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Metabolism‐focused CRISPR screen unveils mitochondrial pyruvate carrier 1 as a critical driver for PARP inhibitor resistance in lung cancer.
- Published in:
- Molecular Carcinogenesis, 2024, v. 63, n. 6, p. 1024, doi. 10.1002/mc.23705
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- Publication type:
- Article
R-loops, type I topoisomerases and cancer.
- Published in:
- NAR Cancer, 2023, v. 5, n. 4, p. 1, doi. 10.1093/narcan/zcad013
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- Publication type:
- Article
The TDRD3-USP9X complex and MIB1 regulate TOP3B homeostasis and prevent deleterious TOP3B cleavage complexes.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-43151-z
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- Publication type:
- Article
Unprecedented reactivity of polyamines with aldehydic DNA modifications: structural determinants of reactivity, characterization and enzymatic stability of adducts.
- Published in:
- Nucleic Acids Research, 2023, v. 51, n. 20, p. 10846, doi. 10.1093/nar/gkad837
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- Publication type:
- Article
Real-time imaging of drug-induced trapping of cellular topoisomerases and poly(ADP-ribose) polymerase 1 at the single-molecule level.
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- Nucleic Acids Research, 2023, v. 51, n. 18, p. e97, doi. 10.1093/nar/gkad735
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- Publication type:
- Article
Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT.
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- Human Molecular Genetics, 2023, v. 32, n. 15, p. 2422, doi. 10.1093/hmg/ddad062
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- Publication type:
- Article
Preclinical Models of Adrenocortical Cancer.
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- Cancers, 2023, v. 15, n. 11, p. 2873, doi. 10.3390/cancers15112873
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- Publication type:
- Article
Synthesis and Biological Activities of 11‐ and 12‐Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB and Tyrosyl‐DNA Phosphodiesterase 1 Inhibitors.
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- ChemMedChem, 2023, v. 18, n. 10, p. 1, doi. 10.1002/cmdc.202200593
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- Publication type:
- Article
A Phase I Study of a Combination of Liposomal Irinotecan and Veliparib in Solid Tumors.
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- Oncologist, 2023, v. 28, n. 5, p. 460, doi. 10.1093/oncolo/oyad023
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- Publication type:
- Article
Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37498-6
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- Publication type:
- Article
R-loops, type I topoisomerases and can.
- Published in:
- NAR Cancer, 2023, v. 5, n. 1, p. 1, doi. 10.1093/narcan/zcad013
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- Publication type:
- Article
Alkyne Activation in the Diversity Oriented Synthesis of sp<sup>2</sup>‐Rich Scaffolds: A Biased Library Approach for Targeting Polynucleotides (DNA/RNA).
- Published in:
- Chemistry - A European Journal, 2022, v. 28, n. 71, p. 1, doi. 10.1002/chem.202201925
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- Publication type:
- Article
Preclinical Models of Neuroendocrine Neoplasia.
- Published in:
- Cancers, 2022, v. 14, n. 22, p. 5646, doi. 10.3390/cancers14225646
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- Publication type:
- Article
Pediatric adrenocortical carcinoma.
- Published in:
- Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2022.961650
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- Publication type:
- Article
Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway.
- Published in:
- 2022
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- Publication type:
- journal article
Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32221-3
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- Publication type:
- Article
Structural, molecular, and functional insights into Schlafen proteins.
- Published in:
- Experimental & Molecular Medicine EMM, 2022, v. 54, n. 6, p. 730, doi. 10.1038/s12276-022-00794-0
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- Publication type:
- Article
Prognostic impact of Schlafen 11 in bladder cancer patients treated with platinum‐based chemotherapy.
- Published in:
- Cancer Science, 2022, v. 113, n. 2, p. 784, doi. 10.1111/cas.15207
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- Publication type:
- Article
Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-021-27686-7
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- Publication type:
- Article
Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1–DNA complexes.
- Published in:
- Nucleic Acids Research, 2021, v. 49, n. 18, p. 10493, doi. 10.1093/nar/gkab777
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- Publication type:
- Article
Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 11.
- Published in:
- Cancers, 2021, v. 13, n. 18, p. 4601, doi. 10.3390/cancers13184601
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- Publication type:
- Article
PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25252-9
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- Publication type:
- Article
The Immunotherapy Landscape in Adrenocortical Cancer.
- Published in:
- Cancers, 2021, v. 13, n. 11, p. 2660, doi. 10.3390/cancers13112660
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- Publication type:
- Article
Association of expression of epigenetic molecular factors with DNA methylation and sensitivity to chemotherapeutic agents in cancer cell lines.
- Published in:
- Clinical Epigenetics, 2021, v. 13, n. 1, p. 1, doi. 10.1186/s13148-021-01026-4
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- Publication type:
- Article
Immunohistochemical analysis of SLFN11 expression uncovers potential non-responders to DNA-damaging agents overlooked by tissue RNA-seq.
- Published in:
- Virchows Archiv: European Journal of Pathology, 2021, v. 478, n. 3, p. 569, doi. 10.1007/s00428-020-02840-6
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- Publication type:
- Article
Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development.
- Published in:
- PLoS ONE, 2021, v. 16, n. 1, p. 1, doi. 10.1371/journal.pone.0237554
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- Publication type:
- Article
Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair–targeted therapies.
- Published in:
- Science Translational Medicine, 2021, v. 13, n. 578, p. 1, doi. 10.1126/scitranslmed.abc7488
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- Publication type:
- Article
The first evidence for SLFN11 expression as an independent prognostic factor for patients with esophageal cancer after chemoradiotherapy.
- Published in:
- 2020
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- Publication type:
- journal article
Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors.
- Published in:
- Cancer Chemotherapy & Pharmacology, 2020, v. 86, n. 4, p. 475, doi. 10.1007/s00280-020-04134-9
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- Publication type:
- Article
Epigenome-wide DNA methylation analysis of small cell lung cancer cell lines suggests potential chemotherapy targets.
- Published in:
- Clinical Epigenetics, 2020, v. 12, n. 1, p. 1, doi. 10.1186/s13148-020-00876-8
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- Publication type:
- Article
Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening.
- Published in:
- Nucleic Acids Research, 2019, v. 47, n. 19, p. 10134, doi. 10.1093/nar/gkz515
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- Publication type:
- Article
Discovery of Novel Integrase Inhibitors Acting outside the Active Site Through High-Throughput Screening.
- Published in:
- Molecules, 2019, v. 24, n. 20, p. 3675, doi. 10.3390/molecules24203675
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- Publication type:
- Article
Tyrosyl-DNA Phosphodiesterase 1 and Topoisomerase I Activities as Predictive Indicators for Glioblastoma Susceptibility to Genotoxic Agents.
- Published in:
- Cancers, 2019, v. 11, n. 10, p. 1416, doi. 10.3390/cancers11101416
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- Publication type:
- Article
Identification of Schlafen-11 as a Target of CD47 Signaling That Regulates Sensitivity to Ionizing Radiation and Topoisomerase Inhibitors.
- Published in:
- Frontiers in Oncology, 2019, p. 1, doi. 10.3389/fonc.2019.00994
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- Publication type:
- Article
Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair.
- Published in:
- International Journal of Molecular Sciences, 2019, v. 20, n. 12, p. 3015, doi. 10.3390/ijms20123015
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- Publication type:
- Article
Endogenous single-strand DNA breaks at RNA polymerase II promoters in Saccharomyces cerevisiae.
- Published in:
- Nucleic Acids Research, 2018, v. 46, n. 20, p. 10649, doi. 10.1093/nar/gky743
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- Publication type:
- Article
TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining.
- Published in:
- Nucleic Acids Research, 2018, v. 46, n. 17, p. 8926, doi. 10.1093/nar/gky694
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- Publication type:
- Article
Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant Ube3a gene associated with Angelman syndrome.
- Published in:
- Molecular Autism, 2018, v. 9, n. 1, p. N.PAG, doi. 10.1186/s13229-018-0228-2
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- Publication type:
- Article
HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence.
- Published in:
- Molecules, 2018, v. 23, n. 8, p. 1858, doi. 10.3390/molecules23081858
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- Publication type:
- Article
PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes.
- Published in:
- Nucleic Acids Research, 2018, v. 46, n. 11, p. 5601, doi. 10.1093/nar/gky291
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- Publication type:
- Article
The evolving landscape of predictive biomarkers of response to PARP inhibitors.
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- 2018
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- Publication type:
- journal article
Mitochondrial tyrosyl-DNA phosphodiesterase 2 and its TDP2<sup>S</sup> short isoform.
- Published in:
- EMBO Reports, 2018, v. 19, n. 3, p. 1, doi. 10.15252/embr.201642139
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- Publication type:
- Article
ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair.
- Published in:
- PLoS ONE, 2017, v. 12, n. 11, p. 1, doi. 10.1371/journal.pone.0188320
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- Publication type:
- Article
Report on the first SLFN11 monothematic workshop: from function to role as a biomarker in cancer.
- Published in:
- 2017
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- Publication type:
- research
Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay.
- Published in:
- PLoS ONE, 2017, v. 12, n. 2, p. 1, doi. 10.1371/journal.pone.0171582
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- Publication type:
- Article
Topoisomerase I-mediated cleavage at unrepaired ribonucleotides generates DNA double-strand breaks.
- Published in:
- EMBO Journal, 2017, v. 36, n. 3, p. 361, doi. 10.15252/embj.201592426
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- Publication type:
- Article
Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage.
- Published in:
- Nucleic Acids Research, 2016, v. 44, n. 21, p. 10201, doi. 10.1093/nar/gkw719
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- Publication type:
- Article
Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action.
- Published in:
- Science Translational Medicine, 2016, v. 8, n. 362, p. 1, doi. 10.1126/scitranslmed.aaf9246
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- Publication type:
- Article
Parallel analysis of ribonucleotide-dependent deletions produced by yeast Top1 in vitro and in vivo.
- Published in:
- Nucleic Acids Research, 2016, v. 44, n. 16, p. 7714, doi. 10.1093/nar/gkw495
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- Publication type:
- Article
Selectivity for strand-transfer over 3-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.
- Published in:
- Nucleic Acids Research, 2016, v. 44, n. 14, p. 6896, doi. 10.1093/nar/gkw592
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- Publication type:
- Article