Works by Ploegh, Hidde L

Results: 149

Enzymatic Blockade of the Ubiquitin-Proteasome Pathway.

Published in:

PLoS Biology, 2011, v. 9, n. 3, p. 1, doi. 10.1371/journal.pbio.1000605

By:

Ernst, Robert;
Claessen, Jasper H. L.;
Mueller, Britta;
Sanyal, Sumana;
Spooner, Eric;
van der Veen, Annemarthe G.;
Kirak, Oktay;
Schlieker, Christian D.;
Weihofen, Wilhelm A.;
Ploegh, Hidde L.

Publication type:

Article

JAMM: A Metalloprotease-Like Zinc Site in the Proteasome and Signalosome.

Published in:

PLoS Biology, 2004, v. 2, n. 1, p. 0001, doi. 10.1371/journal/pbio.0020002

By:

Ambroggio, Xavier I.;
Rees, Douglas C.;
Deshaies, Raymond J.;
Ploegh, Hidde L.

Publication type:

Article

Bilden und Brechen von Peptidbindungen: Protein-Engineering mithilfe von Sortase.

Published in:

Angewandte Chemie, 2011, v. 123, n. 22, p. 5128, doi. 10.1002/ange.201008267

By:

Popp, Maximilian Wei-Lin;
Ploegh, Hidde L.

Publication type:

Article

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9.

Published in:

Nature Immunology, 2008, v. 9, n. 12, p. 1407, doi. 10.1038/ni.1669

By:

Park, Boyoun;
Brinkmann, Melanie M;
Spooner, Eric;
Lee, Clarissa C;
Kim, You-Me;
Ploegh, Hidde L

Publication type:

Article

TLRs bent into shape.

Published in:

Nature Immunology, 2007, v. 8, n. 7, p. 675, doi. 10.1038/ni0707-675

By:

Kim, You-Me;
Brinkmann, Melanie M;
Ploegh, Hidde L

Publication type:

Article

ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.91930

By:

Bates, Timothy A.;
Trank-Greene, Mila;
Nguyenla, Xammy;
Anastas, Aidan;
Gurmessa, Sintayehu K.;
Merutka, Ilaria R.;
Dixon, Shandee D.;
Shumate, Anthony;
Groncki, Abigail R.;
Parson, Matthew A. H.;
Ingram, Jessica R.;
Barklis, Eric;
Burke, John E.;
Shinde, Ujwal;
Ploegh, Hidde L.;
Tafesse, Fikadu G.

Publication type:

Article

The ER-Lumenal Domain of the HHV-7 Immunoevasin U21 Directs Class I MHC Molecules to Lysosomes.

Published in:

Traffic, 2003, v. 4, n. 12, p. 824, doi. 10.1046/j.1398-9219.2003.0137.x

By:

Hudson, Amy W.;
Blom, Daniël;
Howley, Peter M.;
Ploegh, Hidde L.

Publication type:

Article

Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-52110-1

By:

Schiffelers, Lisa D. J.;
Tesfamariam, Yonas M.;
Jenster, Lea-Marie;
Diehl, Stefan;
Binder, Sophie C.;
Normann, Sabine;
Mayr, Jonathan;
Pritzl, Steffen;
Hagelauer, Elena;
Kopp, Anja;
Alon, Assaf;
Geyer, Matthias;
Ploegh, Hidde L.;
Schmidt, Florian I.

Publication type:

Article

A microengraving method for rapid selection of single cells producing antigen-specific antibodies.

Published in:

Nature Biotechnology, 2006, v. 24, n. 6, p. 703, doi. 10.1038/nbt1210

By:

Love, J. Christopher;
Ronan, Jehnna L.;
Grotenbreg, Gijsbert M.;
van der Veen, Annemarthe G.;
Ploegh, Hidde L.

Publication type:

Article

Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor.

Published in:

EMBO Journal, 2001, v. 20, n. 7, p. 1573, doi. 10.1093/emboj/20.7.1573

By:

Rehm, Armin;
Stern, Patrick;
Ploegh, Hidde L.;
Tortorella, Domenico

Publication type:

Article

Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor.

Published in:

EMBO Journal, 2001, v. 20, n. 7, p. 1573, doi. 10.1093/emboj/20.7.1573

By:

Rehm, Armin;
Stern, Patrick;
Ploegh, Hidde L.;
Tortorella, Domenico

Publication type:

Article

Secreted cathepsin L generates endostatin from collagen XVIII.

Published in:

EMBO Journal, 2000, v. 19, n. 6, p. 1187, doi. 10.1093/emboj/19.6.1187

By:

Felbor, Ute;
Dreier, Lars;
Bryant, Rebecca A. R.;
Ploegh, Hidde L.;
Olsen, Bjorn R.;
Mothes, Walther

Publication type:

Article

Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM.

