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Targeting Tropomyosin Receptor Kinase in Cutaneous CYLD Defective Tumors With Pegcantratinib: The TRAC Randomized Clinical Trial.
Published in:
2018
By:
- Danilenko, Marina;
- Stamp, Elaine;
- Stocken, Deborah D.;
- Husain, Akhtar;
- Zangarini, Monique;
- Cranston, Amy;
- Stones, Robert;
- Sinclair, Naomi;
- Hodgson, Kirsty;
- Bowett, Susan A.;
- Roblin, David;
- Traversa, Silvio;
- Plummer, Ruth;
- Veal, Gareth;
- Langtry, James A. A.;
- Ashworth, Alan;
- Burn, John;
- Rajan, Neil
Publication type:
journal article
PARP activity in peripheral blood lymphocytes as a predictive biomarker for PARP inhibition in tumor tissues - A population pharmacokinetic/pharmacodynamic analysis of rucaparib.
Published in:
Clinical Pharmacology in Drug Development, 2015, v. 4, n. 2, p. 89, doi. 10.1002/cpdd.176
By:
- Wang, Diane D.;
- Li, Chunze;
- Sun, Wan;
- Zhang, Shuzhong;
- Shalinsky, David R.;
- Kern, Kenneth A.;
- Curtin, Nicola J.;
- Sam, Wai‐Johnn;
- Kirkpatrick, Tanya R.;
- Plummer, Ruth
Publication type:
Article
A phase I trial of lurbinectedin in combination with cisplatin in patients with advanced solid tumors.
Published in:
Investigational New Drugs, 2022, v. 40, n. 1, p. 91, doi. 10.1007/s10637-021-01142-1
By:
- Metaxas, Yannis;
- Kahatt, Carmen;
- Alfaro, Vicente;
- Fudio, Salvador;
- Zeaiter, Ali;
- Plummer, Ruth;
- Sessa, Cristiana;
- Von Moos, Roger;
- Forster, Martin;
- Stathis, Anastasios
Publication type:
Article
Phase I Study of Lapatinib and Pemetrexed in the Second-Line Treatment of Advanced or Metastatic Non-Small-Cell Lung Cancer With Assessment of Circulating Cell Free Thymidylate Synthase RNA as a Potential Biomarker.
Published in:
2015
By:
- Ramlau, Rodryg;
- Thomas, Michael;
- Novello, Silvia;
- Plummer, Ruth;
- Reck, Martin;
- Kaneko, Tomomi;
- Lau, Mike R;
- Margetts, Jane;
- Lunec, John;
- Nutt, Joyce;
- Scagliotti, Giorgio V
Publication type:
journal article
Phase I Study of Lapatinib and Pemetrexed in the Second-Line Treatment of Advanced or Metastatic Non--Small-Cell Lung Cancer With Assessment of Circulating Cell Free Thymidylate Synthase RNA as a Potential Biomarker.
Published in:
Clinical Lung Cancer, 2015, v. 16, n. 5, p. 348, doi. 10.1016/j.cllc.2015.01.004
By:
- Ramlau, Rodryg;
- Thomas, Michael;
- Novello, Silvia;
- Plummer, Ruth;
- Reck, Martin;
- Kaneko, Tomomi;
- Lau, Mike R.;
- Margetts, Jane;
- Lunec, John;
- Nutt, Joyce;
- Scagliotti, Giorgio V.
Publication type:
Article
Pharmacokinetics of carfilzomib in patients with advanced malignancies and varying degrees of hepatic impairment: an open-label, single-arm, phase 1 study.
Published in:
Experimental Hematology & Oncology, 2017, v. 6, p. 1, doi. 10.1186/s40164-017-0086-1
By:
- Brown, Jennifer;
- Plummer, Ruth;
- Bauer, Todd M.;
- Anthony, Stephen;
- Sarantopoulos, John;
- De Vos, Filip;
- White, Mike;
- Schupp, Marco;
- Ying Ou;
- Vaishampayan, Ulka
Publication type:
Article
Targeting the DNA Double Strand Break Repair Machinery in Prostate Cancer.
