Works by Posgai, Amanda L.

Results: 36

Modeling cell-mediated immunity in human type 1 diabetes by engineering autoreactive CD8+ T cells.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1142648

By:

Peters, Leeana D.;
Wen-I Yeh;
Arnoletti, Juan M.;
Brown, Matthew E.;
Posgai, Amanda L.;
Mathews, Clayton E.;
Brusko, Todd M.

Publication type:

Article

Response to Comment on Dunne et al. The Women's Leadership Gap in Diabetes: A Call for Equity and Excellence. Diabetes Care 2021;44:1734-1743.

Published in:

2022

By:

Dunne, Jessica L.;
Maizel, Jennifer L.;
Posgai, Amanda L.;
Atkinson, Mark A.;
DiMeglio, Linda A.

Publication type:

Letter to the Editor

The Women's Leadership Gap in Diabetes: A Call for Equity and Excellence.

Published in:

2021

By:

Dunne, Jessica L.;
Maizel, Jennifer L.;
Posgai, Amanda L.;
Atkinson, Mark A.;
DiMeglio, Linda A.

Publication type:

journal article

Diagnostic Dilemma: Clinical and Histological Abnormalities in a Hispanic Patient With Diabetes.

Published in:

2016

By:

Jacobsen, Laura M.;
Posgai, Amanda L.;
Campbell-Thompson, Martha;
Schatz, Desmond A.

Publication type:

journal article

Exocrine and Endocrine Inflammation Increases Cellular Replication in the Pancreatic Duct Compartment in Type 1 Diabetes.

Published in:

Journal of the Endocrine Society, 2022, v. 6, n. 11, p. 1, doi. 10.1210/jendso/bvac136

By:

Kulkarni, Shweta;
Posgai, Amanda L;
Kusmartseva, Irina;
Wasserfall, Clive H;
Atkinson, Mark A;
Butler, Alexandra E

Publication type:

Article

De‐coding genetic risk variants in type 1 diabetes.

Published in:

Immunology & Cell Biology, 2021, v. 99, n. 5, p. 496, doi. 10.1111/imcb.12438

By:

Shapiro, Melanie R;
Thirawatananond, Puchong;
Peters, Leeana;
Sharp, Robert C;
Ogundare, Similoluwa;
Posgai, Amanda L;
Perry, Daniel J;
Brusko, Todd M

Publication type:

Article

Guidelines for standardizing T‐cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes.

Published in:

European Journal of Immunology, 2022, v. 52, n. 3, p. 372, doi. 10.1002/eji.202049067

By:

Yang, Jennie H. M.;
Ward‐Hartstonge, Kirsten A.;
Perry, Daniel J.;
Blanchfield, J. Lori;
Posgai, Amanda L.;
Wiedeman, Alice E.;
Diggins, Kirsten;
Rahman, Adeeb;
Tree, Timothy I. M.;
Brusko, Todd M.;
Levings, Megan K.;
James, Eddie A.;
Kent, Sally C.;
Speake, Cate;
Homann, Dirk;
Long, S. Alice

Publication type:

Article

Biomaterials‐based nanoparticles conjugated to regulatory T cells provide a modular system for localized delivery of pharmacotherapeutic agents.

Published in:

Journal of Biomedical Materials Research, Part A, 2023, v. 111, n. 2, p. 185, doi. 10.1002/jbm.a.37442

By:

Marshall, Gregory P.;
Cserny, Judit;
Wang, Chun‐Wei;
Looney, Benjamin;
Posgai, Amanda L.;
Bacher, Rhonda;
Keselowsky, Benjamin;
Brusko, Todd M.

Publication type:

Article

Leveraging artificial intelligence and machine learning to accelerate discovery of disease-modifying therapies in type 1 diabetes.

Published in:

Diabetologia, 2025, v. 68, n. 3, p. 477, doi. 10.1007/s00125-024-06339-6

By:

Shapiro, Melanie R.;
Tallon, Erin M.;
Brown, Matthew E.;
Posgai, Amanda L.;
Clements, Mark A.;
Brusko, Todd M.

