Works by Plückthun, Andreas

Results: 153

Probing the Conformation States of Neurotensin Receptor 1 Variants by NMR Site‐Directed Methyl Labeling.

Published in:

ChemBioChem, 2021, v. 22, n. 1, p. 139, doi. 10.1002/cbic.202000541

By:

Goba, Inguna;
Goricanec, David;
Schum, Dominik;
Hillenbrand, Matthias;
Plückthun, Andreas;
Hagn, Franz

Publication type:

Article

Strategies for Selection from Protein Libraries Composed of de Novo Designed Secondary Structure Modules.

Published in:

Origins of Life & Evolution of the Biosphere, 2004, v. 34, n. 1/2, p. 151, doi. 10.1023/B:ORIG.0000009836.86519.eb

By:

Matsuura, Tomoaki;
Plückthun, Andreas

Publication type:

Article

Molecular features defining the efficiency of bioPROTACs.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08352-w

By:

Winkelvoß, Dorothea;
Vukovic, David;
Hänny, Anna-Carina;
Riermeier, Luca;
Udovcic, Anto;
Kolibius, Jonas;
Honegger, Annemarie;
Mittl, Peer R. E.;
Michel, Erich;
Hansen, Simon;
Plückthun, Andreas

Publication type:

Article

ASSESSING IMMUNOGENICITY BARRIERS OF THE HIV-1 ENVELOPE TRIMER.

Published in:

Topics in Antiviral Medicine, 2023, v. 31, n. 2, p. 124

By:

Friedrich, Nikolas;
Maliqi, Liridona;
Glögl, Matthias;
Rusert, Peter;
Zaheri, Maryam;
Pasin, Chloe;
Schmutz, Stefan;
Abela, Irene A.;
Kouyos, Roger D.;
Günthard, Huldrych F. F.;
van Gils, Marit J.;
Sanders, Rogier W.;
Wagner, Ralf;
Plückthun, Andreas;
Trkola, Alexandra

Publication type:

Article

Signal sequences directing cotranslational translocation expand the range of proteins amenable to phage display.

Published in:

Nature Biotechnology, 2006, v. 24, n. 7, p. 823, doi. 10.1038/nbt1218

By:

Steiner, Daniel;
Forrer, Patrik;
Stumpp, Michael T.;
Plückthun, Andreas

Publication type:

Article

Engineering novel binding proteins from nonimmunoglobulin domains.

Published in:

Nature Biotechnology, 2005, v. 23, n. 10, p. 1257, doi. 10.1038/nbt1127

By:

Binz, H. Kaspar;
Amstutz, Patrick;
Plückthun, Andreas

Publication type:

Article

High-affinity binders selected from designed ankyrin repeat protein libraries.

Published in:

Nature Biotechnology, 2004, v. 22, n. 5, p. 575, doi. 10.1038/nbt962

By:

Binz, H Kaspar;
Amstutz, Patrick;
Kohl, Andreas;
Stumpp, Michael T.;
Briand, Christophe;
Forrer, Patrik;
Grütter, Markus G.;
Plückthun, Andreas

Publication type:

Article

Design of multivalent complexes using the barnase·barstar module.

Published in:

Nature Biotechnology, 2003, v. 21, n. 12, p. 1486, doi. 10.1038/nbt916

By:

Waibel, Robert;
Plückthun, Andreas;
Deyev, Sergey M.;
Lebedenko, Ekaterina N.;
Schubiger, August P.

Publication type:

Article

Picomolar affinity antibodies from a fully synthetic naive library selected and evolved by ribosome display.

Published in:

Nature Biotechnology, 2000, v. 18, n. 12, p. 1287, doi. 10.1038/82407

By:

Hanes, Jozef;
Schaffitzel, Christiane;
Knappik, Achim;
Plückthun, Andreas

Publication type:

Article

Stable one-step technetium-99m labeling of His-tagged recombinant proteins with a novel Tc(I)?carbonyl complex.

Published in:

Nature Biotechnology, 1999, v. 17, n. 9, p. 897, doi. 10.1038/12890

By:

Waibel, Robert;
Alberto, Roger;
Willuda, Jörg;
Finnern, Ricarda;
Schibli, Roger;
Stichelberger, Albert;
Egli, André;
Abram, Ulrich;
Mach, Jean-Pierre;
Plückthun, Andreas;
Schubiger, P. August

Publication type:

Article

An in vivo library-versus-library selection of optimized protein?protein interactions.

