Works matching AU Prehn, J H M

Results: 31

Latrepirdine is a potent activator of AMP-activated protein kinase and reduces neuronal excitability.

Published in:

Translational Psychiatry, 2013, v. 3, n. 10, p. 1, doi. 10.1038/tp.2013.92

By:

Weisova, P.;
Alvarez, S. P.;
Kilbride, S. M.;
Anilkumar, U.;
Baumann, B.;
Jordán, J.;
Bernas, T.;
Huber, H. J.;
Düssmann, H.;
Prehn, J. H. M.

Publication type:

Article

Patient-derived glioblastoma cells show significant heterogeneity in treatment responses to the inhibitor-of-apoptosis-protein antagonist birinapant.

Published in:

2016

By:

Zakaria, Z;
Tivnan, A;
Flanagan, L;
Murray, D W;
Salvucci, M;
Stringer, B W;
Day, B W;
Boyd, A W;
Kögel, D;
Rehm, M;
O'Brien, D F;
Byrne, A T;
Prehn, J H M;
Kögel, D

Publication type:

journal article

Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models.

Published in:

British Journal of Cancer, 2014, v. 111, n. 12, p. 2275, doi. 10.1038/bjc.2014.529

By:

Jarzabek, M A;
Amberger-Murphy, V;
Callanan, J J;
Gao, C;
Zagozdzon, A M;
Shiels, L;
Wang, J;
Ligon, K L;
Rich, B E;
Dicker, P;
Gallagher, W M;
Prehn, J H M;
Byrne, A T

Publication type:

Article

Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer.

Published in:

2012

By:

Hector S;
Conlon S;
Schmid J;
Dicker P;
Cummins RJ;
Concannon CG;
Johnston PG;
Kay EW;
Prehn JH;
Hector, S;
Conlon, S;
Schmid, J;
Dicker, P;
Cummins, R J;
Concannon, C G;
Johnston, P G;
Kay, E W;
Prehn, J H M

Publication type:

journal article

Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer.

Published in:

British Journal of Cancer, 2012, v. 106, n. 9, p. 1499, doi. 10.1038/bjc.2012.133

By:

Hector, S;
Conlon, S;
Schmid, J;
Dicker, P;
Cummins, R J;
Concannon, C G;
Johnston, P G;
Kay, E W;
Prehn, J H M

Publication type:

Article

Characterisation of E12/E47 expression in colorectal cancer.

Published in:

2015

By:

Chugha, A. S.;
Flanagan, L.;
Bane, F.;
Young, L.;
D'Orsi, B.;
Prehn, J. H. M.

Publication type:

Conference Paper/Materials

Dlk/ZIP kinase-induced apoptosis in human medulloblastoma cells: requirement of the mitochondrial apoptosis pathway.

Published in:

British Journal of Cancer, 2001, v. 85, n. 11, p. 1801

By:

Kögel, D;
Reimertz, C;
Mech, P;
Poppe, M;
Frühwald, M C;
Engemann, H;
Scheidtmann, K H;
Prehn, J H M

Publication type:

Article

tRNA‐derived fragments are altered in diabetes.

Published in:

Diabetic Medicine, 2024, v. 41, n. 2, p. 1, doi. 10.1111/dme.15258

By:

Ng, N.;
Gibriel, H. A. Y.;
Halang, L.;
Jirström, E.;
Ioana, J. A.;
Burke, M.;
Byrne, M. M.;
Prehn, J. H. M.

Publication type:

Article

Hypothesis review: are clathrin-mediated endocytosis and clathrin-dependent membrane and protein trafficking core pathophysiological processes in schizophrenia and bipolar disorder?

Published in:

Molecular Psychiatry, 2012, v. 17, n. 7, p. 669, doi. 10.1038/mp.2011.123

By:

Schubert, K O;
Föcking, M;
Prehn, J H M;
Cotter, D R

Publication type:

Article

Low levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: Caspase-3 inhibition as a therapeutic approach.

Published in:

Cell Death & Disease, 2016, v. 7, n. 2, p. e2087, doi. 10.1038/cddis.2016.7

By:

Flanagan, L;
Meyer, M;
Fay, J;
Curry, S;
Bacon, O;
Duessmann, H;
John, K;
Boland, K C;
McNamara, D A;
Kay, E W;
Bantel, H;
Schulze-Bergkamen, H;
Prehn, J H M

Publication type:

Article

Paracrine control of tissue regeneration and cell proliferation by Caspase-3.

