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Discovery and Structural Characterization of a Phospholamban-Binding Cyclic Peptide and Design of Novel Inhibitors of Phospholamban.
Published in:
Chemical Biology & Drug Design, 2013, v. 81, n. 4, p. 463, doi. 10.1111/j.1747-0285.2012.01409.x
By:
- Tilgmann, Carola;
- Pollesello, Piero;
- Ovaska, Martti;
- Kaivola, Juha;
- Pystynen, Jarmo;
- Tiainen, Eija;
- Yliperttula, Marjo;
- Annila, Arto;
- Levijoki, Jouko
Publication type:
Article
Changed Relation between Phosphorylation Potential and Left Ventricular Developed Pressure in Guinea Pig Hearts during Ischemia-Reperfusion a.
Published in:
Annals of the New York Academy of Sciences, 1994, v. 723, n. 1, p. 495, doi. 10.1111/j.1749-6632.1994.tb36788.x
By:
- POLLESELLO, PIERO;
- ERIKSSON, OVE;
- SARIS, NILS-ERIK L.
Publication type:
Article
Levosimendan Improves Oxidative Balance in Cardiogenic Shock/Low Cardiac Output Patients.
Published in:
Journal of Clinical Medicine, 2020, v. 9, n. 2, p. 373, doi. 10.3390/jcm9020373
By:
- Grossini, Elena;
- Farruggio, Serena;
- Pierelli, Daniele;
- Bolzani, Virginia;
- Rossi, Lidia;
- Pollesello, Piero;
- Monaco, Carolina
Publication type:
Article
Short-Term Therapies for Treatment of Acute and Advanced Heart Failure—Why so Few Drugs Available in Clinical Use, Why Even Fewer in the Pipeline?
Published in:
Journal of Clinical Medicine, 2019, v. 8, n. 11, p. 1834, doi. 10.3390/jcm8111834
By:
- Pollesello, Piero;
- Ben Gal, Tuvia;
- Bettex, Dominique;
- Cerny, Vladimir;
- Comin-Colet, Josep;
- Eremenko, Alexandr A.;
- Farmakis, Dimitrios;
- Fedele, Francesco;
- Fonseca, Cândida;
- Harjola, Veli-Pekka;
- Herpain, Antoine;
- Heringlake, Matthias;
- Heunks, Leo;
- Husebye, Trygve;
- Ivancan, Visnja;
- Karason, Kristjan;
- Kaul, Sundeep;
- Kubica, Jacek;
- Mebazaa, Alexandre;
- Mølgaard, Henning
Publication type:
Article
Use of Levosimendan in Patients with Pulmonary Hypertension: What is the Current Evidence?
Published in:
Drugs, 2023, v. 83, n. 3, p. 195, doi. 10.1007/s40265-022-01833-w
By:
- Masarone, Daniele;
- Kittleson, Michelle;
- Pollesello, Piero;
- Tedford, Ryan J.;
- Pacileo, Giuseppe
Publication type:
Article
Levosimendan Inhibits Peroxidation in Hepatocytes by Modulating Apoptosis/Autophagy Interplay.
Published in:
PLoS ONE, 2015, v. 10, n. 4, p. 1, doi. 10.1371/journal.pone.0124742
By:
- Grossini, Elena;
- Bellofatto, Kevin;
- Farruggio, Serena;
- Sigaudo, Lorenzo;
- Marotta, Patrizia;
- Raina, Giulia;
- De Giuli, Veronica;
- Mary, David;
- Pollesello, Piero;
- Minisini, Rosalba;
- Pirisi, Mario;
- Vacca, Giovanni
Publication type:
Article
Detection and quantitation of phosphorus metabolites in crude tissue extracts by 1H and 31P NMR: use of gradient assisted 1H-31P HMQC experiments, with selective pulses, for the assignment of less abundant metabolites
Published in:
NMR in Biomedicine, 1995, v. 8, n. 5, p. 190, doi. 10.1002/nbm.1940080503
By:
- Pollesello, Piero;
- Eriksson, Ove;
