Works matching AU Prabhu, Saileta

Results: 19

Characterization of the pharmacokinetics, pharmacodynamics, and distribution of anti-abeta antibody MABT5102A

Published in:

2009

By:

Mortensen, Deborah;
Deng, Rong;
Adolfsson, Oskar;
Tam, Stephen;
Peng, Kun;
Lu, Yanmei;
Erickson, Richard;
Schofield, Cheryl;
DuPree, Kelly;
Pastuskovas, Cinthia V.;
Boswell, C. Andrew;
Goldman, Hope;
Bormans, Guy;
Iyer, Suhasini;
Khawli, Leslie A.;
Theil, Frank-Peter;
Watts, Ryan;
Prabhu, Saileta

Publication type:

Abstract

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target.

Published in:

Science Translational Medicine, 2011, v. 3, n. 84, p. 1, doi. 10.1126/scitranslmed.3002230

By:

Y. Joy Yu;
Yin Zhang;
Kenrick, Margaret;
Kwame Hoyte;
Wilman Luk;
Yanmei Lu;
Atwal, Jasvinder;
Elliott, J. Michael;
Prabhu, Saileta;
Watts, Ryan J.;
Dennis, Mark S.

Publication type:

Article

Prediction of Human Pharmacokinetics of Antibody–Drug Conjugates From Nonclinical Data.

Published in:

CTS: Clinical & Translational Science, 2019, v. 12, n. 5, p. 534, doi. 10.1111/cts.12649

By:

Li, Chunze;
Zhang, Cindy;
Deng, Rong;
Leipold, Douglas;
Li, Dongwei;
Latifi, Brandon;
Gao, Yuying;
Zhang, Crystal;
Li, Zao;
Miles, Dale;
Chen, Shang‐Chiung;
Samineni, Divya;
Wang, Bei;
Agarwal, Priya;
Lu, Dan;
Prabhu, Saileta;
Girish, Sandhya;
Kamath, Amrita V.

Publication type:

Article

Pharmacokinetic and Pharmacodynamic Considerations in the Design of Therapeutic Antibodies.

Published in:

CTS: Clinical & Translational Science, 2019, v. 12, n. 2, p. 130, doi. 10.1111/cts.12597

By:

Leipold, Douglas;
Prabhu, Saileta

Publication type:

Article

An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans.

Published in:

2019

By:

Chung, Shan;
Nguyen, Van;
Lin, Yuwen Linda;
Lafrance-Vanasse, Julien;
Scales, Suzie J.;
Lin, Kevin;
Deng, Rong;
Williams, Kathi;
Sperinde, Gizette;
Li, Juan Jenny;
Zheng, Kai;
Sukumaran, Siddharth;
Tesar, Devin;
Ernst, James A.;
Fischer, Saloumeh;
Lazar, Greg A.;
Prabhu, Saileta;
Song, An

Publication type:

Report

Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties.

Published in:

mAbs (1942-0862), 2019, v. 11, n. 2, p. 422, doi. 10.1080/19420862.2018.1551676

By:

Ovacik, Ayse Meric;
Li, Ji;
Lemper, Marie;
Danilenko, Dimitry;
Stagg, Nicola;
Mathieu, Mary;
Ellerman, Diego;
Gupta, Vinita;
Kalia, Navdeep;
Nguy, Trung;
Plaks, Vicki;
David Johnson, Clarissa;
Wang, Weiru;
Brumm, Jochen;
Fine, Bernard;
Junttila, Teemu;
Lin, Kedan;
Carter, Paul J.;
Prabhu, Saileta;
Spiess, Christoph

Publication type:

Article

Site-specific conjugation allows modulation of click reaction stoichiometry for pretargeted SPECT imaging.

Published in:

mAbs (1942-0862), 2018, v. 10, n. 8, p. 1269, doi. 10.1080/19420862.2018.1521132

By:

Mandikian, Danielle;
Rafidi, Hanine;
Adhikari, Pragya;
Venkatraman, Priya;
Nazarova, Lidia;
Fung, Gabriel;
Figueroa, Isabel;
Ferl, Gregory Z.;
Ulufatu, Sheila;
Ho, Jason;
McCaughey, Cynthia;
Lau, Jeffrey;
Yu, Shang-Fan;
Prabhu, Saileta;
Sadowsky, Jack;
Boswell, C. Andrew

Publication type:

Article

Quantitative cumulative biodistribution of antibodies in mice.

Published in:

mAbs (1942-0862), 2014, v. 6, n. 3, p. 689, doi. 10.4161/mabs.28254

By:

Yip, Victor;
Palma, Enzo;
Tesar, Devin B.;
Mundo, Eduardo E.;
Bumbaca, Daniela;
Torres, Elizabeth K.;
Reyes, Noe A.;
Shen, Ben Q.;
Fielder, Paul J.;
Prabhu, Saileta;
Khawli, Leslie A.;
Boswell, C. Andrew

Publication type:

Article

A strategy for risk mitigation of antibodies with fast clearance.

Published in:

mAbs (1942-0862), 2012, v. 4, n. 6, p. 753, doi. 10.4161/mabs.22189

By:

Hötzel, Isidro;
Theil, Frank-Peter;
Bernstein, Lisa J.;
Prabhu, Saileta;
Rong Deng;
Quintana, Leah;
Lutman, Jeff;
Sibia, Renuka;
Chan, Pamela;
Bumbaca, Daniela;
Fielder, Paul;
Carter, Paul J.;
Kelley, Robert F.

Publication type:

Article

Effect of antigen binding affinity and effector function on the pharmacokinetics and pharmacodynamics of anti-IgE monoclonal antibodies.