Published in:

Cell Death & Disease, 2013, v. 4, n. 7, p. 1, doi. 10.1038/cddis.2013.250

By:

Boland, K.;
Flanagan, L.;
Prehn, J. H. M.

Publication type:

Article

Activation of executioner caspases is a predictor of progression-free survival in glioblastoma patients: a systems medicine approach.

Published in:

Cell Death & Disease, 2013, v. 4, n. 5, p. 1, doi. 10.1038/cddis.2013.157

By:

Murphy, Á. C.;
Weyhenmeyer, B.;
Schmid, J.;
Kilbride, S. M.;
Rehm, M.;
Huber, H. J.;
Senft, C.;
Weissenberger, J.;
Seifert, V.;
Dunst, M.;
Mittelbronn, M.;
Kögel, D.;
Prehn, J. H. M.;
Murphy, B. M.

Publication type:

Article

Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death.

Published in:

Cell Death & Disease, 2013, v. 4, n. 4, p. 1, doi. 10.1038/cddis.2013.136

By:

Moran, C.;
Sanz-Rodriguez, A.;
Jimenez-Pacheco, A.;
Martinez-Villareal, J.;
McKiernan, R. C.;
Jimenez-Mateos, E. M.;
Mooney, C.;
Woods, I.;
Prehn, J. H. M.;
Henshall, D. C.;
Engel, T.

Publication type:

Article

Central roles of apoptotic proteins in mitochondrial function.

Published in:

Oncogene, 2013, v. 32, n. 22, p. 2703, doi. 10.1038/onc.2012.348

By:

Kilbride, S M;
Prehn, J H M

Publication type:

Article

Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival.

Published in:

Cell Death & Differentiation, 2015, v. 22, n. 9, p. 1502, doi. 10.1038/cdd.2014.241

By:

Walter, F;
Schmid, J;
Düssmann, H;
Concannon, C G;
Prehn, J H M

Publication type:

Article

Acidotoxicity and acid-sensing ion channels contribute to motoneuron degeneration.

Published in:

Cell Death & Differentiation, 2014, v. 21, n. 2, p. 344, doi. 10.1038/cdd.2013.162

By:

Behan, Á T;
Breen, B;
Hogg, M;
Woods, I;
Coughlan, K;
Mitchem, M;
Prehn, J H M

Publication type:

Article

Acidotoxicity and acid-sensing ion channels contribute to motoneuron degeneration.

Published in:

Cell Death & Differentiation, 2013, v. 20, n. 4, p. 589, doi. 10.1038/cdd.2012.158

By:

Behan, Á T;
Breen, B;
Hogg, M;
Woods, I;
Coughlan, K;
Mitchem, M;
Prehn, J H M

Publication type:

Article

Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate.

Published in:

Cell Death & Differentiation, 2012, v. 19, n. 10, p. 1677, doi. 10.1038/cdd.2012.49

By:

Davila, D;
Connolly, N M C;
Bonner, H;
Weisová, P;
Dussmann, H;
Concannon, C G;
Huber, H J;
Prehn, J H M

Publication type:

Article

Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8.

Published in:

Cell Death & Differentiation, 2011, v. 18, n. 10, p. 1584, doi. 10.1038/cdd.2011.27

By:

Laussmann, M A;
Passante, E;
Düssmann, H;
Rauen, J A;
Würstle, M L;
Delgado, M E;
Devocelle, M;
Prehn, J H M;
Rehm, M

Publication type:

Article

MicroRNAs 10a and 10b are potent inducers of neuroblastoma cell differentiation through targeting of nuclear receptor corepressor 2.

Published in:

Cell Death & Differentiation, 2011, v. 18, n. 7, p. 1089, doi. 10.1038/cdd.2010.172

By:

Foley, N. H.;
Bray, I.;
Watters, K. M.;
Das, S.;
Bryan, K.;
Bernas, T.;
Prehn, J. H. M.;
Stallings, R. L.

Publication type:

Article

Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus.

Published in:

Cell Death & Differentiation, 2010, v. 17, n. 3, p. 459, doi. 10.1038/cdd.2009.134

By:

Murphy, B. M.;
Engel, T.;
Paucard, A.;
Hatazaki, S.;
Mouri, G.;
Tanaka, K.;
Tuffy, L. P.;
Jimenez-Mateos, E. M.;
Woods, I.;
Dunleavy, M.;
Bonner, H. P.;
Meller, R.;
Simon, R. P.;
Strasser, A.;
Prehn, J. H. M.;
Henshall, D. C.