- Geimonen, Erika;
- Vittur, Franco;
- Paoletti, Sergio;
- Toffanin, Renato
Publication type:
Article
Use of Levosimendan in Patients with Advanced Heart Failure: An Update.
Published in:
Journal of Clinical Medicine, 2022, v. 11, n. 21, p. 6408, doi. 10.3390/jcm11216408
By:
- Masarone, Daniele;
- Kittleson, Michelle M.;
- Pollesello, Piero;
- Marini, Marco;
- Iacoviello, Massimo;
- Oliva, Fabrizio;
- Caiazzo, Angelo;
- Petraio, Andrea;
- Pacileo, Giuseppe
Publication type:
Article
Levosimendan as a "Bridge to Optimization" in Patients with Advanced Heart Failure with Reduced Ejection—A Single-Center Study.
Published in:
Journal of Clinical Medicine, 2022, v. 11, n. 14, p. 4227, doi. 10.3390/jcm11144227
By:
- Masarone, Daniele;
- Kittleson, Michelle M.;
- Martucci, Maria L.;
- Valente, Fabio;
- Gravino, Rita;
- Verrengia, Marina;
- Ammendola, Ernesto;
- Contaldi, Carla;
- Di Palma, Vito;
- Caiazzo, Angelo;
- Petraio, Andrea;
- Pollesello, Piero;
- Pacileo, Giuseppe
Publication type:
Article
Novel Na+/Ca2+ Exchanger Inhibitor ORM-10962 Supports Coupled Function of Funny-Current and Na+/Ca2+ Exchanger in Pacemaking of Rabbit Sinus Node Tissue.
Published in:
Frontiers in Pharmacology, 2020, p. 1, doi. 10.3389/fphar.2019.01632
By:
- Kohajda, Zsófia;
- Tóth, Noémi;
- Szlovák, Jozefina;
- Loewe, Axel;
- Bitay, Gergő;
- Gazdag, Péter;
- Prorok, János;
- Jost, Norbert;
- Levijoki, Jouko;
- Pollesello, Piero;
- Papp, Julius Gy.;
- Varró, András;
- Nagy, Norbert
Publication type:
Article
Mechanism of Action of Levosimendan: A Calcium Sensitizer for Treatment of Heart Failure.
Published in:
2003
By:
- Pollesello, Piero
Publication type:
Abstract
Structural and functional implications of the phospholamban hinge domain: impaired SR Ca2+ uptake as a primary cause of heart failure
Published in:
Cardiovascular Research, 2002, v. 56, n. 2, p. 248, doi. 10.1016/S0008-6363(02)00541-2
By:
- Schmidt, Albrecht G.;
- Zhai, Jing;
- Carr, Andrew N.;
- Gerst, Mike J.;
- Lorenz, John N.;
- Pollesello, Piero;
- Annila, Arto;
- Hoit, Brian D.;
- Kranias, Evangelia G.
Publication type:
Article
A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function.
Published in:
European Journal of Heart Failure, 2024, v. 26, n. 4, p. 707, doi. 10.1002/ejhf.3236
By:
- Ameri, Pietro;
- Mercurio, Valentina;
- Pollesello, Piero;
- Anker, Markus S.;
- Backs, Johannes;
- Bayes‐Genis, Antoni;
- Borlaug, Barry A.;
- Burkhoff, Daniel;
- Caravita, Sergio;
- Chan, Stephen Y.;
- de Man, Frances;
- Giannakoulas, George;
- González, Aránzazu;
- Guazzi, Marco;
- Hassoun, Paul M.;
- Hemnes, Anna R.;
- Maack, Cristoph;
- Madden, Brendan;
- Melenovsky, Vojtech;
- Müller, Oliver J.
Publication type:
Article
Long-term effects of Na+ /Ca2+ exchanger inhibition with ORM-11035 improves cardiac function and remodelling without lowering blood pressure in a model of heart failure with preserved ejection fraction.
Published in:
2019
By:
- Primessnig, Uwe;
- Bracic, Taja;
