Works by Porta, Sílvia

Results: 19

Anti‐epilepsy drug therapy in a dox‐regulatable TDP‐43 mouse model of ALS‐FTD with seizures.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S8, p. 1, doi. 10.1002/alz.095761

By:

Ra, Irene;
Jia, Elizabeth;
Gujral, Jaskreet;
Rodemer, William;
Porta, Sílvia;
Lee, Virginia M.‐Y.

Publication type:

Article

Evaluate the Efficacy of the Axl inhibitor Bemcentinib in the 5xFAD mouse model of Alzheimer's Disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.089525

By:

Chen, Guyin;
Ozturk, Gizem;
Porta, Sílvia;
Lee, Virginia M.‐Y.

Publication type:

Article

Exploring the pathophysiological consequences of TDP‐43 mislocalization in retinal cells.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.088965

By:

Sørensen, Maja Højvang;
Xu, Yan;
Lee, Virginia M.‐Y.;
Porta, Sílvia

Publication type:

Article

A myriad of miRNA variants in control and Huntington’s disease brain regions detected by massively parallel sequencing.

Published in:

Nucleic Acids Research, 2010, v. 38, n. 20, p. 7219

By:

Martí, Eulàlia;
Pantano, Lorena;
Bañez-Coronel, Mónica;
Llorens, Franc;
Miñones-Moyano, Elena;
Porta, Sílvia;
Sumoy, Lauro;
Ferrer, Isidre;
Estivill, Xavier

Publication type:

Article

DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease.

Published in:

Human Molecular Genetics, 2008, v. 17, n. 7, p. 1020, doi. 10.1093/hmg/ddm374

By:

Keating, Damien J.;
Dubach, Daphne;
Zanin, Mark P.;
Yu, Yong;
Martin, Katherine;
Zhao, Yu-Feng;
Chen, Chen;
Porta, Sílvia;
Arbonés, Maria L.;
Mittaz, Laureane;
Pritchard, Melanie A.

Publication type:

Article

RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration.

Published in:

Human Molecular Genetics, 2007, v. 16, n. 9, p. 1039, doi. 10.1093/hmg/ddm049

By:

Porta, Sílvia;
Serra, Selma A.;
Huch, Meritxell;
Valverde, Miguel A.;
Llorens, Franc;
Estivill, Xavier;
Arbonés, Maria L.;
Martí, Eulàlia

Publication type:

Article

Distinct brain‐derived TDP‐43 strains from FTLD‐TDP subtypes induce diverse morphological TDP‐43 aggregates and spreading patterns in vitro and in vivo.

Published in:

Neuropathology & Applied Neurobiology, 2021, v. 47, n. 7, p. 1033, doi. 10.1111/nan.12732

By:

Porta, Sílvia;
Xu, Yan;
Lehr, Tagan;
Zhang, Bin;
Meymand, Emily;
Olufemi, Modupe;
Stieber, Anna;
Lee, Edward B.;
Trojanowski, John Q.;
Lee, Virginia M.‐Y.

Publication type:

Article

Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease.

Published in:

Acta Neuropathologica, 2022, v. 143, n. 1, p. 15, doi. 10.1007/s00401-021-02383-3

By:

Uemura, Maiko T.;
Robinson, John L.;
Cousins, Katheryn A. Q.;
Tropea, Thomas F.;
Kargilis, Daniel C.;
McBride, Jennifer D.;
Suh, EunRan;
Xie, Sharon X.;
Xu, Yan;
Porta, Sílvia;
Uemura, Norihito;
Van Deerlin, Vivianna M.;
Wolk, David A.;
Irwin, David J.;
Brunden, Kurt R.;
Lee, Virginia M.-Y.;
Lee, Edward B.;
Trojanowski, John Q.

Publication type:

Article

TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy.

Published in:

Acta Neuropathologica, 2021, v. 142, n. 4, p. 629, doi. 10.1007/s00401-021-02330-2

By:

Mao, Fei;
Robinson, John L.;
Unger, Travis;
Posavi, Marijan;
Amado, Defne A.;
Elman, Lauren;
Grossman, Murray;
Wolk, David A.;
Lee, Edward B.;
Van Deerlin, Vivianna M.;
Porta, Sílvia;
Lee, Virginia M. Y.;
Trojanowski, John Q.;
Chen-Plotkin, Alice S.

Publication type:

Article

Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration.