Published in:

Nature Biotechnology, 1999, v. 17, n. 7, p. 683, doi. 10.1038/10897

By:

Pelletier, Joelle N.;
Arndt, Katja M.;
Plückthun, Andreas;
Michnick, Stephen W.

Publication type:

Article

The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection.

Published in:

PLoS Pathogens, 2021, v. 17, n. 12, p. 1, doi. 10.1371/journal.ppat.1010083

By:

Bieri, Manuela;
Hendrickx, Rodinde;
Bauer, Michael;
Yu, Bin;
Jetzer, Tania;
Dreier, Birgit;
Mittl, Peer R. E.;
Sobek, Jens;
Plückthun, Andreas;
Greber, Urs F.;
Hemmi, Silvio

Publication type:

Article

Wege zu neuen Enzymen: Protein Engineering und Katalytische Antikörper.

Published in:

Chemie in unserer Zeit, 1990, v. 24, n. 4, p. 182, doi. 10.1002/ciuz.19900240408

By:

Plückthun, Andreas

Publication type:

Article

Correction to: An automated iterative approach for protein structure refinement using pseudocontact shifts.

Published in:

2021

By:

Cucuzza, Stefano;
Güntert, Peter;
Plückthun, Andreas;
Zerbe, Oliver

Publication type:

Correction Notice

An automated iterative approach for protein structure refinement using pseudocontact shifts.

Published in:

Journal of Biomolecular NMR, 2021, v. 75, n. 8/9, p. 319, doi. 10.1007/s10858-021-00376-8

By:

Cucuzza, Stefano;
Güntert, Peter;
Plückthun, Andreas;
Zerbe, Oliver

Publication type:

Article

Segmental isotopic labeling by asparaginyl endopeptidase-mediated protein ligation.

Published in:

Journal of Biomolecular NMR, 2018, v. 71, n. 4, p. 225, doi. 10.1007/s10858-018-0175-4

By:

Mikula, Kornelia M.;
Krumwiede, Luisa;
Plückthun, Andreas;
Iwaï, Hideo

Publication type:

Article

Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02253-4

By:

Stüber, Jakob C.;
Richter, Christian P.;
Bellón, Junel Sotolongo;
Schwill, Martin;
König, Iwo;
Schuler, Benjamin;
Piehler, Jacob;
Plückthun, Andreas

Publication type:

Article

Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol.

Published in:

Communications Biology, 2020, v. 3, n. 1, p. 1, doi. 10.1038/s42003-020-1072-4

By:

Chabloz, Antoine;
Schaefer, Jonas V.;
Kozieradzki, Ivona;
Cronin, Shane J. F.;
Strebinger, Daniel;
Macaluso, Francesca;
Wald, Jiri;
Rabbitts, Terence H.;
Plückthun, Andreas;
Marlovits, Thomas C.;
Penninger, Josef M.

Publication type:

Article

Structure of a hydrophobic leucinostatin derivative determined by host lattice display.

Published in:

Acta Crystallographica: Section D, Structural Biology, 2022, v. 78, n. 12, p. 1439, doi. 10.1107/S2059798322010762

By:

Kiss, Cedric;
Gall, Flavio M.;
Dreier, Birgit;
Adams, Michael;
Riedl, Rainer;
Plückthun, Andreas;
Mittl, Peer R. E.

Publication type:

Article

Protein degradation kinetics measured by microinjection and live-cell fluorescence microscopy.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-76224-0

By:

Vukovic, David;
Winkelvoß, Dorothea;
Kapp, Jonas N.;
Hänny, Anna-Carina;
Bürgisser, Héloïse;
Riermeier, Luca;
Udovcic, Anto;
Tiefenboeck, Peter;
Plückthun, Andreas

Publication type:

Article

Structural basis of adenylyl cyclase 9 activation.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28685-y

By:

Qi, Chao;
Lavriha, Pia;
Mehta, Ved;
Khanppnavar, Basavraj;
Mohammed, Inayathulla;
Li, Yong;
Lazaratos, Michalis;
Schaefer, Jonas V.;
Dreier, Birgit;
Plückthun, Andreas;
Bondar, Ana-Nicoleta;
Dessauer, Carmen W.;
Korkhov, Volodymyr M.

