Works by Poelarends, Gerrit

Results: 79

Expanding the Substrate Scope of C−N Lyases by Homologue Discovery.

Published in:

ChemBioChem, 2025, v. 26, n. 7, p. 1, doi. 10.1002/cbic.202500068

By:

Bothof, Laura;
Iacovelli, Riccardo;
Tepper, Pieter G.;
Poelarends, Gerrit J.

Publication type:

Article

Synthesis of Pharmaceutically Relevant Arylamines Enabled by a Nitroreductase from Bacillus tequilensis.

Published in:

ChemBioChem, 2024, v. 25, n. 10, p. 1, doi. 10.1002/cbic.202300846

By:

Russo, Sara;
Luján, Alejandro Prats;
Fraaije, Marco W.;
Poelarends, Gerrit J.

Publication type:

Article

Enantiocomplementary Michael Additions of Acetaldehyde to Aliphatic Nitroalkenes Catalyzed by Proline‐Based Carboligases.

Published in:

ChemBioChem, 2022, v. 23, n. 6, p. 1, doi. 10.1002/cbic.202100644

By:

Kunzendorf, Andreas;
Saifuddin, Mohammad;
Poelarends, Gerrit J.

Publication type:

Article

Using Mutability Landscapes To Guide Enzyme Thermostabilization.

Published in:

ChemBioChem, 2021, v. 22, n. 1, p. 170, doi. 10.1002/cbic.202000442

By:

Guo, Chao;
Ni, Yan;
Biewenga, Lieuwe;
Pijning, Tjaard;
Thunnissen, Andy‐Mark W. H.;
Poelarends, Gerrit J.

Publication type:

Article

Recent Applications of Carbon‐Nitrogen Lyases in Asymmetric Synthesis of Noncanonical Amino Acids and Heterocyclic Compounds.

Published in:

ChemBioChem, 2020, v. 21, n. 19, p. 2733, doi. 10.1002/cbic.202000214

By:

Zhang, Jielin;
Abidin, Mohammad Z.;
Saravanan, Thangavelu;
Poelarends, Gerrit J.

Publication type:

Article

Tuning Enzyme Activity for Nonaqueous Solvents: Engineering an Enantioselective "Michaelase" for Catalysis in High Concentrations of Ethanol.

Published in:

ChemBioChem, 2020, v. 21, n. 10, p. 1499, doi. 10.1002/cbic.201900721

By:

Guo, Chao;
Biewenga, Lieuwe;
Lubberink, Max;
Merkerk, Ronald;
Poelarends, Gerrit J.

Publication type:

Article

In Situ Acetaldehyde Synthesis for Carboligation Reactions.

Published in:

ChemBioChem, 2020, v. 21, n. 10, p. 1505, doi. 10.1002/cbic.201900666

By:

Biewenga, Lieuwe;
Kunzendorf, Andreas;
Poelarends, Gerrit J.

Publication type:

Article

Engineering a Promiscuous Tautomerase into a More Efficient Aldolase for Self-Condensations of Linear Aliphatic Aldehydes.

Published in:

ChemBioChem, 2017, v. 18, n. 14, p. 1435, doi. 10.1002/cbic.201700121

By:

Rahimi, Mehran;
van der Meer, Jan‐Ytzen;
Geertsema, Edzard M.;
Poelarends, Gerrit J.

Publication type:

Article

The Generation and Exploitation of Protein Mutability Landscapes for Enzyme Engineering.

Published in:

ChemBioChem, 2016, v. 17, n. 19, p. 1792, doi. 10.1002/cbic.201600382

By:

van der Meer, Jan‐Ytzen;
Biewenga, Lieuwe;
Poelarends, Gerrit J.

Publication type:

Article

CORRIGENDUM: Mutations Closer to the Active Site Improve the Promiscuous Aldolase Activity of 4-Oxalocrotonate Tautomerase More Effectively than Distant Mutations.

