Works by Ploegh, Hidde L

Results: 149

Enzymatic Blockade of the Ubiquitin-Proteasome Pathway.

Published in:

PLoS Biology, 2011, v. 9, n. 3, p. 1, doi. 10.1371/journal.pbio.1000605

By:

Ernst, Robert;
Claessen, Jasper H. L.;
Mueller, Britta;
Sanyal, Sumana;
Spooner, Eric;
van der Veen, Annemarthe G.;
Kirak, Oktay;
Schlieker, Christian D.;
Weihofen, Wilhelm A.;
Ploegh, Hidde L.

Publication type:

Article

Bilden und Brechen von Peptidbindungen: Protein-Engineering mithilfe von Sortase.

Published in:

Angewandte Chemie, 2011, v. 123, n. 22, p. 5128, doi. 10.1002/ange.201008267

By:

Popp, Maximilian Wei-Lin;
Ploegh, Hidde L.

Publication type:

Article

DM exchange mechanism.

Published in:

Nature, 1995, v. 376, n. 6540, p. 464, doi. 10.1038/376464a0

By:

Wolf, Paula R.;
Ploegh, Hidde L.

Publication type:

Article

ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.91930

By:

Bates, Timothy A.;
Trank-Greene, Mila;
Nguyenla, Xammy;
Anastas, Aidan;
Gurmessa, Sintayehu K.;
Merutka, Ilaria R.;
Dixon, Shandee D.;
Shumate, Anthony;
Groncki, Abigail R.;
Parson, Matthew A. H.;
Ingram, Jessica R.;
Barklis, Eric;
Burke, John E.;
Shinde, Ujwal;
Ploegh, Hidde L.;
Tafesse, Fikadu G.

Publication type:

Article

Protein Ligation in Living Cells Using Sortase.

Published in:

Traffic, 2012, v. 13, n. 6, p. 780, doi. 10.1111/j.1600-0854.2012.01345.x

By:

Strijbis, Karin;
Spooner, Eric;
Ploegh, Hidde L.

Publication type:

Article

Cellular internalization of cytolethal distending toxin: a new end to a known pathway.

Published in:

Cellular Microbiology, 2005, v. 7, n. 7, p. 921, doi. 10.1111/j.1462-5822.2005.00520.x

By:

Guerra, Lina;
Teter, Ken;
Lilley, Brendan N.;
Stenerlöw, Bo;
Holmes, Randall K.;
Ploegh, Hidde L.;
Sandvig, Kirsten;
Thelestam, Monica;
Frisan, Teresa

Publication type:

Article

Mice deficient in invariant-chain and MHC class II exhibit a normal mature B2 cell compartment.

Published in:

European Journal of Immunology, 2004, v. 34, n. 8, p. 2230, doi. 10.1002/eji.200425246

By:

Maehr, Rene´;
Kraus, Manfred;
Ploegh, Hidde L.

Publication type:

Article

Control of cross-presentation during dendritic cell maturation.

Published in:

European Journal of Immunology, 2004, v. 34, n. 2, p. 398, doi. 10.1002/eji.200324508

By:

Gil-Torregrosa, Beatriz C.;
Lennon-Duménil, Ana Maria;
Kessler, Benedikt;
Guermonprez, Pierre;
Ploegh, Hidde L.;
Fruci, Doriana;
Endert, Peter Van;
Amigorena, Sebastian

Publication type:

Article

Mouse MHC class I tetramers that are unable to bind to CD8 reveal the need for CD8 engagement in order to activate naive CD8 T cells.

Published in:

European Journal of Immunology, 2002, v. 32, n. 12, p. 3425, doi. 10.1002/1521-4141(200212)32:12<3425::AID-IMMU3425>3.0.CO;2-7

By:

Schott, Eckart;
Ploegh, Hidde L.

Publication type:

Article

Specific role for cathepsin S in the generation of antigenic peptides in vivo.

Published in:

European Journal of Immunology, 2002, v. 32, n. 2, p. 467, doi. 10.1002/1521-4141(200202)32:2<467::AID-IMMU467>3.0.CO;2-Y

By:

Plüger, Esther B. E.;
Boes, Marianne;
Alfonso, Christopher;
Schröter, Christian J.;
Kalbacher, Hubert;
Ploegh, Hidde L.;
Driessen, Christoph

Publication type:

Article

Individual cathepsins degrade immune complexes internalized by antigen-presenting cells via Fcγ receptors.