Published in:
PLoS ONE, 2011, v. 6, n. 5, p. 1, doi. 10.1371/journal.pone.0020311
By:
- Shaheen, Fadhel S.;
- Znojek, Pawel;
- Fisher, Ann;
- Webster, Martin;
- Plummer, Ruth;
- Gaughan, Luke;
- Smith, Graeme C. M.;
- Leung, Hing Y.;
- Curtin, Nicola J.;
- Robson, Craig N.
Publication type:
Article
Ipilimumab in pretreated patients with metastatic uveal melanoma: safety and clinical efficacy.
Published in:
Cancer Immunology, Immunotherapy, 2012, v. 61, n. 1, p. 41, doi. 10.1007/s00262-011-1089-0
By:
- Danielli, Riccardo;
- Ridolfi, Ruggero;
- Chiarion-Sileni, Vanna;
- Queirolo, Paola;
- Testori, Alessandro;
- Plummer, Ruth;
- Boitano, Monica;
- Calabrò, Luana;
- Rossi, Costanza;
- Giacomo, Anna;
- Ferrucci, Pier;
- Ridolfi, Laura;
- Altomonte, Maresa;
- Miracco, Clelia;
- Balestrazzi, Angelo;
- Maio, Michele
Publication type:
Article
Phase 1b study of berzosertib and cisplatin in patients with advanced triple-negative breast cancer.
Published in:
NPJ Breast Cancer, 2022, v. 8, n. 1, p. 1, doi. 10.1038/s41523-022-00406-0
By:
- Telli, Melinda L.;
- Tolaney, Sara M.;
- Shapiro, Geoffrey I.;
- Middleton, Mark;
- Lord, Simon R.;
- Arkenau, Hendrik Tobias;
- Tutt, Andrew;
- Abramson, Vandana;
- Dean, Emma;
- Haddad, Tufia C.;
- Wesolowski, Robert;
- Ferrer-Playan, Jordi;
- Goddemeier, Thomas;
- Grombacher, Thomas;
- Dong, Jennifer;
- Fleuranceau-Morel, Patricia;
- Diaz-Padilla, Ivan;
- Plummer, Ruth
Publication type:
Article
Impact of an educational intervention for advanced cancer patients referred for early phase clinical trials.
Published in:
British Journal of Nursing, 2023, v. 32, n. 15, p. 748, doi. 10.12968/bjon.2023.32.15.748
By:
- Hood, Ben;
- Plummer, Ruth;
- Hogarth, Linda;
- Brown, Gary;
- Porteous, Helen;
- Armstrong, Alan;
- Grice, Carole;
- Barron, Chris
Publication type:
Article
O17 Endogenous double-stranded RNA (dsRNA) in melanoma: an attack from within.
Published in:
British Journal of Dermatology, 2023, v. 189, n. 1, p. e11, doi. 10.1093/bjd/ljad174.017
By:
- Sadeq, Shaymaa;
- Plummer, Ruth;
- Chitcharoen, Suwalak;
- Lovat, Penny;
- Nelson, Glyn;
- Werner, Andreas
Publication type:
Article
Erratum to: Phase I study of PM00104 (Zalypsis®) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors.
Published in:
2013
By:
- Massard, Christophe;
- Margetts, Jane;
- Amellal, Nadia;
- Drew, Yvette;
- Bahleda, Ratislav;
- Stephens, Peter;
- Armand, Jean;
- Calvert, Hilary;
- Soria, Jean;
- Coronado, Cinthya;
- Kahatt, Carmen;
- Alfaro, Vicente;
- Siguero, Mariano;
- Fernández-Teruel, Carlos;
- Plummer, Ruth
Publication type:
Journal Article
Phase I study of PM00104 (Zalypsis®) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors.