Published in:

ChemBioChem, 2016, v. 17, n. 13, p. 1290, doi. 10.1002/cbic.201600321

By:

Rahimi, Mehran;
van der Meer, Jan‐Ytzen;
Geertsema, Edzard M.;
Poddar, Harshwardhan;
Baas, Bert‐Jan;
Poelarends, Gerrit J.

Publication type:

Article

Evidence for the Formation of an Enamine Species during Aldol and Michael-type Addition Reactions Promiscuously Catalyzed by 4-Oxalocrotonate Tautomerase.

Published in:

ChemBioChem, 2015, v. 16, n. 5, p. 738, doi. 10.1002/cbic.201402687

By:

Poddar, Harshwardhan;
Rahimi, Mehran;
Geertsema, Edzard M.;
Thunnissen, Andy‐Mark W. H.;
Poelarends, Gerrit J.

Publication type:

Article

Aqueous Oxidative Heck Reaction as a Protein-Labeling Strategy.

Published in:

ChemBioChem, 2014, v. 15, n. 2, p. 209, doi. 10.1002/cbic.201300714

By:

Ourailidou, Maria Eleni;
van der Meer, Jan‐Ytzen;
Baas, Bert‐Jan;
Jeronimus‐Stratingh, Margot;
Gottumukkala, Aditya L.;
Poelarends, Gerrit J.;
Minnaard, Adriaan J.;
Dekker, Frank J.

Publication type:

Article

Berichtigung: Bridging between Organocatalysis and Biocatalysis: Asymmetric Addition of Acetaldehyde to β-Nitrostyrenes Catalyzed by a Promiscuous Proline-Based Tautomerase.

Published in:

Angewandte Chemie, 2012, v. 124, n. 25, p. 6140, doi. 10.1002/ange.201203188

By:

Zandvoort, Ellen;
Geertsema, Edzard M.;
Baas, Bert-Jan;
Quax, Wim J.;
Poelarends, Gerrit J.

Publication type:

Article

Bridging between Organocatalysis and Biocatalysis: Asymmetric Addition of Acetaldehyde to β-Nitrostyrenes Catalyzed by a Promiscuous Proline-Based Tautomerase.

Published in:

Angewandte Chemie, 2012, v. 124, n. 5, p. 1266, doi. 10.1002/ange.201107404

By:

Zandvoort, Ellen;
Geertsema, Edzard M.;
Baas, Bert-Jan;
Quax, Wim J.;
Poelarends, Gerrit J.

Publication type:

Article

Mechanism-Inspired Engineering of Phenylalanine Aminomutase for Enhanced β-Regioselective Asymmetric Amination of Cinnamates.

Published in:

Angewandte Chemie, 2012, v. 124, n. 2, p. 497, doi. 10.1002/ange.201106372

By:

Wu, Bian;
Szymański, Wiktor;
Wybenga, Gjalt G.;
Heberling, Matthew M.;
Bartsch, Sebastian;
de Wildeman, Stefaan;
Poelarends, Gerrit J.;
Feringa, Ben L.;
Dijkstra, Bauke W.;
Janssen, Dick B.

Publication type:

Article

Characterization of a thermostable methylaspartate ammonia lyase from Carboxydothermus hydrogenoformans.

Published in:

Applied Microbiology & Biotechnology, 2012, v. 94, n. 2, p. 385, doi. 10.1007/s00253-011-3615-6

By:

Raj, Hans;
Puthan Veetil, Vinod;
Szymanski, Wiktor;
Dekker, Frank;
Quax, Wim;
Feringa, Ben;
Janssen, Dick;
Poelarends, Gerrit

Publication type:

Article

Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids.

Published in:

Nature Chemistry, 2012, v. 4, n. 6, p. 478, doi. 10.1038/nchem.1338

By:

Raj, Hans;
Szyma?ski, Wiktor;
de Villiers, Jandré;
Rozeboom, Henriëtte J.;
Veetil, Vinod Puthan;
Reis, Carlos R.;
de Villiers, Marianne;
Dekker, Frank J.;
de Wildeman, Stefaan;
Quax, Wim J.;
Thunnissen, Andy-Mark W. H.;
Feringa, Ben L.;
Janssen, Dick B.;
Poelarends, Gerrit J.

