Works by Povala, Guilherme

Results: 73

    • Soluble amyloid-beta isoforms predict downstream Alzheimer's disease pathology.

      Published in:
      Cell & Bioscience, 2021, v. 11, n. 1, p. 1, doi. 10.1186/s13578-021-00712-3
      By:
      • Povala, Guilherme;
      • Bellaver, Bruna;
      • De Bastiani, Marco Antônio;
      • Brum, Wagner S.;
      • Ferreira, Pamela C. L.;
      • Bieger, Andrei;
      • Pascoal, Tharick A.;
      • Benedet, Andrea L.;
      • Souza, Diogo O.;
      • Araujo, Ricardo M.;
      • Zatt, Bruno;
      • Rosa-Neto, Pedro;
      • Zimmer, Eduardo R.
      Publication type:
      Article

    • Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease.

      Published in:
      JAMA Network Open, 2023, v. 6, n. 11, p. e2345175, doi. 10.1001/jamanetworkopen.2023.45175
      By:
      • Schaffer Aguzzoli, Cristiano;
      • Ferreira, Pâmela C. L.;
      • Povala, Guilherme;
      • Ferrari-Souza, João Pedro;
      • Bellaver, Bruna;
      • Soares Katz, Carolina;
      • Zalzale, Hussein;
      • Lussier, Firoza Z.;
      • Rohden, Francieli;
      • Abbas, Sarah;
      • Leffa, Douglas T.;
      • Scop Medeiros, Marina;
      • Therriault, Joseph;
      • Benedet, Andréa L.;
      • Tissot, Cécile;
      • Servaes, Stijn;
      • Rahmouni, Nesrine;
      • Cassa Macedo, Arthur;
      • Bezgin, Gleb;
      • Kang, Min Su
      Publication type:
      Article

    • Multi-analyte proteomic analysis identifies blood-based neuroinflammation, cerebrovascular and synaptic biomarkers in preclinical Alzheimer's disease.

      Published in:
      Molecular Neurodegeneration, 2024, v. 19, n. 1, p. 1, doi. 10.1186/s13024-024-00753-5
      By:
      • Zeng, Xuemei;
      • Lafferty, Tara K.;
      • Sehrawat, Anuradha;
      • Chen, Yijun;
      • Ferreira, Pamela C. L.;
      • Bellaver, Bruna;
      • Povala, Guilherme;
      • Kamboh, M. Ilyas;
      • Klunk, William E.;
      • Cohen, Ann D.;
      • Lopez, Oscar L.;
      • Ikonomovic, Milos D.;
      • Pascoal, Tharick A.;
      • Ganguli, Mary;
      • Villemagne, Victor L.;
      • Snitz, Beth E.;
      • Karikari, Thomas K.
      Publication type:
      Article

    • Evaluating Congruence Between Clinical and Biological Staging Across The Alzheimer's Disease Spectrum.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.093241
      By:
      • Zalzale, Hussein;
      • Madeiros, Marina Scop;
      • Soares, Carolina;
      • Bauer‐Negrini, Guilherme;
      • Povala, Guilherme;
      • Ferreira, Pamela C.L.;
      • Amaral, Livia;
      • Lussier, Firoza Z;
      • Bellaver, Bruna;
      • Abbas, Sarah;
      • Rodrigues, Matheus Scarpatto;
      • Tudorascu, Dana;
      • Oliveira, Markley;
      • Felix, Cynthia;
      • Leffa, Douglas Teixeira;
      • Tissot, Cécile;
      • Aguzzoli, Cristiano Schaffer;
      • Ruppert, Emma Patrice;
      • Saha, Pampa;
      • Rahmouni, Nesrine
      Publication type:
      Article

    • Associations between brain metabolism and financial capacity in Alzheimer's disease.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.093143
      By:
      • Michel, Luca Marie;
      • Borelli, Wyllians Vendramini;
      • Schlickmann, Thomas Hugentobler;
      • Gehres, Sarah Wehle;
      • De Bastiani, Marco;
      • Bieger, Andrei;
      • Povala, Guilherme;
      • Machado, Luiza Santos;
      • Zimmer, Eduardo R.
      Publication type:
      Article

    • Association between Long COVID and neuropsychological outcomes in a Brazilian Cohort: preliminary results.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.093084
      By:
      • Senger, Joana Emilia;
      • Machado, Luiza Santos;
      • Silveira, Maiele Dornelles;
      • da Silva, Ana Paula Bornes;
      • Ferrari‐Souza, João Pedro;
      • de Bastiani, Marco Antônio;
      • Povala, Guilherme;
      • Borelli, Wyllians Vendramini;
      • de Mello, Guilherme Bastos;
      • da Ros, João Pedro Uglione;
      • Jotz, Arthur Viana;
      • Kadan, Matheus Fakhri;
      • Radaelli, Graciane;
      • Pascoal, Tharick A.;
      • Matushita, Cristina Sebastião;
      • Soder, Ricardo Benardi;
      • Schumacher‐Schuh, Artur Francisco;
      • Souza, Diogo O.;
      • Lourenco, Mychael V.;
      • de Paula de Paula Faria, Daniele
      Publication type:
      Article

