Works by Prag, Hiran A.

Results: 12

Type 2 diabetes worsens the outcome of ischemia/reperfusion in female STEMI patients and female db/db mice with HFpEF cardiometabolic phenotype.

Published in:

Cardiovascular Diabetology, 2025, v. 24, n. 1, p. 1, doi. 10.1186/s12933-025-02771-z

By:

Iveljic, Ivana;
Young, Megan;
Corhodzic, Elvira;
Cullen, Fenn;
Prag, Hiran A.;
Murphy, Michael P.;
Aksentijevic, Dunja

Publication type:

Article

Malonate given at reperfusion prevents post-myocardial infarction heart failure by decreasing ischemia/reperfusion injury.

Published in:

Basic Research in Cardiology, 2024, v. 119, n. 4, p. 691, doi. 10.1007/s00395-024-01063-z

By:

Abe, Jiro;
Vujic, Ana;
Prag, Hiran A.;
Murphy, Michael P.;
Krieg, Thomas

Publication type:

Article

Preventing mitochondrial reverse electron transport as a strategy for cardioprotection.

Published in:

Basic Research in Cardiology, 2023, v. 118, n. 1, p. 1, doi. 10.1007/s00395-023-01002-4

By:

Prag, Hiran A.;
Murphy, Michael P.;
Krieg, Thomas

Publication type:

Article

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.72593

By:

Ryan, Dylan Gerard;
Ming Yang;
Prag, Hiran A.;
Blanco, Giovanny Rodriguez;
Nikitopoulou, Efterpi;
Segarra-Mondejar, Marc;
Powell, Christopher A.;
Young, Tim;
Burger, Nils;
Lj Miljkovic, Jan;
Minczuk, Michal;
Murphy, Michael P.;
von Kriegsheim, Alex;
Frezza, Christian

Publication type:

Article

Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo.

Published in:

Cardiovascular Drugs & Therapy, 2022, v. 36, n. 1, p. 1, doi. 10.1007/s10557-020-07033-6

By:

Prag, Hiran A.;
Pala, Laura;
Kula-Alwar, Duvaraka;
Mulvey, John F.;
Luping, Du;
Beach, Timothy E.;
Booty, Lee M.;
Hall, Andrew R.;
Logan, Angela;
Sauchanka, Volha;
Caldwell, Stuart T.;
Robb, Ellen L.;
James, Andrew M.;
Xu, Zhelong;
Saeb-Parsy, Kourosh;
Hartley, Richard C.;
Murphy, Michael P.;
Krieg, Thomas

Publication type:

Article

Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart.

Published in:

Cardiovascular Drugs & Therapy, 2020, v. 34, n. 6, p. 823, doi. 10.1007/s10557-020-07086-7

By:

Park, Min;
Nishimura, Takanori;
Baeza-Garza, Carlos D.;
Caldwell, Stuart T.;
Pun, Pamela Boon Li;
Prag, Hiran A.;
Young, Tim;
Sauchanka, Olga;
Logan, Angela;
Forkink, Marleen;
Gruszczyk, Anja V.;
Prime, Tracy A.;
Arndt, Sabine;
Naudi, Alba;
Pamplona, Reinald;
Coughlan, Melinda T.;
Tate, Mitchel;
Ritchie, Rebecca H.;
Caicci, Federico;
Kaludercic, Nina

Publication type:

Article

Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD models.

Published in:

Life Science Alliance, 2024, v. 7, n. 9, p. 1, doi. 10.26508/lsa.202402853

By:

Wing Hei Au;
Miller-Fleming, Leonor;
Sanchez-Martinez, Alvaro;
Lee, James A. K.;
Twyning, Madeleine J.;
Prag, Hiran A.;
Raik, Laura;
Allen, Scott P.;
Shaw, Pamela J.;
Ferraiuolo, Laura;
Mortiboys, Heather;
Whitworth, Alexander J.

Publication type:

Article

Structural basis for a complex I mutation that blocks pathological ROS production.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-20942-w

By:

Yin, Zhan;
Burger, Nils;
Kula-Alwar, Duvaraka;
Aksentijević, Dunja;
Bridges, Hannah R.;
Prag, Hiran A.;
Grba, Daniel N.;
Viscomi, Carlo;
James, Andrew M.;
Mottahedin, Amin;
Krieg, Thomas;
Murphy, Michael P.;
Hirst, Judy

Publication type:

Article

Mechanism of succinate efflux upon reperfusion of the ischaemic heart.

Published in:

Cardiovascular Research, 2021, v. 117, n. 4, p. 1188, doi. 10.1093/cvr/cvaa148

By:

Prag, Hiran A;
Gruszczyk, Anja V;
Huang, Margaret M;
Beach, Timothy E;
Young, Timothy;
Tronci, Laura;
Nikitopoulou, Efterpi;
Mulvey, John F;
Ascione, Raimondo;
Hadjihambi, Anna;
Shattock, Michael J;
Pellerin, Luc;
Saeb-Parsy, Kourosh;
Frezza, Christian;
James, Andrew M;
Krieg, Thomas;
Murphy, Michael P;
Aksentijević, Dunja

Publication type:

Article

Cardiac metabolism as a driver and therapeutic target of myocardial infarction.

Published in:

Journal of Cellular & Molecular Medicine, 2020, v. 24, n. 11, p. 5937, doi. 10.1111/jcmm.15180

By:

Zuurbier, Coert J.;
Bertrand, Luc;
Beauloye, Christoph R.;
Andreadou, Ioanna;
Ruiz‐Meana, Marisol;
Jespersen, Nichlas R.;
Kula‐Alwar, Duvaraka;
Prag, Hiran A.;
Eric Botker, Hans;
Dambrova, Maija;
Montessuit, Christophe;
Kaambre, Tuuli;
Liepinsh, Edgars;
Brookes, Paul S.;
Krieg, Thomas

Publication type:

Article

Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-46470-x

By:

Faulkes, Chris G.;
Eykyn, Thomas R.;
Miljkovic, Jan Lj.;
Gilbert, James D.;
Charles, Rebecca L.;
Prag, Hiran A.;
Patel, Nikayla;
Hart, Daniel W.;
Murphy, Michael P.;
Bennett, Nigel C.;
Aksentijevic, Dunja

Publication type:

Article

Rapid fractionation of mitochondria from mouse liver and heart reveals in vivo metabolite compartmentation.

Published in:

FEBS Letters, 2023, v. 597, n. 2, p. 246, doi. 10.1002/1873-3468.14511

By:

Allen, Fay M.;
Costa, Ana S. H.;
Gruszczyk, Anja V.;
Bates, Georgina R.;
Prag, Hiran A.;
Nikitopoulou, Efterpi;
Viscomi, Carlo;
Frezza, Christian;
James, Andrew M.;
Murphy, Michael P.

Publication type:

Article