Publication type:

Article

Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation.

Published in:

Cell Death & Differentiation, 2010, v. 17, n. 2, p. 278, doi. 10.1038/cdd.2009.123

By:

Düssmann, H.;
Rehm, M.;
Concannon, C. G.;
Anguissola, S.;
Würstle, M.;
Kacmar, S.;
Völler, P.;
Huber, H. J.;
Prehn, J. H. M.

Publication type:

Article

Angiogenin protects motoneurons against hypoxic injury.

Published in:

Cell Death & Differentiation, 2009, v. 16, n. 9, p. 1238, doi. 10.1038/cdd.2009.52

By:

Sebastià, J.;
Kieran, D.;
Breen, B.;
King, M. A.;
Netteland, D. F.;
Joyce, D.;
Fitzpatrick, S. F.;
Taylor, C. T.;
Prehn, J. H. M.

Publication type:

Article

Dynamics of outer mitochondrial membrane permeabilization during apoptosis.

Published in:

Cell Death & Differentiation, 2009, v. 16, n. 4, p. 613, doi. 10.1038/cdd.2008.187

By:

Rehm, M.;
Huber, H. J.;
Hellwig, C. T.;
Anguissola, S.;
Dussmann, H.;
Prehn, J. H. M.

Publication type:

Article

Role of Smac in cephalostatin-induced cell death.

Published in:

Cell Death & Differentiation, 2008, v. 15, n. 12, p. 1930, doi. 10.1038/cdd.2008.125

By:

Rudy, A;
López-Antón, N;
Barth, N;
Pettit, G R;
Dirsch, V M;
Schulze-Osthoff, K;
Rehm, M;
Prehn, J H M;
Vogler, M;
Fulda, S;
Vollmar, A M

Publication type:

Article

Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway.

Published in:

Cell Death & Differentiation, 2005, v. 12, n. 1, p. 1, doi. 10.1038/sj.cdd.4401495

By:

Kögel, D.;
Schomburg, R.;
Copanaki, E.;
Prehn, J. H. M.

Publication type:

Article

Ca<sup>2+</sup> and Reactive Oxygen Species in Staurosporine-Induced Neuronal Apoptosis.

Published in:

Journal of Neurochemistry, 1997, v. 68, n. 4, p. 1679, doi. 10.1046/j.1471-4159.1997.68041679.x

By:

Prehn, J. H. M.;
Jordán, J.;
Ghadge, G. D.;
Preis, E.;
Galindo, M. F.;
Roos, R. P.;
Krieglstein, J.;
Miller, R. J.

Publication type:

Article

Downregulation of protein kinase B/Akt-1 mediates INS-1 insulinoma cell apoptosis induced by dominant-negative suppression of hepatocyte nuclear factor-1alpha function.

Published in:

Diabetologia, 2006, v. 49, n. 3, p. 519, doi. 10.1007/s00125-005-0119-x

By:

Wobser, H.;
Bonner, C.;
Nolan, J. J.;
Byrne, M. M.;
Prehn, J. H. M.

Publication type:

Article

High levels of X-linked Inhibitor-of-Apoptosis Protein (XIAP) are indicative of radio chemotherapy resistance in rectal cancer.

Published in:

Radiation Oncology, 2015, v. 10, n. 1, p. 1, doi. 10.1186/s13014-015-0437-1

By:

Flanagan, L.;
Kehoe, J.;
Fay, J.;
Bacon, O.;
Lindner, A. U.;
Kay, E. W.;
Deasy, J.;
McNamara, D. A.;
Prehn, J. H. M.

Publication type:

Article

Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway.

Published in:

Oncogene, 2007, v. 26, n. 12, p. 1681, doi. 10.1038/sj.onc.1209974

By:

Concannon, C. G.;
Koehler, B. F.;
Reimertz, Claus;
Murphy, B. M.;
Bonner, C.;
Thurow, N.;
Ward, M. W.;
Villunger, A.;
Strasser, A.;
Kögel, D.;
Prehn, J. H. M.

Publication type:

Article

Meta‐analysis of the molecular associations of mucinous colorectal cancer.

Published in:

British Journal of Surgery, 2019, v. 106, n. 6, p. 682, doi. 10.1002/bjs.11142

By:

Reynolds, I. S.;
Furney, S. J.;
Kay, E. W.;
McNamara, D. A.;
Prehn, J. H. M.;
Burke, J. P.

Publication type:

Article