Publication type:

Article

Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-021-27911-3

By:

Deluigi, Mattia;
Morstein, Lena;
Schuster, Matthias;
Klenk, Christoph;
Merklinger, Lisa;
Cridge, Riley R.;
de Zhang, Lazarus A.;
Klipp, Alexander;
Vacca, Santiago;
Vaid, Tasneem M.;
Mittl, Peer R. E.;
Egloff, Pascal;
Eberle, Stefanie A.;
Zerbe, Oliver;
Chalmers, David K.;
Scott, Daniel J.;
Plückthun, Andreas

Publication type:

Article

Author Correction: Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc.

Published in:

2022

By:

Matsuda, Shinya;
Schaefer, Jonas V.;
Mii, Yusuke;
Hori, Yutaro;
Bieli, Dimitri;
Taira, Masanori;
Plückthun, Andreas;
Affolter, Markus

Publication type:

Correction Notice

Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26726-6

By:

Matsuda, Shinya;
Schaefer, Jonas V.;
Mii, Yusuke;
Hori, Yutaro;
Bieli, Dimitri;
Taira, Masanori;
Plückthun, Andreas;
Affolter, Markus

Publication type:

Article

Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23948-6

By:

Kast, Florian;
Schwill, Martin;
Stüber, Jakob C.;
Pfundstein, Svende;
Nagy-Davidescu, Gabriela;
Rodríguez, Josep M. Monné;
Seehusen, Frauke;
Richter, Christian P.;
Honegger, Annemarie;
Hartmann, Karen Patricia;
Weber, Thomas G.;
Kroener, Felix;
Ernst, Patrick;
Piehler, Jacob;
Plückthun, Andreas

Publication type:

Article

Thermodynamic Stability Is a Strong Predictor for the Delivery of DARPins to the Cytosol via Anthrax Toxin.

Published in:

Pharmaceutics, 2021, v. 13, n. 8, p. 1285, doi. 10.3390/pharmaceutics13081285

By:

Becker, Lukas;
Singh Badwal, Jasleen;
Brandl, Fabian;
Verdurmen, Wouter P. R.;
Plückthun, Andreas

Publication type:

Article

Labeling surface proteins with high specificity: Intrinsic limitations of phosphopantetheinyl transferase systems.

Published in:

PLoS ONE, 2019, v. 14, n. 12, p. N.PAG, doi. 10.1371/journal.pone.0226579

By:

Stüber, Jakob C.;
Plückthun, Andreas

Publication type:

Article

Molecular dynamics study of the stabilities of consensus designed ankyrin repeat proteins.

Published in:

Proteins, 2006, v. 65, n. 2, p. 285, doi. 10.1002/prot.20991

By:

Yu, Haibo;
Kohl, Andreas;
Binz, H. Kaspar;
Plückthun, Andreas;
Grütter, Markus G.;
van Gunsteren, Wilfred F.

Publication type:

Article

Crystal structure of a consensus-designed ankyrin repeat protein: Implications for stability.

Published in:

Proteins, 2006, v. 65, n. 2, p. 280, doi. 10.1002/prot.20930

By:

Binz, H. Kaspar;
Kohl, Andreas;
Plückthun, Andreas;
Grütter, Markus G.

Publication type:

Article

Crystal structure of a truncated version of the phage λ protein gpD.

Published in:

Proteins, 2004, v. 57, n. 4, p. 866, doi. 10.1002/prot.20254

By:

Chang, Changsoo;
Plückthun, Andreas;
Wlodawer, Alexander

Publication type:

Article

Modular peptide binders – development of a predictive technology as alternative for reagent antibodies.

Published in:

Biological Chemistry, 2022, v. 403, n. 5/6, p. 535, doi. 10.1515/hsz-2021-0384

By:

Gisdon, Florian J.;
Kynast, Josef P.;
Ayyildiz, Merve;
Hine, Anna V.;
Plückthun, Andreas;
Höcker, Birte

Publication type:

Article

Peptide binding affinity redistributes preassembled repeat protein fragments.