Publication type:

Article

Exploiting Nitroreductases for the Tailored Photoenzymatic Synthesis of Structurally Diverse Heterocyclic Compounds.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 56, p. 1, doi. 10.1002/chem.202402380

By:

Prats Luján, Alejandro;
Faizan Bhat, Mohammad;
Acosta Marko, Edgar Eduardo;
Fodran, Peter;
Poelarends, Gerrit J.

Publication type:

Article

Biocatalytic Cascade Synthesis of Enantioenriched Epoxides and Triols from Biomass‐Derived Synthons Driven by Specifically Designed Enzymes.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 31, p. 1, doi. 10.1002/chem.202300697

By:

Grandi, Eleonora;
Crotti, Michele;
Sigmund, Marie‐Cathérine;
Xu, Guangcai;
Tepper, Pieter G.;
Poelarends, Gerrit J.

Publication type:

Article

Enhancing the Peroxygenase Activity of a Cofactor‐Independent Peroxyzyme by Directed Evolution Enabling Gram‐Scale Epoxide Synthesis.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 59, p. 1, doi. 10.1002/chem.202201651

By:

Sigmund, Marie‐Cathérine;
Xu, Guangcai;
Grandi, Eleonora;
Poelarends, Gerrit J.

Publication type:

Article

4‐Iodopyrimidine Labeling Reveals Nuclear Translocation and Nuclease Activity for Both MIF and MIF2**.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 1, p. 1, doi. 10.1002/chem.202103030

By:

Xiao, Zhangping;
Chen, Deng;
Mulder, Fabian;
Song, Shanshan;
van der Wouden, Petra E.;
Cool, Robbert H.;
Melgert, Barbro N.;
Poelarends, Gerrit J.;
Dekker, Frank J.

Publication type:

Article

Enzymatic Oxy‐ and Amino‐Functionalization in Biocatalytic Cascade Synthesis: Recent Advances and Future Perspectives.

Published in:

Angewandte Chemie, 2023, v. 135, n. 48, p. 1, doi. 10.1002/ange.202309012

By:

Grandi, Eleonora;
Feyza Özgen, Fatma;
Schmidt, Sandy;
Poelarends, Gerrit J.

Publication type:

Article

Unlocking New Reactivities in Enzymes by Iminium Catalysis.

Published in:

Angewandte Chemie, 2022, v. 134, n. 30, p. 1, doi. 10.1002/ange.202203613

By:

Xu, Guangcai;
Poelarends, Gerrit J.

Publication type:

Article

Rücktitelbild: Gene Fusion and Directed Evolution to Break Structural Symmetry and Boost Catalysis by an Oligomeric C−C Bond‐Forming Enzyme (Angew. Chem. 8/2022).

Published in:

Angewandte Chemie, 2022, v. 134, n. 8, p. 1, doi. 10.1002/ange.202200436

By:

Xu, Guangcai;
Kunzendorf, Andreas;
Crotti, Michele;
Rozeboom, Henriëtte J.;
Thunnissen, Andy‐Mark W. H.;
Poelarends, Gerrit J.

Publication type:

Article

Gene Fusion and Directed Evolution to Break Structural Symmetry and Boost Catalysis by an Oligomeric C−C Bond‐Forming Enzyme.

Published in:

Angewandte Chemie, 2022, v. 134, n. 8, p. 1, doi. 10.1002/ange.202113970

By:

Xu, Guangcai;
Kunzendorf, Andreas;
Crotti, Michele;
Rozeboom, Henriëtte J.;
Thunnissen, Andy‐Mark W. H.;
Poelarends, Gerrit J.

Publication type:

Article

Biocatalytic Asymmetric Cyclopropanations via Enzyme‐Bound Iminium Ion Intermediates.

Published in:

Angewandte Chemie, 2021, v. 133, n. 45, p. 24261, doi. 10.1002/ange.202110719

By:

Kunzendorf, Andreas;
Xu, Guangcai;
Saifuddin, Mohammad;
Saravanan, Thangavelu;
Poelarends, Gerrit J.