Published in:
2013
By:
- Massard, Christophe;
- Margetts, Jane;
- Amellal, Nadia;
- Drew, Yvette;
- Bahleda, Ratislav;
- Stevens, Peter;
- Armand, Jean;
- Calvert, Hilary;
- Soria, Jean;
- Coronado, Cinthya;
- Kahatt, Carmen;
- Alfaro, Vicente;
- Siguero, Mariano;
- Fernández-Teruel, Carlos;
- Plummer, Ruth
Publication type:
Journal Article
Erratum to: Phase I study of PM00104 (Zalypsis®) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors.
Published in:
2013
By:
- Massard, Christophe;
- Margetts, Jane;
- Amellal, Nadia;
- Drew, Yvette;
- Bahleda, Ratislav;
- Stephens, Peter;
- Armand, Jean;
- Calvert, Hilary;
- Soria, Jean;
- Coronado, Cinthya;
- Kahatt, Carmen;
- Alfaro, Vicente;
- Siguero, Mariano;
- Fernández-Teruel, Carlos;
- Plummer, Ruth
Publication type:
Correction Notice
Phase I study of PM00104 (Zalypsis®) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors.
Published in:
Investigational New Drugs, 2013, v. 31, n. 3, p. 623, doi. 10.1007/s10637-012-9843-5
By:
- Massard, Christophe;
- Margetts, Jane;
- Amellal, Nadia;
- Drew, Yvette;
- Bahleda, Ratislav;
- Stevens, Peter;
- Armand, Jean;
- Calvert, Hilary;
- Soria, Jean;
- Coronado, Cinthya;
- Kahatt, Carmen;
- Alfaro, Vicente;
- Siguero, Mariano;
- Fernández-Teruel, Carlos;
- Plummer, Ruth
Publication type:
Article
Phase I study of weekly plitidepsin as 1-hour infusion combined with carboplatin in patients with advanced solid tumors or lymphomas.
Published in:
Investigational New Drugs, 2011, v. 29, n. 6, p. 1406, doi. 10.1007/s10637-010-9488-1
By:
- Salazar, Ramón;
- Plummer, Ruth;
- Oaknin, Ana;
- Robinson, Angela;
- Pardo, Beatriz;
- Soto-Matos, Arturo;
- Yovine, Alejandro;
- Szyldergemajn, Sergio;
- Calvert, Alan
Publication type:
Article
Immune-related adverse events in checkpoint blockade: Observations from human tissue and therapeutic considerations.
Published in:
Frontiers in Immunology, 2023, v. 13, p. 1, doi. 10.3389/fimmu.2023.1122430
By:
- Williams, Kristian C.;
- Gault, Abigail;
- Anderson, Amy E.;
- Stewart, Christopher J.;
- Lamb, Christopher A.;
- Ally Speight, R.;
- Rajan, Neil;
- Plummer, Ruth;
- Pratt, Arthur G.
Publication type:
Article
Safety, pharmacokinetic, pharmacodynamic and clinical activity of molibresib for the treatment of nuclear protein of the testis carcinoma and other cancers: Results of a Phase I/II open‐label, dose escalation study.
Published in:
International Journal of Cancer, 2022, v. 150, n. 6, p. 993, doi. 10.1002/ijc.33861
By:
- Cousin, Sophie;
- Blay, Jean‐Yves;
- Garcia, Irene Braña;
- de Bono, Johann S.;
- Le Tourneau, Christophe;
- Moreno, Victor;
- Trigo, Jose;
- Hann, Christine L.;
- Azad, Arun A.;
- Im, Seock‐Ah;
- Cassier, Philippe A.;
- French, Christopher A.;
- Italiano, Antoine;
- Keedy, Vicki L.;
- Plummer, Ruth;
- Sablin, Marie‐Paule;
- Hemming, Matthew L.;
- Ferron‐Brady, Geraldine;
- Wyce, Anastasia;
- Khaled, Ahmed
Publication type:
Article
Poly(ADP-ribose) polymerase inhibition: a new direction for BRCA and triple-negative breast cancer?