Published in:

EMBO Journal, 2000, v. 19, n. 5, p. 882, doi. 10.1093/emboj/19.5.882

By:

Villadangos, José A.;
Driessen, Christoph;
Shi, Guo-Ping;
Chapman, Harold A.;
Ploegh, Hidde L.

Publication type:

Article

A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface.

Published in:

EMBO Journal, 1997, v. 16, n. 4, p. 685, doi. 10.1093/emboj/16.4.685

By:

Kleijnen, Maurits F.;
Huppa, Johannes B.;
Lucin, Pero;
Mukherjee, Siddhartha;
Farrell, Helen;
Campbell, Ann E.;
Koszinowski, Ulrich H.;
Hill, Ann B.;
Ploegh, Hidde L.

Publication type:

Article

Noninvasive Imaging of Human Immune Responses in a Human Xenograft Model of Graft-Versus-Host Disease.

Published in:

Journal of Nuclear Medicine, 2017, v. 58, n. 6, p. 1003, doi. 10.2967/jnumed.116.186007

By:

Van Elssen, Catharina H. M. J.;
Rashidian, Mohammad;
Vrbanac, Vladimir;
Wucherpfennig, Kai W.;
el Habre, Zeina;
Sticht, Jana;
Freund, Christian;
Jacobsen, Johanne T.;
Cragnolini, Juanjo;
Ingram, Jessica;
Plaisier, Loes;
Spierings, Eric;
Tager, Andrew M.;
Ploegh, Hidde L.

Publication type:

Article

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes.

Published in:

Nature, 2008, v. 452, n. 7184, p. 234, doi. 10.1038/nature06726

By:

Kim, You-Me;
Brinkmann, Melanie M.;
Paquet, Marie-Eve;
Ploegh, Hidde L.

Publication type:

Article

A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum.

Published in:

Nature, 2007, v. 448, n. 7152, p. 435, doi. 10.1038/nature06004

By:

Ploegh, Hidde L.

Publication type:

Article

Signal peptide peptidase is required for dislocation from the endoplasmic reticulum.

Published in:

2006

By:

Loureiro, Joana;
Lilley, Brendan N.;
Spooner, Eric;
Noriega, Vanessa;
Tortorella, Domenico;
Ploegh, Hidde L.

Publication type:

Letter

Translating cell biology in vitro to immunity in vivo.

Published in:

Nature, 2004, v. 430, n. 6996, p. 264, doi. 10.1038/nature02762

By:

Boes, Mariann;
Ploegh, Hidde L.

Publication type:

Article

A membrane protein required for dislocation of misfolded proteins from the ER.

Published in:

Nature, 2004, v. 429, n. 6994, p. 834, doi. 10.1038/nature02592

By:

Lilley, Brendann N.;
Ploegh, Hidde L.

Publication type:

Article

Early BCR events and antigen capture, processing, and loading on MHC class II on B cells.

Published in:

Frontiers in Immunology, 2014, v. 5, p. 1, doi. 10.3389/fimmu.2014.00092

By:

Avalos, Ana M.;
Ploegh, Hidde L.

Publication type:

Article

Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum.

Published in:

Molecular Microbiology, 2006, v. 61, n. 5, p. 1187, doi. 10.1111/j.1365-2958.2006.05307.x

By:

Artavanis-Tsakonas, Katerina;
Misaghi, Shahram;
Comeaux, Christy A.;
Catic, Andre;
Spooner, Eric;
Duraisingh, Manoj T.;
Ploegh, Hidde L.

Publication type:

Article

Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection.

Published in:

Molecular Microbiology, 2006, v. 61, n. 1, p. 142, doi. 10.1111/j.1365-2958.2006.05199.x

By:

Misaghi, Shahram;
Balsara, Zarine R.;
Catic, Andre;
Spooner, Eric;
Ploegh, Hidde L.;
Starnbach, Michael N.

Publication type:

Article

Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24574-y

By:

De Groof, Timo W. M.;
Bergkamp, Nick D.;
Heukers, Raimond;
Giap, Truc;
Bebelman, Maarten P.;
Goeij-de Haas, Richard;
Piersma, Sander R.;
Jimenez, Connie R.;
Garcia, K. Christopher;
Ploegh, Hidde L.;
Siderius, Marco;
Smit, Martine J.

Publication type:

Article

Cathepsin L is essential for onset of autoimmune diabetes in NOD mice.

Published in:

2005

By:

Maehr, René;
Mintern, Justine D.;
Herman, Ann E.;
Lennon-Duménil, Ana-Maria;
Mathis, Diane;
Benoist, Christophe;
Ploegh, Hidde L.;
Maehr, René;
Lennon-Duménil, Ana-Maria

Publication type:

journal article

A molecule's right to choose: how diabetogenic class II MHC products bind peptides.

