Works matching AU Przedborski, Serge

Results: 108

Synaptic and cognitive impairment associated with L444P heterozygous glucocerebrosidase mutation.

Published in:

Brain: A Journal of Neurology, 2025, v. 148, n. 5, p. 1621, doi. 10.1093/brain/awae380

By:

Lado, Wudu;
Ham, Ahrom;
Li, Hongyu;
Zhang, Hong;
Chang, Audrey Yuen;
Sardi, Sergio Pablo;
Alcalay, Roy N;
Arancio, Ottavio;
Przedborski, Serge;
Tang, Guomei

Publication type:

Article

Deciphering amyotrophic lateral sclerosis: What phenotype, neuropathology and genetics are telling us about pathogenesis.

Published in:

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2013, p. 5, doi. 10.3109/21678421.2013.778548

By:

RAVITS, JOHN;
APPEL, STANLEY;
BALOH, ROBERT H.;
BAROHN, RICHARD;
BROOKS, BENJAMIN RIX;
ELMAN, LAUREN;
FLOETER, MARY KAY;
HENDERSON, CHRISTOPHER;
LOMEN-HOERTH, CATHERINE;
MACKLIS, JEFFREY D.;
MCCLUSKEY, LEO;
MITSUMOTO, HIROSHI;
PRZEDBORSKI, SERGE;
ROTHSTEIN, JEFFREY;
TROJANOWSKI, JOHN Q.;
VAN DEN BERG, LEONARD H.;
RINGEL, STEVEN

Publication type:

Article

Deciphering amyotrophic lateral sclerosis: What phenotype, neuropathology and genetics are telling us about pathogenesis.

Published in:

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2013, v. 14, p. 5, doi. 10.3109/21678421.2013.778548

By:

Ravits, John;
Appel, Stanley;
Baloh, Robert H.;
Barohn, Richard;
Rix Brooks, Benjamin;
Elman, Lauren;
Floeter, Mary Kay;
Henderson, Christopher;
Lomen-Hoerth, Catherine;
Macklis, Jeffrey D.;
McCluskey, Leo;
Mitsumoto, Hiroshi;
Przedborski, Serge;
Rothstein, Jeffrey;
Trojanowski, John Q.;
van den Berg, Leonard H.;
Ringel, Steven

Publication type:

Article

Peroxiredoxin-2 links Cdk5 to neurodegeneration.

Published in:

Nature Medicine, 2007, v. 13, n. 8, p. 907, doi. 10.1038/nm0807-907

By:

Przedborski, Serge

Publication type:

Article

Genetic clues to the pathogenesis of Parkinson's disease.

Published in:

Nature Medicine, 2004, v. 10, p. S58, doi. 10.1038/nm1068

By:

Vila, Miquel;
Przedborski, Serge

Publication type:

Article

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease.

Published in:

Nature Medicine, 1999, v. 5, n. 12, p. 1403, doi. 10.1038/70978

By:

Liberatore, Gabriel T.;
Jackson-Lewis, Vernice;
Vukosavic, Slobodanka;
Mandir, Allen S.;
Vila, Miquel;
McAuliffe, W. Geoffrey;
Dawson, Valina L.;
Dawson, Ted M.;
Przedborski, Serge

Publication type:

Article

A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication.

Published in:

Movement Disorders, 2015, v. 30, n. 8, p. 1026, doi. 10.1002/mds.26239

By:

Guardia-Laguarta, Cristina;
Area-Gomez, Estela;
Schon, Eric A.;
Przedborski, Serge

Publication type:

Article

Pathogenesis of Parkinson's disease.

Published in:

Movement Disorders, 2013, v. 28, n. 1, p. 24, doi. 10.1002/mds.25032

By:

Hirsch, Etienne C.;
Jenner, Peter;
Przedborski, Serge

Publication type:

Article

Can we reverse alpha-synuclein lesions?

Published in:

2011

By:

Przedborski, Serge

Publication type:

journal article

New insights into the pathophysiology of dystonia.

Published in:

Movement Disorders, 2011, v. 26, n. 8, p. 1407, doi. 10.1002/mds.23856

By:

Przedborski, Serge

Publication type:

Article

Can a defect in bioenergetics be involved in the pathogenesis of Parkinson's disease after all?

Published in:

Movement Disorders, 2011, v. 26, n. 8, p. 1408, doi. 10.1002/mds.23857

By:

Przedborski, Serge

Publication type:

Article

A tale on animal models of Parkinson's Disease.