Published in:

Acta Neuropathologica, 2017, v. 134, n. 1, p. 65, doi. 10.1007/s00401-017-1679-9

By:

Lee, Edward;
Porta, Sílvia;
Michael Baer, G.;
Xu, Yan;
Suh, EunRan;
Kwong, Linda;
Elman, Lauren;
Grossman, Murray;
Lee, Virginia;
Irwin, David;
Deerlin, Vivianna;
Trojanowski, John

Publication type:

Article

Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity.

Published in:

Nature Communications, 2018, v. 9, p. 1, doi. 10.1038/s41467-018-06543-0

By:

Chung, Chia-Yu;
Berson, Amit;
Kennerdell, Jason R.;
Sartoris, Ashley;
Unger, Travis;
Porta, Sílvia;
Kim, Hyung-Jun;
Smith, Edwin R.;
Shilatifard, Ali;
Van Deerlin, Vivianna;
Lee, Virginia M.-Y.;
Chen-Plotkin, Alice;
Bonini, Nancy M.

Publication type:

Article

Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06548-9

By:

Porta, Sílvia;
Xu, Yan;
Restrepo, Clark R.;
Kwong, Linda K.;
Zhang, Bin;
Brown, Hannah J.;
Lee, Edward B.;
Trojanowski, John Q.;
Lee, Virginia M.-Y.

Publication type:

Article

Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration.

Published in:

2020

By:

Robinson, John L;
Porta, Sílvia;
Garrett, Filip G;
Zhang, Panpan;
Xie, Sharon X;
Suh, EunRan;
Deerlin, Vivianna M Van;
Abner, Erin L;
Jicha, Gregory A;
Barber, Justin M;
Lee, Virginia M -Y;
Lee, Edward B;
Trojanowski, John Q;
Nelson, Peter T;
Van Deerlin, Vivianna M

Publication type:

journal article

Upregulation of a small vault RNA (svtRNA2-1a) is an early event in parkinson disease and induces neuronal dysfunction.

Published in:

RNA Biology, 2013, v. 10, n. 7, p. 1093, doi. 10.4161/rna.24813

By:

Miñones-Moyano, Elena;
Friedländer, Marc R.;
Pallares, Joan;
Kagerbauer, Birgit;
Porta, Sílvia;
Escaramís, Georgia;
Ferrer, Isidre;
Estivill, Xavier;
Martí, Eulàlia

Publication type:

Article

Biochemical and molecular heterogeneity of human TDP‐43 proteinopathies in age‐related dementias.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.075524

By:

Porta, Sílvia

Publication type:

Article

Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 13, p. 3025, doi. 10.1093/hmg/dds134

By:

Martin, Katherine R.;
Corlett, Alicia;
Dubach, Daphne;
Mustafa, Tomris;
Coleman, Harold A.;
Parkington, Helena C.;
Merson, Tobias D.;
Bourne, James A.;
Porta, Sílvia;
Arbonés, Maria L.;
Finkelstein, David I.;
Pritchard, Melanie A.

Publication type:

Article

MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function.

Published in:

Human Molecular Genetics, 2011, v. 20, n. 15, p. 3067

By:

Miñones-Moyano, Elena;
Porta, Sílvia;
Escaramís, Georgia;
Rabionet, Raquel;
Iraola, Susana;
Kagerbauer, Birgit;
Espinosa-Parrilla, Yolanda;
Ferrer, Isidre;
Estivill, Xavier;
Martí, Eulàlia

Publication type:

Article

Author Correction: Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-08562-x

By:

Chung, Chia-Yu;
Berson, Amit;
Kennerdell, Jason R.;
Sartoris, Ashley;
Unger, Travis;
Porta, Sílvia;
Kim, Hyung-Jun;
Smith, Edwin R.;
Shilatifard, Ali;
Van Deerlin, Vivianna;
Lee, Virginia M. -Y.;
Chen-Plotkin, Alice;
Bonini, Nancy M.

Publication type:

Article

Differential expression of members of the RCAN family of calcineurin regulators suggests selective functions for these proteins in the brain.

Published in:

European Journal of Neuroscience, 2007, v. 26, n. 5, p. 1213, doi. 10.1111/j.1460-9568.2007.05749.x

By:

Porta, Sílvia;
Martí, Eulàlia;
De La Luna, Susana;
Arbonés, Maria L.

Publication type:

Article