Published in:

Journal of Clinical Investigation, 2005, v. 115, n. 8, p. 2077, doi. 10.1172/JCI26018

By:

Ploegh, Hidde L.

Publication type:

Article

Chemistry in Living Cells: Detection of Active Proteasomes by a Two-Step Labeling Strategy ( This work is supported by NIH Grant GM 62502 to H.L.P and NIH Training Grant T32 HL07574 to P.J.G. E.F. is supported by the APART program of the Austrian Academy of Sciences. H.O., P.F.S., and H.S.O. are financially supported by the Netherlands Organization for Scientific Research (NWO). )

Published in:

Angewandte Chemie, 2003, v. 115, n. 31, p. 3754, doi. 10.1002/ange.200351314

By:

Huib Ovaa;
Paul F. van Swieten;
Benedikt M. Kessler;
Michiel A. Leeuwenburgh;
Edda Fiebiger;
Adrianus M. C. H. van den Nieuwendijk;
Paul J. Galardy;
Gijsbert A. van der Marel;
Hidde L. Ploegh;
Herman S. Overkleeft

Publication type:

Article

Preferred in vivo ubiquitination sites.

Published in:

Bioinformatics, 2004, v. 20, n. 18, p. 3302, doi. 10.1093/bioinformatics/bth407

By:

Catic, André;
Collins, Cal;
Church, George M.;
Ploegh, Hidde L.

Publication type:

Article

Accessory molecules for Toll-like receptors and their function.

Published in:

Nature Reviews Immunology, 2012, v. 12, n. 3, p. 168, doi. 10.1038/nri3151

By:

Lee, Clarissa C.;
Avalos, Ana M.;
Ploegh, Hidde L.

Publication type:

Article

Making and Breaking Peptide Bonds: Protein Engineering Using Sortase.

Published in:

Angewandte Chemie International Edition, 2011, v. 50, n. 22, p. 5024, doi. 10.1002/anie.201008267

By:

Popp, Maximilian Wei-Lin;
Ploegh, Hidde L.

Publication type:

Article

Proteasome inhibitors and antigen presentation.

Published in:

Biopolymers, 1997, v. 43, n. 4, p. 269, doi. 10.1002/(SICI)1097-0282(1997)43:4<269::AID-BIP2>3.0.CO;2-T

By:

Bogyo, Matthew;
Gaczynska, Maria;
Ploegh, Hidde L.

Publication type:

Article

Immune and Other Responses to Viral Infections.

Published in:

Nutrition Reviews, 2000, v. 58, n. 2, p. S25

By:

Ploegh, Hidde L.

Publication type:

Article

Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase.

Published in:

Nature, 1987, v. 330, n. 6143, p. 74, doi. 10.1038/330074a0

By:

Gruters, Rob A.;
Neefjes, Jacques J.;
Tersmette, Matthijs;
de Goede, Ruud E. Y.;
Tulp, Abraham;
Huisman, Han G.;
Miedema, Frank;
Ploegh, Hidde L.

Publication type:

Article

HLA-restricted recognition of viral antigens in HLA transgenic mice.

Published in:

Nature, 1987, v. 329, n. 6138, p. 447, doi. 10.1038/329447a0

By:

Kievits, Femia;
Ivanyi, Pavol;
Krimpenfort, Paul;
Berns, Anton;
Ploegh, Hidde L.

Publication type:

Article

Yeast N-glycanase distinguishes between native and non-native glycoproteins.

Published in:

EMBO Reports, 2004, v. 5, n. 2, p. 201, doi. 10.1038/sj.embor.7400066

By:

Hirsch, Christian;
Misaghi, Shahram;
Blom, Daniël;
Pacold, Michael E;
Ploegh, Hidde L.

Publication type:

Article

The known unknowns of antigen processing and presentation.

Published in:

2008

By:

Vyas, Jatin M.;
Van der Veen, Annemarthe G.;
Ploegh, Hidde L.

Publication type:

journal article

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling.

Published in:

Journal of Cell Biology, 2007, v. 177, n. 2, p. 265, doi. 10.1083/jcb.200612056

By:

Brinkmann, Melanie M.;
Spooner, Eric;
Hoebe, Kasper;
Beutler, Bruce;
Ploegh, Hidde L.;
Kim, You-Me

Publication type:

Article

SEL1 L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER.

Published in:

Journal of Cell Biology, 2006, v. 175, n. 2, p. 261, doi. 10.1083/jcb.200605196

By:

Mueller, Britta;
Lilley, Brendan N.;
Ploegh, Hidde L.