Published in:

Movement Disorders, 2011, v. 26, n. 6, p. 993, doi. 10.1002/mds.23696

By:

Bezard, Erwan;
Przedborski, Serge

Publication type:

Article

Inflammation and Parkinson's disease pathogenesis.

Published in:

Movement Disorders, 2010, v. 25, n. S1, p. S55, doi. 10.1002/mds.22638

By:

Przedborski, Serge

Publication type:

Article

Clarification: Pathogenic role of glial cells in Parkinson's disease.

Published in:

Movement Disorders, 2004, v. 19, n. 1, p. 118, doi. 10.1002/mds.10701

By:

Serge Przedborski

Publication type:

Article

Pathogenic role of glial cells in Parkinson's disease.

Published in:

Movement Disorders, 2003, v. 18, n. 2, p. 121, doi. 10.1002/mds.10332

By:

Teismann, Peter;
Tieu, Kim;
Cohen, Oren;
Choi, Dong-Kug;
Wu, Du Chu;
Marks, Daniel;
Vila, Miquel;
Jackson-Lewis, Vernice;
Przedborski, Serge

Publication type:

Article

α-Synuclein expression in substantia nigra and cortex in Parkinson's disease.

Published in:

Movement Disorders, 1999, v. 14, n. 3, p. 417, doi. 10.1002/1531-8257(199905)14:3<417::AID-MDS1005>3.0.CO;2-X

By:

Neystat, Michael;
Lynch, Timothy;
Przedborski, Serge;
Kholodilov, Nikolai;
Rzhetskaya, Margarita;
Burke, Robert E.

Publication type:

Article

Functional Neural Transplantation. Edited by Stephen B. Dunnett and Anders Björklund. New York: Raven Press, 1994, 608 pp. Price: $145.00.

Published in:

Movement Disorders, 1996, v. 11, n. 5, p. 590, doi. 10.1002/mds.870110525

By:

Levivier, Marc;
Przedborski, Serge

Publication type:

Article

Fentanyl-induced dyskinesias.

Published in:

Movement Disorders, 1995, v. 10, n. 5, p. 679, doi. 10.1002/mds.870100526

By:

Petzinger, Giselle;
Mayer, Stephan A.;
Przedborski, Serge

Publication type:

Article

Antiparkinsonian therapies and brain mitochondrial complex I activity.

Published in:

Movement Disorders, 1995, v. 10, n. 3, p. 312, doi. 10.1002/mds.870100314

By:

Przedborski, Serge;
Jackson-Lewis, Vernice;
Fahn, Stanley

Publication type:

Article

Peripheral and central pharmacokinetics of apomorphine and its effect on dopamine metabolism in humans.

Published in:

Movement Disorders, 1995, v. 10, n. 1, p. 28, doi. 10.1002/mds.870100107

By:

Przedborski, Serge;
Levivier, Marc;
Raftopoulos, Christian;
Naini, Ali B.;
Hildebrand, Jerzy

Publication type:

Article

The role of alpha-synuclein in synucleinopathy: Impact on lipid regulation at mitochondria–ER membranes.

Published in:

NPJ Parkinson's Disease, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41531-025-00960-x

By:

Barbuti, Peter A.;
Guardia-Laguarta, Cristina;
Yun, Taekyung;
Chatila, Zena K.;
Flowers, Xena;
Wong, Chantel;
Santos, Bruno F. R.;
Larsen, Simone B.;
Lotti, James S.;
Hattori, Nobutaka;
Bradshaw, Elizabeth;
Dettmer, Ulf;
Fanning, Saranna;
Menon, Vilas;
Reddy, Hasini;
Teich, Andrew F.;
Krüger, Rejko;
Area-Gomez, Estela;
Przedborski, Serge

Publication type:

Article

Glial cell response: A pathogenic factor in Parkinson's disease.

Published in:

Journal of NeuroVirology, 2002, v. 8, n. 6, p. 551, doi. 10.1080/13550280290100905

By:

Wu, Du Chu;
Tieu, Kim;
Cohen, Oren;
Choi, Dong-Kug;
Vila, Miquel;
Jackson-Lewis, Vernice;
Teismann, Peter;
Przedborski, Serge

Publication type:

Article

Sumoylation regulates the assembly and activity of the SMN complex.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25272-5

By:

Riboldi, Giulietta M.;
Faravelli, Irene;
Kuwajima, Takaaki;
Delestrée, Nicolas;
Dermentzaki, Georgia;
De Planell-Saguer, Mariangels;
Rinchetti, Paola;
Hao, Le Thi;
Beattie, Christine C.;
Corti, Stefania;
Przedborski, Serge;
Mentis, George Z.;
Lotti, Francesco

Publication type:

Article

Nitric Oxide and Reactive Oxygen Species in Parkinson's Disease.

