Works by Popel, Aleksander

Results: 112

Generating immunogenomic data-guided virtual patients using a QSP model to predict response of advanced NSCLC to PD-L1 inhibition.

Published in:

NPJ Precision Oncology, 2023, v. 7, n. 1, p. 1, doi. 10.1038/s41698-023-00405-9

By:

Wang, Hanwen;
Arulraj, Theinmozhi;
Kimko, Holly;
Popel, Aleksander S.

Publication type:

Article

Author Correction: Deciphering microvascular changes after myocardial infarction through 3D fully automated image analysis.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-32598-6

By:

Gkontra, Polyxeni;
Norton, Kerri-Ann;
Żak, Magdalena M.;
Clemente, Cristina;
Agüero, Jaume;
Ibáñez, Borja;
Santos, Andrés;
Popel, Aleksander S.;
Arroyo, Alicia G.

Publication type:

Article

Antiangiogenic cancer drug sunitinib exhibits unexpected proangiogenic effects on endothelial cells.

Published in:

OncoTargets & Therapy, 2014, v. 7, p. 1571, doi. 10.2147/OTT.S65055

By:

Norton, Kerri-Ann;
Zheyi Han;
Popel, Aleksander S.;
Pandey, Niranjan B.

Publication type:

Article

The tumor microenvironment and triple-negative breast cancer aggressiveness: shedding light on mechanisms and targeting.

Published in:

Expert Opinion on Therapeutic Targets, 2022, v. 26, n. 12, p. 1041, doi. 10.1080/14728222.2022.2170779

By:

Furukawa, Natsuki;
Stearns, Vered;
Santa-Maria, Cesar A.;
Popel, Aleksander S.

Publication type:

Article

Pentastatin-1, a collagen IV derived 20-mer peptide, suppresses tumor growth in a small cell lung cancer xenograft model.

Published in:

BMC Cancer, 2010, v. 10, p. 1, doi. 10.1186/1471-2407-10-29

By:

Koskimaki, Jacob E.;
Karagiannis, Emmanouil D.;
Tang, Benjamin C.;
Hammers, Hans;
Watkins, D. Neil;
Pili, Roberto;
Popel, Aleksander S.

Publication type:

Article

Experiment-based computational model predicts that IL-6 classic and trans-signaling exhibit similar potency in inducing downstream signaling in endothelial cells.

Published in:

NPJ Systems Biology & Applications, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41540-023-00308-2

By:

Song, Min;
Wang, Youli;
Annex, Brian H.;
Popel, Aleksander S.

Publication type:

Article

A systems biology model of junctional localization and downstream signaling of the Ang–Tie signaling pathway.

Published in:

NPJ Systems Biology & Applications, 2021, v. 7, n. 1, p. 1, doi. 10.1038/s41540-021-00194-6

By:

Zhang, Yu;
Kontos, Christopher D.;
Annex, Brian H.;
Popel, Aleksander S.

Publication type:

Article

Mechanistically detailed systems biology modeling of the HGF/Met pathway in hepatocellular carcinoma.

Published in:

NPJ Systems Biology & Applications, 2019, v. 5, n. 1, p. N.PAG, doi. 10.1038/s41540-019-0107-2

By:

Jafarnejad, Mohammad;
Sové, Richard J.;
Danilova, Ludmila;
Mirando, Adam C.;
Zhang, Yu;
Yarchoan, Mark;
Tran, Phuoc T.;
Pandey, Niranjan B.;
Fertig, Elana J.;
Popel, Aleksander S.

Publication type:

Article

Eliciting the antitumor immune response with a conditionally activated PD‐L1 targeting antibody analyzed with a quantitative systems pharmacology model.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 1, p. 93, doi. 10.1002/psp4.13060

By:

Ippolito, Alberto;
Wang, Hanwen;
Zhang, Yu;
Vakil, Vahideh;
Bazzazi, Hojjat;
Popel, Aleksander S.