- Levijoki, Jouko;
- Otsomaa, Leena;
- Pollesello, Piero;
- Falcke, Martin;
- Pieske, Burkert;
- Heinzel, Frank R.
Publication type:
journal article
Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology.
Published in:
2019
By:
- de Boer, Rudolf A.;
- De Keulenaer, Gilles;
- Bauersachs, Johann;
- Brutsaert, Dirk;
- Cleland, John G.;
- Diez, Javier;
- Du, Xiao‐Jun;
- Ford, Paul;
- Heinzel, Frank R.;
- Lipson, Kenneth E.;
- McDonagh, Theresa;
- Lopez‐Andres, Natalia;
- Lunde, Ida G.;
- Lyon, Alexander R.;
- Pollesello, Piero;
- Prasad, Sanjay K.;
- Tocchetti, Carlo G.;
- Mayr, Manuel;
- Sluijter, Joost P.G.;
- Thum, Thomas
Publication type:
journal article
The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology.
Published in:
2017
By:
- van Bilsen, Marc;
- Patel, Hitesh C.;
- Bauersachs, Johann;
- Böhm, Michael;
- Borggrefe, Martin;
- Brutsaert, Dirk;
- Coats, Andrew J.S.;
- de Boer, Rudolf A.;
- de Keulenaer, Gilles W.;
- Filippatos, Gerasimos S.;
- Floras, John;
- Grassi, Guido;
- Jankowska, Ewa A.;
- Kornet, Lilian;
- Lunde, Ida G.;
- Maack, Christoph;
- Mahfoud, Felix;
- Pollesello, Piero;
- Ponikowski, Piotr;
- Ruschitzka, Frank
Publication type:
journal article
Effects of Levosimendan on Inflammation and Oxidative Stress Pathways in a Lipopolysaccharide-Stimulated Human Endothelial Cell Model.
Published in:
Biological Research for Nursing, 2019, v. 21, n. 5, p. 466, doi. 10.1177/1099800419861694
By:
- Rodríguez-González, Raquel;
- Pollesello, Piero;
- Baluja, Aurora;
- Álvarez, Julián
Publication type:
Article
Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis.
Published in:
1995
By:
- Longo, Renata;
- Pollesello, Piero;
- Ricci, Claudio;
- Masutti, Flora;
- Kvam, Bjarne J.;
- Bercich, Luisa;
- Croce, Lory S.;
- Grigolato, Piergiovanni;
- Paoletti, Sergio;
- De Bernard, Benedetto;
- Tiribelli, Claudio;
- Dalla Palma, Ludovico;
- Longo, R;
- Pollesello, P;
- Ricci, C;
- Masutti, F;
- Kvam, B J;
- Bercich, L;
- Crocè, L S;
- Grigolato, P
Publication type:
journal article
Recognizing early signs in the translational phase is essential for drug development in cardiovascular medicine.
Published in:
ESC Heart Failure, 2023, v. 10, n. 4, p. 2147, doi. 10.1002/ehf2.14402
By:
- Papp, Zoltán;
- Pollesello, Piero;
- Borbély, Attila
Publication type:
Article
Levosimendan‐induced venodilation is mediated by opening of potassium channels.
Published in:
ESC Heart Failure, 2021, v. 8, n. 6, p. 4454, doi. 10.1002/ehf2.13669
By:
- Burkhoff, Daniel;
- Rich, Stuart;
- Pollesello, Piero;
- Papp, Zoltán
Publication type:
Article
Rehospitalization after intermittent levosimendan treatment in advanced heart failure patients: a meta‐analysis of randomized trials.
Published in:
ESC Heart Failure, 2017, v. 4, n. 4, p. 595, doi. 10.1002/ehf2.12177
By:
- Silvetti, Simona;
- Belletti, Alessandro;
- Fontana, Antonella;
- Pollesello, Piero
Publication type:
Article
Prolonged Antispasmodic Effect in Isolated Radial Artery Graft and Pronounced Platelet Inhibition Induced by the Inodilator Drug, Levosimendan.
