Works matching AU Popel, Aleksander

Results: 113

High-frequency force generation in the constrained cochlear outer hair cell: a model study.

Published in:

2005

By:

Liao, Zhuie;
Popel, Aleksander S.;
Brownell, William E.;
Spector, Alexander A.;
Liao, Zhijie

Publication type:

journal article

An experimental and theoretical study on the dissolution of mural fibrin clots by tissue-type plasminogen activator.

Published in:

Biotechnology & Bioengineering, 2002, v. 77, n. 4, p. 405, doi. 10.1002/bit.10127

By:

Wootton, David M.;
Popel, Aleksander S.;
Rita Alevriadou, B.

Publication type:

Article

Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-01932-5

By:

Furukawa, Natsuki;
Yang, Wendy;
Chao, Alex R.;
Patil, Akash;
Mirando, Adam C.;
Pandey, Niranjan B.;
Popel, Aleksander S.

Publication type:

Article

Inhibition of breast cancer growth and metastasis by a biomimetic peptide.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep07139

By:

Esak Lee;
Seung Jae Lee;
Koskimaki, Jacob E.;
Zheyi Han;
Pandey, Niranjan B.;
Popel, Aleksander S.

Publication type:

Article

Lymphatic endothelial cells support tumor growth in breast cancer.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep05853

By:

Esak Lee;
Pandey, Niranjan B.;
Popel, Aleksander S.

Publication type:

Article

Blood Flow and Cell-Free Layer in Microvessels.

Published in:

Microcirculation, 2010, v. 17, n. 8, p. 615, doi. 10.1111/j.1549-8719.2010.00056.x

By:

FEDOSOV, DMITRY A.;
CASWELL, BRUCE;
POPEL, ALEKSANDER S.;
KARNIADAKIS, GEORGE EM

Publication type:

Article

Systems Biology of Vascular Endothelial Growth Factors.

Published in:

Microcirculation, 2008, v. 15, n. 8, p. 715, doi. 10.1080/10739680802095964

By:

Gabhann, Feilim Mac;
Popel, Aleksander S.

Publication type:

Article

A Computer-Based Method for Determination of the Cell-Free Layer Width in Microcirculation.

Published in:

Microcirculation, 2006, v. 13, n. 3, p. 199, doi. 10.1080/10739680600556878

By:

Kim, Sangho;
Kong, Robert;
Popel, Aleksander;
Intaglietta, Marcos;
Johnson, Paul

Publication type:

Article

A Model of Nitric Oxide Capillary Exchange.

Published in:

Microcirculation, 2003, v. 10, n. 6, p. 479, doi. 10.1038/sj.mn.7800210

By:

Tsoukias, Nikolaos M.;
Popel, Aleksander S.

Publication type:

Article

Endothelial Regulation of Microvascular Growth and Stability by Ang‐Tie and VEGF Signaling Pathways: A Mechanistic Computational Systems Biology Model.

Published in:

FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R2072

By:

Zhang, Yu;
Kontos, Christopher D.;
Annex, Brian H.;
Popel, Aleksander S.

Publication type:

Article

Image‐Based Modeling of the Invasive Vascular Front in Breast Cancer.

Published in:

FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.04594

By:

Bhargava, Akanksha;
Popel, Aleksander;
Pathak, Arvind

Publication type:

Article

Computational Systems Biology Modeling of the Angiopoietin‐Tie Signaling Pathway and its Crosstalk with α5β1 Integrin in Endothelial Cells.

Published in:

FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.02368

By:

Zhang, Yu;
Kontos, Christopher;
Annex, Brian;
Popel, Aleksander

Publication type:

Article

Pre-treatment of mice with tumor-conditioned media accelerates metastasis to lymph nodes and lungs: a new spontaneous breast cancer metastasis model.