Publication type:

Article

Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function.

Published in:

Diabetologia, 2025, v. 68, n. 2, p. 397, doi. 10.1007/s00125-024-06329-8

By:

Brown, Matthew E.;
Thirawatananond, Puchong;
Peters, Leeana D.;
Kern, Elizabeth J.;
Vijay, Sonali;
Sachs, Lindsey K.;
Posgai, Amanda L.;
Brusko, Maigan A.;
Shapiro, Melanie R.;
Mathews, Clayton E.;
Bacher, Rhonda;
Brusko, Todd M.

Publication type:

Article

The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium.

Published in:

Diabetologia, 2025, v. 68, n. 1, p. 186, doi. 10.1007/s00125-024-06298-y

By:

Hanna, Stephanie J.;
Bonami, Rachel H.;
Corrie, Brian;
Westley, Monica;
Posgai, Amanda L.;
Luning Prak, Eline T.;
Breden, Felix;
Michels, Aaron W.;
Brusko, Todd M.;
Baschal, Erin;
Cerosaletti, Karen;
Corrie, Lorissa;
Gomez-Tourino, Iria;
Higdon, Lauren;
Kent, Sally C.;
Linsley, Peter;
Nakayama, Maki;
Neller, Kira;
Ruff, William E.;
Teyton, Luc

Publication type:

Article

Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrPC, in type 1 diabetes.

Published in:

Diabetologia, 2021, v. 64, n. 10, p. 2279, doi. 10.1007/s00125-021-05501-8

By:

Hiller, Helmut;
Yang, Changjun;
Beachy, Dawn E.;
Kusmartseva, Irina;
Candelario-Jalil, Eduardo;
Posgai, Amanda L.;
Nick, Harry S.;
Schatz, Desmond;
Atkinson, Mark A.;
Wasserfall, Clive H.

Publication type:

Article

Sulfatide Preserves Insulin Crystals Not by Being Integrated in the Lattice but by Stabilizing Their Surface.

Published in:

Journal of Diabetes Research, 2016, p. 1, doi. 10.1155/2016/6179635

By:

Buschard, Karsten;
Bracey, Austin W.;
McElroy, Daniel L.;
Magis, Andrew T.;
Osterbye, Thomas;
Atkinson, Mark A.;
Bailey, Kate M.;
Posgai, Amanda L.;
Ostrov, David A.

Publication type:

Article

Immune Mechanisms and Pathways Targeted in Type 1 Diabetes.

Published in:

2018

By:

Jacobsen, Laura M.;
Newby, Brittney N.;
Perry, Daniel J.;
Posgai, Amanda L.;
Haller, Michael J.;
Brusko, Todd M.

Publication type:

journal article

The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes.

Published in:

Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.739048

By:

Sharp, Robert C.;
Brown, Matthew E.;
Shapiro, Melanie R.;
Posgai, Amanda L.;
Brusko, Todd M.

Publication type:

Article

CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.

Published in:

Frontiers in Immunology, 2020, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.02180

By:

Shapiro, Melanie R.;
Yeh, Wen-I;
Longfield, Joshua R.;
Gallagher, John;
Infante, Caridad M.;
Wellford, Sarah;
Posgai, Amanda L.;
Atkinson, Mark A.;
Campbell-Thompson, Martha;
Lieberman, Scott M.;
Serreze, David V.;
Geurts, Aron M.;
Chen, Yi-Guang;
Brusko, Todd M.

Publication type:

Article

Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.

Published in:

2016

By:

Haller, Michael J.;
Gitelman, Stephen E.;
Gottlieb, Peter A.;
Michels, Aaron W.;
Perry, Daniel J.;
Schultz, Andrew R.;
Hulme, Maigan A.;
Shuster, Jonathan J.;
Baiming Zou;
Wasserfall, Clive H.;
Posgai, Amanda L.;
Mathews, Clayton E.;
Brusko, Todd M.;
Atkinson, Mark A.;
Schatz, Desmond A.;
Zou, Baiming

Publication type:

journal article

Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes.