Publication type:

Article

QSP‐IO: A Quantitative Systems Pharmacology Toolbox for Mechanistic Multiscale Modeling for Immuno‐Oncology Applications.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 9, p. 484, doi. 10.1002/psp4.12546

By:

Sové, Richard J.;
Jafarnejad, Mohammad;
Zhao, Chen;
Wang, Hanwen;
Ma, Huilin;
Popel, Aleksander S.

Publication type:

Article

Red blood cell velocity profiles in skeletal muscle venules at low flow rates are described by the Casson model.

Published in:

Clinical Hemorheology & Microcirculation, 2007, v. 36, n. 3, p. 217

By:

Das, Bigyani;
Bishop, Jeffrey J.;
Kim, Sangho;
Meiselman, Herbert J.;
Johnson, Paul C.;
Popel, Aleksander S.

Publication type:

Article

Computational drug repositioning for peripheral arterial disease: prediction of anti-inflammatory and pro-angiogenic therapeutics.

Published in:

Frontiers in Pharmacology, 2015, p. 1, doi. 10.3389/fphar.2015.00179

By:

Liang-Hui Chu;
Annex, Brian H.;
Popel, Aleksander S.;
Azevedo, Luis;
Moreira-Rodrigues, Mónica Isa

Publication type:

Article

Endothelial cells decode VEGF-mediated Ca<sup>2+</sup> signaling patterns to produce distinct functional responses.

Published in:

Science Signaling, 2016, v. 9, n. 416, p. 1, doi. 10.1126/scisignal.aad3188

By:

Noren, David P.;
Chou, Wesley H.;
Sung Hoon Lee;
Qutub, Amina A.;
Warmflash, Aryeh;
Wagner, Daniel S.;
Popel, Aleksander S.;
Levchenko, Andre

Publication type:

Article

A Biomimetic Collagen Derived Peptide Exhibits Anti-Angiogenic Activity in Triple Negative Breast Cancer.

Published in:

PLoS ONE, 2014, v. 9, n. 11, p. 1, doi. 10.1371/journal.pone.0111901

By:

Rosca, Elena V.;
Penet, Marie-France;
Mori, Noriko;
Koskimaki, Jacob E.;
Lee, Esak;
Pandey, Niranjan B.;
Bhujwalla, Zaver M.;
Popel, Aleksander S.

Publication type:

Article

Angiogenesis Interactome and Time Course Microarray Data Reveal the Distinct Activation Patterns in Endothelial Cells.

Published in:

PLoS ONE, 2014, v. 9, n. 10, p. 1, doi. 10.1371/journal.pone.0110871

By:

Chu, Liang-Hui;
Lee, Esak;
Bader, Joel S.;
Popel, Aleksander S.

Publication type:

Article

Computational Model of Gab1/2-Dependent VEGFR2 Pathway to Akt Activation.

Published in:

PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0067438

By:

Tan, Wan Hua;
Popel, Aleksander S.;
Mac Gabhann, Feilim

Publication type:

Article

Expression of VEGF Receptors on Endothelial Cells in Mouse Skeletal Muscle.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0044791

By:

Imoukhuede, Princess I.;
Popel, Aleksander S.;
Madeddu, Paolo

Publication type:

Article

Effects of Fiber Type and Size on the Heterogeneity of Oxygen Distribution in Exercising Skeletal Muscle.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0044375

By:

Gang Liu;
Gabhann, Feilim Mac;
Popel, Aleksander S.;
Secomb, Timothy W.

Publication type:

Article

A Two-Compartment Model of VEGF Distribution in the Mouse.

Published in:

PLoS ONE, 2011, v. 6, n. 11, p. 1, doi. 10.1371/journal.pone.0027514

By:

Yen, Phillip;
Finley, Stacey D.;
Engel-Stefanini, Marianne O.;
Popel, Aleksander S.

Publication type:

Article

Analysis of VEGF-A Regulated Gene Expression in Endothelial Cells to Identify Genes Linked to Angiogenesis.