Published in:

Clinical & Experimental Metastasis, 2014, v. 31, n. 1, p. 67, doi. 10.1007/s10585-013-9610-9

By:

Lee, Esak;
Pandey, Niranjan;
Popel, Aleksander

Publication type:

Article

Computational models of VEGF-associated angiogenic processes in cancer.

Published in:

Mathematical Medicine & Biology: A Journal of the IMA, 2012, v. 29, n. 1, p. 85, doi. 10.1093/imammb/dqq025

By:

Stefanini, Marianne O.;
Qutub, Amina A.;
Gabhann, Feilim Mac;
Popel, Aleksander S.

Publication type:

Article

Red blood cell velocity profiles in skeletal muscle venules at low flow rates are described by the Casson model.

Published in:

Clinical Hemorheology & Microcirculation, 2007, v. 36, n. 3, p. 217

By:

Das, Bigyani;
Bishop, Jeffrey J.;
Kim, Sangho;
Meiselman, Herbert J.;
Johnson, Paul C.;
Popel, Aleksander S.

Publication type:

Article

Quantitative fluorescent profiling of VEGFRs reveals tumor cell and endothelial cell heterogeneity in breast cancer xenografts.

Published in:

Cancer Medicine, 2014, v. 3, n. 2, p. 225, doi. 10.1002/cam4.188

By:

Imoukhuede, Princess. I.;
Popel, Aleksander S.

Publication type:

Article

Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells.

Published in:

PLoS Computational Biology, 2017, v. 13, n. 2, p. 1, doi. 10.1371/journal.pcbi.1005332

By:

Bazzazi, Hojjat;
Popel, Aleksander S.

Publication type:

Article

Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model.

Published in:

PLoS Computational Biology, 2017, v. 13, n. 1, p. 1, doi. 10.1371/journal.pcbi.1005272

By:

Zhao, Chen;
Isenberg, Jeffrey S.;
Popel, Aleksander S.

Publication type:

Article

A systems biology model of junctional localization and downstream signaling of the Ang–Tie signaling pathway.

Published in:

NPJ Systems Biology & Applications, 2021, v. 7, n. 1, p. 1, doi. 10.1038/s41540-021-00194-6

By:

Zhang, Yu;
Kontos, Christopher D.;
Annex, Brian H.;
Popel, Aleksander S.

Publication type:

Article

Mechanistically detailed systems biology modeling of the HGF/Met pathway in hepatocellular carcinoma.

Published in:

NPJ Systems Biology & Applications, 2019, v. 5, n. 1, p. N.PAG, doi. 10.1038/s41540-019-0107-2

By:

Jafarnejad, Mohammad;
Sové, Richard J.;
Danilova, Ludmila;
Mirando, Adam C.;
Zhang, Yu;
Yarchoan, Mark;
Tran, Phuoc T.;
Pandey, Niranjan B.;
Fertig, Elana J.;
Popel, Aleksander S.

Publication type:

Article

Dynamic Changes in Microvascular Flow Conductivity and Perfusion After Myocardial Infarction Shown by Image-Based Modeling.

Published in:

2019

By:

Gkontra, Polyxeni;
El-Bouri, Wahbi K.;
Norton, Kerri-Ann;
Santos, Andrßs;
Popel, Aleksander S.;
Payne, Stephen J.;
Arroyo, Alicia G.;
Santos, Andrés

Publication type:

journal article

Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation.

Published in:

Frontiers in Physiology, 2017, v. 8, p. 1, doi. 10.3389/fphys.2017.00048

By:

Bazzazi, Hojjat;
Isenberg, Jeffery S.;
Popel, Aleksander S.

Publication type:

Article

Human expression patterns: qualitative and quantitative analysis of thrombospondin‐1 under physiological and pathological conditions.

Published in:

Journal of Cellular & Molecular Medicine, 2018, v. 22, n. 4, p. 2086, doi. 10.1111/jcmm.13565

By:

Zhao, Chen;
Isenberg, Jeffrey S.;
Popel, Aleksander S.

Publication type:

Article

A systems biology view of blood vessel growth and remodelling.