Published in:

Biological Chemistry, 2019, v. 400, n. 3, p. 395, doi. 10.1515/hsz-2018-0355

By:

Michel, Erich;
Plückthun, Andreas;
Zerbe, Oliver

Publication type:

Article

Advances in the design and engineering of peptide-binding repeat proteins.

Published in:

Biological Chemistry, 2017, v. 398, n. 1, p. 23, doi. 10.1515/hsz-2016-0233

By:

Ernst, Patrick;
Plückthun, Andreas

Publication type:

Article

Crystal structures of HER3 extracellular domain 4 in complex with the designed ankyrin‐repeat protein D5.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2021, v. 77, n. 7, p. 192, doi. 10.1107/S2053230X21006002

By:

Radom, Filip;
Vonrhein, Clemens;
Mittl, Peer R. E.;
Plückthun, Andreas

Publication type:

Article

Docking small ligands in flexible binding sites.

Published in:

Journal of Computational Chemistry, 1998, v. 19, n. 1, p. 21, doi. 10.1002/(SICI)1096-987X(19980115)19:1<21::AID-JCC2>3.0.CO;2-0

By:

Apostolakis, Joannis;
Plückthun, Andreas;
Caflisch, Amedeo

Publication type:

Article

Enzymatic Construction of DARPin-Based Targeted Delivery Systems Using Protein Farnesyltransferase and a Capture and Release Strategy.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 19, p. 11537, doi. 10.3390/ijms231911537

By:

Zhang, Yi;
Wang, Yiao;
Uslu, Safak;
Venkatachalapathy, Sneha;
Rashidian, Mohammad;
Schaefer, Jonas V.;
Plückthun, Andreas;
Distefano, Mark D.

Publication type:

Article

Thermal Shift Assay for Small GTPase Stability Screening: Evaluation and Suitability.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 13, p. 7095, doi. 10.3390/ijms23137095

By:

Kopra, Kari;
Valtonen, Salla;
Mahran, Randa;
Kapp, Jonas N.;
Hassan, Nazia;
Gillette, William;
Dennis, Bryce;
Li, Lianbo;
Westover, Kenneth D.;
Plückthun, Andreas;
Härmä, Harri

Publication type:

Article

Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor.

Published in:

PLoS Pathogens, 2018, v. 14, n. 3, p. 1, doi. 10.1371/journal.ppat.1006914

By:

Stichling, Nicole;
Suomalainen, Maarit;
Flatt, Justin W.;
Schmid, Markus;
Pacesa, Martin;
Hemmi, Silvio;
Jungraithmayr, Wolfgang;
Maler, Mareike D.;
Freudenberg, Marina A.;
Plückthun, Andreas;
May, Tobias;
Köster, Mario;
Fejer, György;
Greber, Urs F.

Publication type:

Article

Comparison of the Fv Fragments of Different Phosphorylcholine Binding Antibodies Expressed in Escherichia coli.

Published in:

Annals of the New York Academy of Sciences, 1992, v. 646, n. 1, p. 115, doi. 10.1111/j.1749-6632.1991.tb18570.x

By:

PLÜCKTHUN, ANDREAS;
PFITZINGER, ILSE

Publication type:

Article

Preclinical evaluation of EpCAM-binding designed ankyrin repeat proteins (DARPins) as targeting moieties for bimodal near-infrared fluorescence and photoacoustic imaging of cancer.

Published in:

European Journal of Nuclear Medicine & Molecular Imaging, 2024, v. 51, n. 8, p. 2179, doi. 10.1007/s00259-023-06407-w

By:

Houvast, Ruben D.;
Badr, Nada;
March, Taryn;
de Muynck, Lysanne D. A. N.;
Sier, Vincent Q.;
Schomann, Timo;
Bhairosingh, Shadhvi;
Baart, Victor M.;
Peeters, Judith A. H. M.;
van Westen, Gerard J. P.;
Plückthun, Andreas;
Burggraaf, Jacobus;
Kuppen, Peter J. K.;
Vahrmeijer, Alexander L.;
Sier, Cornelis F. M.

Publication type:

Article

Development of the designed ankyrin repeat protein (DARPin) G3 for HER2 molecular imaging.