Published in:
2011
By:
- Plummer, Ruth
Publication type:
journal article
The DANTE trial protocol: a randomised phase III trial to evaluate the Duration of ANti-PD-1 monoclonal antibody Treatment in patients with metastatic mElanoma.
Published in:
2021
By:
- Coen, Oliver;
- Corrie, Pippa;
- Marshall, Helen;
- Plummer, Ruth;
- Ottensmeier, Christian;
- Hook, Jane;
- Bell, Sue;
- Sagoo, Gurdeep S.;
- Meads, David;
- Bestall, Janine;
- Velikova, Galina;
- Gallagher, Ferdia A.;
- Smith, Alexandra;
- Howard, Helen;
- Mason, Ellen;
- Katona, Eszter;
- Silva, Shobha;
- Collinson, Michelle;
- Rodwell, Simon;
- Danson, Sarah
Publication type:
journal article
Vemurafenib for the Treatment of Locally Advanced or Metastatic BRAF V600 Mutation-Positive Malignant Melanoma: A NICE Single Technology Appraisal.
Published in:
PharmacoEconomics, 2013, v. 31, n. 12, p. 1121, doi. 10.1007/s40273-013-0094-x
By:
- Beale, Sophie;
- Dickson, Rumona;
- Bagust, Adrian;
- Blundell, Michaela;
- Dundar, Yenal;
- Boland, Angela;
- Marshall, Ernie;
- Plummer, Ruth;
- Proudlove, Chris
Publication type:
Article
Correction: A case of malignant hyperlactaemic acidosis appearing upon treatment with the mono-carboxylase transporter 1 inhibitor AZD3965.
Published in:
2020
By:
- McNeillis, Rosie;
- Greystoke, Alastair;
- Walton, Jon;
- Bacon, Chris;
- Keun, Hector;
- Siskos, Alexandros;
- Petrides, George;
- Leech, Nicola;
- Jenkinson, Fiona;
- Bowron, Ann;
- Halford, Sarah;
- Plummer, Ruth
Publication type:
corrected article
A case of malignant hyperlactaemic acidosis appearing upon treatment with the mono-carboxylase transporter 1 inhibitor AZD3965.
Published in:
British Journal of Cancer, 2020, v. 122, n. 8, p. 1141, doi. 10.1038/s41416-020-0727-8
By:
- McNeillis, Rosie;
- Greystoke, Alastair;
- Walton, Jon;
- Bacon, Chris;
- Keun, Hector;
- Siskos, Alexandros;
- Petrides, George;
- Leech, Nicola;
- Jenkinson, Fiona;
- Bowron, Ann;
- Halford, Sarah;
- Plummer, Ruth
Publication type:
Article
A case of malignant hyperlactaemic acidosis appearing upon treatment with the mono-carboxylase transporter 1 inhibitor AZD3965.
Published in:
2020
By:
- McNeillis, Rosie;
- Greystoke, Alastair;
- Walton, Jon;
- Bacon, Chris;
- Keun, Hector;
- Siskos, Alexandros;
- Petrides, George;
- Leech, Nicola;
- Jenkinson, Fiona;
- Bowron, Ann;
- Halford, Sarah;
- Plummer, Ruth
Publication type:
journal article
A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours.
Published in:
2019
By:
- Mak, Gabriel;
- Soria, Jean-Charles;
- Blagden, Sarah P.;
- Plummer, Ruth;
- Fleming, Ronald A.;
- Nebot, Noelia;
- Zhang, Jianping;
- Mazumdar, Jolly;
- Rogan, Debra;
- Gazzah, Anas;
- Rizzuto, Ivana;
- Greystoke, Alastair;
- Yan, Li;
- Tolson, Jerry;
- Auger, Kurt R.;
- Arkenau, Hendrik-Tobias
Publication type:
journal article
A phase 1b/2, open-label, dose-escalation, and dose-confirmation study of eribulin mesilate in combination with capecitabine.