Published in:

Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.01313

By:

Wen-I Yeh;
Seay, Howard R.;
Newby, Brittney;
Posgai, Amanda L.;
Moniz, Filipa Botelho;
Michels, Aaron;
Mathews, Clayton E.;
Bluestone, Jeffrey A.;
Brusko, Todd M.

Publication type:

Article

Immune Depletion in Combination with Allogeneic Islets Permanently Restores Tolerance to Self-Antigens in Diabetic NOD Mice.

Published in:

PLoS ONE, 2015, v. 10, n. 11, p. 1, doi. 10.1371/journal.pone.0142318

By:

Gagliani, Nicola;
Jofra, Tatiana;
Posgai, Amanda L.;
Atkinson, Mark A.;
Battaglia, Manuela

Publication type:

Article

Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood.

Published in:

Frontiers in Immunology, 2020, p. 1, doi. 10.3389/fimmu.2020.00611

By:

Motwani, Keshav;
Peters, Leeana D.;
Vliegen, Willem H.;
El-sayed, Ahmed Gomaa;
Seay, Howard R.;
Lopez, M. Cecilia;
Baker, Henry V.;
Posgai, Amanda L.;
Brusko, Maigan A.;
Perry, Daniel J.;
Bacher, Rhonda;
Larkin, Joseph;
Haller, Michael J.;
Brusko, Todd M.

Publication type:

Article

The Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D): An NIDDK Initiative to Advance Understanding of Mechanisms Underlying Cardiovascular Disease in Type 1 Versus Type 2 Diabetes.

Published in:

Diabetes, 2025, v. 74, n. 7, p. 1078, doi. 10.2337/db25-0017

By:

Jones, Teresa L.Z.;
Kusmartseva, Irina;
Litovsky, Silvio;
Thakar, Rahul;
Posgai, Amanda L.;
Eckel, Robert H.;
Atkinson, Mark A.

Publication type:

Article

Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability.

Published in:

Diabetes, 2023, v. 72, n. 11, p. 1629, doi. 10.2337/db23-0307

By:

Thirawatananond, Puchong;
Brown, Matthew E.;
Sachs, Lindsey K.;
Arnoletti, Juan M.;
Yeh, Wen-I;
Posgai, Amanda L.;
Shapiro, Melanie R.;
Chen, Yi-Guang;
Brusko, Todd M.

Publication type:

Article

Incidence Trends of New-Onset Diabetes in Children and Adolescents Before and During the COVID-19 Pandemic: Findings from Florida.

Published in:

Diabetes, 2022, v. 71, n. 12, p. 2702, doi. 10.2337/db22-0549

By:

Guo, Yi;
Bian, Jiang;
Chen, Aokun;
Wang, Fei;
Posgai, Amanda L.;
Schatz, Desmond A.;
Shenkman, Elizabeth A.;
Atkinson, Mark A.

Publication type:

Article

Erratum. The Women's Leadership Gap in Diabetes: A Call for Equity and Excellence. Diabetes 2021;70:1623-1633.

Published in:

2022

By:

Dunne, Jessica L.;
Maizel, Jennifer L.;
Posgai, Amanda L.;
Atkinson, Mark A.;
DiMeglio, Linda A.

Publication type:

corrected article

Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes.

Published in:

2021

By:

Hiller, Helmut;
Beachy, Dawn E.;
Lebowitz, Joseph J.;
Engler, Stefanie;
Mason, Justin R.;
Miller, Douglas R.;
Kusmarteva, Irina;
Jacobsen, Laura M.;
Posgai, Amanda L.;
Khoshbouei, Habibeh;
Oram, Richard A.;
Schatz, Desmond A.;
Hattersley, Andrew T.;
Bodenmiller, Bernd;
Atkinson, Mark A.;
Nick, Harry S.;
Wasserfall, Clive H.;
Lebowitz, Joeseph J

Publication type:

journal article

The Women's Leadership Gap in Diabetes: A Call for Equity and Excellence.

Published in:

2021

By:

Dunne, Jessica L.;
Maizel, Jennifer L.;
Posgai, Amanda L.;
Atkinson, Mark A.;
DiMeglio, Linda A.