Published in:

European Journal of Nuclear Medicine & Molecular Imaging, 2015, v. 42, n. 2, p. 288, doi. 10.1007/s00259-014-2940-2

By:

Goldstein, Robert;
Sosabowski, Jane;
Livanos, Maria;
Leyton, Julius;
Vigor, Kim;
Bhavsar, Gaurav;
Nagy-Davidescu, Gabriela;
Rashid, Mohammed;
Miranda, Enrique;
Yeung, Jenny;
Tolner, Berend;
Plückthun, Andreas;
Mather, Stephen;
Meyer, Tim;
Chester, Kerry

Publication type:

Article

Structural basis of adenylyl cyclase 9 activation.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28685-y

By:

Qi, Chao;
Lavriha, Pia;
Mehta, Ved;
Khanppnavar, Basavraj;
Mohammed, Inayathulla;
Li, Yong;
Lazaratos, Michalis;
Schaefer, Jonas V.;
Dreier, Birgit;
Plückthun, Andreas;
Bondar, Ana-Nicoleta;
Dessauer, Carmen W.;
Korkhov, Volodymyr M.

Publication type:

Article

Structural basis for the activation and ligand recognition of the human oxytocin receptor.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31325-0

By:

Waltenspühl, Yann;
Ehrenmann, Janosch;
Vacca, Santiago;
Thom, Cristian;
Medalia, Ohad;
Plückthun, Andreas

Publication type:

Article

Universal platform for the generation of thermostabilized GPCRs that crystallize in LCP.

Published in:

Nature Protocols, 2022, v. 17, n. 3, p. 698, doi. 10.1038/s41596-021-00660-9

By:

Schöppe, Jendrik;
Ehrenmann, Janosch;
Waltenspühl, Yann;
Plückthun, Andreas

Publication type:

Article

SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands.

Published in:

PLoS ONE, 2017, v. 12, n. 5, p. 1, doi. 10.1371/journal.pone.0175842

By:

Huber, Sylwia;
Casagrande, Fabio;
Hug, Melanie N.;
Wang, Lisha;
Heine, Philipp;
Kummer, Lutz;
Plückthun, Andreas;
Hennig, Michael

Publication type:

Article

Side‐chain dynamics of the α1B‐adrenergic receptor determined by NMR via methyl relaxation.

Published in:

Protein Science: A Publication of the Protein Society, 2023, v. 32, n. 11, p. 1, doi. 10.1002/pro.4801

By:

Baumann, Christian;
Chiang, Wan‐Chin;
Valsecchi, Renato;
Jurt, Simon;
Deluigi, Mattia;
Schuster, Matthias;
Rosengren, Karl Johan;
Plückthun, Andreas;
Zerbe, Oliver

Publication type:

Article

Analysis of IgG kinetic stability by differential scanning calorimetry, probe fluorescence and light scattering.

Published in:

Protein Science: A Publication of the Protein Society, 2017, v. 26, n. 11, p. 2229, doi. 10.1002/pro.3278

By:

Nemergut, Michal;
Žoldák, Gabriel;
Schaefer, Jonas V.;
Kast, Florian;
Miškovský, Pavol;
Plückthun, Andreas;
Sedlák, Erik

Publication type:

Article

Structures of designed armadillo repeat proteins binding to peptides fused to globular domains.

Published in:

Protein Science: A Publication of the Protein Society, 2017, v. 26, n. 10, p. 1942, doi. 10.1002/pro.3229

By:

Hansen, Simon;
Kiefer, Jonathan D.;
Madhurantakam, Chaithanya;
Mittl, Peer R. E.;
Plückthun, Andreas

Publication type:

Article

Rigidity of the extracellular part of HER2: Evidence from engineering subdomain interfaces and shared-helix DARPin-DARPin fusions.

Published in:

Protein Science: A Publication of the Protein Society, 2017, v. 26, n. 9, p. 1796, doi. 10.1002/pro.3216

By:

Jost, Christian;
Stüber, Jakob C.;
Honegger, Annemarie;
Wu, Yufan;
Batyuk, Alexander;
Plückthun, Andreas

Publication type:

Article

Advanced analyses of kinetic stabilities of iggs modified by mutations and glycosylation.

Published in:

Protein Science: A Publication of the Protein Society, 2015, v. 24, n. 7, p. 1100, doi. 10.1002/pro.2691

By:

Sedlák, Erik;
Schaefer, Jonas V.;
Marek, Jozef;
Gimeson, Peter;
Plückthun, Andreas

Publication type:

Article