Published in:

PLoS ONE, 2011, v. 6, n. 9, p. 1, doi. 10.1371/journal.pone.0024887

By:

Rivera, Corban G.;
Mellberg, Sofie;
Claesson-Welsh, Lena;
Bader, Joel S.;
Popel, Aleksander S.

Publication type:

Article

Quantifying the Proteolytic Release of Extracellular Matrix-Sequestered VEGF with a Computational Model.

Published in:

PLoS ONE, 2010, v. 5, n. 7, p. 1, doi. 10.1371/journal.pone.0011860

By:

Vempati, Prakash;
Gabhann, Feilim Mac;
Popel, Aleksander S.

Publication type:

Article

A Compartment Model of VEGF Distribution in Humans in the Presence of Soluble VEGF Receptor-1 Acting as a Ligand Trap.

Published in:

PLoS ONE, 2009, v. 4, n. 4, p. 1, doi. 10.1371/journal.pone.0005108

By:

Wu, Florence T. H.;
Stefanini, Marianne O.;
Gabhann, Feilim Mac;
Popel, Aleksander S.

Publication type:

Article

Structure-Activity Relationship Study of Collagen-Derived Anti-Angiogenic Biomimetic Peptides.

Published in:

Chemical Biology & Drug Design, 2012, v. 80, n. 1, p. 27, doi. 10.1111/j.1747-0285.2012.01376.x

By:

Rosca, Elena V.;
Koskimaki, Jacob E.;
Pandey, Niranjan B.;
Tamiz, Amir P.;
Popel, Aleksander S.

Publication type:

Article

Endothelial Regulation of Microvascular Growth and Stability by Ang‐Tie and VEGF Signaling Pathways: A Mechanistic Computational Systems Biology Model.

Published in:

FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R2072

By:

Zhang, Yu;
Kontos, Christopher D.;
Annex, Brian H.;
Popel, Aleksander S.

Publication type:

Article

Image‐Based Modeling of the Invasive Vascular Front in Breast Cancer.

Published in:

FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.04594

By:

Bhargava, Akanksha;
Popel, Aleksander;
Pathak, Arvind

Publication type:

Article

Computational Systems Biology Modeling of the Angiopoietin‐Tie Signaling Pathway and its Crosstalk with α5β1 Integrin in Endothelial Cells.

Published in:

FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.02368

By:

Zhang, Yu;
Kontos, Christopher;
Annex, Brian;
Popel, Aleksander

Publication type:

Article

Identification of morphological and hemodynamic biomarkers for tumor vascular perfusion through mathematical modeling and high‐resolution imaging.

Published in:

FASEB Journal, 2013, v. 27, p. 685.12, doi. 10.1096/fasebj.27.1_supplement.685.12

By:

Stamatelos, Spyros K;
Kim, Eugene;
Pathak, Arvind P;
Popel, Aleksander S

Publication type:

Article

Nitric Oxide Delivered By Intraerythrocytic SNOHb To Vascular Smooth Muscle: A Theoretical Analysis.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A1231, doi. 10.1096/fasebj.21.6.a1231-a

By:

Kejing Chen;
Pittman, Roland N.;
Popel, Aleksander S.

Publication type:

Article

Computational Modeling of Enzymatic Nitric Oxide Production And Transport In The Microvasculature.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A1218, doi. 10.1096/fasebj.21.6.a1218-a

By:

Chen, Kejing;
Popel, Aleksander S.

Publication type:

Article

Combinations of pro-angiogenic therapies targeting VEGF and VEGF receptors outperform monotherapies in computational models of human skeletal muscle.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A1214

By:

Gabhann, Feilim Mac;
Popel, Aleksander S.

Publication type:

Article

Three autocrine feedback loops determine HIF1α expression in chronic hypoxia.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A857, doi. 10.1096/fasebj.21.6.a857

By:

Qutub, Amina Ann;
Popel, Aleksander S.