Published in:
Basic & Clinical Pharmacology & Toxicology, 2012, v. 110, n. 3, p. 269, doi. 10.1111/j.1742-7843.2011.00801.x
By:
- Ambrus, Nóra;
- Szolnoky, Jenő;
- Pollesello, Piero;
- Kun, Attila;
- Varró, András;
- Papp, J. Gyula;
- Pataricza, János
Publication type:
Article
The Effect of Levosimendan during Long-Term Amiodarone Treatment in Dogs.
Published in:
Basic & Clinical Pharmacology & Toxicology, 2006, v. 99, n. 1, p. 27, doi. 10.1111/j.1742-7843.2006.pto_394.x
By:
- Papp, Julius Gy.;
- Pollesello, Piero;
- Varr, András;
- Végh, Ágnes;
- Udvary, Eva
Publication type:
Article
Positive Inotropic Effect of Levosimendan is Correlated to its Stereoselective Ca2+-Sensitizing Effect but not to Stereoselective Phosphodiesterase Inhibition.
Published in:
Basic & Clinical Pharmacology & Toxicology, 2006, v. 98, n. 1, p. 74, doi. 10.1111/j.1742-7843.2006.pto_231.x
By:
- Kaheinen, Petri;
- Pollesello, Piero;
- Hertelendi, Zita;
- Borbély, Attila;
- Szilágyi, Szabolcs;
- Nissinen, Erkki;
- Haikala, Heimo;
- Papp, Zoltán
Publication type:
Article
The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments.
Published in:
PLoS ONE, 2016, v. 11, n. 11, p. 1, doi. 10.1371/journal.pone.0166041
By:
- Kohajda, Zsófia;
- Farkas-Morvay, Nikolett;
- Jost, Norbert;
- Nagy, Norbert;
- Geramipour, Amir;
- Horváth, András;
- Varga, Richárd S.;
- Hornyik, Tibor;
- Corici, Claudia;
- Acsai, Károly;
- Horváth, Balázs;
- Prorok, János;
- Ördög, Balázs;
- Déri, Szilvia;
- Tóth, Dániel;
- Levijoki, Jouko;
- Pollesello, Piero;
- Koskelainen, Tuula;
- Otsomaa, Leena;
- Tóth, András
Publication type:
Article
Levosimendan in Acute and Advanced Heart Failure: an Expert Perspective on Posology and Therapeutic Application.
Published in:
Cardiovascular Drugs & Therapy, 2018, v. 32, n. 6, p. 617, doi. 10.1007/s10557-018-6838-2
By:
- Bouchez, S.;
- Fedele, F.;
- Giannakoulas, G.;
- Gustafsson, F.;
- Harjola, V.-P.;
- Karason, K.;
- Kivikko, M.;
- von Lewinski, D.;
- Oliva, F.;
- Papp, Z.;
- Parissis, J.;
- Pollesello, Piero;
- Pölzl, G.;
- Tschöpe, C.
Publication type:
Article
Renal Effects of Levosimendan: A Consensus Report.
Published in:
Cardiovascular Drugs & Therapy, 2013, v. 27, n. 6, p. 581, doi. 10.1007/s10557-013-6485-6
By:
- Yilmaz, Mehmet B.;
- Grossini, Elena;
- Silva Cardoso, José C.;
- Édes, István;
- Fedele, Francesco;
- Pollesello, Piero;
- Kivikko, Matti;
- Harjola, Veli-Pekka;
- Hasslacher, Julia;
- Mebazaa, Alexandre;
- Morelli, Andrea;
- le Noble, Jos;
- Oldner, Anders;
- Oulego Erroz, Ignacio;
- Parissis, John T.;
- Parkhomenko, Alexander;
- Poelzl, Gerhard;
- Rehberg, Sebastian;
- Ricksten, Sven-Erik;
- Rodríguez Fernández, Luís M.
Publication type:
Article
Effect of Levosimendan and Milrinone on Regional Myocardial Ischemia/Reperfusion-Induced Arrhythmias in Dogs.
Published in:
Journal of Cardiovascular Pharmacology & Therapeutics, 2006, v. 11, n. 2, p. 129, doi. 10.1177/1074248406289286