Published in:

European Journal of Immunology, 2001, v. 31, n. 5, p. 1592, doi. 10.1002/1521-4141(200105)31:5<1592::AID-IMMU1592>3.0.CO;2-K

By:

Driessen, Christoph;
Lennon-Duménil, Ana-Maria;
Ploegh, Hidde L.

Publication type:

Article

Deviant trafficking of I-A.

Published in:

European Journal of Immunology, 1999, v. 29, n. 9, p. 2729, doi. 10.1002/(SICI)1521-4141(199909)29:09<2729::AID-IMMU2729>3.0.CO;2-A

By:

Bryant, Paula Wolf;
Roos, Petra;
Ploegh, Hidde L.;
Sant, Andrea J.

Publication type:

Article

The phenotype of H-2M-deficient mice is dependent on the MHC class II molecules expressed.

Published in:

European Journal of Immunology, 1998, v. 28, n. 9, p. 2605, doi. 10.1002/(SICI)1521-4141(199809)28:09<2605::AID-IMMU2605>3.0.CO;2-B

By:

Wolf, Paula R.;
Tourne, Sylvie;
Miyazaki, Toru;
Benoist, Christophe;
Mathis, Diane;
Ploegh, Hidde L.

Publication type:

Article

Differential reactivity of residual CD8.

Published in:

European Journal of Immunology, 1995, v. 25, n. 1, p. 174, doi. 10.1002/eji.1830250129

By:

Ljunggren, Hans-Gustaf;
van Kaer, Luc;
Ashton-Rickardt, Philip G.;
Tonegawa, Susumu;
Ploegh, Hidde L.

Publication type:

Article

A soluble, single-chain K.

Published in:

European Journal of Immunology, 1993, v. 23, n. 8, p. 1776, doi. 10.1002/eji.1830230807

By:

Abastado, Jean-Pierre;
Ojcius, David M.;
Casrouge, Armanda;
Yeh, Patrice;
Schumacher, Ton N. M.;
Ploegh, Hidde L.;
Kourilsky, Philippe

Publication type:

Article

The assembly of H2-K.

Published in:

European Journal of Immunology, 1993, v. 23, n. 6, p. 1305, doi. 10.1002/eji.1830230618

By:

Bijlmakers, Mariejose J. E.;
Neefjes, Jacques J.;
Wojcik-Jacobs, Eldine H. M.;
Ploegh, Hidde L.

Publication type:

Article

The effect of anchor residue modifications on the stability of major histocompatibility complex class I-peptide interactions.

Published in:

European Journal of Immunology, 1993, v. 23, n. 4, p. 840, doi. 10.1002/eji.1830230411

By:

Neefjes, Jacques J.;
And, John Dierx;
Ploegh, Hidde L.

Publication type:

Article

Mechanisms of induction of primary virus-specific cytotoxic T lymphocyte responses.

Published in:

European Journal of Immunology, 1992, v. 22, n. 11, p. 3013, doi. 10.1002/eji.1830221137

By:

De Bruijn, Marloes L. H.;
Nieland, John D.;
Schumacher, Ton N. M.;
Ploegh, Hidde L.;
Martin Kast, W.;
Melief, Cornelis J. M.

Publication type:

Article

The fate of the three subunits of major histocompatibility complex class I molecules.

Published in:

European Journal of Immunology, 1992, v. 22, n. 6, p. 1609, doi. 10.1002/eji.1830220639

By:

Neefjes, Jacques J.;
Smit, Linda;
Gehrmann, Matthias;
Ploegh, Hidde L.

Publication type:

Article

Synthetic peptide libraries in the determination of T cell epitopes and peptide binding specificity of class I molecules.

Published in:

European Journal of Immunology, 1992, v. 22, n. 6, p. 1405, doi. 10.1002/eji.1830220612

By:

Schumacher, Ton N. M.;
Van Bleek, Grada M.;
Heemels, Marie-ThéRèSe;
Deres, Karl;
Li, Ka Wan;
Imarai, Monica;
Vernie, Leen N.;
Nathenson, Stanley G.;
Ploegh, Hidde L.

Publication type:

Article

Preferred size of peptides that bind to H-2 K.

Published in:

European Journal of Immunology, 1992, v. 22, n. 6, p. 1603, doi. 10.1002/eji.1830220638

By:

Deres, Karl;
Schumacher, Ton N. M.;
Wiesmüller, Karl-Heinz;
Stevanovic, Stefan;
Greiner, Georg;
Jung, Günther;
Ploegh, Hidde L.