Publication type:

Article

Proteolysis Targeting Chimera (PROTAC) for Macrophage Migration Inhibitory Factor (MIF) Has Anti‐Proliferative Activity in Lung Cancer Cells.

Published in:

Angewandte Chemie, 2021, v. 133, n. 32, p. 17655, doi. 10.1002/ange.202101864

By:

Xiao, Zhangping;
Song, Shanshan;
Chen, Deng;
Merkerk, Ronald;
Wouden, Petra E.;
Cool, Robbert H.;
Quax, Wim J.;
Poelarends, Gerrit J.;
Melgert, Barbro N.;
Dekker, Frank J.

Publication type:

Article

Enantiocomplementary Epoxidation Reactions Catalyzed by an Engineered Cofactor‐Independent Non‐natural Peroxygenase.

Published in:

Angewandte Chemie, 2020, v. 132, n. 26, p. 10460, doi. 10.1002/ange.202001373

By:

Xu, Guangcai;
Crotti, Michele;
Saravanan, Thangavelu;
Kataja, Kim M.;
Poelarends, Gerrit J.

Publication type:

Article

Engineered C–N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners.

Published in:

Angewandte Chemie, 2020, v. 132, n. 1, p. 437, doi. 10.1002/ange.201910704

By:

Zhang, Jielin;
Grandi, Eleonora;
Fu, Haigen;
Saravanan, Thangavelu;
Bothof, Laura;
Tepper, Pieter G.;
Thunnissen, Andy‐Mark W. H.;
Poelarends, Gerrit J.

Publication type:

Article

TEMPO‐Mediated Electrochemical N‐demethylation of Opiate Alkaloids.

Published in:

ChemElectroChem, 2021, v. 8, n. 13, p. 2590, doi. 10.1002/celc.202100784

By:

Najmi, Ali Alipour;
Bhat, M. Faizan;
Bischoff, Rainer;
Poelarends, Gerrit J.;
Permentier, Hjalmar P.

Publication type:

Article

Bacterial degradation of xenobiotic compounds: evolution and distribution of novel enzyme activities.

Published in:

Environmental Microbiology, 2005, v. 7, n. 12, p. 1868, doi. 10.1111/j.1462-2920.2005.00966.x

By:

Janssen, Dick B.;
Dinkla, Inez J. T.;
Poelarends, Gerrit J.;
Terpstra, Peter

Publication type:

Article

Site-directed mutagenesis, kinetic and inhibition studies of aspartate ammonia lyase from Bacillus sp. YM55-1.

Published in:

FEBS Journal, 2009, v. 276, n. 11, p. 2994, doi. 10.1111/j.1742-4658.2009.07015.x

By:

Puthan Veetil, Vinod;
Raj, Hans;
Quax, Wim J.;
Janssen, Dick B.;
Poelarends, Gerrit J.

Publication type:

Article

Investigation of AMA Synthase from Pyrenophora teres f. teres 0–1 for the Synthesis of Aspergillomarasmine A Analogues and Non‐Canonical Amino Acids.

Published in:

Advanced Synthesis & Catalysis, 2024, v. 366, n. 24, p. 5160, doi. 10.1002/adsc.202401118

By:

Zhu, Zhixi;
Ma, Yue;
Xie, Xiaoying;
Wang, Zhiyuan;
Han, Lu;
Song, Jingwu;
Liang, Yuzong;
Poelarends, Gerrit J.;
Chen, Yijun;
Lu, Meiling;
Zhang, Jielin

Publication type:

Article

Exploring the Substrate Scope and Catalytic Promiscuity of Nitroreductase‐Like Enzymes.

Published in:

Advanced Synthesis & Catalysis, 2024, v. 366, n. 22, p. 4679, doi. 10.1002/adsc.202400220

By:

Luján, Alejandro Prats;
Bhat, Mohammad Faizan;
Saravanan, Thangavelu;
Poelarends, Gerrit J.