Published in:
2019
By:
- Twelves, Chris;
- Anthoney, Alan;
- Savulsky, Claudio I.;
- Guo, Matthew;
- Reyderman, Larisa;
- Cresti, Nicola;
- Semiglazov, Vladimir;
- Timcheva, Constanta;
- Zubairi, Ishtiaq;
- Morrison, Rosemary;
- Plummer, Ruth;
- Evans, T. R. Jeffry
Publication type:
journal article
Detection of circulating tumour cell clusters in human glioblastoma.
Published in:
2018
By:
- Krol, Ilona;
- Castro-Giner, Francesc;
- Maurer, Martina;
- Gkountela, Sofia;
- Szczerba, Barbara Maria;
- Scherrer, Ramona;
- Coleman, Niamh;
- Carreira, Suzanne;
- Bachmann, Felix;
- Anderson, Stephanie;
- Engelhardt, Marc;
- Lane, Heidi;
- Evans, Thomas Ronald Jeffry;
- Plummer, Ruth;
- Kristeleit, Rebecca;
- Lopez, Juanita;
- Aceto, Nicola
Publication type:
journal article
SELECT-3: a phase I study of selumetinib in combination with platinum-doublet chemotherapy for advanced NSCLC in the first-line setting.
Published in:
2017
By:
- Greystoke, Alastair;
- Steele, Nicola;
- Arkenau, Hendrik-Tobias;
- Blackhall, Fiona;
- Md Haris, Noor;
- Lindsay, Colin R;
- Califano, Raffaele;
- Voskoboynik, Mark;
- Summers, Yvonne;
- So, Karen;
- Ghiorghiu, Dana;
- Dymond, Angela W;
- Hossack, Stuart;
- Plummer, Ruth;
- Dean, Emma
Publication type:
journal article
A phase I study of intravenous and oral rucaparib in combination with chemotherapy in patients with advanced solid tumours.
Published in:
2017
By:
- Wilson, Richard H;
- Evans, TR Jeffry;
- Middleton, Mark R;
- Molife, L Rhoda;
- Spicer, James;
- Dieras, Veronique;
- Roxburgh, Patricia;
- Giordano, Heidi;
- Jaw-Tsai, Sarah;
- Goble, Sandra;
- Plummer, Ruth
Publication type:
journal article
Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer.
Published in:
2016
By:
- Drew, Yvette;
- Ledermann, Jonathan;
- Hall, Geoff;
- Rea, Daniel;
- Glasspool, Ros;
- Highley, Martin;
- Jayson, Gordon;
- Sludden, Julieann;
- Murray, James;
- Jamieson, David;
- Halford, Sarah;
- Acton, Gary;
- Backholer, Zoe;
- Mangano, Raffaella;
- Boddy, Alan;
- Curtin, Nicola;
- Plummer, Ruth
Publication type:
journal article
Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer.
Published in:
2016
By:
- Drew, Yvette;
- Ledermann, Jonathan;
- Hall, Geoff;
- Rea, Daniel;
- Glasspool, Ros;
- Highley, Martin;
- Jayson, Gordon;
- Sludden, Julieann;
- Murray, James;
- Jamieson, David;
- Halford, Sarah;
- Acton, Gary;
- Backholer, Zoe;
- Mangano, Raffaella;
- Boddy, Alan;
- Curtin, Nicola;
- Plummer, Ruth
Publication type:
journal article
Phase 1 study of the pan-RAF inhibitor tovorafenib in patients with advanced solid tumors followed by dose expansion in patients with metastatic melanoma.
Published in:
Cancer Chemotherapy & Pharmacology, 2023, v. 92, n. 1, p. 15, doi. 10.1007/s00280-023-04544-5
By:
- Rasco, Drew W.;
- Medina, Theresa;
- Corrie, Pippa;
- Pavlick, Anna C.;
- Middleton, Mark R.;
- Lorigan, Paul;
- Hebert, Chris;
- Plummer, Ruth;
- Larkin, James;
- Agarwala, Sanjiv S.;
- Daud, Adil I.;
- Qiu, Jiaheng;
- Bozon, Viviana;
- Kneissl, Michelle;
- Barry, Elly;
- Olszanski, Anthony J.