Publication type:

Article

A viral peptide can mimic an endogenous peptide for allorecognition of a major histocompatibility complex class I product.

Published in:

European Journal of Immunology, 1992, v. 22, n. 6, p. 1651, doi. 10.1002/eji.1830220647

By:

Guimezanes, Annick;
Schumacher, Ton N. M.;
Ploegh, Hidde L.;
Schmitt-Verhulst, Anne-Marie

Publication type:

Article

Peptide loading of empty major histocompatibility complex molecules on RMA-S cells allows the induction of primary cytotoxic T lymphocyte responses.

Published in:

European Journal of Immunology, 1991, v. 21, n. 12, p. 2963, doi. 10.1002/eji.1830211210

By:

De Bruijn, Marloes L. H.;
Schumacher, Ton N. M.;
Nieland, John D.;
Ploegh, Hidde L.;
Martin Kast, W.;
Melief, Cornelis J. M.

Publication type:

Article

The ligand recognized by ELAM-1 on HL60 cells is not carried by N-linked oligosaccharides.

Published in:

European Journal of Immunology, 1991, v. 21, n. 12, p. 3057, doi. 10.1002/eji.1830211225

By:

Leeuwenberg, Jet F. M.;
Tan, Agnes;
Jeunhomme, Trudi M. A. A.;
Ploegh, Hidde L.;
Buurman, Wim A.

Publication type:

Article

Specific immune responses restored by alteration in carbohydrate chains of surface molecules on antigen-presenting cells.

Published in:

European Journal of Immunology, 1989, v. 19, n. 3, p. 537, doi. 10.1002/eji.1830190319

By:

Boog, Claire J. P.;
Neefjes, Jacques J.;
Boes, Jolande;
Ploegh, Hidde L.;
Melief, Cornelis J. M.

Publication type:

Article

Allele and locus-specific differences in cell surface expression and the association of HLA class I heavy chain with β.

Published in:

European Journal of Immunology, 1988, v. 18, n. 5, p. 801, doi. 10.1002/eji.1830180522

By:

Neefjes, Jacques J.;
Ploegh, Hidde L.

Publication type:

Article

XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells.

Published in:

EMBO Journal, 2009, v. 28, n. 11, p. 1624, doi. 10.1038/emboj.2009.117

By:

Hu, Chih-Chi Andrew;
Dougan, Stephanie K.;
McGehee, Annette M.;
Love, J. Christopher;
Ploegh, Hidde L.

Publication type:

Article

Sequence and structure evolved separately in a ribosomal ubiquitin variant.

Published in:

EMBO Journal, 2007, v. 26, n. 14, p. 3474, doi. 10.1038/sj.emboj.7601772

By:

Catic, André;
Sun, Zhen-Yu J.;
Ratner, Daniel M.;
Misaghi, Shahram;
Spooner, Eric;
Samuelson, John;
Wagner, Gerhard;
Ploegh, Hidde L.

Publication type:

Article

The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance.

Published in:

EMBO Journal, 2007, v. 26, n. 11, p. 2693, doi. 10.1038/sj.emboj.7601722

By:

Kwon-Yul Ryu;
Maehr, René;
Gilchrist, Catherine A.;
Long, Michael A.;
Bouley, Donna M.;
Mueller, Britta;
Ploegh, Hidde L.;
Kopito, Ron R.

Publication type:

Article

A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised.

Published in:

EMBO Journal, 2004, v. 23, n. 3, p. 650, doi. 10.1038/sj.emboj.7600090

By:

Blom, Daniel;
Hirsch, Christian;
Stern, Patrick;
Tortorella, Domenico;
Ploegh, Hidde L.

Publication type:

Article

A role for N-glycanase in the cytosolic turnover of glycoproteins.

Published in:

EMBO Journal, 2003, v. 22, n. 5, p. 1036, doi. 10.1093/emboj/cdg107

By:

Hirsch, Christian;
Blom, Daniël;
Ploegh, Hidde L.