Publication type:

Article

Protein Ligation in Living Cells Using Sortase.

Published in:

Traffic, 2012, v. 13, n. 6, p. 780, doi. 10.1111/j.1600-0854.2012.01345.x

By:

Strijbis, Karin;
Spooner, Eric;
Ploegh, Hidde L.

Publication type:

Article

aberrant expression of HLA Class-I antigens in burkitt lymphoma cells.

Published in:

International Journal of Cancer, 1991, v. 47, n. 4, p. 544, doi. 10.1002/ijc.2910470412

By:

Andersson, Monika L.;
Stam, Nico J.;
Klein, George;
Ploegh, Hidde L.;
Masucci, Maria G.

Publication type:

Article

The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy.

Published in:

Science Translational Medicine, 2018, v. 10, n. 436, p. 1, doi. 10.1126/scitranslmed.aan3464

By:

Krall, Jordan A.;
Reinhardt, Ferenc;
Mercury, Oblaise A.;
Pattabiraman, Diwakar R.;
Brooks, Mary W.;
Dougan, Michael;
Lambert, Arthur W.;
Bierie, Brian;
Ploegh, Hidde L.;
Dougan, Stephanie K.;
Weinberg, Robert A.

Publication type:

Article

Editorial: Crystal death: it's not always the inflammasome.

Published in:

Journal of Leukocyte Biology, 2017, v. 102, n. 1, p. 1, doi. 10.1189/jlb.3CE0117-022R

By:

Schmidt, Florian I.;
Ploegh, Hidde L.

Publication type:

Article

The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones.

Published in:

PLoS Genetics, 2016, v. 12, n. 5, p. 1, doi. 10.1371/journal.pgen.1006023

By:

Truttmann, Matthias C.;
Cruz, Victor E.;
Guo, Xuanzong;
Engert, Christoph;
Schwartz, Thomas U.;
Ploegh, Hidde L.

Publication type:

Article

Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond.

Published in:

Immunological Reviews, 2005, v. 207, n. 1, p. 126, doi. 10.1111/j.0105-2896.2005.00318.x

By:

Lilley, Brendan N.;
Ploegh, Hidde L.

Publication type:

Article

Proteases involved in MHC class II antigen presentation.

Published in:

Immunological Reviews, 1999, v. 172, n. 1, p. 109, doi. 10.1111/j.1600-065X.1999.tb01360.x

By:

Villadangos, Jose A.;
Bryant, Rebecca A. R.;
Deussing, Jan;
Driessen, Christoph;
Lennon-Dumenil, Ana-Maria;
Riese, Richard J.;
Roth, Wera;
Saftig, Paul;
Guo-Ping Shi;
Chapman, Harold A.;
Peters, Christoph;
Ploegh, Hidde L.

Publication type:

Article

Cellular internalization of cytolethal distending toxin: a new end to a known pathway.

Published in:

Cellular Microbiology, 2005, v. 7, n. 7, p. 921, doi. 10.1111/j.1462-5822.2005.00520.x

By:

Guerra, Lina;
Teter, Ken;
Lilley, Brendan N.;
Stenerlöw, Bo;
Holmes, Randall K.;
Ploegh, Hidde L.;
Sandvig, Kirsten;
Thelestam, Monica;
Frisan, Teresa

Publication type:

Article

LMP2 expression and proteasome activity in NOD mice.

Published in:

Nature Medicine, 2000, v. 6, n. 10, p. 1064, doi. 10.1038/80346

By:

Kessler, Benedikt M.;
Lennon-Duménil, Ana-Maria;
Shinohara, Mari L.;
Lipes, Myra A.;
Ploegh, Hidde L.

Publication type:

Article

Dendritic Cells: Biology and Clinical Applications.

Published in:

1999

By:

Ploegh, Hidde L.

Publication type:

Book Review

Development of Intravital Intermittent Confocal Imaging System for Studying Langerhans Cell Turnover.

Published in:

Journal of Investigative Dermatology, 2006, v. 126, n. 11, p. 2452, doi. 10.1038/sj.jid.5700448

By:

Vishwanath, Mridula;
Nishibu, Akiko;
Saeland, Sem;
Ward, Brant R.;
Mizumoto, Norikatsu;
Ploegh, Hidde L.;
Boes, Marianne;
Takashima, Akira

Publication type:

Article

Behavioral Responses of Epidermal Langerhans Cells In Situ to Local Pathological Stimuli.

Published in:

Journal of Investigative Dermatology, 2006, v. 126, n. 4, p. 787, doi. 10.1038/sj.jid.5700107

By:

Nishibu, Akiko;
Ward, Brant R.;
Jester, James V.;
Ploegh, Hidde L.;
Boes, Marianne;
Takashima, Akira

Publication type:

Article