Published in:

Journal of Cellular & Molecular Medicine, 2014, v. 18, n. 8, p. 1491, doi. 10.1111/jcmm.12164

By:

Logsdon, Elizabeth A.;
Finley, Stacey D.;
Popel, Aleksander S.;
Gabhann, Feilim Mac

Publication type:

Article

A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use.

Published in:

Journal of Cellular & Molecular Medicine, 2010, v. 14, n. 3, p. 528, doi. 10.1111/j.1582-4934.2009.00941.x

By:

Wu, Florence T. H.;
Stefanini, Marianne O.;
Gabhann, Feilim Mac;
Kontos, Christopher D.;
Annex, Brian H.;
Popel, Aleksander S.

Publication type:

Article

Suppression of Ocular Vascular Inflammation through Peptide-Mediated Activation of Angiopoietin-Tie2 Signaling.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 14, p. 5142, doi. 10.3390/ijms21145142

By:

Mirando, Adam C.;
Lima e Silva, Raquel;
Chu, Zenny;
Campochiaro, Peter A.;
Pandey, Niranjan B.;
Popel, Aleksander S.

Publication type:

Article

Mechanistic Computational Models of MicroRNA-Mediated Signaling Networks in Human Diseases.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 2, p. 421, doi. 10.3390/ijms20020421

By:

Zhao, Chen;
Zhang, Yu;
Popel, Aleksander S.

Publication type:

Article

Simulations of tumor growth and response to immunotherapy by coupling a spatial agent-based model with a whole-patient quantitative systems pharmacology model.

Published in:

PLoS Computational Biology, 2022, v. 18, n. 7, p. 1, doi. 10.1371/journal.pcbi.1010254

By:

Ruiz-Martinez, Alvaro;
Gong, Chang;
Wang, Hanwen;
Sov́e, Richard J.;
Mi, Haoyang;
Kimko, Holly;
Popel, Aleksander S.

Publication type:

Article

Virtual clinical trials via a QSP immuno-oncology model to simulate the response to a conditionally activated PD-L1 targeting antibody in NSCLC.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2024, v. 51, n. 6, p. 747, doi. 10.1007/s10928-024-09928-5

By:

Ippolito, Alberto;
Wang, Hanwen;
Zhang, Yu;
Vakil, Vahideh;
Popel, Aleksander S.

Publication type:

Article

Computational methods and biomarker discovery strategies for spatial proteomics: a review in immuno-oncology.

Published in:

Briefings in Bioinformatics, 2024, v. 25, n. 5, p. 1, doi. 10.1093/bib/bbae421

By:

Mi, Haoyang;
Sivagnanam, Shamilene;
Ho, Won Jin;
Zhang, Shuming;
Bergman, Daniel;
Deshpande, Atul;
Baras, Alexander S;
Jaffee, Elizabeth M;
Coussens, Lisa M;
Fertig, Elana J;
Popel, Aleksander S

Publication type:

Article

Leveraging multi-omics data to empower quantitative systems pharmacology in immuno-oncology.

Published in:

Briefings in Bioinformatics, 2024, v. 25, n. 3, p. 1, doi. 10.1093/bib/bbae131

By:

Arulraj, Theinmozhi;
Wang, Hanwen;
Ippolito, Alberto;
Zhang, Shuming;
Fertig, Elana J;
Popel, Aleksander S

Publication type:

Article

Regulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptide.

Published in:

OncoImmunology, 2020, v. 9, n. 1, p. 1, doi. 10.1080/2162402X.2020.1760685

By:

Mirando, Adam C.;
Patil, Akash;
Rafie, Christine I.;
Christmas, Brian J.;
Pandey, Niranjan B.;
Stearns, Vered;
Jaffee, Elizabeth M.;
Roussos Torres, Evanthia T.;
Popel, Aleksander S.

Publication type:

Article

Tyrosine kinase blocking collagen IV–derived peptide suppresses ocular neovascularization and vascular leakage.

Published in:

Science Translational Medicine, 2017, v. 9, n. 373, p. 1, doi. 10.1126/scitranslmed.aai8030

By:

e Silva, Raquel Lima;
Kanan, Yogita;
Mirando, Adam C.;
Jayoung Kim;
Shmueli, Ron B.;
Lorenc, Valeria E.;
Fortmann, Seth D.;
Sciamanna, Jason;
Pandey, Niranjan B.;
Green, Jordan J.;
Popel, Aleksander S.;
Campochiaro, Peter A.

Publication type:

Article

A Quantitative Systems Pharmacology Model of T Cell Engager Applied to Solid Tumor.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00450-3

By:

Ma, Huilin;
Wang, Hanwen;
Sove, Richard J.;
Jafarnejad, Mohammad;
Tsai, Chia-Hung;
Wang, Jun;
Giragossian, Craig;
Popel, Aleksander S.

Publication type:

Article

A Computational Model of Neoadjuvant PD-1 Inhibition in Non-Small Cell Lung Cancer.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0350-x

By:

Jafarnejad, Mohammad;
Gong, Chang;
Gabrielson, Edward;
Bartelink, Imke H.;
Vicini, Paolo;
Wang, Bing;
Narwal, Rajesh;
Roskos, Lorin;
Popel, Aleksander S.

Publication type:

Article

Predicting the Effects of Anti-angiogenic Agents Targeting Specific VEGF Isoforms.

Published in:

AAPS Journal, 2012, v. 14, n. 3, p. 500, doi. 10.1208/s12248-012-9363-4

By:

Finley, Stacey;
Popel, Aleksander

Publication type:

Article

Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence.

Published in:

Genome Medicine, 2023, v. 15, n. 1, p. 1, doi. 10.1186/s13073-023-01218-y

By:

Zhang, Shuming;
Yuan, Long;
Danilova, Ludmila;
Mo, Guanglan;
Zhu, Qingfeng;
Deshpande, Atul;
Bell, Alexander T. F.;
Elisseeff, Jennifer;
Popel, Aleksander S.;
Anders, Robert A.;
Jaffee, Elizabeth M.;
Yarchoan, Mark;
Fertig, Elana J.;
Kagohara, Luciane T.

Publication type:

Article

Development of a biomimetic peptide derived from collagen IV with anti-angiogenic activity in breast cancer.

Published in:

Cancer Biology & Therapy, 2011, v. 12, n. 9, p. 808, doi. 10.4161/cbt.12.9.17677

By:

Rosca, Elena V.;
Koskimaki, Jacob E.;
Pandey, Niranjan B.;
Wolff, Antonio C.;
Popel, Aleksander S.

Publication type:

Article

Targeting Neuropilin-1 to Inhibit VEGF Signaling in Cancer: Comparison of Therapeutic Approaches.

Published in:

PLoS Computational Biology, 2006, v. 2, n. 12, p. 1649, doi. 10.1371/journal.pcbi.0020180

By:

Gabhann, Feilim Mac;
Popel, Aleksander S.

Publication type:

Article

Computational Model of Vascular Endothelial Growth Factor Spatial Distribution in Muscle and Pro-Angiogenic Cell Therapy.

Published in:

PLoS Computational Biology, 2006, v. 2, n. 9, p. e127, doi. 10.1371/journal.pcbi.0020127

By:

Mac Gabhann, Feilim;
Ji, James W.;
Popel, Aleksander S.

Publication type:

Article

Novel anti-angiogenic peptides derived From ELR-containing CXC chemokines.

Published in:

Journal of Cellular Biochemistry, 2008, v. 104, n. 4, p. 1356, doi. 10.1002/jcb.21712

By:

Karagiannis, Emmanouil D.;
Popel, Aleksander S.

Publication type:

Article

Multiscale Modeling in the Clinic: Drug Design and Development.