Published in:

mAbs (1942-0862), 2012, v. 4, n. 6, p. 724, doi. 10.4161/mabs.22216

By:

Mortensen, Deborah L.;
Prabhu, Saileta;
Stefanich, Eric G.;
Kadkhodayan-Fischer, Saloumeh;
Gelzleichter, Thomas R.;
Baker, Dana;
Jiang, Jenny;
Wallace, Kristin;
Iyer, Suhasini;
Fielder, Paul J.;
Putnam, Wendy S.

Publication type:

Article

Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice.

Published in:

mAbs (1942-0862), 2012, v. 4, n. 1, p. 101, doi. 10.4161/mabs.4.1.18543

By:

Deng, Rong;
Meng, Y. Gloria;
Hoyte, Kwame;
Lutman, Jeff;
Lu, Yanmei;
Iyer, Suhasini;
DeForge, Laura E.;
Theil, Frank-Peter;
Fielder, Paul J.;
Prabhu, Saileta

Publication type:

Article

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier.

Published in:

Science Translational Medicine, 2013, v. 5, n. 183, p. 1, doi. 10.1126/scitranslmed.3005338

By:

Couch, Jessica A.;
Yu, Y. Joy;
Yin Zhang;
Tarrant, Jacqueline M.;
Fuji, Reina N.;
Meilandt, William J.;
Solanoy, Hilda;
Tong, Raymond K.;
Kwame Hoyte;
Luk, Wilman;
Yanmei Lu;
Gadkar, Kapil;
Prabhu, Saileta;
Ordonia, Benjamin A.;
Nguyen, Quyen;
Yuwen Lin;
Zhonghua Lin;
Balazs, Mercedesz;
Scearce-Levie, Kimberly;
Ernst, James A.

Publication type:

Article

Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys.

Published in:

Pharmaceutical Research, 2015, v. 32, n. 6, p. 1907, doi. 10.1007/s11095-014-1585-y

By:

Lu, Dan;
Jin, Jin;
Girish, Sandhya;
Agarwal, Priya;
Li, Dongwei;
Prabhu, Saileta;
Dere, Randall;
Saad, Ola;
Nazzal, Denise;
Koppada, Neelima;
Ramanujan, Saroja;
Ng, Chee

Publication type:

Article

Subcutaneous Administration of Monoclonal Antibodies: Pharmacology, Delivery, Immunogenicity, and Learnings From Applications to Clinical Development.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 3, p. 422, doi. 10.1002/cpt.3150

By:

Davis, John D.;
Bravo Padros, Marçal;
Conrado, Daniela J.;
Ganguly, Samit;
Guan, Xiaowen;
Hassan, Hazem E.;
Hazra, Anasuya;
Irvin, Susan C.;
Jayachandran, Priya;
Kosloski, Matthew P.;
Lin, Kuan‐Ju;
Mukherjee, Kamalika;
Paccaly, Anne;
Papachristos, Apostolos;
Partridge, Michael A.;
Prabhu, Saileta;
Visich, Jennifer;
Welf, Erik S.;
Xu, Xiaoying;
Zhao, An

Publication type:

Article

Evaluation and use of an anti-cynomolgus monkey CD79b surrogate antibody-drug conjugate to enable clinical development of polatuzumab vedotin.

Published in:

2019

By:

Li, Dongwei;
Lee, Donna;
Dere, Randall C.;
Zheng, Bing;
Yu, Shang‐Fan;
Fuh, Franklin K.;
Kozak, Katherine R.;
Chung, Shan;
Bumbaca Yadav, Daniela;
Nazzal, Denise;
Danilenko, Dimitry;
Go, Mary Ann T.;
Williams, Marna;
Polson, Andrew G.;
Poon, Kirsten Achilles;
Prabhu, Saileta;
Yu, Shang-Fan

Publication type:

journal article

Anti-CD22 and anti-CD79b antibody-drug conjugates preferentially target proliferating B cells.

Published in:

2017

By:

Fuh, Franklin K;
Looney, Caroline;
Li, Dongwei;
Poon, Kirsten A;
Dere, Randall C;
Danilenko, Dimitry M;
McBride, Jacqueline;
Reed, Chae;
Chung, Shan;
Zheng, Bing;
Mathews, William Rodney;
Polson, Andrew;
Prabhu, Saileta;
Williams, Marna

Publication type:

journal article

Tissue Physiology of Cynomolgus Monkeys: Cross-Species Comparison and Implications for Translational Pharmacology.

Published in:

AAPS Journal, 2018, v. 20, n. 6, p. 1, doi. 10.1208/s12248-018-0264-z

By:

Mandikian, Danielle;
Figueroa, Isabel;
Oldendorp, Amy;
Rafidi, Hanine;
Ulufatu, Sheila;
Schweiger, Michelle G.;
Couch, Jessica A.;
Dybdal, Noel;
Joseph, Sean B.;
Prabhu, Saileta;
Ferl, Gregory Z.;
Boswell, C. Andrew

Publication type:

Article

Enhancing antibody uptake in brain to target BACE1

Published in:

2012

By:

Atwal, Jasi;
Yu, Joy;
Zhang, Yin;
Chen, Yongmei;
Chiu, Cecilia;
Meilandt, William;
Scearce-Levie, Kimberly;
Lu, Yanmei;
Kenrick, Margaret;
Prabhu, Saileta;
Wu, Yan;
Dennis, Mark;
Watts, Ryan

Publication type:

Abstract

Prevention of carcinogenesis by tea polyphenols.

Published in:

Drug Metabolism Reviews, 2001, v. 33, n. 3/4, p. 237, doi. 10.1081/DMR-120000651

By:

Yang, Chung S.;
Prabhu, Saileta;
Landau, Janelle

Publication type:

Article