Published in:

IUBMB Life, 2003, v. 55, n. 6, p. 329, doi. 10.1080/1521654032000114320

By:

Tieu, Kim;
Ischiropoulos, Harry;
Przedborski, Serge

Publication type:

Article

D-β-Hydroxybutyrate Is Protective in Mouse Models of Huntington's Disease.

Published in:

PLoS ONE, 2011, v. 6, n. 9, p. 1, doi. 10.1371/journal.pone.0024620

By:

Lim, Soyeon;
Chesser, Adrianne S.;
Grima, Jonathan C.;
Rappold, Phillip M.;
Blum, David;
Przedborski, Serge;
Tieu, Kim

Publication type:

Article

Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice.

Published in:

PLoS ONE, 2008, v. 3, n. 7, p. 1, doi. 10.1371/journal.pone.0002740

By:

Banerjee, Rebecca;
Mosley, R. Lee;
Reynolds, Ashley D.;
Dhar, Alok;
Jackson-Lewis, Vernice;
Gordon, Paul H.;
Przedborski, Serge;
Gendelman, Howard E.

Publication type:

Article

Nitrated α-Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons.

Published in:

PLoS ONE, 2008, v. 3, n. 1, p. 1, doi. 10.1371/journal.pone.0001376

By:

Benner, Eric J.;
Banerjee, Rebecca;
Reynolds, Ashley D.;
Sherman, Simon;
Pisarev, Vladimir M.;
Tsiperson, Vladislav;
Nemachek, Craig;
Ciborowski, Pawel;
Przedborski, Serge;
Mosley, R. Lee;
Gendelman, Howard E.

Publication type:

Article

Ablation of the Inflammatory Enzyme Myeloperoxidase Mitigates Features of Parkinson's Disease in Mice.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 28, p. 6594, doi. 10.1523/JNEUROSCI.0970-05.2005

By:

Dong-Kug Choi;
Pennathur, Subramaniam;
Perier, Celine;
Tieu, Kim;
Teismann, Peter;
Du-Chu Wu;
Jackson-Lewis, Vernice;
Vila, Miquel;
Vonsattel, Jean-Paul;
Heinecke, Jay W.;
Przedborski, Serge

Publication type:

Article

Regulation of Dopaminergic Loss by Fas in a 1-Methyl-4-Phenyl- 1,2,3,6-Tetrahydropyridine Model of Parkinson's Disease.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 8, p. 2045, doi. 10.1523/JNEUROSCI.4564-03.2004

By:

Hayley, Shawn;
Crocker, Stephen J.;
Smith, Patrice D.;
Shree, Tanaya;
Jackson-Lewis, Vernice;
Przedborski, Serge;
Mount, Matthew;
Slack, Ruth;
Anisman, Hymie;
Park, David S.

Publication type:

Article

Enriched Environment Confers Resistance to 1-Methyl-4-Phenyl-1, 2,3,6-Tetrahydropyridine and Cocaine: Involvement of Dopamine Transporter and Trophic Factors.

Published in:

Journal of Neuroscience, 2003, v. 23, n. 35, p. 10999, doi. 10.1523/JNEUROSCI.23-35-10999.2003

By:

Bezard, Erwan;
Dovero, Sandra;
Belin, David;
Duconger, Sophie;
Jackson-Lewis, Vernice;
Przedborski, Serge;
Piazza, Pier Vincenzo;
Gross, Christian E.;
Jaber, Mohamed

Publication type:

Article

Inhibition of Calpains Prevents Neuronal and Behavioral Deficits in an MPTP Mouse Model of Parkinson's Disease.

Published in:

Journal of Neuroscience, 2003, v. 23, n. 10, p. 4081, doi. 10.1523/JNEUROSCI.23-10-04081.2003

By:

Crocker, Stephen J.;
Smith, Patrice D.;
Jackson-Lewis, Vernice;
Lamba, Wiplore R.;
Hayley, Shawn P.;
Grimm, Erich;
Callaghan, Steve M.;
Slack, Ruth S.;
Melloni, Edon;
Przedborski, Serge;
Robertson, George S.;
Anisman, Hymie;
Merali, Zul;
Park, David S.