    • Hippocampal degeneration is associated with GFAP levels in individuals with vascular dementia independently of amyloidosis.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.092720
      By:
      • Oliveira, Markley;
      • Bellaver, Bruna;
      • Lussier, Firoza Z;
      • Ferreira, Pamela C.L.;
      • Povala, Guilherme;
      • Leffa, Douglas Teixeira;
      • Bauer‐Negrini, Guilherme;
      • Rodrigues, Matheus Scarpatto;
      • Abbas, Sarah;
      • Zalzale, Hussein;
      • Rohden, Francieli;
      • Felix, Cynthia;
      • Soares, Carolina;
      • Saha, Pampa;
      • Ruppert, Emma Patrice;
      • Machado, Vitor Hugo;
      • da Rocha, Andreia Silva;
      • Tudorascu, Dana;
      • Benedet, Andrea L.;
      • Ashton, Nicholas J.
      Publication type:
      Article

    • Plasma high‐density lipoprotein levels is associated with preserved hippocampal volume in Alzheimer's disease individuals without vascular co‐pathology.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.092693
      By:
      • Rodrigues, Matheus Scarpatto;
      • Oliveira, Markley Silva;
      • Lussier, Firoza Z;
      • Ferreira, Pamela C.L.;
      • Povala, Guilherme;
      • Bauer‐Negrini, Guilherme;
      • Felix, Cynthia;
      • Abbas, Sarah;
      • Zalzale, Hussein;
      • Soares, Carolina;
      • Saha, Pampa;
      • Madeiros, Marina Scop;
      • Bloomquist, Madeleine;
      • Hong, Chang‐Hyung;
      • Roh, Hyun Woong;
      • Karim, Helmet T.;
      • de Oliveira, Jade;
      • Karikari, Thomas K;
      • Tudorascu, Dana;
      • Zimmer, Eduardo R.
      Publication type:
      Article

    • Tau exacerbates the development of distinct neuropsychiatric symptoms in late braak stage – the head study.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.092310
      By:
      • Aguzzoli, Cristiano Schaffer;
      • Povala, Guilherme;
      • Ferreira, Pamela C.L.;
      • Lussier, Firoza Z;
      • Bauer‐Negrini, Guilherme;
      • Amaral, Livia;
      • Soares, Carolina;
      • Ferrari‐Souza, João Pedro;
      • Zalzale, Hussein;
      • Bellaver, Bruna;
      • Rohden, Francieli;
      • Abbas, Sarah;
      • Leffa, Douglas Teixeira;
      • Schilling, Lucas Porcello;
      • Zimmer, Eduardo R.;
      • Tudorascu, Dana;
      • Pascual, Belen;
      • Gordon, Brian A.;
      • Lowe, Val J.;
      • Oh, Hwamee
      Publication type:
      Article

    • Robust Symptomatic Subtypes of Typical Alzheimer's Disease Characterized by Differential Neuropathological Patterns and Functional Decline.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.091322
      By:
      • Zalzale, Hussein;
      • Ferreira, Pamela C.L.;
      • Lemaire, Peter;
      • Madeiros, Marina Scop;
      • Soares, Carolina;
      • Bellaver, Bruna;
      • Bauer‐Negrini, Guilherme;
      • Lussier, Firoza Z;
      • Povala, Guilherme;
      • Ferrari‐Souza, João Pedro;
      • Abbas, Sarah;
      • Aguzzoli, Cristiano Schaffer;
      • Rodrigues, Matheus Scarpatto;
      • Rohden, Francieli;
      • Amaral, Livia;
      • Leffa, Douglas Teixeira;
      • Oliveira, Markley;
      • Tudorascu, Dana;
      • Tissot, Cécile;
      • Rahmouni, Nesrine
      Publication type:
      Article

    • Attention‐deficit/hyperactivity disorder impacts the development of neuropsychiatric symptoms in Alzheimer's disease.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.089857
      By:
      • Leffa, Douglas Teixeira;
      • Bellaver, Bruna;
      • Povala, Guilherme;
      • Ferreira, Pamela C. L.;
      • Ferrari‐Souza, João Pedro;
      • Lussier, Firoza Z;
      • Soares, Carolina;
      • Zalzale, Hussein;
      • Bauer‐Negrini, Guilherme;
      • Abbas, Sarah;
      • Karikari, Thomas K;
      • Rohde, Luis Augusto;
      • Molina, Brooke;
      • Pascoal, Tharick Ali
      Publication type:
      Article

    • ZNF653 transcription factor activity is associated with FDG‐PET changes in AD brain‐vulnerable regions.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.084700
      By:
      • De Bastiani, Marco;
      • Povala, Guilherme;
      • Bellaver, Bruna;
      • Ferreira, Pamela C.L.;
      • Ferrari‐Souza, João Pedro;
      • Rosa‐Neto, Pedro;
      • Zatt, Bruno;
      • Pascoal, Tharick A.;
      • Zimmer, Eduardo R.
      Publication type:
      Article

    • Omics‐derived biological modules reflect metabolic brain changes in Alzheimer's disease.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 10, p. 6709, doi. 10.1002/alz.14095
      By:
      • Povala, Guilherme;
      • De Bastiani, Marco Antônio;
      • Bellaver, Bruna;
      • Ferreira, Pamela C. L.;
      • Ferrari‐Souza, João Pedro;
      • Lussier, Firoza Z.;
      • Souza, Diogo O.;
      • Rosa‐Neto, Pedro;
      • Pascoal, Tharick A.;
      • Zatt, Bruno;
      • Zimmer, Eduardo R.
      Publication type:
      Article