Publication type:

Article

Biocatalytic Enantioselective Hydroaminations for Production of N‐Cycloalkyl‐Substituted L‐Aspartic Acids Using Two C−N Lyases.

Published in:

Advanced Synthesis & Catalysis, 2019, v. 361, n. 11, p. 2433, doi. 10.1002/adsc.201801569

By:

Zhang, Jielin;
Fu, Haigen;
Tepper, Pieter G.;
Poelarends, Gerrit J.

Publication type:

Article

Corrigendum: Bridging between Organocatalysis and Biocatalysis: Asymmetric Addition of Acetaldehyde to β-Nitrostyrenes Catalyzed by a Promiscuous Proline-Based Tautomerase.

Published in:

Angewandte Chemie International Edition, 2012, v. 51, n. 25, p. 6035, doi. 10.1002/anie.201203188

By:

Zandvoort, Ellen;
Geertsema, Edzard M.;
Baas, Bert-Jan;
Quax, Wim J.;
Poelarends, Gerrit J.

Publication type:

Article

Bridging between Organocatalysis and Biocatalysis: Asymmetric Addition of Acetaldehyde to β-Nitrostyrenes Catalyzed by a Promiscuous Proline-Based Tautomerase.

Published in:

Angewandte Chemie International Edition, 2012, v. 51, n. 5, p. 1240, doi. 10.1002/anie.201107404

By:

Zandvoort, Ellen;
Geertsema, Edzard M.;
Baas, Bert-Jan;
Quax, Wim J.;
Poelarends, Gerrit J.

Publication type:

Article

Mechanism-Inspired Engineering of Phenylalanine Aminomutase for Enhanced β-Regioselective Asymmetric Amination of Cinnamates.

Published in:

Angewandte Chemie International Edition, 2012, v. 51, n. 2, p. 482, doi. 10.1002/anie.201106372

By:

Wu, Bian;
Szymański, Wiktor;
Wybenga, Gjalt G.;
Heberling, Matthew M.;
Bartsch, Sebastian;
de Wildeman, Stefaan;
Poelarends, Gerrit J.;
Feringa, Ben L.;
Dijkstra, Bauke W.;
Janssen, Dick B.

Publication type:

Article

Stereochemical Control of Enzymatic Carbon-Carbon Bond-Forming Michael-Type Additions by 'Substrate Engineering'.

Published in:

European Journal of Organic Chemistry, 2016, v. 2016, n. 32, p. 5350, doi. 10.1002/ejoc.201601126

By:

Miao, Yufeng;
Tepper, Pieter G.;
Geertsema, Edzard M.;
Poelarends, Gerrit J.

Publication type:

Article

Enzymatic Oxy‐ and Amino‐Functionalization in Biocatalytic Cascade Synthesis: Recent Advances and Future Perspectives.

Published in:

Angewandte Chemie International Edition, 2023, v. 62, n. 48, p. 1, doi. 10.1002/anie.202309012

By:

Grandi, Eleonora;
Feyza Özgen, Fatma;
Schmidt, Sandy;
Poelarends, Gerrit J.

Publication type:

Article

Unlocking New Reactivities in Enzymes by Iminium Catalysis.

Published in:

Angewandte Chemie International Edition, 2022, v. 61, n. 30, p. 1, doi. 10.1002/anie.202203613

By:

Xu, Guangcai;
Poelarends, Gerrit J.

Publication type:

Article

Back Cover: Gene Fusion and Directed Evolution to Break Structural Symmetry and Boost Catalysis by an Oligomeric C−C Bond‐Forming Enzyme (Angew. Chem. Int. Ed. 8/2022).

Published in:

Angewandte Chemie International Edition, 2022, v. 61, n. 8, p. 1, doi. 10.1002/anie.202200436

By:

Xu, Guangcai;
Kunzendorf, Andreas;
Crotti, Michele;
Rozeboom, Henriëtte J.;
Thunnissen, Andy‐Mark W. H.;
Poelarends, Gerrit J.