Published in:

Annals of Biomedical Engineering, 2016, v. 44, n. 9, p. 2591, doi. 10.1007/s10439-016-1563-0

By:

Clancy, Colleen;
An, Gary;
Cannon, William;
Liu, Yaling;
May, Elebeoba;
Ortoleva, Peter;
Popel, Aleksander;
Sluka, James;
Su, Jing;
Vicini, Paolo;
Zhou, Xiaobo;
Eckmann, David

Publication type:

Article

Multi-scale Modeling in Clinical Oncology: Opportunities and Barriers to Success.

Published in:

Annals of Biomedical Engineering, 2016, v. 44, n. 9, p. 2626, doi. 10.1007/s10439-016-1691-6

By:

Yankeelov, Thomas;
An, Gary;
Saut, Oliver;
Luebeck, E.;
Popel, Aleksander;
Ribba, Benjamin;
Vicini, Paolo;
Zhou, Xiaobo;
Weis, Jared;
Ye, Kaiming;
Genin, Guy

Publication type:

Article

Multiscale Imaging and Computational Modeling of Blood Flow in the Tumor Vasculature.

Published in:

Annals of Biomedical Engineering, 2012, v. 40, n. 11, p. 2425, doi. 10.1007/s10439-012-0585-5

By:

Kim, Eugene;
Stamatelos, Spyros;
Cebulla, Jana;
Bhujwalla, Zaver;
Popel, Aleksander;
Pathak, Arvind

Publication type:

Article

Angiogenesis-Associated Crosstalk Between Collagens, CXC Chemokines, and Thrombospondin Domain-Containing Proteins.

Published in:

Annals of Biomedical Engineering, 2011, v. 39, n. 8, p. 2213, doi. 10.1007/s10439-011-0325-2

By:

Rivera, Corban;
Bader, Joel;
Popel, Aleksander

Publication type:

Article

Multi-scale Computational Models of Pro-angiogenic Treatments in Peripheral Arterial Disease.

Published in:

Annals of Biomedical Engineering, 2007, v. 35, n. 6, p. 982, doi. 10.1007/s10439-007-9303-0

By:

Feilim Mac Gabhann;
James Ji;
Aleksander Popel

Publication type:

Article

Protein Transport to Choroid and Retina following Periocular Injection: Theoretical and Experimental Study.

Published in:

Annals of Biomedical Engineering, 2007, v. 35, n. 4, p. 615, doi. 10.1007/s10439-006-9238-x

By:

Feilim Mac Gabhann;
Anna Demetriades;
Tye Deering;
Jonathan Packer;
Syed Shah;
Elia Duh;
Peter Campochiaro;
Aleksander Popel

Publication type:

Article

Identifying biomarkers for treatment of uveal melanoma by T cell engager using a QSP model.

Published in:

NPJ Systems Biology & Applications, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41540-024-00434-5

By:

Anbari, Samira;
Wang, Hanwen;
Arulraj, Theinmozhi;
Nickaeen, Masoud;
Pilvankar, Minu;
Wang, Jun;
Hansel, Steven;
Popel, Aleksander S.

Publication type:

Article

Experiment-based computational model predicts that IL-6 classic and trans-signaling exhibit similar potency in inducing downstream signaling in endothelial cells.

Published in:

NPJ Systems Biology & Applications, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41540-023-00308-2

By:

Song, Min;
Wang, Youli;
Annex, Brian H.;
Popel, Aleksander S.

Publication type:

Article

A QSP Model for Predicting Clinical Responses to Monotherapy, Combination and Sequential Therapy Following CTLA-4, PD-1, and PD-L1 Checkpoint Blockade.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-47802-4

By:

Milberg, Oleg;
Gong, Chang;
Jafarnejad, Mohammad;
Bartelink, Imke H.;
Wang, Bing;
Vicini, Paolo;
Narwal, Rajesh;
Roskos, Lorin;
Popel, Aleksander S.

Publication type:

Article