    • A novel ultrasensitive assay for plasma p‐tau217: Performance in individuals with subjective cognitive decline and early Alzheimer's disease.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 2, p. 1239, doi. 10.1002/alz.13525
      By:
      • Gonzalez‐Ortiz, Fernando;
      • Ferreira, Pamela C. L.;
      • González‐Escalante, Armand;
      • Montoliu‐Gaya, Laia;
      • Ortiz‐Romero, Paula;
      • Kac, Przemyslaw R.;
      • Turton, Michael;
      • Kvartsberg, Hlin;
      • Ashton, Nicholas J.;
      • Zetterberg, Henrik;
      • Harrison, Peter;
      • Bellaver, Bruna;
      • Povala, Guilherme;
      • Villemagne, Victor L.;
      • Pascoal, Tharick A.;
      • Ganguli, Mary;
      • Cohen, Anne D.;
      • Minguillon, Carolina;
      • Contador, Jose;
      • Suárez‐Calvet, Marc
      Publication type:
      Article

    • Employing transfer learning to optimize deep learning models for Alzheimer's disease classification using two tau PET tracers.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082824
      By:
      • Bauer‐Negrini, Guilherme;
      • Povala, Guilherme;
      • Lucchese, Luisa Vieira;
      • Lussier, Firoza Z;
      • Bellaver, Bruna;
      • Ferreira, Pamela C.L.;
      • Aguzzoli, Cristiano Schaffer;
      • Soares, Carolina;
      • Zalzale, Hussein;
      • Rohden, Francieli;
      • Abbas, Sarah;
      • Ferrari‐Souza, João Pedro;
      • Leffa, Douglas Teixeira;
      • Lemaire, Peter Charles;
      • Cabrera, Arlec;
      • Tissot, Cécile;
      • Therriault, Joseph;
      • Bezgin, Gleb;
      • Servaes, Stijn;
      • Stevenson, Jenna
      Publication type:
      Article

    • Increased Genetic Risk for ADHD Potentiates Cognitive Impairment and Brain Hypometabolism in Alzheimer's Disease Patients.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080519
      By:
      • Leffa, Douglas Teixeira;
      • Povala, Guilherme;
      • Bellaver, Bruna;
      • Lussier, Firoza Z;
      • Ferrari‐Souza, João Pedro;
      • Ferreira, Pamela C.L.;
      • Zalzale, Hussein;
      • Aguzzoli, Cristiano Schaffer;
      • Rohden, Francieli;
      • Soares, Carolina;
      • Abbas, Sarah;
      • Tissot, Cécile;
      • Therriault, Joseph;
      • Lopez, Oscar L.;
      • Villemagne, Victor L;
      • Klunk, William E;
      • Cohen, Annie;
      • Zimmer, Eduardo R.;
      • Karikari, Thomas K;
      • Rosa‐Neto, Pedro
      Publication type:
      Article

    • Neuroinflammation Exacerbates Irritability and Agitation in Alzheimer's Disease.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080138
      By:
      • Aguzzoli, Cristiano Schaffer;
      • Ferreira, Pamela C.L.;
      • Povala, Guilherme;
      • Soares, Carolina;
      • Ferrari‐Souza, João Pedro;
      • Bellaver, Bruna;
      • Zalzale, Hussein;
      • Lussier, Firoza Z;
      • Rohden, Francieli;
      • Abbas, Sarah;
      • Lemaire, Peter Charles;
      • Leffa, Douglas Teixeira;
      • Cabrera, Arlec;
      • Therriault, Joseph;
      • Benedet, Andrea Lessa;
      • Tissot, Cécile;
      • Wang, Yi‐Ting;
      • Chamoun, Mira;
      • Servaes, Stijn;
      • Macedo, Arthur C.
      Publication type:
      Article

    • Microglial Activation Contributes to Neuropsychiatric Dysfunction in Alzheimer's Disease.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079969
      By:
      • Aguzzoli, Cristiano Schaffer;
      • Ferreira, Pamela C.L.;
      • Povala, Guilherme;
      • Soares, Carolina;
      • Ferrari‐Souza, João Pedro;
      • Bellaver, Bruna;
      • Zalzale, Hussein;
      • Lussier, Firoza Z;
      • Rohden, Francieli;
      • Abbas, Sarah;
      • Lemaire, Peter Charles;
      • Leffa, Douglas Teixeira;
      • Cabrera, Arlec;
      • Therriault, Joseph;
      • Benedet, Andrea Lessa;
      • Tissot, Cécile;
      • Servaes, Stijn;
      • Macedo, Arthur C.;
      • Vermeiren, Marie;
      • Bezgin, Gleb
      Publication type:
      Article

    • Microglial activation interacts with amyloid‐β to drive longitudinal tau tangle accumulation and cognitive decline.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079188
      By:
      • Povala, Guilherme;
      • Bellaver, Bruna;
      • Lussier, Firoza Z;
      • Ferreira, Pamela C.L.;
      • Ferrari‐Souza, João Pedro;
      • Leffa, Douglas Teixeira;
      • Aguzzoli, Cristiano Schaffer;
      • Zalzale, Hussein;
      • Soares, Carolina;
      • Abbas, Sarah;
      • Rohden, Francieli;
      • Tissot, Cécile;
      • Therriault, Joseph;
      • Bezgin, Gleb;
      • Servaes, Stijn;
      • Benedet, Andrea Lessa;
      • Stevenson, Jenna;
      • Rahmouni, Nesrine;
      • Cohen, Annie;
      • Lopez, Oscar L.
      Publication type:
      Article