Publication type:

Article

Gene Fusion and Directed Evolution to Break Structural Symmetry and Boost Catalysis by an Oligomeric C−C Bond‐Forming Enzyme.

Published in:

Angewandte Chemie International Edition, 2022, v. 61, n. 8, p. 1, doi. 10.1002/anie.202113970

By:

Xu, Guangcai;
Kunzendorf, Andreas;
Crotti, Michele;
Rozeboom, Henriëtte J.;
Thunnissen, Andy‐Mark W. H.;
Poelarends, Gerrit J.

Publication type:

Article

Biocatalytic Asymmetric Cyclopropanations via Enzyme‐Bound Iminium Ion Intermediates.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 45, p. 24059, doi. 10.1002/anie.202110719

By:

Kunzendorf, Andreas;
Xu, Guangcai;
Saifuddin, Mohammad;
Saravanan, Thangavelu;
Poelarends, Gerrit J.

Publication type:

Article

Proteolysis Targeting Chimera (PROTAC) for Macrophage Migration Inhibitory Factor (MIF) Has Anti‐Proliferative Activity in Lung Cancer Cells.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 32, p. 17514, doi. 10.1002/anie.202101864

By:

Xiao, Zhangping;
Song, Shanshan;
Chen, Deng;
Merkerk, Ronald;
Wouden, Petra E.;
Cool, Robbert H.;
Quax, Wim J.;
Poelarends, Gerrit J.;
Melgert, Barbro N.;
Dekker, Frank J.

Publication type:

Article

Enantiocomplementary Epoxidation Reactions Catalyzed by an Engineered Cofactor‐Independent Non‐natural Peroxygenase.

Published in:

Angewandte Chemie International Edition, 2020, v. 59, n. 26, p. 10374, doi. 10.1002/anie.202001373

By:

Xu, Guangcai;
Crotti, Michele;
Saravanan, Thangavelu;
Kataja, Kim M.;
Poelarends, Gerrit J.

Publication type:

Article

Engineered C–N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners.

Published in:

Angewandte Chemie International Edition, 2020, v. 59, n. 1, p. 429, doi. 10.1002/anie.201910704

By:

Zhang, Jielin;
Grandi, Eleonora;
Fu, Haigen;
Saravanan, Thangavelu;
Bothof, Laura;
Tepper, Pieter G.;
Thunnissen, Andy‐Mark W. H.;
Poelarends, Gerrit J.

Publication type:

Article

SLC1A3 contributes to L‐asparaginase resistance in solid tumors.

Published in:

EMBO Journal, 2019, v. 38, n. 21, p. N.PAG, doi. 10.15252/embj.2019102147

By:

Sun, Jianhui;
Nagel, Remco;
Zaal, Esther A;
Ugalde, Alejandro Piñeiro;
Han, Ruiqi;
Proost, Natalie;
Song, Ji‐Ying;
Pataskar, Abhijeet;
Burylo, Artur;
Fu, Haigen;
Poelarends, Gerrit J;
Ven, Marieke;
Tellingen, Olaf;
Berkers, Celia R;
Agami, Reuven

Publication type:

Article

Engineering 2‐Deoxy‐D‐ribose‐5‐phosphate Aldolase for anti‐ and syn‐Selective Epoxidations of α,β‐Unsaturated Aldehydes.

Published in:

Angewandte Chemie, 2025, v. 137, n. 20, p. 1, doi. 10.1002/ange.202503054

By:

Zhou, Hangyu;
Kunzendorf, Andreas;
Xu, Guangcai;
Frietema, Hylke O. T.;
Thunnissen, Andy‐Mark W. H.;
Poelarends, Gerrit J.

Publication type:

Article

Tailored photoenzymatic systems for selective reduction of aliphatic and aromatic nitro compounds fueled by light.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41194-w

By:

Luján, Alejandro Prats;
Bhat, Mohammad Faizan;
Tsaturyan, Sona;
van Merkerk, Ronald;
Fu, Haigen;
Poelarends, Gerrit J.

Publication type:

Article