Publication type:

Article

Local stimulation of angiogenesis following cell-based therapy in peripheral arterial disease: computational simulations.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A856

By:

Gabhann, Feilim Mac;
Ji, James W.;
Popel, Aleksander S.

Publication type:

Article

Comparison of anti-angiogenesis drugs targeting VEGF receptors and the VEGF co-receptor Neuropilin.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A747

By:

Gabhann, Feilim Mac;
Popel, Aleksander S.

Publication type:

Article

An experimental and theoretical study on the dissolution of mural fibrin clots by tissue-type plasminogen activator.

Published in:

Biotechnology & Bioengineering, 2002, v. 77, n. 4, p. 405, doi. 10.1002/bit.10127

By:

Wootton, David M.;
Popel, Aleksander S.;
Rita Alevriadou, B.

Publication type:

Article

Multiscale Modeling in the Clinic: Drug Design and Development.

Published in:

Annals of Biomedical Engineering, 2016, v. 44, n. 9, p. 2591, doi. 10.1007/s10439-016-1563-0

By:

Clancy, Colleen;
An, Gary;
Cannon, William;
Liu, Yaling;
May, Elebeoba;
Ortoleva, Peter;
Popel, Aleksander;
Sluka, James;
Su, Jing;
Vicini, Paolo;
Zhou, Xiaobo;
Eckmann, David

Publication type:

Article

Multi-scale Modeling in Clinical Oncology: Opportunities and Barriers to Success.

Published in:

Annals of Biomedical Engineering, 2016, v. 44, n. 9, p. 2626, doi. 10.1007/s10439-016-1691-6

By:

Yankeelov, Thomas;
An, Gary;
Saut, Oliver;
Luebeck, E.;
Popel, Aleksander;
Ribba, Benjamin;
Vicini, Paolo;
Zhou, Xiaobo;
Weis, Jared;
Ye, Kaiming;
Genin, Guy

Publication type:

Article

Multiscale Imaging and Computational Modeling of Blood Flow in the Tumor Vasculature.

Published in:

Annals of Biomedical Engineering, 2012, v. 40, n. 11, p. 2425, doi. 10.1007/s10439-012-0585-5

By:

Kim, Eugene;
Stamatelos, Spyros;
Cebulla, Jana;
Bhujwalla, Zaver;
Popel, Aleksander;
Pathak, Arvind

Publication type:

Article

Angiogenesis-Associated Crosstalk Between Collagens, CXC Chemokines, and Thrombospondin Domain-Containing Proteins.

Published in:

Annals of Biomedical Engineering, 2011, v. 39, n. 8, p. 2213, doi. 10.1007/s10439-011-0325-2

By:

Rivera, Corban;
Bader, Joel;
Popel, Aleksander

Publication type:

Article

Multi-scale Computational Models of Pro-angiogenic Treatments in Peripheral Arterial Disease.

Published in:

Annals of Biomedical Engineering, 2007, v. 35, n. 6, p. 982, doi. 10.1007/s10439-007-9303-0

By:

Feilim Mac Gabhann;
James Ji;
Aleksander Popel

Publication type:

Article

Protein Transport to Choroid and Retina following Periocular Injection: Theoretical and Experimental Study.

Published in:

Annals of Biomedical Engineering, 2007, v. 35, n. 4, p. 615, doi. 10.1007/s10439-006-9238-x

By:

Feilim Mac Gabhann;
Anna Demetriades;
Tye Deering;
Jonathan Packer;
Syed Shah;
Elia Duh;
Peter Campochiaro;
Aleksander Popel

Publication type:

Article

Systems biology of angiogenesis signaling: Computational models and omics.

Published in:

WIREs: Mechanisms of Disease, 2022, v. 14, n. 4, p. 1, doi. 10.1002/wsbm.1550

By:

Zhang, Yu;
Wang, Hanwen;
Oliveira, Rebeca Hannah M.;
Zhao, Chen;
Popel, Aleksander S.

Publication type:

Article

Effect of Tumor Microenvironment on Tumor VEGF During Anti-VEGF Treatment: Systems Biology Predictions.

Published in:

JNCI: Journal of the National Cancer Institute, 2013, v. 105, n. 11, p. 802, doi. 10.1093/jnci/djt093

By:

Finley, Stacey D.;
Popel, Aleksander S.

Publication type:

Article

Development of a biomimetic peptide derived from collagen IV with anti-angiogenic activity in breast cancer.

Published in:

Cancer Biology & Therapy, 2011, v. 12, n. 9, p. 808, doi. 10.4161/cbt.12.9.17677

By:

Rosca, Elena V.;
Koskimaki, Jacob E.;
Pandey, Niranjan B.;
Wolff, Antonio C.;
Popel, Aleksander S.

Publication type:

Article

Trans-scleral Delivery of Antiangiogenic Proteins.

Published in:

Journal of Ocular Pharmacology & Therapeutics, 2008, v. 24, n. 1, p. 70, doi. 10.1089/jop.2007.0061

By:

Demetriades, Anna M.;
Deering, Tye;
Liu, Hansheng;
Lu, Lili;
Gehlbach, Peter;
Packer, Jonathan D.;
Gabhann, Feilim Mac;
Popel, Aleksander S.;
Wei, Lisa L.;
Campochiaro, Peter A.

Publication type:

Article

Biomimetic peptide display from a polymeric nanoparticle surface for targeting and antitumor activity to human triple‐negative breast cancer cells.

Published in:

Journal of Biomedical Materials Research, Part A, 2018, v. 106, n. 6, p. 1753, doi. 10.1002/jbm.a.36360

By:

Bressler, Eric M.;
Kim, Jayoung;
Shmueli, Ron B.;
Mirando, Adam C.;
Bazzazi, Hojjat;
Lee, Esak;
Popel, Aleksander S.;
Pandey, Niranjan B.;
Green, Jordan J.

Publication type:

Article

Targeting Neuropilin-1 to Inhibit VEGF Signaling in Cancer: Comparison of Therapeutic Approaches.

Published in:

PLoS Computational Biology, 2006, v. 2, n. 12, p. 1649, doi. 10.1371/journal.pcbi.0020180

By:

Gabhann, Feilim Mac;
Popel, Aleksander S.

Publication type:

Article

Computational Model of Vascular Endothelial Growth Factor Spatial Distribution in Muscle and Pro-Angiogenic Cell Therapy.

Published in:

PLoS Computational Biology, 2006, v. 2, n. 9, p. e127, doi. 10.1371/journal.pcbi.0020127

By:

Mac Gabhann, Feilim;
Ji, James W.;
Popel, Aleksander S.

Publication type:

Article

Virtual clinical trials via a QSP immuno-oncology model to simulate the response to a conditionally activated PD-L1 targeting antibody in NSCLC.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2024, v. 51, n. 6, p. 747, doi. 10.1007/s10928-024-09928-5

By:

Ippolito, Alberto;
Wang, Hanwen;
Zhang, Yu;
Vakil, Vahideh;
Popel, Aleksander S.

Publication type:

Article

Novel anti-angiogenic peptides derived From ELR-containing CXC chemokines.

Published in:

Journal of Cellular Biochemistry, 2008, v. 104, n. 4, p. 1356, doi. 10.1002/jcb.21712

By:

Karagiannis, Emmanouil D.;
Popel, Aleksander S.

Publication type:

Article

From virtual patients to digital twins in immuno-oncology: lessons learned from mechanistic quantitative systems pharmacology modeling.

Published in:

NPJ Digital Medicine, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s41746-024-01188-4

By:

Wang, Hanwen;
Arulraj, Theinmozhi;
Ippolito, Alberto;
Popel, Aleksander S.

Publication type:

Article