    • Increased regional brain inflammation predicts longitudinal brain atrophy in individuals in the Alzheimer's disease continuum.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079000
      By:
      • Povala, Guilherme;
      • Bellaver, Bruna;
      • Ferreira, Pamela C.L.;
      • Lussier, Firoza Z;
      • Ferrari‐Souza, João Pedro;
      • Leffa, Douglas Teixeira;
      • Tissot, Cécile;
      • Therriault, Joseph;
      • Bezgin, Gleb;
      • Servaes, Stijn;
      • Benedet, Andrea Lessa;
      • Stevenson, Jenna;
      • Rahmouni, Nesrine;
      • Cohen, Ann D.;
      • Lopez, Oscar L.;
      • Tudorascu, Dana;
      • Klunk, William E;
      • Villemagne, Victor L;
      • Karikari, Thomas K;
      • Zimmer, Eduardo R
      Publication type:
      Article

    • Association of reactive astrogliosis and microglial activation with tau pathology in Alzheimer's disease.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078423
      By:
      • Ferrari‐Souza, João Pedro;
      • Bellaver, Bruna;
      • Ferreira, Pamela C.L.;
      • Povala, Guilherme;
      • Lussier, Firoza Z;
      • Leffa, Douglas Teixeira;
      • Therriault, Joseph;
      • Tissot, Cécile;
      • Benedet, Andrea Lessa;
      • Soares, Carolina;
      • Aguzzoli, Cristiano Schaffer;
      • Zalzale, Hussein;
      • Rohden, Francieli;
      • Wang, Yi‐Ting;
      • Chamoun, Mira;
      • Servaes, Stijn;
      • Macedo, Arthur C.;
      • Vermeiren, Marie;
      • Bezgin, Gleb;
      • Kang, Min Su
      Publication type:
      Article

    • Astrocyte reactivity potentiates longitudinal tau tangle accumulation in cognitively unimpaired individuals.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078421
      By:
      • Bellaver, Bruna;
      • Povala, Guilherme;
      • Ferreira, Pamela C.L.;
      • Ferrari‐Souza, João Pedro;
      • Leffa, Douglas Teixeira;
      • Lussier, Firoza Z;
      • Zalzale, Hussein;
      • Soares, Carolina;
      • Aguzzoli, Cristiano Schaffer;
      • Rohden, Francieli;
      • Abbas, Sarah;
      • Ashton, Nicholas J.;
      • Tissot, Cécile;
      • Therriault, Joseph;
      • Servaes, Stijn;
      • Stevenson, Jenna;
      • Rahmouni, Nesrine;
      • Lopez, Oscar L.;
      • Tudorascu, Dana;
      • Villemagne, Victor L
      Publication type:
      Article

    • Amyloid and Tau Predominance Subtyping Identifies CI Patients With Different Clinical Phenotypes.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078343
      By:
      • Zalzale, Hussein;
      • Povala, Guilherme;
      • Ferreira, Pamela C.L.;
      • Bellaver, Bruna;
      • Ferrari‐Souza, João Pedro;
      • Soares, Carolina;
      • Lussier, Firoza Z;
      • Aguzzoli, Cristiano Schaffer;
      • Lemaire, Peter Charles;
      • Abbas, Sarah;
      • Rohden, Francieli;
      • Leffa, Douglas Teixeira;
      • Cabrera, Arlec;
      • Therriault, Joseph;
      • Stevenson, Alyssa;
      • Pallen, Vanessa;
      • Ashton, Nicholas J.;
      • Benedet, Andrea Lessa;
      • Blennow, Kaj;
      • Zetterberg, Henrik
      Publication type:
      Article

    • The relationship between [<sup>18</sup>F]FDG‐PET signal and key‐players of brain glucose metabolism.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080440
      By:
      • Limberger, Christian;
      • Machado, Luiza Santos;
      • Ferrari‐Souza, João Pedro;
      • Povala, Guilherme;
      • Carello‐Collar, Giovanna;
      • Pascoal, Tharick A.;
      • Bouzier‐Sore, Anne‐Karine;
      • Pellerin, Luc;
      • de Souza, Débora Guerini;
      • Zimmer, Eduardo R.
      Publication type:
      Article

    • Association between brain [<sup>18</sup>F]FDG‐PET signal and genetic cell markers in the brain tissue.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080168
      By:
      • Machado, Luiza Santos;
      • Ant, Marco;
      • Bastiani, De;
      • da Rocha, Andreia Silva;
      • Bellaver, Bruna;
      • Soares, Carolina;
      • Povala, Guilherme;
      • Rahmouni, Nesrine;
      • de Souza, Débora Guerini;
      • Pascoal, Tharick A.;
      • Souza, Diogo O.;
      • Rosa‐Neto, Pedro;
      • Benedet, Andrea Lessa;
      • Blennow, Kaj;
      • Zetterberg, Henrik;
      • Ashton, Nicholas J.;
      • Ferreira, Pamela C.L.;
      • Zimmer, Eduardo R.
      Publication type:
      Article

