusheng Tang;
Jian-Min Wang;
Yi Li;
Wai-Sang Poon;
Weiqing Wan;
Liwei Zhang;
Wai-Kin Mat;
Pun, Frank W.;
Peggy Lee;
Cheong, Timothy H. Y.;
Xiaofan Ding;
Siu-Kin Ng;
Shui-Ying Tsang

Publication type:

Article

Massive interstitial copy-neutral loss-of-heterozygosity as evidence for cancer being a disease of the DNA-damage response.

Published in:

BMC Medical Genomics, 2015, v. 8, n. 1, p. 1, doi. 10.1186/s12920-015-0104-2

By:

Kumar, Yogesh;
Jianfeng Yang;
Taobo Hu;
Lei Chen;
Zhi Xu;
Lin Xu;
Xiao-Xia Hu;
Gusheng Tang;
Jian-Min Wang;
Yi Li;
Wai-Sang Poon;
Weiqing Wan;
Liwei Zhang;
Wai-Kin Mat;
Pun, Frank W.;
Peggy Lee;
Cheong, Timothy H. Y.;
Xiaofan Ding;
Siu-Kin Ng;
Shui-Ying Tsang

Publication type:

Article

Leveraging AI to identify dual-purpose aging and disease targets.

Published in:

2024

By:

Leung, Geoffrey Ho Duen;
Wong, Chun Wai;
Pun, Frank W.;
Aliper, Alex;
Ren, Feng;
Zhavoronkov, Alex

Publication type:

Editorial

A comprehensive AI‐driven analysis of large‐scale omic datasets reveals novel dual‐purpose targets for the treatment of cancer and aging.

Published in:

Aging Cell, 2023, v. 22, n. 12, p. 1, doi. 10.1111/acel.14017

By:

Pun, Frank W.;
Leung, Geoffrey Ho Duen;
Leung, Hoi Wing;
Rice, Jared;
Schmauck‐Medina, Tomas;
Lautrup, Sofie;
Long, Xi;
Liu, Bonnie Hei Man;
Wong, Chun Wai;
Ozerov, Ivan V.;
Aliper, Alex;
Ren, Feng;
Rosenberg, Ari J.;
Agrawal, Nishant;
Izumchenko, Evgeny;
Fang, Evandro F.;
Zhavoronkov, Alex

Publication type:

Article

High-confidence cancer patient stratification through multiomics investigation of DNA repair disorders.

Published in:

Cell Death & Disease, 2022, v. 13, n. 11, p. 1, doi. 10.1038/s41419-022-05437-w

By:

Mkrtchyan, Garik V.;
Veviorskiy, Alexander;
Izumchenko, Evgeny;
Shneyderman, Anastasia;
Pun, Frank W.;
Ozerov, Ivan V.;
Aliper, Alex;
Zhavoronkov, Alex;
Scheibye-Knudsen, Morten

Publication type:

Article

Glioma Association and Balancing Selection of ZFPM2.

Published in:

PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0133003

By:

Tsang, Shui-Ying;
Mei, Lingling;
Wan, Weiqing;
Li, Jun;
Li, Yi;
Zhao, Cunyou;
Ding, Xiaofan;
Pun, Frank W.;
Hu, Xiaoxia;
Wang, Jianmin;
Zhang, Junyi;
Luo, Rongcheng;
Cheung, Siu-Tim;
Leung, Gilberto K. K.;
Poon, Wai-Sang;
Ng, Ho-Keung;
Zhang, Liwei;
Xue, Hong

Publication type:

Article

Social Cognitive Role of Schizophrenia Candidate Gene <i>GABRB2</i>.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0062322

By:

Tsang, Shui Ying;
Zhong, Songfa;
Mei, Lingling;
Chen, Jianhuan;
Ng, Siu-Kin;
Pun, Frank W.;
Zhao, Cunyou;
Jing, Bingyi;
Chark, Robin;
Guo, Jianhua;
Tan, Yunlong;
Li, Lijun;
Wang, Chuanyue;
Chew, Soo Hong;
Xue, Hong

Publication type:

Article

A Recombination Hotspot in a Schizophrenia-Associated Region of GABRB2.

Published in:

PLoS ONE, 2010, v. 5, n. 3, p. 1, doi. 10.1371/journal.pone.0009547

By:

Siu-Kin Ng;
Wing-Sze Lo;
Pun, Frank W.;
Cunyou Zhao;
Zhiliang Yu;
Jianhuan Chen;
Ka-Lok Tong;
Zhiwen Xu;
Shui-Ying Tsang;
Qiang Yang;
Weichuan Yu;
Nimgaonkar, Vishwajit;
Stöber, Gerald;
Harano, Mutsuo;
Hong Xue

Publication type:

Article

Alternative-Splicing in the Exon-10 Region of GABA<sub>A</sub> Receptor β2 Subunit Gene: Relationships between Novel Isoforms and Psychotic Disorders.