Publication type:
Article
First-in-human, open-label, phase 1/2 study of the monoclonal antibody programmed cell death protein-1 (PD-1) inhibitor cetrelimab (JNJ-63723283) in patients with advanced cancers.
Published in:
2022
By:
- Felip, Enriqueta;
- Moreno, Victor;
- Morgensztern, Daniel;
- Curigliano, Giuseppe;
- Rutkowski, Piotr;
- Trigo, José Manuel;
- Calvo, Aitana;
- Kowalski, Dariusz;
- Cortinovis, Diego;
- Plummer, Ruth;
- Maio, Michele;
- Ascierto, Paolo A.;
- Vladimirov, Vladimir I.;
- Cervantes, Andres;
- Zudaire, Enrique;
- Hazra, Anasuya;
- T'jollyn, Huybrecht;
- Bandyopadhyay, Nibedita;
- Greger, James G.;
- Attiyeh, Edward
Publication type:
journal article
Olaparib does not cause clinically relevant QT/QTc interval prolongation in patients with advanced solid tumours: results from two phase I studies.
Published in:
2016
By:
- Swaisland, Helen;
- Plummer, Ruth;
- So, Karen;
- Garnett, Sally;
- Bannister, Wendy;
- Fabre, Marc-Antoine;
- Dota, Corina;
- Fielding, Anitra
Publication type:
journal article
Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours.
Published in:
2015
By:
- Plummer, Ruth;
- Swaisland, Helen;
- Leunen, Karin;
- Herpen, Carla;
- Jerusalem, Guy;
- Grève, Jacques;
- Lolkema, Martijn;
- Soetekouw, Patricia;
- Mau-Sørensen, Morten;
- Nielsen, Dorte;
- Spicer, James;
- Fielding, Anitra;
- So, Karen;
- Bannister, Wendy;
- Molife, L. Rhoda;
- van Herpen, Carla M L;
- De Grève, Jacques;
- Lolkema, Martijn P;
- Mau-Sørensen, Morten
Publication type:
journal article
Phase 1 dose-escalation study of the PARP inhibitor CEP-9722 as monotherapy or in combination with temozolomide in patients with solid tumors.
Published in:
Cancer Chemotherapy & Pharmacology, 2014, v. 74, n. 2, p. 257, doi. 10.1007/s00280-014-2486-9
By:
- Plummer, Ruth;
- Stephens, Peter;
- Aissat-Daudigny, Louiza;
- Cambois, Anne;
- Moachon, Gilbert;
- Brown, Peter;
- Campone, Mario
Publication type:
Article
A phase II study of the potent PARP inhibitor, Rucaparib (PF-01367338, AG014699), with temozolomide in patients with metastatic melanoma demonstrating evidence of chemopotentiation.
Published in:
Cancer Chemotherapy & Pharmacology, 2013, v. 71, n. 5, p. 1191, doi. 10.1007/s00280-013-2113-1
By:
- Plummer, Ruth;
- Lorigan, Paul;
- Steven, Neil;
- Scott, Lucy;
- Middleton, Mark;
- Wilson, Richard;
- Mulligan, Evan;
- Curtin, Nicola;
- Wang, Diane;
- Dewji, Raz;
- Abbattista, Antonello;
- Gallo, Jorge;
- Calvert, Hilary
Publication type:
Article
A Phase I study of pazopanib in combination with gemcitabine in patients with advanced solid tumors.
Published in:
Cancer Chemotherapy & Pharmacology, 2013, v. 71, n. 1, p. 93, doi. 10.1007/s00280-012-1982-z
By:
- Plummer, Ruth;
- Madi, Ayman;
- Jeffels, Melinda;
- Richly, Heike;
- Nokay, Bahar;
- Rubin, Stephen;
- Ball, Howard;
- Weller, Steve;
- Botbyl, Jeffrey;
- Gibson, Diana;
- Scheulen, Max
Publication type:
Article
Pharmacological study of paclitaxel duration of infusion combined with GFR-based carboplatin in the treatment of ovarian cancer.