    • Potential utility of using both APOEε4 and Aβ positivity to enrich clinical trials of tau‐targeting therapies.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079764
      By:
      • Ferrari‐Souza, João Pedro;
      • Ferreira, Pamela C.L.;
      • Bellaver, Bruna;
      • Povala, Guilherme;
      • Lussier, Firoza Z;
      • Leffa, Douglas Teixeira;
      • Therriault, Joseph;
      • Tissot, Cécile;
      • Soares, Carolina;
      • Benedet, Andrea Lessa;
      • Wang, Yi‐Ting;
      • Chamoun, Mira;
      • Servaes, Stijn;
      • Macedo, Arthur C.;
      • Vermeiren, Marie;
      • Bezgin, Gleb;
      • Kang, Min Su;
      • Stevenson, Jenna;
      • Rahmouni, Nesrine;
      • Pallen, Vanessa
      Publication type:
      Article

    • APOEε4 potentiates the effects of Aβ pathology on the deposition of neurofibrillary tangles via tau phosphorylation.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079681
      By:
      • Ferrari‐Souza, João Pedro;
      • Bellaver, Bruna;
      • Ferreira, Pamela C.L.;
      • Benedet, Andrea Lessa;
      • Povala, Guilherme;
      • Lussier, Firoza Z;
      • Leffa, Douglas Teixeira;
      • Therriault, Joseph;
      • Tissot, Cécile;
      • Soares, Carolina;
      • Wang, Yi‐Ting;
      • Chamoun, Mira;
      • Servaes, Stijn;
      • Macedo, Arthur C.;
      • Vermeiren, Marie;
      • Bezgin, Gleb;
      • Kang, Min Su;
      • Stevenson, Jenna;
      • Rahmouni, Nesrine;
      • Pallen, Vanessa
      Publication type:
      Article

    • Astrocyte reactivity is associated with synaptic dysfunction across the aging and Alzheimer's disease spectrum, whereas microglial reactivity is specifically associated with synaptic dysfunction related to cognitive impairment.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080143
      By:
      • Rohden, Francieli;
      • Ferreira, Pamela C.L.;
      • Bellaver, Bruna;
      • Aguzzoli, Cristiano Schaffer;
      • Soares, Carolina;
      • Povala, Guilherme;
      • Ferrari‐Souza, João Pedro;
      • Lussier, Firoza Z;
      • Zalzale, Hussein;
      • Abbas, Sarah;
      • Lemaire, Peter Charles;
      • Leffa, Douglas Teixeira;
      • Cabrera, Arlec;
      • Tissot, Cécile;
      • Therriault, Joseph;
      • Servaes, Stijn;
      • Stevenson, Jenna;
      • Rahmouni, Nesrine;
      • Benedet, Andrea Lessa;
      • Cohen, Annie
      Publication type:
      Article

    • CSF total tau is more closely associated with synaptic dysfunction than overt neurodegeneration.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079855
      By:
      • Soares, Carolina;
      • Bellaver, Bruna;
      • Ferreira, Pamela C.L.;
      • Povala, Guilherme;
      • Aguzzoli, Cristiano Schaffer;
      • Ferrari‐Souza, João Pedro;
      • Zalzale, Hussein;
      • Lussier, Firoza Z;
      • Rohden, Francieli;
      • Abbas, Sarah;
      • Lemaire, Peter Charles;
      • Leffa, Douglas Teixeira;
      • Cabrera, Arlec;
      • Therriault, Joseph;
      • Benedet, Andrea Lessa;
      • Tissot, Cécile;
      • Servaes, Stijn;
      • Macedo, Arthur C.;
      • Vermeiren, Marie;
      • Bezgin, Gleb
      Publication type:
      Article

    • Synapse dysfunction and astrocyte reactivity are associated independently of amyloid‐β and tau pathologies.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079816
      By:
      • Rohden, Francieli;
      • Bellaver, Bruna;
      • Ferreira, Pamela C.L.;
      • Aguzzoli, Cristiano Schaffer;
      • Lussier, Firoza Z;
      • Soares, Carolina;
      • Povala, Guilherme;
      • Ferrari‐Souza, João Pedro;
      • Zalzale, Hussein;
      • Leffa, Douglas Teixeira;
      • Abbas, Sarah;
      • Cabrera, Arlec;
      • Lemaire, Peter Charles;
      • Tissot, Cécile;
      • Therriault, Joseph;
      • Servaes, Stijn;
      • Stevenson, Jenna;
      • Rahmouni, Nesrine;
      • Benedet, Andrea Lessa;
      • Cohen, Annie
      Publication type:
      Article

    • Sex impacts the association of plasma Glial Fibrillary Acidic Protein with neurodegeneration in Alzheimer's disease.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076402
      By:
      • Abbas, Sarah;
      • Bellaver, Bruna;
      • Ferreira, Pamela C.L.;
      • Povala, Guilherme;
      • Ferrari‐Souza, João Pedro;
      • Lussier, Firoza Z;
      • Zalzale, Hussein;
      • Lemaire, Peter Charles;
      • Soares, Carolina;
      • Rohden, Francieli;
      • Aguzzoli, Cristiano Schaffer;
      • Cabrera, Arlec;
      • Leffa, Douglas Teixeira;
      • Therriault, Joseph;
      • Tissot, Cécile;
      • Servaes, Stijn;
      • Macedo, Arthur C.;
      • Chamoun, Mira;
      • Bezgin, Gleb;
      • Stevenson, Jenna
      Publication type:
      Article

    • Synaptic dysfunction, Tau pathology and Neurodegeneration.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080006
      By:
      • Soares, Carolina;
      • Bellaver, Bruna;
      • Ferreira, Pamela C.L.;
      • Povala, Guilherme;
      • Aguzzoli, Cristiano Schaffer;
      • Rohden, Francieli;
      • Ferrari‐Souza, João Pedro;
      • Zalzale, Hussein;
      • Abbas, Sarah;
      • Lemaire, Peter Charles;
      • Leffa, Douglas Teixeira;
      • Cabrera, Arlec;
      • Therriault, Joseph;
      • Benedet, Andrea Lessa;
      • Tissot, Cécile;
      • Servaes, Stijn;
      • Macedo, Arthur C.;
      • Vermeiren, Marie;
      • Bezgin, Gleb;
      • Kang, Min Su
      Publication type:
      Article

    • Plasma p‐tau and brain‐derived total tau biomarkers predict longitudinal changes in Aβ, tau, and cognition across the AD continuum.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078070
      By:
      • Ferreira, Pamela C.L.;
      • Bellaver, Bruna;
      • Povala, Guilherme;
      • Rodriguez, Juan Lantero;
      • Snellman, Anniina;
      • Leffa, Douglas Teixeira;
      • Ferrari‐Souza, Pedro;
      • Lussier, Firoza Z;
      • Zalzale, Hussein;
      • Soares, Carolina;
      • Aguzzoli, Cristiano Schaffer;
      • Tissot, Cécile;
      • Benedet, Andrea Lessa;
      • Rohden, Francieli;
      • Therriault, Joseph;
      • Abbas, Sarah;
      • Bezgin, Gleb;
      • Servaes, Stijn;
      • Lopez, Oscar L.;
      • Rahmouni, Nesrine
      Publication type:
      Article

    • Sex modulates the role of astrocyte reactivity in preclinical Alzheimer's disease.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077995
      By:
      • Bellaver, Bruna;
      • Povala, Guilherme;
      • Ferreira, Pamela C.L.;
      • Leffa, Douglas Teixeira;
      • Ferrari‐Souza, João Pedro;
      • Lussier, Firoza Z;
      • Zalzale, Hussein;
      • Soares, Carolina;
      • Aguzzoli, Cristiano Schaffer;
      • Rohden, Francieli;
      • Abbas, Sarah;
      • Benedet, Andrea Lessa;
      • Ashton, Nicholas J.;
      • Tissot, Cécile;
      • Therriault, Joseph;
      • Servaes, Stijn;
      • Stevenson, Jenna;
      • Rahmouni, Nesrine;
      • Lopez, Oscar L.;
      • Tudorascu, Dana
      Publication type:
      Article

    • Plasma p‐tau181 and nfl as surrogates biomarkers in clinical trials targeting preclinical stage of Alzheimer's disease.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077906
      By:
      • Ferreira, Pamela C.L.;
      • Ferrari‐Souza, João Pedro;
      • Tissot, Cécile;
      • Bellaver, Bruna;
      • Leffa, Douglas Teixeira;
      • Povala, Guilherme;
      • Lussier, Firoza Z;
      • Therriault, Joseph;
      • Benedet, Andrea Lessa;
      • Ashton, Nicholas J.;
      • Cohen, Ann D.;
      • Lopez, Oscar L.;
      • Tudorascu, Dana;
      • Klunk, William E;
      • Soucy, Jean‐Paul;
      • Gauthier, Serge;
      • Villemagne, Victor L;
      • Zetterberg, Henrik;
      • Blennow, Kaj;
      • Rosa‐Neto, Pedro
      Publication type:
      Article

    • Amyloid β‐dependent tau phosphorylation is triggered by reactive astrocytes in preclinical Alzheimer's disease.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077861
      By:
      • Bellaver, Bruna;
      • Povala, Guilherme;
      • Ferreira, Pamela C.L.;
      • Ferrari‐Souza, João Pedro;
      • Leffa, Douglas Teixeira;
      • Lussier, Firoza Z;
      • Benedet, Andrea Lessa;
      • Ashton, Nicholas J.;
      • Tissot, Cécile;
      • Therriault, Joseph;
      • Servaes, Stijn;
      • Stevenson, Jenna;
      • Rahmouni, Nesrine;
      • Lopez, Oscar L.;
      • Tudorascu, Dana;
      • Villemagne, Victor L;
      • Ikonomovic, Milos D;
      • Gauthier, Serge;
      • Zimmer, Eduardo R;
      • Zetterberg, Henrik
      Publication type:
      Article

    • Plasma p‐tau231 and p‐tau217 provides information on tau tangle deposition in symptomatic Alzheimer's disease individuals.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076691
      By:
      • Ferreira, Pamela C.L.;
      • Bellaver, Bruna;
      • Povala, Guilherme;
      • Therriault, Joseph;
      • Ferrari‐Souza, João Pedro;
      • Tissot, Cécile;
      • Leffa, Douglas Teixeira;
      • Brum, Wagner S.;
      • Benedet, Andrea Lessa;
      • Lussier, Firoza Z;
      • Cabrera, Arlec;
      • Zalzale, Hussein;
      • Soares, Carolina;
      • Aguzzoli, Cristiano Schaffer;
      • Bezgin, Gleb;
      • Servaes, Stijn;
      • Stevenson, Jenna;
      • Triana‐Baltzer, Gallen;
      • Kolb, Hartmuth C.;
      • Rahmouni, Nesrine
      Publication type:
      Article

    • GABA transporters gene expression associates with [<sup>18</sup>F]FDG‐PET signal in regions typically hypometabolic in Alzheimer's disease.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079619
      By:
      • Carello‐Collar, Giovanna;
      • Ferrari‐Souza, João Pedro;
      • Machado, Luiza Santos;
      • Povala, Guilherme;
      • Limberger, Christian;
      • Pascoal, Tharick A.;
      • Zimmer, Eduardo R
      Publication type:
      Article

    • Association of reactive astrogliosis and microglial activation with tau pathology in Alzheimer's disease.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.082041
      By:
      • Ferrari‐Souza, João Pedro;
      • Bellaver, Bruna;
      • Ferreira, Pamela C.L.;
      • Povala, Guilherme;
      • Lussier, Firoza Z;
      • Leffa, Douglas Teixeira;
      • Therriault, Joseph;
      • Tissot, Cécile;
      • Benedet, Andrea Lessa;
      • Soares, Carolina;
      • Aguzzoli, Cristiano Schaffer;
      • Zalzale, Hussein;
      • Rohden, Francieli;
      • Wang, Yi‐Ting;
      • Chamoun, Mira;
      • Servaes, Stijn;
      • Macedo, Arthur C.;
      • Vermeiren, Marie;
      • Bezgin, Gleb;
      • Kang, Min Su
      Publication type:
      Article

    • Association between brain [18F]FDG‐PET signal and genetic cell markers in the brain tissue.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081980
      By:
      • Machado, Luiza Santos;
      • De Bastiani, Marco Antônio;
      • da Rocha, Andreia Silva;
      • Bellaver, Bruna;
      • Soares, Carolina;
      • Povala, Guilherme;
      • Rahmouni, Nesrine;
      • de Souza, Débora Guerini;
      • Pascoal, Tharick A.;
      • Souza, Diogo O.;
      • Rosa‐Neto, Pedro;
      • Benedet, Andrea Lessa;
      • Blennow, Kaj;
      • Zetterberg, Henrik;
      • Ashton, Nicholas J.;
      • Ferreira, Pamela C.L.;
      • Zimmer, Eduardo R.
      Publication type:
      Article

    • Neuroinflammation Exacerbates Irritability and Agitation in Alzheimer's Disease.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081973
      By:
      • Aguzzoli, Cristiano Schaffer;
      • Ferreira, Pamela C.L.;
      • Povala, Guilherme;
      • Soares, Carolina;
      • Ferrari‐Souza, João Pedro;
      • Bellaver, Bruna;
      • Zalzale, Hussein;
      • Lussier, Firoza Z;
      • Rohden, Francieli;
      • Abbas, Sarah;
      • Lemaire, Peter Charles;
      • Leffa, Douglas Teixeira;
      • Cabrera, Arlec;
      • Therriault, Joseph;
      • Benedet, Andrea Lessa;
      • Tissot, Cécile;
      • Wang, Yi‐Ting;
      • Chamoun, Mira;
      • Servaes, Stijn;
      • Macedo, Arthur C.
      Publication type:
      Article

    • Astrocyte reactivity is associated with synaptic dysfunction across the aging and Alzheimer's disease spectrum, whereas microglial reactivity is specifically associated with synaptic dysfunction related to cognitive impairment.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081975
      By:
      • Rohden, Francieli;
      • Ferreira, Pamela C.L.;
      • Bellaver, Bruna;
      • Aguzzoli, Cristiano Schaffer;
      • Soares, Carolina;
      • Povala, Guilherme;
      • Ferrari‐Souza, João Pedro;
      • Lussier, Firoza Z;
      • Zalzale, Hussein;
      • Abbas, Sarah;
      • Lemaire, Peter Charles;
      • Leffa, Douglas Teixeira;
      • Cabrera, Arlec;
      • Tissot, Cécile;
      • Therriault, Joseph;
      • Servaes, Stijn;
      • Stevenson, Jenna;
      • Rahmouni, Nesrine;
      • Benedet, Andrea Lessa;
      • Cohen, Annie
      Publication type:
      Article

    • Synaptic dysfunction in the presence of tau tangles is not a strong predictor of atrophy.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081954
      By:
      • Soares, Carolina;
      • Bellaver, Bruna;
      • Ferreira, Pamela C.L.;
      • Povala, Guilherme;
      • Aguzzoli, Cristiano Schaffer;
      • Rohden, Francieli;
      • Ferrari‐Souza, João Pedro;
      • Zalzale, Hussein;
      • Abbas, Sarah;
      • Lemaire, Peter Charles;
      • Leffa, Douglas Teixeira;
      • Cabrera, Arlec;
      • Therriault, Joseph;
      • Benedet, Andrea Lessa;
      • Tissot, Cécile;
      • Servaes, Stijn;
      • Macedo, Arthur C.;
      • Vermeiren, Marie;
      • Bezgin, Gleb;
      • Kang, Min Su
      Publication type:
      Article

    • Microglial Activation Contributes to Neuropsychiatric Dysfunction in Alzheimer's Disease.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081950
      By:
      • Aguzzoli, Cristiano Schaffer;
      • Ferreira, Pamela C.L.;
      • Povala, Guilherme;
      • Soares, Carolina;
      • Ferrari‐Souza, João Pedro;
      • Bellaver, Bruna;
      • Zalzale, Hussein;
      • Lussier, Firoza Z;
      • Rohden, Francieli;
      • Abbas, Sarah;
      • Lemaire, Peter Charles;
      • Leffa, Douglas Teixeira;
      • Cabrera, Arlec;
      • Therriault, Joseph;
      • Benedet, Andrea Lessa;
      • Tissot, Cécile;
      • Servaes, Stijn;
      • Macedo, Arthur C.;
      • Vermeiren, Marie;
      • Bezgin, Gleb
      Publication type:
      Article