Publication type:

Article

Blood transcriptomic signatures associated with molecular changes in the brain and clinical outcomes in Parkinson’s disease.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39652-6

By:

Irmady, Krithi;
Hale, Caryn R.;
Qadri, Rizwana;
Fak, John;
Simelane, Sitsandziwe;
Carroll, Thomas;
Przedborski, Serge;
Darnell, Robert B.

Publication type:

Article

Recent advances in amyotrophic lateral sclerosis research.

Published in:

Current Neurology & Neuroscience Reports, 2003, v. 3, n. 1, p. 70, doi. 10.1007/s11910-003-0041-x

By:

Przedborski, Serge;
Mitsumoto, Hiroshi;
Rowland, Lewis

Publication type:

Article

α-Synuclein-Independent Histopathological and Motor Deficits in Mice Lacking the Endolysosomal Parkinsonism Protein Atp13a2.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 14, p. 5724, doi. 10.1523/JNEUROSCI.0632-14.2015

By:

Kett, Lauren R.;
Stiller, Barbara;
Bernath, Megan M.;
Tasset, Inmaculada;
Blesa, Javier;
Jackson-Lewis, Vernice;
Chan, Robin B.;
Zhou, Bowen;
Di Paolo, Gilbert;
Przedborski, Serge;
Cuervo, Ana Maria;
Dauer, William T.

Publication type:

Article

α-Synuclein Is Localized to Mitochondria-Associated ER Membranes.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 1, p. 249, doi. 10.1523/JNEUROSCI.2507-13.2014

By:

Guardia-Laguarta, Cristina;
Area-Gomez, Estela;
Rüb, Cornelia;
Yuhui Liu;
Magrané, Jordi;
Becker, Dorothea;
Voos, Wolfgang;
Schon, Eric A.;
Przedborski, Serge

Publication type:

Article

Exploring the role of T cells in Alzheimer's and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2025, v. 21, n. 2, p. 1, doi. 10.1002/alz.14548

By:

Elyaman, Wassim;
Stern, Lawrence J.;
Jiang, Ning;
Dressman, Dallin;
Bradley, Philip;
Klatzmann, David;
Bradshaw, Elizabeth M.;
Farber, Donna L.;
Kent, Sally C.;
Chizari, Shahab;
Funk, Kristen;
Devanand, Davangere;
Thakur, Kiran T.;
Raj, Towfique;
Dalahmah, Osama Al;
Sarkis, Rani A.;
Weiner, Howard L.;
Shneider, Neil A.;
Przedborski, Serge

Publication type:

Article

F4‐09‐01: NEURORESTORATION OF THE DOPAMINERGIC PATHWAY USING FOCUSED ULTRASOUND‐MEDIATED PROTEIN AND GENE DELIVERY IN A PARKINSONIAN MODEL.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1396, doi. 10.1016/j.jalz.2018.06.2896

By:

Karakatsani, Maria Eleni;
Wang, Shutao;
Samiotaki, Gesthimani;
Kugelman, Tara;
Olumolade, Oluyemi;
Acosta, Camilo;
Jackson-Lewis, Vernice;
Przedborski, Serge;
Konofagou, Elisa

Publication type:

Article

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy.

Published in:

2008

By:

Martinez-Vicente, Marta;
Talloczy, Zsolt;
Kaushik, Susmita;
Massey, Ashish C.;
Mazzulli, Joseph;
Mosharov, Eugene V.;
Hodara, Roberto;
Fredenburg, Ross;
Du-Chu Wu;
Follenzi, Antonia;
Dauer, William;
Przedborski, Serge;
Ischiropoulos, Harry;
Lansbury, Peter T.;
Sulzer, David;
Cuervo, Ana Maria;
Wu, Du-Chu

Publication type:

journal article

Neuromelanin Activates Microglia and Induces Degeneration of Dopaminergic Neurons: Implications for Progression of Parkinson's Disease.

Published in:

Neurotoxicity Research, 2011, v. 19, n. 1, p. 63, doi. 10.1007/s12640-009-9140-z

By:

Zhang, Wei;
Phillips, Kester;
Wielgus, Albert;
Liu, Jie;
Albertini, Alberto;
Zucca, Fabio;
Faust, Rudolph;
Qian, Steven;
Miller, David;
Chignell, Colin;
Wilson, Belinda;
Jackson-Lewis, Vernice;
Przedborski, Serge;
Joset, Danielle;
Loike, John;
Hong, Jau-Shyong;
Sulzer, David;
Zecca, Luigi

Publication type:

Article

Identification of neurodegenerative factors using translatome-regulatory network analysis.