Published in:

PLoS ONE, 2009, v. 4, n. 9, p. 1, doi. 10.1371/journal.pone.0006977

By:

Cunyou Zhao;
Zhiwen Xu;
Feng Wang;
Jianhuan Chen;
Siu-Kin Ng;
Pak-Wing Wong;
Zhiliang Yu;
Pun, Frank W.;
Lihuan Ren;
Wing-Sze Lo;
Shui-Ying Tsang;
Hong Xue

Publication type:

Article

AttenhERG: a reliable and interpretable graph neural network framework for predicting hERG channel blockers.

Published in:

Journal of Cheminformatics, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13321-024-00940-y

By:

Yang, Tianbiao;
Ding, Xiaoyu;
McMichael, Elizabeth;
Pun, Frank W.;
Aliper, Alex;
Ren, Feng;
Zhavoronkov, Alex;
Ding, Xiao

Publication type:

Article

PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2025, v. 44, n. 1, p. 1, doi. 10.1186/s13046-024-03270-x

By:

Mishra, Vasudha;
Singh, Alka;
Korzinkin, Michael;
Cheng, Xiangying;
Wing, Claudia;
Sarkisova, Viktoria;
Koppayi, Ashwin L.;
Pogorelskaya, Alexandra;
Glushchenko, Oksana;
Sundaresan, Manu;
Thodima, Venkat;
Carter, Jack;
Ito, Koichi;
Scherle, Peggy;
Trzcinska, Anna;
Ozerov, Ivan;
Vokes, Everett E.;
Cole, Grayson;
Pun, Frank W.;
Shen, Le

Publication type:

Article

Precious2GPT: the combination of multiomics pretrained transformer and conditional diffusion for artificial multi-omics multi-species multi-tissue sample generation.

Published in:

NPJ Aging, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41514-024-00163-3

By:

Sidorenko, Denis;
Pushkov, Stefan;
Sakip, Akhmed;
Leung, Geoffrey Ho Duen;
Lok, Sarah Wing Yan;
Urban, Anatoly;
Zagirova, Diana;
Veviorskiy, Alexander;
Tihonova, Nina;
Kalashnikov, Aleksandr;
Kozlova, Ekaterina;
Naumov, Vladimir;
Pun, Frank W.;
Aliper, Alex;
Ren, Feng;
Zhavoronkov, Alex

Publication type:

Article

Applying Artificial Intelligence to Identify Common Targets for Treatment of Asthma, Eczema, and Food Allergy.

Published in:

International Archives of Allergy & Immunology, 2024, v. 185, n. 2, p. 99, doi. 10.1159/000534827

By:

Liu, Hei Man;
Rayner, Andre;
Mendelsohn, Andrew R.;
Shneyderman, Anastasia;
Chen, Michelle;
Pun, Frank W.

Publication type:

Article

Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics – An AI-Enabled Biological Target Discovery Platform.

Published in:

Frontiers in Aging Neuroscience, 2022, v. 14, p. 1, doi. 10.3389/fnagi.2022.914017

By:

Pun, Frank W.;
Liu, Bonnie Hei Man;
Long, Xi;
Leung, Hoi Wing;
Leung, Geoffrey Ho Duen;
Mewborne, Quinlan T.;
Gao, Junli;
Shneyderman, Anastasia;
Ozerov, Ivan V.;
Wang, Ju;
Ren, Feng;
Aliper, Alexander;
Bischof, Evelyne;
Izumchenko, Evgeny;
Guan, Xiaoming;
Zhang, Ke;
Lu, Bai;
Rothstein, Jeffrey D.;
Cudkowicz, Merit E.;
Zhavoronkov, Alex

Publication type:

Article

A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models.

Published in:

Nature Biotechnology, 2025, v. 43, n. 1, p. 63, doi. 10.1038/s41587-024-02143-0

By:

Ren, Feng;
Aliper, Alex;
Chen, Jian;
Zhao, Heng;
Rao, Sujata;
Kuppe, Christoph;
Ozerov, Ivan V.;
Zhang, Man;
Witte, Klaus;
Kruse, Chris;
Aladinskiy, Vladimir;
Ivanenkov, Yan;
Polykovskiy, Daniil;
Fu, Yanyun;
Babin, Eugene;
Qiao, Junwen;
Liang, Xing;
Mou, Zhenzhen;
Wang, Hui;
Pun, Frank W.

Publication type:

Article