    • Synapse dysfunction and astrocyte reactivity are associated independently of amyloid‐β and tau pathologies.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081939
      By:
      • Rohden, Francieli;
      • Bellaver, Bruna;
      • Ferreira, Pamela C.L.;
      • Aguzzoli, Cristiano Schaffer;
      • Lussier, Firoza Z;
      • Soares, Carolina;
      • Povala, Guilherme;
      • Ferrari‐Souza, João Pedro;
      • Zalzale, Hussein;
      • Leffa, Douglas Teixeira;
      • Abbas, Sarah;
      • Cabrera, Arlec;
      • Lemaire, Peter Charles;
      • Tissot, Cécile;
      • Therriault, Joseph;
      • Servaes, Stijn;
      • Stevenson, Jenna;
      • Rahmouni, Nesrine;
      • Benedet, Andrea Lessa;
      • Cohen, Annie
      Publication type:
      Article

    • CSF total tau is more closely associated with synaptic dysfunction than overt neurodegeneration.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081943
      By:
      • Soares, Carolina;
      • Bellaver, Bruna;
      • Ferreira, Pamela C.L.;
      • Povala, Guilherme;
      • Aguzzoli, Cristiano Schaffer;
      • Ferrari‐Souza, João Pedro;
      • Zalzale, Hussein;
      • Lussier, Firoza Z;
      • Rohden, Francieli;
      • Abbas, Sarah;
      • Lemaire, Peter Charles;
      • Leffa, Douglas Teixeira;
      • Cabrera, Arlec;
      • Therriault, Joseph;
      • Benedet, Andrea Lessa;
      • Tissot, Cécile;
      • Servaes, Stijn;
      • Macedo, Arthur C.;
      • Vermeiren, Marie;
      • Bezgin, Gleb
      Publication type:
      Article

    • Potential utility of using both APOEε4 and Aβ positivity to enrich clinical trials of tau‐targeting therapies.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081933
      By:
      • Ferrari‐Souza, João Pedro;
      • Ferreira, Pamela C.L.;
      • Bellaver, Bruna;
      • Povala, Guilherme;
      • Lussier, Firoza Z;
      • Leffa, Douglas Teixeira;
      • Therriault, Joseph;
      • Tissot, Cécile;
      • Soares, Carolina;
      • Benedet, Andrea Lessa;
      • Wang, Yi‐Ting;
      • Chamoun, Mira;
      • Servaes, Stijn;
      • Macedo, Arthur C.;
      • Vermeiren, Marie;
      • Bezgin, Gleb;
      • Kang, Min Su;
      • Stevenson, Jenna;
      • Rahmouni, Nesrine;
      • Pallen, Vanessa
      Publication type:
      Article

    • GABA transporters gene expression associates with [18F]FDG‐PET signal in regions typically hypometabolic in Alzheimer's disease.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081920
      By:
      • Carello‐Collar, Giovanna;
      • Ferrari‐Souza, João Pedro;
      • Machado, Luiza Santos;
      • Povala, Guilherme;
      • Limberger, Christian;
      • Pascoal, Tharick A.;
      • Zimmer, Eduardo R
      Publication type:
      Article

    • APOEε4 potentiates the effects of Aβ pathology on the deposition of neurofibrillary tangles via tau phosphorylation.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081925
      By:
      • Ferrari‐Souza, João Pedro;
      • Bellaver, Bruna;
      • Ferreira, Pamela C.L.;
      • Benedet, Andrea Lessa;
      • Povala, Guilherme;
      • Lussier, Firoza Z;
      • Leffa, Douglas Teixeira;
      • Therriault, Joseph;
      • Tissot, Cécile;
      • Soares, Carolina;
      • Wang, Yi‐Ting;
      • Chamoun, Mira;
      • Servaes, Stijn;
      • Macedo, Arthur C.;
      • Vermeiren, Marie;
      • Bezgin, Gleb;
      • Kang, Min Su;
      • Stevenson, Jenna;
      • Rahmouni, Nesrine;
      • Pallen, Vanessa
      Publication type:
      Article

    • Microglial activation interacts with amyloid‐β to drive longitudinal tau tangle accumulation and cognitive decline.

      Published in:
      Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081881
      By:
      • Povala, Guilherme;
      • Bellaver, Bruna;
      • Lussier, Firoza Z;
      • Ferreira, Pamela C.L.;
      • Ferrari‐Souza, João Pedro;
      • Leffa, Douglas Teixeira;
      • Aguzzoli, Cristiano Schaffer;
      • Zalzale, Hussein;
      • Soares, Carolina;
      • Abbas, Sarah;
      • Rohden, Francieli;
      • Tissot, Cécile;
      • Therriault, Joseph;
      • Bezgin, Gleb;
      • Servaes, Stijn;
      • Benedet, Andrea Lessa;
      • Stevenson, Jenna;
      • Rahmouni, Nesrine;
      • Cohen, Annie;
      • Lopez, Oscar L.
      Publication type:
      Article