Works by Piwnica-Worms, Helen

Results: 32

Intratumoral Heterogeneity in Ductal Carcinoma In Situ: Chaos and Consequence.

Published in:

Journal of Mammary Gland Biology & Neoplasia, 2018, v. 23, n. 4, p. 191, doi. 10.1007/s10911-018-9410-6

By:

Sinha, Vidya C.;
Piwnica-Worms, Helen

Publication type:

Article

HIF2 Regulates Intestinal Wnt5a Expression.

Published in:

Frontiers in Oncology, 2021, v. 11, p. 1, doi. 10.3389/fonc.2021.769385

By:

García García, Carolina J.;
Acevedo Diaz, Ariana C.;
Kumari, Neeraj;
Govindaraju, Suman;
de la Cruz Bonilla, Marimar;
San Lucas, F. Anthony;
Nguyen, Nicholas D.;
Jiménez Sacarello, Iancarlos;
Piwnica-Worms, Helen;
Maitra, Anirban;
Taniguchi, Cullen M.

Publication type:

Article

Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25240-z

By:

Sinha, Vidya C.;
Rinkenbaugh, Amanda L.;
Xu, Mingchu;
Zhou, Xinhui;
Zhang, Xiaomei;
Jeter-Jones, Sabrina;
Shao, Jiansu;
Qi, Yuan;
Zebala, John A.;
Maeda, Dean Y.;
McAllister, Florencia;
Piwnica-Worms, Helen

Publication type:

Article

Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 4, p. 1541, doi. 10.1172/JCI58765

By:

Ma, Cynthia X.;
Shirong Cai;
Shunqiang Li;
Ryan, Christine E.;
Zhanfang Guo;
Schaiff, W. Timothy;
Li Lin;
Hoog, Jeremy;
Goiffon, Reece J.;
Prat, Aleix;
Aft, Rebecca L.;
Ellis, Matthew J.;
Piwnica-Worms, Helen

Publication type:

Article

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate.

Published in:

Nature, 1988, v. 336, n. 6201, p. 738, doi. 10.1038/336738a0

By:

Draetta, Giulio;
Piwnica-Worms, Helen;
Morrison, Deborah;
Druker, Brian;
Roberts, Thomas;
Beach, David

Publication type:

Article

Targeting neddylation and sumoylation in chemoresistant triple negative breast cancer.

Published in:

NPJ Breast Cancer, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41523-024-00644-4

By:

Powell, Reid T.;
Rinkenbaugh, Amanda L.;
Guo, Lei;
Cai, Shirong;
Shao, Jiansu;
Zhou, Xinhui;
Zhang, Xiaomei;
Jeter-Jones, Sabrina;
Fu, Chunxiao;
Qi, Yuan;
Baameur Hancock, Faiza;
White, Jason B.;
Stephan, Clifford;
Davies, Peter J.;
Moulder, Stacy;
Symmans, W. Fraser;
Chang, Jeffrey T.;
Piwnica-Worms, Helen

Publication type:

Article

Identification of biomarkers of response to preoperative talazoparib monotherapy in treatment naïve gBRCA+ breast cancers.

Published in:

NPJ Breast Cancer, 2022, v. 8, n. 1, p. 1, doi. 10.1038/s41523-022-00427-9

By:

Liu, Xuan;
Ge, Zhongqi;
Yang, Fei;
Contreras, Alejandro;
Lee, Sanghoon;
White, Jason B.;
Lu, Yiling;
Labrie, Marilyne;
Arun, Banu K.;
Moulder, Stacy L.;
Mills, Gordon B.;
Piwnica-Worms, Helen;
Litton, Jennifer K.;
Chang, Jeffrey T.

Publication type:

Article

The cytosolic iron–sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors.

Published in:

NPJ Breast Cancer, 2021, v. 7, n. 1, p. 1, doi. 10.1038/s41523-021-00353-2

By:

Redwood, Abena B.;
Zhang, Xiaomei;
Seth, Sahil B.;
Ge, Zhongqi;
Bindeman, Wendy E.;
Zhou, Xinhui;
Sinha, Vidya C.;
Heffernan, Timothy P.;
Piwnica-Worms, Helen

Publication type:

Article

Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit.

Published in:

Journal of Cell Biology, 2008, v. 181, n. 1, p. 89, doi. 10.1083/jcb.200708176

By:

Nakajima, Hiroyuki;
Nishida, Eisuke;
Yonemura, Shigenobu;
Murata, Masayuki;
Nakamura, Nobuhiro;
Piwnica-Worms, Helen

Publication type:

Article

Identification of protein phosphorylation sites within Ser/Thr-rich cluster domains using site-directed mutagenesis and hybrid linear quadrupole ion trap Fourier transform ion cyclotron resonance mass spectrometry.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2007, v. 21, n. 21, p. 3443, doi. 10.1002/rcm.3223

By:

King, Julie B.;
Gross, Julia;
Lovly, Christine M.;
Piwnica-Worms, Helen;
Townsend, R. Reid

Publication type:

Article

The Par-1/MARK Family of Protein Kinases.