Publication type:

Article

Chemistry in Living Cells: Detection of Active Proteasomes by a Two-Step Labeling Strategy ( This work is supported by NIH Grant GM 62502 to H.L.P and NIH Training Grant T32 HL07574 to P.J.G. E.F. is supported by the APART program of the Austrian Academy of Sciences. H.O., P.F.S., and H.S.O. are financially supported by the Netherlands Organization for Scientific Research (NWO). )

Published in:

Angewandte Chemie, 2003, v. 115, n. 31, p. 3754, doi. 10.1002/ange.200351314

By:

Huib Ovaa;
Paul F. van Swieten;
Benedikt M. Kessler;
Michiel A. Leeuwenburgh;
Edda Fiebiger;
Adrianus M. C. H. van den Nieuwendijk;
Paul J. Galardy;
Gijsbert A. van der Marel;
Hidde L. Ploegh;
Herman S. Overkleeft

Publication type:

Article

Protein visualization and manipulation in Drosophila through the use of epitope tags recognized by nanobodies.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.74326

By:

Jun Xu;
Ah-Ram Kim;
Cheloha, Ross W.;
Fischer, Fabian A.;
Shing Shun Li, Joshua;
Yuan Feng;
Stoneburner, Emily;
Binari, Richard;
Mohr, Stephanie E.;
Zirin, Jonathan;
Ploegh, Hidde L.;
Perrimon, Norbert

Publication type:

Article

A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens.

Published in:

Nature Cell Biology, 2013, v. 15, n. 12, p. 1473, doi. 10.1038/ncb2865

By:

Reiling, Jan H.;
Olive, Andrew J.;
Sanyal, Sumana;
Carette, Jan E.;
Brummelkamp, Thijn R.;
Ploegh, Hidde L.;
Starnbach, Michael N.;
Sabatini, David M.

Publication type:

Article

Regulation of monoubiquitinated PCNA by DUB autocleavage.

Published in:

Nature Cell Biology, 2006, v. 8, n. 4, p. 341, doi. 10.1038/ncb1378

By:

Huang, Tony T.;
Nijman, Sebastian M. B.;
Mirchandani, Kanchan D.;
Galardy, Paul J.;
Cohn, Martin A.;
Haas, Wilhelm;
Gygi, Steven P.;
Ploegh, Hidde L.;
Bernards, René;
D'Andrea, Alan D.

Publication type:

Article

PD-L1 is an activation-independent marker of brown adipocytes.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00799-8

By:

Ingram, Jessica R.;
Dougan, Michael;
Rashidian, Mohammad;
Knoll, Marko;
Keliher, Edmund J.;
Garrett, Sarah;
Garforth, Scott;
Blomberg, Olga S.;
Espinosa, Camilo;
Bhan, Atul;
Almo, Steven C.;
Weissleder, Ralph;
Lodish, Harvey;
Dougan, Stephanie K.;
Ploegh, Hidde L.

Publication type:

Article

Sortase A as a tool for high-yield histatin cyclization.

Published in:

FASEB Journal, 2011, v. 25, n. 8, p. 2650, doi. 10.1096/fj.11-182212

By:

Bolscher, Jan G. M.;
Oudhoff, Menno J.;
Nazmi, Kamran;
Antos, John M.;
Guimaraes, Carla P.;
Spooner, Eric;
Haney, Evan F.;
Garcia Vallejo, Juan J.;
Vogel, Hans J.;
Van't Hof, Wim;
Ploegh, Hidde L.;
Veerman, Enno C. I.

Publication type:

Article

Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans.

Published in:

PLoS Pathogens, 2015, v. 11, n. 10, p. 1, doi. 10.1371/journal.ppat.1005188

By:

Tafesse, Fikadu G.;
Rashidfarrokhi, Ali;
Schmidt, Florian I.;
Freinkman, Elizaveta;
Dougan, Stephanie;
Dougan, Michael;
Esteban, Alexandre;
Maruyama, Takeshi;
Strijbis, Karin;
Ploegh, Hidde L.

Publication type:

Article

Catch-and-Release Probes Applied to Semi-Intact Cells Reveal Ubiquitin-Specific Protease Expression in Chlamydia trachomatis Infection.

Published in:

ChemBioChem, 2013, v. 14, n. 3, p. 343, doi. 10.1002/cbic.201200701

By:

Claessen, Jasper H. L.;
Witte, Martin D.;
Yoder, Nicholas C.;
Zhu, Angela Y.;
Spooner, Eric;
Ploegh, Hidde L.

Publication type:

Article

Cover Picture: Catch-and-Release Probes Applied to Semi-Intact Cells Reveal Ubiquitin-Specific Protease Expression in Chlamydia trachomatis Infection (ChemBioChem 3/2013).

Published in:

ChemBioChem, 2013, v. 14, n. 3, p. 269, doi. 10.1002/cbic.201390004

By:

Claessen, Jasper H. L.;
Witte, Martin D.;
Yoder, Nicholas C.;
Zhu, Angela Y.;
Spooner, Eric;
Ploegh, Hidde L.