Publication type:

journal article

Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report.

Published in:

Diabetes, 2021, v. 70, n. 5, p. 1123, doi. 10.2337/db20-1103

By:

Lin, Andrea;
Mack, Jasmine A.;
Bruggeman, Brittany;
Jacobsen, Laura M.;
Posgai, Amanda L.;
Wasserfall, Clive H.;
Brusko, Todd M.;
Atkinson, Mark A.;
Gitelman, Stephen E.;
Gottlieb, Peter A.;
Gurka, Matthew J.;
Mathews, Clayton E.;
Schatz, Desmond A.;
Haller, Michael J.

Publication type:

Article

How Do We Move Type 1 Diabetes Immunotherapies Forward During the Current COVID-19 Pandemic?

Published in:

Diabetes, 2021, v. 70, n. 5, p. 1021, doi. 10.2337/dbi20-0045

By:

Haller, Michael J.;
Jacobsen, Laura M.;
Posgai, Amanda L.;
Schatz, Desmond A.

Publication type:

Article

Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size.

Published in:

2021

By:

Ross, James J.;
Wasserfall, Clive H.;
Bacher, Rhonda;
Perry, Daniel J.;
McGrail, Kieran;
Posgai, Amanda L.;
Dong, Xiaoru;
Muir, Andrew;
Li, Xia;
Campbell-Thompson, Martha;
Brusko, Todd M.;
Schatz, Desmond A.;
Haller, Michael J.;
Atkinson, Mark A.

Publication type:

journal article

Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis.

Published in:

2021

By:

Williams, MacKenzie D.;
Bacher, Rhonda;
Perry, Daniel J.;
Grace, C. Ramsey;
McGrail, Kieran M.;
Posgai, Amanda L.;
Muir, Andrew;
Chamala, Srikar;
Haller, Michael J.;
Schatz, Desmond A.;
Brusko, Todd M.;
Atkinson, Mark A.;
Wasserfall, Clive H.

Publication type:

journal article

1663-P: Gene Editing of the Human T-Cell Receptor Locus Enables Optimized In Vitro Testing of Autoreactive T-Cell Function in Type 1 Diabetes.

Published in:

Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-1663-P

By:

PETERS, LEEANA D.;
POSGAI, AMANDA L.;
BRUSKO, TODD M.

Publication type:

Article

Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis.

Published in:

2020

By:

Shapiro, Melanie R.;
Wasserfall, Clive H.;
McGrail, Sean M.;
Posgai, Amanda L.;
Bacher, Rhonda;
Muir, Andrew;
Haller, Michael J.;
Schatz, Desmond A.;
Wesley, Johnna D.;
von Herrath, Matthias;
Hagopian, William A.;
Speake, Cate;
Atkinson, Mark A.;
Brusko, Todd M.

Publication type:

journal article

1366-P: Effect of Substance Use on Type 1 Diabetes (T1D) Pancreas Histopathology.

Published in:

Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-1366-P

By:

BRUGGEMAN, BRITTANY S.;
CAMPBELL-THOMPSON, MARTHA;
POSGAI, AMANDA L.;
ATKINSON, MARK A.;
SCHATZ, DESMOND;
JACOBSEN, LAURA M.

Publication type:

Article

A genomic data archive from the Network for Pancreatic Organ donors with Diabetes.

Published in:

Scientific Data, 2023, v. 10, n. 1, p. 1, doi. 10.1038/s41597-023-02244-6

By:

Perry, Daniel J.;
Shapiro, Melanie R.;
Chamberlain, Sonya W.;
Kusmartseva, Irina;
Chamala, Srikar;
Balzano-Nogueira, Leandro;
Yang, Mingder;
Brant, Jason O.;
Brusko, Maigan;
Williams, MacKenzie D.;
McGrail, Kieran M.;
McNichols, James;
Peters, Leeana D.;
Posgai, Amanda L.;
Kaddis, John S.;
Mathews, Clayton E.;
Wasserfall, Clive H.;
Webb-Robertson, Bobbie-Jo M.;
Campbell-Thompson, Martha;
Schatz, Desmond

Publication type:

Article

Plant-based vaccines for oral delivery of type 1 diabetes-related autoantigens: Evaluating oral tolerance mechanisms and disease prevention in NOD mice.