By:
- Papp, Julius Gy.;
- Pollesello, Piero;
- Varró, András F.;
- Végh, Ágnes S.
Publication type:
Article
Selective Na(+) /Ca(2+) exchanger inhibition prevents Ca(2+) overload-induced triggered arrhythmias.
Published in:
2014
By:
- Nagy, Norbert;
- Kormos, Anita;
- Kohajda, Zsófia;
- Szebeni, Aron;
- Szepesi, Judit;
- Pollesello, Piero;
- Levijoki, Jouko;
- Acsai, Károly;
- Virág, László;
- Nánási, Péter P;
- Papp, Julius Gy;
- Varró, András;
- Tóth, András;
- Szebeni, Áron
Publication type:
journal article
Selective Na+/ Ca2+ exchanger inhibition prevents Ca2+ overload-induced triggered arrhythmias.
Published in:
British Journal of Pharmacology, 2014, v. 171, n. 24, p. 5665, doi. 10.1111/bph.12867
By:
- Nagy, Norbert;
- Kormos, Anita;
- Kohajda, Zsófia;
- Szebeni, Áron;
- Szepesi, Judit;
- Pollesello, Piero;
- Levijoki, Jouko;
- Acsai, Károly;
- Virág, László;
- Nánási, Péter P;
- Papp, Julius Gy;
- Varró, András;
- Tóth, András
Publication type:
Article
The levosimendan metabolite OR-1896 elicits vasodilation by activating the KATP and BKCa channels in rat isolated arterioles.
Published in:
British Journal of Pharmacology, 2006, v. 148, n. 5, p. 696, doi. 10.1038/sj.bjp.0706781
By:
- Erdei, Nóra;
- Papp, Zoltán;
- Pollesello, Piero;
- Édes, István;
- Bagi, Zsolt
Publication type:
Article
31P NMR studies of resting zone cartilage from growth plate.
Published in:
Magnetic Resonance in Medicine, 1992, v. 25, n. 2, p. 355, doi. 10.1002/mrm.1910250215
By:
- Kvam, Bjarne J.;
- Pollesello, Piero;
- Vittur, Franco;
- Paoletti, Sergio
Publication type:
Article
The Catechol O-Methyltransferase Inhibitor Entacapone in the Treatment of Parkinson's Disease: Personal Reflections on a First-in-Class Drug Development Programme 40 Years On.
Published in:
Neurology & Therapy, 2024, v. 13, n. 4, p. 1039, doi. 10.1007/s40120-024-00629-2
By:
- Männistö, Pekka T.;
- Keränen, Tapani;
- Reinikainen, Kari J.;
- Hanttu, Anna;
- Pollesello, Piero
Publication type:
Article
Economic Evaluation of Levosimendan Versus Dobutamine for the Treatment of Acute Heart Failure in Italy.
Published in:
Advances in Therapy, 2012, v. 29, n. 12, p. 1037, doi. 10.1007/s12325-012-0070-4
By:
- Lucioni, Carlo;
- D'Ambrosi, Alessandra;
- Mazzi, Silvio;
- Pollesello, Piero;
- Apajasalo, Marjo;
- Fedele, Francesco
Publication type:
Article
The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology.
Published in:
European Journal of Heart Failure. Supplements, 2017, v. 19, n. 11, p. 1361, doi. 10.1002/ejhf.921
By:
- van Bilsen, Marc;
- Patel, Hitesh C.;
- Bauersachs, Johann;
- Böhm, Michael;
- Borggrefe, Martin;
- Brutsaert, Dirk;
- Coats, Andrew J. S.;
- de Boer, Rudolf A.;
- de Keulenaer, GillesW.;
- Filippatos, Gerasimos S.;
- Floras, John;
- Grassi, Guido;
- Jankowska, Ewa A.;
- Kornet, Lilian;
- Lunde, Ida G.;
- Maack, Christoph;
- Mahfoud, Felix;
- Pollesello, Piero;
- Ponikowski, Piotr;
- Ruschitzka, Frank
Publication type:
Article