Published in:
2001
By:
- Boddy, Alan V.;
- Griffin, Melanie J.;
- Sludden, Julieann;
- Thomas, Huw D.;
- Fishwick, Kevin;
- Wright, James G.;
- Plummer, Ruth E.;
- Highley, Martin;
- Calvert, Hilary A.;
- Boddy, A V;
- Griffin, M J;
- Sludden, J;
- Thomas, H D;
- Fishwick, K;
- Wright, J G;
- Plumner, E R;
- Highley, M;
- Calvert, A H
Publication type:
journal article
High-resolution imaging for the detection and characterisation of circulating tumour cells from patients with oesophageal, hepatocellular, thyroid and ovarian cancers.
Published in:
International Journal of Cancer, 2016, v. 138, n. 1, p. 206, doi. 10.1002/ijc.29680
By:
- Dent, Barry M.;
- Ogle, Laura F.;
- O'Donnell, Rachel L.;
- Hayes, Nicholas;
- Malik, Ujjal;
- Curtin, Nicola J.;
- Boddy, Alan V.;
- Plummer, E. Ruth;
- Edmondson, Richard J.;
- Reeves, Helen L.;
- May, Felicity E.B.;
- Jamieson, David
Publication type:
Article
A Phase 1/2A trial of idroxioleic acid: first-in-class sphingolipid regulator and glioma cell autophagy inducer with antitumor activity in refractory glioma.
Published in:
British Journal of Cancer, 2023, v. 129, n. 5, p. 811, doi. 10.1038/s41416-023-02356-1
By:
- Lopez, Juanita;
- Lai-Kwon, Julia;
- Molife, Rhoda;
- Welsh, Liam;
- Tunariu, Nina;
- Roda, Desamparados;
- Fernández-García, Paula;
- Lladó, Victoria;
- McNicholl, Adrian G.;
- Rosselló, Catalina A.;
- Taylor, Richard J.;
- Azaro, Analía;
- Rodón, Jordi;
- Sludden, Julieann;
- Veal, Gareth J.;
- Plummer, Ruth;
- Urruticoechea, Ander;
- Lahuerta, Ainhara;
- Mujika, Karmele;
- Escribá, Pablo V.
Publication type:
Article
A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer.
Published in:
British Journal of Cancer, 2023, v. 129, n. 1, p. 38, doi. 10.1038/s41416-023-02279-x
By:
- Kristeleit, Rebecca;
- Plummer, Ruth;
- Jones, Robert;
- Carter, Louise;
- Blagden, Sarah;
- Sarker, Debashis;
- Arkenau, Tobias;
- Evans, Thomas R. Jeffry;
- Danson, Sarah;
- Symeonides, Stefan N.;
- Veal, Gareth J.;
- Klencke, Barbara J.;
- Kowalski, Mark M.;
- Banerji, Udai
Publication type:
Article
A first-in-human Phase I dose-escalation trial of the novel therapeutic peptide, ALM201, demonstrates a favourable safety profile in unselected patients with ovarian cancer and other advanced solid tumours.
Published in:
2022
By:
- El Helali, Aya;
- Plummer, Ruth;
- Jayson, Gordon C.;
- Coyle, Vicky M.;
- Drew, Yvette;
- Mescallado, Nerissa;
- Harris, Noor;
- Clamp, Andrew R.;
- McCann, Janine;
- Swaisland, Helen;
- Kennedy, Richard D.;
- Cranston, Aaron N.;
- Wilson, Richard H.
Publication type:
journal article
Phase 1 study of the ATR inhibitor berzosertib in combination with cisplatin in patients with advanced solid tumours.
Published in:
2021
By:
- Shapiro, Geoffrey I.;
- Wesolowski, Robert;
- Devoe, Craig;
- Lord, Simon;
- Pollard, John;
- Hendriks, Bart S.;
- Falk, Martin;
- Diaz-Padilla, Ivan;
- Plummer, Ruth;
- Yap, Timothy A.