Publication type:

Article

Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases.

Published in:

ChemBioChem, 2005, v. 6, n. 2, p. 287, doi. 10.1002/cbic.200400236

By:

Anna Borodovsky;
Huib Ovaa;
Wim J. N. Meester;
Emily S. Venanzi;
Matthew S. Bogyo;
Brian G. Hekking;
Hidde L. Ploegh;
Benedikt M. Kessler;
Herman S. Overkleeft

Publication type:

Article

Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus.

Published in:

Nature, 2013, v. 503, n. 7476, p. 406, doi. 10.1038/nature12637

By:

Dougan, Stephanie K.;
Ashour, Joseph;
Karssemeijer, Roos A.;
Popp, Maximilian W.;
Avalos, Ana M.;
Barisa, Marta;
Altenburg, Arwen F.;
Ingram, Jessica R.;
Cragnolini, Juan Jose;
Guo, Chunguang;
Alt, Frederick W.;
Jaenisch, Rudolf;
Ploegh, Hidde L.

Publication type:

Article

Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication.

Published in:

EMBO Reports, 2017, v. 18, n. 6, p. 1027, doi. 10.15252/embr.201643764

By:

Hanke, Leo;
Schmidt, Florian I;
Knockenhauer, Kevin E;
Morin, Benjamin;
Whelan, Sean PJ;
Schwartz, Thomas U;
Ploegh, Hidde L

Publication type:

Article

Yeast N-glycanase distinguishes between native and non-native glycoproteins.

Published in:

EMBO Reports, 2004, v. 5, n. 2, p. 201, doi. 10.1038/sj.embor.7400066

By:

Hirsch, Christian;
Misaghi, Shahram;
Blom, Daniël;
Pacold, Michael E;
Ploegh, Hidde L.

Publication type:

Article

NanoTag Nanobody Tools for Drosophila In Vitro and In Vivo Studies.

Published in:

Current Protocols, 2022, v. 2, n. 12, p. 1, doi. 10.1002/cpz1.628

By:

Kim, Ah‐Ram;
Xu, Jun;
Cheloha, Ross;
Mohr, Stephanie E.;
Zirin, Jonathan;
Ploegh, Hidde L.;
Perrimon, Norbert

Publication type:

Article

Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-52110-1

By:

Schiffelers, Lisa D. J.;
Tesfamariam, Yonas M.;
Jenster, Lea-Marie;
Diehl, Stefan;
Binder, Sophie C.;
Normann, Sabine;
Mayr, Jonathan;
Pritzl, Steffen;
Hagelauer, Elena;
Kopp, Anja;
Alon, Assaf;
Geyer, Matthias;
Ploegh, Hidde L.;
Schmidt, Florian I.

Publication type:

Article

Structurally Defined αMHC-II Nanobody-Drug Conjugates: A Therapeutic and Imaging System for B-Cell Lymphoma.

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 7, p. 2416, doi. 10.1002/anie.201509432

By:

Fang, Tao;
Duarte, Joao N.;
Ling, Jingjing;
Li, Zeyang;
Guzman, Jonathan S.;
Ploegh, Hidde L.

Publication type:

Article

Fluorophore-Conjugated Holliday Junctions for Generating Super-Bright Antibodies and Antibody Fragments.

Published in:

Angewandte Chemie International Edition, 2015, v. 54, n. 40, p. 11706, doi. 10.1002/anie.201505277

By:

Li, Zeyang;
Theile, Christopher S.;
Chen, Guan‐Yu;
Bilate, Angelina M.;
Duarte, Joao N.;
Avalos, Ana M.;
Fang, Tao;
Barberena, Roberto;
Sato, Shuji;
Ploegh, Hidde L.

Publication type:

Article

Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum.

Published in:

Molecular Microbiology, 2006, v. 61, n. 5, p. 1187, doi. 10.1111/j.1365-2958.2006.05307.x

By:

Artavanis-Tsakonas, Katerina;
Misaghi, Shahram;
Comeaux, Christy A.;
Catic, Andre;
Spooner, Eric;
Duraisingh, Manoj T.;
Ploegh, Hidde L.

Publication type:

Article

Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection.

Published in:

Molecular Microbiology, 2006, v. 61, n. 1, p. 142, doi. 10.1111/j.1365-2958.2006.05199.x

By:

Misaghi, Shahram;
Balsara, Zarine R.;
Catic, Andre;
Spooner, Eric;
Ploegh, Hidde L.;
Starnbach, Michael N.

Publication type:

Article