Found: 35

Discovery and Structural Characterization of a Phospholamban-Binding Cyclic Peptide and Design of Novel Inhibitors of Phospholamban.

Changed Relation between Phosphorylation Potential and Left Ventricular Developed Pressure in Guinea Pig Hearts during Ischemia-Reperfusion a.

Levosimendan Improves Oxidative Balance in Cardiogenic Shock/Low Cardiac Output Patients.

Short-Term Therapies for Treatment of Acute and Advanced Heart Failure—Why so Few Drugs Available in Clinical Use, Why Even Fewer in the Pipeline?

Use of Levosimendan in Patients with Pulmonary Hypertension: What is the Current Evidence?

Levosimendan Inhibits Peroxidation in Hepatocytes by Modulating Apoptosis/Autophagy Interplay.

Detection and quantitation of phosphorus metabolites in crude tissue extracts by <sup>1</sup>H and <sup>31</sup>P NMR: use of gradient assisted <sup>1</sup>H-<sup>31</sup>P HMQC experiments, with selective pulses, for the assignment of less abundant metabolites

Use of Levosimendan in Patients with Advanced Heart Failure: An Update.

Levosimendan as a "Bridge to Optimization" in Patients with Advanced Heart Failure with Reduced Ejection—A Single-Center Study.

Novel Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger Inhibitor ORM-10962 Supports Coupled Function of Funny-Current and Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger in Pacemaking of Rabbit Sinus Node Tissue.

Mechanism of Action of Levosimendan: A Calcium Sensitizer for Treatment of Heart Failure.

Structural and functional implications of the phospholamban hinge domain: impaired SR Ca<sup>2+</sup> uptake as a primary cause of heart failure

A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function.

Long-term effects of Na<sup>+</sup> /Ca<sup>2+</sup> exchanger inhibition with ORM-11035 improves cardiac function and remodelling without lowering blood pressure in a model of heart failure with preserved ejection fraction.

Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology.

The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology.

Effects of Levosimendan on Inflammation and Oxidative Stress Pathways in a Lipopolysaccharide-Stimulated Human Endothelial Cell Model.

Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis.

Recognizing early signs in the translational phase is essential for drug development in cardiovascular medicine.

Levosimendan‐induced venodilation is mediated by opening of potassium channels.

Rehospitalization after intermittent levosimendan treatment in advanced heart failure patients: a meta‐analysis of randomized trials.

Prolonged Antispasmodic Effect in Isolated Radial Artery Graft and Pronounced Platelet Inhibition Induced by the Inodilator Drug, Levosimendan.

The Effect of Levosimendan during Long-Term Amiodarone Treatment in Dogs.

Positive Inotropic Effect of Levosimendan is Correlated to its Stereoselective Ca<sup>2+</sup>-Sensitizing Effect but not to Stereoselective Phosphodiesterase Inhibition.

The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments.

Levosimendan in Acute and Advanced Heart Failure: an Expert Perspective on Posology and Therapeutic Application.

Renal Effects of Levosimendan: A Consensus Report.

Effect of Levosimendan and Milrinone on Regional Myocardial Ischemia/Reperfusion-Induced Arrhythmias in Dogs.

Selective Na(+) /Ca(2+) exchanger inhibition prevents Ca(2+) overload-induced triggered arrhythmias.

Selective Na<sup>+</sup>/ Ca<sup>2+</sup> exchanger inhibition prevents Ca<sup>2+</sup> overload-induced triggered arrhythmias.

The levosimendan metabolite OR-1896 elicits vasodilation by activating the K<sub>ATP</sub> and BK<sub>Ca</sub> channels in rat isolated arterioles.

<sup>31</sup>P NMR studies of resting zone cartilage from growth plate.

The Catechol O-Methyltransferase Inhibitor Entacapone in the Treatment of Parkinson's Disease: Personal Reflections on a First-in-Class Drug Development Programme 40 Years On.

Economic Evaluation of Levosimendan Versus Dobutamine for the Treatment of Acute Heart Failure in Italy.

The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology.