Works matching AU Prchal, Lukas

Results: 30

Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents.

Published in:

Archives of Toxicology, 2024, v. 98, n. 9, p. 2937, doi. 10.1007/s00204-024-03791-6

By:

Prchalova, Eliska;
Andrys, Rudolf;
Pejchal, Jaroslav;
Kohoutova, Zuzana;
Knittelova, Karolina;
Hofmanova, Tereza;
Skarka, Adam;
Dlabkova, Alzbeta;
Psotka, Miroslav;
Prchal, Lukas;
Musilek, Kamil;
Karasova, Jana Zdarova;
Malinak, David

Publication type:

Article

Development of versatile and potent monoquaternary reactivators of acetylcholinesterase.

Published in:

Archives of Toxicology, 2021, v. 95, n. 3, p. 985, doi. 10.1007/s00204-021-02981-w

By:

Gorecki, Lukas;
Hepnarova, Vendula;
Karasova, Jana Zdarova;
Hrabinova, Martina;
Courageux, Charlotte;
Dias, José;
Kucera, Tomas;
Kobrlova, Tereza;
Muckova, Lubica;
Prchal, Lukas;
Malinak, David;
Jun, Daniel;
Musilek, Kamil;
Worek, Franz;
Nachon, Florian;
Soukup, Ondrej;
Korabecny, Jan

Publication type:

Article

The Antibacterial Effects of New N -Alkylpyridinium Salts on Planktonic and Biofilm Bacteria.

Published in:

Frontiers in Microbiology, 2020, v. 11, p. N.PAG, doi. 10.3389/fmicb.2020.573951

By:

Hympanova, Michaela;
Terlep, Saša;
Markova, Aneta;
Prchal, Lukáš;
Dogsa, Iztok;
Pulkrabkova, Lenka;
Benkova, Marketa;
Marek, Jan;
Stopar, David

Publication type:

Article

Assessing the Anthelmintic Candidates BLK127 and HBK4 for Their Efficacy on Haemonchus contortus Adults and Eggs, and Their Hepatotoxicity and Biotransformation.

Published in:

Pharmaceutics, 2022, v. 14, n. 4, p. N.PAG, doi. 10.3390/pharmaceutics14040754

By:

Zajíčková, Markéta;
Prchal, Lukáš;
Vokřál, Ivan;
Nguyen, Linh Thuy;
Kurz, Thomas;
Gasser, Robin;
Bednářová, Klára;
Mičundová, Magdalena;
Lungerich, Beate;
Michel, Oliver;
Skálová, Lenka

Publication type:

Article

The Effect of Tacrine on Functional Response of the Lower Oesophageal Sphincter Assessed by Endoscopic Luminal Impedance Planimetry in Experimental Pigs.

Published in:

Pharmaceuticals (14248247), 2024, v. 17, n. 12, p. 1588, doi. 10.3390/ph17121588

By:

Bures, Jan;
Novak, Martin;
Radochova, Vera;
Kohoutova, Darina;
Prchal, Lukas;
Martinek, Jan;
Mares, Jan;
Cerny, Jaroslav;
Suchanek, Stepan;
Pejchal, Jaroslav;
Voxova, Barbora;
Urbanek, Petr;
Zavoral, Miroslav;
Soukup, Ondrej

Publication type:

Article

Synthesis, Antimicrobial Effect and Lipophilicity‐Activity Dependence of Three Series of Dichained N‐Alkylammonium Salts.

Published in:

ChemistrySelect, 2019, v. 4, n. 41, p. 12076, doi. 10.1002/slct.201902357

By:

Benkova, Marketa;
Soukup, Ondrej;
Prchal, Lukas;
Sleha, Radek;
Eleršek, Tina;
Novak, Martin;
Sepčić, Kristina;
Gunde‐Cimerman, Nina;
Dolezal, Rafael;
Bostik, Vanda;
Bostik, Pavel;
Marek, Jan

Publication type:

Article

Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 760, doi. 10.1080/14756366.2022.2041628

By:

Kohoutova, Zuzana;
Malinak, David;
Andrys, Rudolf;
Svobodova, Jana;
Psotka, Miroslav;
Schmidt, Monika;
Prchal, Lukas;
Musilek, Kamil

Publication type:

Article

Synthesis and Decontamination Effect on Chemical and Biological Agents of Benzoxonium-Like Salts.

Published in:

Toxics, 2021, v. 9, n. 9, p. 222, doi. 10.3390/toxics9090222

By:

Markova, Aneta;
Hympanova, Michaela;
Matula, Marek;
Prchal, Lukas;
Sleha, Radek;
Benkova, Marketa;
Pulkrabkova, Lenka;
Soukup, Ondrej;
Krocova, Zuzana;
Jun, Daniel;
Marek, Jan

Publication type:

Article

Structure-Guided Design of N -Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9124, doi. 10.3390/ijms24119124

By:

Svobodova, Barbora;
Pulkrabkova, Lenka;
Panek, Dawid;
Misiachna, Anna;
Kolcheva, Marharyta;
Andrys, Rudolf;
Handl, Jiri;
Capek, Jan;
Nyvltova, Pavlina;
Rousar, Tomas;
Prchal, Lukas;
Hepnarova, Vendula;
Hrabinova, Martina;
Muckova, Lubica;
Tosnerova, Daniela;
Karabanovich, Galina;
Finger, Vladimir;
Soukup, Ondrej;
Horak, Martin;
Korabecny, Jan

Publication type:

Article

Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17β-HSD10 with Implications to Alzheimer's Disease Treatment.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 6, p. 2059, doi. 10.3390/ijms21062059

By:

Schmidt, Monika;
Benek, Ondrej;
Vinklarova, Lucie;
Hrabinova, Martina;
Zemanova, Lucie;
Chribek, Matej;
Kralova, Vendula;
Hroch, Lukas;
Dolezal, Rafael;
Lycka, Antonin;
Prchal, Lukas;
Jun, Daniel;
Aitken, Laura;
Gunn-Moore, Frank;
Kuca, Kamil;
Musilek, Kamil

Publication type:

Article

Multifunctional, Fluorene‐Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease.

Published in:

Angewandte Chemie, 2025, v. 137, n. 6, p. 1, doi. 10.1002/ange.202420510

By:

Panek, Dawid;
Pasieka, Anna;
Jończyk, Jakub;
Gawlińska, Milena;
Zaręba, Paula;
Siwek, Agata;
Wolak, Małgorzata;
Mordyl, Barbara;
Głuch‐Lutwin, Monika;
Latacz, Gniewomir;
Brazzolotto, Xavier;
Chantegreil, Fabien;
Nachon, Florian;
Zdarova Karasova, Jana;
Pejchal, Jaroslav;
Mzik, Martin;
Sestak, Vit;
Prchal, Lukas;
Odvarkova, Jitka;
Soukup, Ondrej

Publication type:

Article

Synthesis and In Vitro Evaluation of Novel Dopamine Receptor D 2 3,4-dihydroquinolin-2(1 H)-one Derivatives Related to Aripiprazole.

Published in:

Biomolecules (2218-273X), 2021, v. 11, n. 9, p. 1262, doi. 10.3390/biom11091262

By:

Juza, Radomir;
Stefkova, Kristyna;
Dehaen, Wim;
Randakova, Alena;
Petrasek, Tomas;
Vojtechova, Iveta;
Kobrlova, Tereza;
Pulkrabkova, Lenka;
Muckova, Lubica;
Mecava, Marko;
Prchal, Lukas;
Mezeiova, Eva;
Musilek, Kamil;
Soukup, Ondrej;
Korabecny, Jan

Publication type:

Article

Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N -Methyl-d-Aspartate Receptor Antagonists.

Published in:

Biomolecules (2218-273X), 2021, v. 11, n. 1, p. 3, doi. 10.3390/biom11010003

By:

Konecny, Jan;
Misiachna, Anna;
Hrabinova, Martina;
Pulkrabkova, Lenka;
Benkova, Marketa;
Prchal, Lukas;
Kucera, Tomas;
Kobrlova, Tereza;
Finger, Vladimir;
Kolcheva, Marharyta;
Kortus, Stepan;
Jun, Daniel;
Valko, Marian;
Horak, Martin;
Soukup, Ondrej;
Korabecny, Jan

Publication type:

Article

Front Cover: Highly hydrophilic cationic gold nanorods stabilized by novel quaternary ammonium surfactant with negligible cytotoxicity (J. Biophotonics 12/2019).

Published in:

Journal of Biophotonics, 2019, v. 12, n. 12, p. N.PAG, doi. 10.1002/jbio.201970041

By:

Salajkova, Sarka;
Sramek, Michal;
Malinak, David;
Havel, Filip;
Musilek, Kamil;
Benkova, Marketa;
Soukup, Ondrej;
Vasicova, Pavla;
Prchal, Lukas;
Dolezal, Rafael;
Hodny, Zdenek;
Bartek, Jiri;
Zarska, Monika;
Kuca, Kamil

Publication type:

Article

Highly hydrophilic cationic gold nanorods stabilized by novel quaternary ammonium surfactant with negligible cytotoxicity.

Published in:

Journal of Biophotonics, 2019, v. 12, n. 12, p. N.PAG, doi. 10.1002/jbio.201900024

By:

Salajkova, Sarka;
Sramek, Michal;
Malinak, David;
Havel, Filip;
Musilek, Kamil;
Benkova, Marketa;
Soukup, Ondrej;
Vasicova, Pavla;
Prchal, Lukas;
Dolezal, Rafael;
Hodny, Zdenek;
Bartek, Jiri;
Zarska, Monika;
Kuca, Kamil

Publication type:

Article

TARGETING TACRINE HEPATOTOXICITY ASSOCIATED WITH THE CYP BIOTRANSFORMATION.

Published in:

2022

By:

Soukup, Ondrej;
Novak, Martin;
Prchal, Lukas;
Korabecny, Jan;
Horak, Martin;
Vales, Karel

Publication type:

Abstract

FLUORINATED AND CHLORINATED PYRIDINIUM OXIMES REACTIVATING CHOLINESTERASES INHIBITED BY NERVE AGENTS.

Published in:

2022

By:

Malinak, David;
Zorbaz, Tamara;
Hofmanova, Tereza;
Andrys, Rudolf;
Psotka, Miroslav;
Svobodova, Jana;
Prchal, Lukas;
Kovarik, Zrinka;
Musilek, Kamil

Publication type:

Abstract

SYNTHESIS AND IN VITRO EVALUATION OF NONSYMMETRICAL MONOQUATERNARY AMMONIUM SALTS AS POTENTIAL REACTIVATORS OF INHIBITED CHOLINESTERASES.

Published in:

2022

By:

Kohoutova, Zuzana;
Malinak, David;
Hofmanova, Tereza;
Andrys, Rudolf;
Prchal, Lukas;
Svobodova, Jana;
Musilek, Kamil

Publication type:

Abstract

PHENOTHIAZINE-TACRINE HETERODIMERS: PURSUING MULTITARGET DIRECTED APPROACH IN ALZHEIMER'S DISEASE.

Published in:

2022

By:

Gorecki, Lukas;
Uliassi, Elisa;
Bartolini, Manuela;
Janockova, Jana;
Hrabinova, Martina;
Hepnarova, Vendula;
Prchal, Lukas;
Muckova, Lubica;
Pejchal, Jaroslav;
Karasova, Jana Z.;
Mezeiova, Eva;
Benkova, Marketa;
Kobrlova, Tereza;
Soukup, Ondrej;
Petralla, Sabrina;
Monti, Barbara;
Korabecny, Jan;
Laura Bolognesi, Maria

Publication type:

Abstract

OPCW BIOMEDICAL PROFICIENCY TEST V LABORATOŘI ANALYTICKÉ CHEMIE KATEDRY TOXIKOLOGIE A VOJENSKÉ FARMACIE.

Published in:

Military Medical Science Letters / Vojenské zdravotnické Listy, 2020, v. 89, n. 3, p. 126, doi. 10.31482/mmsl.2020.011

By:

Herman, David;
Dlabková, Alžběta;
Váňová, Nela;
Prchal, Lukáš;
Vajrychová, Marie;
Doležal, Rafael;
Bzonek, Petr;
Jun, Daniel

Publication type:

Article

Biotransformation of anthelmintics and the activity of drug-metabolizing enzymes in the tapeworm Moniezia expansa.

Published in:

Parasitology, 2015, v. 142, n. 5, p. 648, doi. 10.1017/S0031182014001711

By:

PRCHAL, LUKÁŠ;
BÁRTÍKOVÁ, HANA;
BEČANOVÁ, ANETA;
JIRÁSKO, ROBERT;
VOKŘÁL, IVAN;
STUCHLÍKOVÁ, LUCIE;
SKÁLOVÁ, LENKA;
KUBÍČEK, VLADIMÍR;
LAMKA, JIŘÍ;
TREJTNAR, FRANTIŠEK;
SZOTÁKOVÁ, BARBORA

Publication type:

Article

The metabolism of flubendazole and the activities of selected biotransformation enzymes in Haemonchus contortus strains susceptible and resistant to anthelmintics.

Published in:

Parasitology, 2012, v. 139, n. 10, p. 1309, doi. 10.1017/S0031182012000595

By:

VOKŘÁL, IVAN;
BÁRTÍKOVÁ, HANA;
PRCHAL, LUKÁŠ;
STUCHLÍKOVÁ, LUCIE;
SKÁLOVÁ, LENKA;
SZOTÁKOVÁ, BARBORA;
LAMKA, JIŘÍ;
VÁRADY, MARIÁN;
KUBÍČEK, VLADIMÍR

Publication type:

Article

Metabolism of drugs and other xenobiotics in giant liver fluke ( Fascioloides magna ).

Published in:

Xenobiotica, 2016, v. 46, n. 2, p. 132, doi. 10.3109/00498254.2015.1060370

By:

Prchal, Lukáš;
Vokřál, Ivan;
Kašný, Martin;
Rejšková, Lenka;
Zajíčková, Markéta;
Lamka, Jiří;
Skálová, Lenka;
Lecová, Lenka;
Szotáková, Barbora

Publication type:

Article

Albendazole in environment: faecal concentrations in lambs and impact on lower development stages of helminths and seed germination.

Published in:

Environmental Science & Pollution Research, 2016, v. 23, n. 13, p. 13015, doi. 10.1007/s11356-016-6472-0

By:

Prchal, Lukáš;
Podlipná, Radka;
Lamka, Jiří;
Dědková, Tereza;
Skálová, Lenka;
Vokřál, Ivan;
Lecová, Lenka;
Vaněk, Tomáš;
Szotáková, Barbora

Publication type:

Article

The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6- O -desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs.

Published in:

Molecules, 2021, v. 26, n. 8, p. 2160, doi. 10.3390/molecules26082160

By:

Bures, Jan;
Tacheci, Ilja;
Kvetina, Jaroslav;
Radochova, Vera;
Prchal, Lukas;
Kohoutova, Darina;
Valis, Martin;
Novak, Martin;
Dolezal, Rafael;
Kopacova, Marcela;
Rejchrt, Stanislav;
Sestak, Vit;
Knoblochova, Veronika;
Peterova, Eva;
Zdarova Karasova, Jana

Publication type:

Article

Wide-Antimicrobial Spectrum of Picolinium Salts.

Published in:

Molecules, 2020, v. 25, n. 9, p. 2254, doi. 10.3390/molecules25092254

By:

Salajkova, Sarka;
Benkova, Marketa;
Marek, Jan;
Sleha, Radek;
Prchal, Lukas;
Malinak, David;
Dolezal, Rafael;
Sepčić, Kristina;
Gunde-Cimerman, Nina;
Kuca, Kamil;
Soukup, Ondrej;
Chang, Cheng-Wei Tom;
Takemoto, Jon Y.;
Zhan, Jixun

Publication type:

Article

Substituted Piperazines as Novel Potential Radioprotective Agents.

Published in:

Molecules, 2020, v. 25, n. 3, p. 532, doi. 10.3390/molecules25030532

By:

Filipova, Alzbeta;
Marek, Jan;
Havelek, Radim;
Pejchal, Jaroslav;
Jelicova, Marcela;
Cizkova, Jana;
Majorosova, Martina;
Muckova, Lubica;
Kucera, Tomas;
Prchal, Lukas;
Psotka, Miroslav;
Zivna, Natalie;
Koutova, Darja;
Sinkorova, Zuzana;
Rezacova, Martina;
Tichy, Ales

Publication type:

Article

Sertraline as a new potential anthelmintic against Haemonchus contortus: toxicity, efficacy, and biotransformation.

Published in:

Veterinary Research, 2021, v. 52, n. 1, p. 1, doi. 10.1186/s13567-021-01012-x

By:

Zajíčková, Markéta;
Prchal, Lukáš;
Navrátilová, Martina;
Vodvárková, Nikola;
Matoušková, Petra;
Vokřál, Ivan;
Nguyen, Linh Thuy;
Skálová, Lenka

Publication type:

Article

The Effect of Chemical Structure of OEG Ligand Shells with Quaternary Ammonium Moiety on the Colloidal Stabilization, Cellular Uptake and Photothermal Stability of Gold Nanorods.

Published in:

International Journal of Nanomedicine, 2021, v. 16, p. 3407, doi. 10.2147/IJN.S304953

By:

Salajkova, Sarka;
Havel, Filip;
Sramek, Michal;
Novotny, Filip;
Malinak, David;
Dolezal, Rafael;
Prchal, Lukas;
Benkova, Marketa;
Soukup, Ondrej;
Musilek, Kamil;
Kuca, Kamil;
Bartek, Jiri;
Proska, Jan;
Zarska, Monika;
Hodny, Zdenek

Publication type:

Article

Multifunctional, Fluorene‐Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease.

Published in:

Angewandte Chemie International Edition, 2025, v. 64, n. 6, p. 1, doi. 10.1002/anie.202420510

By:

Panek, Dawid;
Pasieka, Anna;
Jończyk, Jakub;
Gawlińska, Milena;
Zaręba, Paula;
Siwek, Agata;
Wolak, Małgorzata;
Mordyl, Barbara;
Głuch‐Lutwin, Monika;
Latacz, Gniewomir;
Brazzolotto, Xavier;
Chantegreil, Fabien;
Nachon, Florian;
Zdarova Karasova, Jana;
Pejchal, Jaroslav;
Mzik, Martin;
Sestak, Vit;
Prchal, Lukas;
Odvarkova, Jitka;
Soukup, Ondrej

Publication type:

Article