Published in:

Scientific Reports, 2017, p. 42372, doi. 10.1038/srep42372

By:

Posgai, Amanda L.;
Wasserfall, Clive H.;
Kwon, Kwang-Chul;
Daniell, Henry;
Schatz, Desmond A.;
Atkinson, Mark A.

Publication type:

Article

Human CD4+CD25+CD226- Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4+CD25+CD127lo/- Tregs for Adoptive Cell Therapy.

Published in:

Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.873560

By:

Brown, Matthew E.;
Peters, Leeana D.;
Hanbali, Seif R.;
Arnoletti, Juan M.;
Sachs, Lindsey K.;
Nguyen, Kayla Q.;
Carpenter, Emma B.;
Seay, Howard R.;
Fuhrman, Christopher A.;
Posgai, Amanda L.;
Shapiro, Melanie R.;
Brusko, Todd M.

Publication type:

Article

Works by Posgai, Amanda L.

Modeling cell-mediated immunity in human type 1 diabetes by engineering autoreactive CD8<sup>+</sup> T cells.

Response to Comment on Dunne et al. The Women's Leadership Gap in Diabetes: A Call for Equity and Excellence. Diabetes Care 2021;44:1734-1743.

The Women's Leadership Gap in Diabetes: A Call for Equity and Excellence.

Diagnostic Dilemma: Clinical and Histological Abnormalities in a Hispanic Patient With Diabetes.

Exocrine and Endocrine Inflammation Increases Cellular Replication in the Pancreatic Duct Compartment in Type 1 Diabetes.

De‐coding genetic risk variants in type 1 diabetes.

Guidelines for standardizing T‐cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes.

Biomaterials‐based nanoparticles conjugated to regulatory T cells provide a modular system for localized delivery of pharmacotherapeutic agents.

Leveraging artificial intelligence and machine learning to accelerate discovery of disease-modifying therapies in type 1 diabetes.

Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function.

The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium.

Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrP<sup>C</sup>, in type 1 diabetes.

Sulfatide Preserves Insulin Crystals Not by Being Integrated in the Lattice but by Stabilizing Their Surface.

Immune Mechanisms and Pathways Targeted in Type 1 Diabetes.

The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes.

CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.

Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.

Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes.

Immune Depletion in Combination with Allogeneic Islets Permanently Restores Tolerance to Self-Antigens in Diabetic NOD Mice.

Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood.

The Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D): An NIDDK Initiative to Advance Understanding of Mechanisms Underlying Cardiovascular Disease in Type 1 Versus Type 2 Diabetes.

Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability.

Incidence Trends of New-Onset Diabetes in Children and Adolescents Before and During the COVID-19 Pandemic: Findings from Florida.

Erratum. The Women's Leadership Gap in Diabetes: A Call for Equity and Excellence. Diabetes 2021;70:1623-1633.

Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes.

The Women's Leadership Gap in Diabetes: A Call for Equity and Excellence.

Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report.

How Do We Move Type 1 Diabetes Immunotherapies Forward During the Current COVID-19 Pandemic?

Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size.

Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis.

1663-P: Gene Editing of the Human T-Cell Receptor Locus Enables Optimized In Vitro Testing of Autoreactive T-Cell Function in Type 1 Diabetes.

Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis.

1366-P: Effect of Substance Use on Type 1 Diabetes (T1D) Pancreas Histopathology.

A genomic data archive from the Network for Pancreatic Organ donors with Diabetes.

Plant-based vaccines for oral delivery of type 1 diabetes-related autoantigens: Evaluating oral tolerance mechanisms and disease prevention in NOD mice.

Human CD4<sup>+</sup>CD25<sup>+</sup>CD226<sup>-</sup> Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4<sup>+</sup>CD25<sup>+</sup>CD127<sup>lo/-</sup> Tregs for Adoptive Cell Therapy.