Publication type:
journal article
Phase 1 study of the ATR inhibitor berzosertib (formerly M6620, VX-970) combined with gemcitabine ± cisplatin in patients with advanced solid tumours.
Published in:
2021
By:
- Middleton, Mark R.;
- Dean, Emma;
- Evans, Thomas R. J.;
- Shapiro, Geoffrey I.;
- Pollard, John;
- Hendriks, Bart S.;
- Falk, Martin;
- Diaz-Padilla, Ivan;
- Plummer, Ruth
Publication type:
journal article
Melanoma recurrence patterns and management after adjuvant targeted therapy: a multicentre analysis.
Published in:
2021
By:
- Bhave, Prachi;
- Pallan, Lalit;
- Long, Georgina V.;
- Menzies, Alexander M.;
- Atkinson, Victoria;
- Cohen, Justine V.;
- Sullivan, Ryan J.;
- Chiarion-Sileni, Vanna;
- Nyakas, Marta;
- Kahler, Katharina;
- Hauschild, Axel;
- Plummer, Ruth;
- Trojaniello, Claudia;
- Ascierto, Paolo A.;
- Zimmer, Lisa;
- Schadendorf, Dirk;
- Allayous, Clara;
- Lebbe, Celeste;
- Maurichi, Andrea;
- Santinami, Mario
Publication type:
journal article
First-in-human Phase 1 open label study of the BET inhibitor ODM-207 in patients with selected solid tumours.
Published in:
2020
By:
- Ameratunga, Malaka;
- Braña, Irene;
- Bono, Petri;
- Postel-Vinay, Sophie;
- Plummer, Ruth;
- Aspegren, John;
- Korjamo, Timo;
- Snapir, Amir;
- de Bono, Johann S
Publication type:
journal article
First-in-human study of the PARP/tankyrase inhibitor E7449 in patients with advanced solid tumours and evaluation of a novel drug-response predictor.
Published in:
2020
By:
- Plummer, Ruth;
- Dua, Divyanshu;
- Cresti, Nicola;
- Drew, Yvette;
- Stephens, Peter;
- Foegh, Marie;
- Knudsen, Steen;
- Sachdev, Pallavi;
- Mistry, Bipin M.;
- Dixit, Vaishali;
- McGonigle, Sharon;
- Hall, Nancy;
- Matijevic, Mark;
- McGrath, Shannon;
- Sarker, Debashis
Publication type:
journal article
Early switch from intravenous to oral antibiotic therapy in patients with cancer who have low-risk neutropenic sepsis: the EASI-SWITCH RCT.
Published in:
Health Technology Assessment, 2024, v. 28, n. 11-15, p. vii
By:
- Coyle, Vicky;
- Forde, Caroline;
- Adams, Richard;
- Agus, Ashley;
- Barnes, Rosemary;
- Chau, Ian;
- Clarke, Mike;
- Doran, Annmarie;
- Grayson, Margaret;
- McAuley, Danny;
- McDowell, Cliona;
- Phair, Glenn;
- Plummer, Ruth;
- Storey, Dawn;
- Thomas, Anne;
- Wilson, Richard;
- McMullan, Ronan
Publication type:
Article
Pharmacokinetics and Safety of Olaparib in Patients with Advanced Solid Tumours and Renal Impairment.
Published in:
2019
By:
- Rolfo, Christian;
- de Vos-Geelen, Judith;
- Isambert, Nicolas;
- Molife, L. Rhoda;
- Schellens, Jan H. M.;
- De Grève, Jacques;
- Dirix, Luc;
- Grundtvig-Sørensen, Peter;
- Jerusalem, Guy;
- Leunen, Karin;
- Mau-Sørensen, Morten;
- Plummer, Ruth;
- Learoyd, Maria;
- Bannister, Wendy;
- Fielding, Anitra;
- Ravaud, Alain
Publication type:
journal article

Found: 60