Published in:

Nature Neuroscience, 2015, v. 18, n. 9, p. 1325, doi. 10.1038/nn.4070

By:

Brichta, Lars;
Shin, William;
Jackson-Lewis, Vernice;
Blesa, Javier;
Yap, Ee-Lynn;
Walker, Zachary;
Zhang, Jack;
Roussarie, Jean-Pierre;
Alvarez, Mariano J;
Califano, Andrea;
Przedborski, Serge;
Greengard, Paul

Publication type:

Article

What can pluripotent stem cells teach us about neurodegenerative diseases?

Published in:

Nature Neuroscience, 2010, v. 13, n. 7, p. 800, doi. 10.1038/nn.2577

By:

Wichterle, Hynek;
Przedborski, Serge

Publication type:

Article

Mutant LRRK2<sup>R1441G</sup> BAC transgenic mice recapitulate cardinal features of Parkinson's disease.

Published in:

Nature Neuroscience, 2009, v. 12, n. 7, p. 826, doi. 10.1038/nn.2349

By:

Yanping Li;
WenchengLiu;
Oo, Tinmarla F.;
Lei Wang;
Yi Tang;
Jackson-Lewis, Vernice;
Chun Zhou;
Geghman, Kindiya;
Bogdanov, Mikhail;
Przedborski, Serge;
Beal, M. Flint;
Burke, Robert E.;
Chenjian Li

Publication type:

Article

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons.

Published in:

Nature Neuroscience, 2007, v. 10, n. 5, p. 615, doi. 10.1038/nn1876

By:

Nagai, Makiko;
Re, Diane B;
Nagata, Tetsuya;
Chalazonitis, Alcmène;
Jessell, Thomas M;
Wichterle, Hynek;
Przedborski, Serge

Publication type:

Article

Fractalkine: moving from chemotaxis to neuroprotection.

Published in:

Nature Neuroscience, 2006, v. 9, n. 7, p. 859, doi. 10.1038/nn0706-859

By:

Bérangère Ré, Diane;
Przedborski, Serge

Publication type:

Article

Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration.

Published in:

Human Molecular Genetics, 2001, v. 10, n. 12, p. 1243, doi. 10.1093/hmg/10.12.1243

By:

Petersén, Åsa;
Larsen, Kristin E.;
Behr, Gerald G.;
Romero, Norma;
Przedborski, Serge;
Brundin, Patrik;
Sulzer, David

Publication type:

Article

Apoptosis-inducing factor deficiency sensitizes dopaminergic neurons to parkinsonian neurotoxins.

Published in:

Annals of Neurology, 2010, v. 68, n. 2, p. 184, doi. 10.1002/ana.22034

By:

Perier, Celine;
Bové, Jordi;
Dehay, Benjamin;
Jackson-Lewis, Vernice;
Rabinovitch, Peter S.;
Przedborski, Serge;
Vila, Miquel

Publication type:

Article

Proteasome inhibition and Parkinson's disease modeling.

Published in:

Annals of Neurology, 2006, v. 60, n. 2, p. 260

By:

Jordi Bové;
Chun Zhou;
Vernice Jackson‐Lewis;
Julie Taylor;
Yaping Chu;
Hardy J. Rideout;
Du‐Chu Wu;
Jeffrey H. Kordower;
Leonard Petrucelli;
Serge Przedborski

Publication type:

Article

Is prostaglandin E2 a pathogenic factor in amyotrophic lateral sclerosis?

Published in:

Annals of Neurology, 2006, v. 59, n. 6, p. 980

By:

Gabriele Almer;
Hitoshi Kikuchi;
Peter Teismann;
Serge Przedborski

Publication type:

Article

Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia.

Published in:

Annals of Neurology, 2005, v. 58, n. 6, p. 858

By:

Xiaohong Li;
Lewis P. Rowland;
Hiroshi Mitsumoto;
Serge Przedborski;
Thomas D. Bird;
Gerard D. Schellenberg;
Elaine Peskind;
Nancy Johnson;
Teepu Siddique;
M‐Marsel Mesulam;
Sandra Weintraub;
James A. Mastrianni

Publication type:

Article

L‐3‐hydroxyacyl‐CoA dehydrogenase II protects in a model of Parkinson's disease.

Published in:

Annals of Neurology, 2004, v. 56, n. 1, p. 51

By:

Kim Tieu;
Celine Perier;
Miquel Vila;
Casper Caspersen;
Hui‐Ping Zhang;
Peter Teismann;
Vernice Jackson‐Lewis;
David M. Stern;
Shi Du Yan;
Serge Przedborski

Publication type:

Article