Published in:

Cell Cycle, 2007, v. 6, n. 16, p. 1966, doi. 10.4161/cc.6.16.4576

By:

Hurov, Jonathan;
Piwnica-Worms, Helen

Publication type:

Article

Cdc25A Regulation.

Published in:

Cell Cycle, 2003, v. 2, n. 5, p. 455

By:

Neely, Kristen E.;
Piwnica-Worms, Helen

Publication type:

Article

Human Cytomegalovirus Protein pUL117 Targets the Mini-Chromosome Maintenance Complex and Suppresses Cellular DNA Synthesis.

Published in:

PLoS Pathogens, 2010, v. 6, n. 3, p. 1, doi. 10.1371/journal.ppat.1000814

By:

Zhikang Qian;
Van Leung-Pineda;
Baoqin Xuan;
Piwnica-Worms, Helen;
Dong Yu

Publication type:

Article

CRL4<sup>CDT2</sup> Targets CHK1 for PCNA-Independent Destruction.

Published in:

Molecular & Cellular Biology, 2013, v. 33, n. 2, p. 213, doi. 10.1128/MCB.00847-12

By:

Jiwon Huh;
Piwnica-Worms, Helen

Publication type:

Article

Bioluminescence Imaging Captures the Expression and Dynamics of Endogenous p21 Promoter Activity in Living Mice and Intact Cells.

Published in:

Molecular & Cellular Biology, 2011, v. 31, n. 18, p. 3709, doi. 10.1128/MCB.05243-11

By:

Tinkum, Kelsey L.;
Marpegan, Luciano;
White, Lynn S.;
Sun, Jinwu;
Herzog, Erik D.;
Piwnica-Worms, David;
Piwnica-Worms, Helen

Publication type:

Article

Loss of Par-1a/MARK3/C-TAK1 Kinase Leads to Reduced Adiposity, Resistance to Hepatic Steatosis, and Defective Gluconeogenesis.

Published in:

Molecular & Cellular Biology, 2010, v. 30, n. 21, p. 6, doi. 10.1128/MCB.01472-09

By:

Lennerz, Jochen K.;
Hurov, Jonathan B.;
White, Lynn S.;
Lewandowski, Katherine T.;
Prior, Julie L.;
Planer, G. James;
Gereau IV, Robert W.;
Piwnica-Worms, David;
Schmidt, Robert E.;
Piwnica-Worms, Helen

Publication type:

Article

Regulation of Chk2 Ubiquitination and Signaling through Autophosphorylation of Serine 379.

Published in:

2008

By:

Lovly, Christine M.;
Ling Yan;
Ryan, Christine E.;
Takada, Saeko;
Piwnica-Worms, Helen

Publication type:

Abstract

Phosphorylation of Chk1 by ATR Is Antagonized by a Chk1-Regulated Protein Phosphatase 2A Circuit.

Published in:

Molecular & Cellular Biology, 2006, v. 26, n. 20, p. 16, doi. 10.1128/MCB.00447-06

By:

Leung-Pineda, Van;
Ryan, Christine E.;
Piwnica-Worms, Helen

Publication type:

Article

Enteral Activation of WR-2721 Mediates Radioprotection and Improved Survival from Lethal Fractionated Radiation.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-018-37147-9

By:

Molkentine, Jessica M.;
Fujimoto, Tara N.;
Horvath, Thomas D.;
Grossberg, Aaron J.;
Garcia, Carolina J. Garcia;
Deorukhkar, Amit;
de la Cruz Bonilla, Marimar;
Lin, Daniel;
Samuel, Errol L. G.;
Chan, Wai Kin;
Lorenzi, Philip L.;
Piwnica-Worms, Helen;
Dantzer, Robert;
Tour, James M.;
Mason, Kathryn A.;
Taniguchi, Cullen M.

Publication type:

Article

Stem cell enriched-epithelial spheroid cultures for rapidly assaying small intestinal radioprotectors and radiosensitizers in vitro.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-33747-7

By:

de la Cruz Bonilla, Marimar;
Stemler, Kristina M.;
Taniguchi, Cullen M.;
Piwnica-Worms, Helen

Publication type:

Article

Metabolic stress induces GD2<sup>+</sup> cancer stem cell-like phenotype in triple-negative breast cancer.

Published in:

2022

By:

Jaggupilli, Appalaraju;
Ly, Stanley;
Nguyen, Khoa;
Anand, Vivek;
Yuan, Bin;
El-Dana, Fouad;
Yan, Yuanqing;
Arvanitis, Zoe;
Piyarathna, Danthasinghe Waduge Badrajee;
Putluri, Nagireddy;
Piwnica-Worms, Helen;
Manning, Henry Charles;
Andreeff, Michael;
Battula, V. Lokesh

Publication type:

journal article

Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding.

Published in:

Oncogene, 2001, v. 20, n. 15, p. 1839, doi. 10.1038/sj.onc.1204259

By:

Graves, Paul R;
Lovly, Christine M;
Uy, Geoffrey L;
Piwnica-Worms, Helen

Publication type:

Article

p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer.

Published in:

2016

By:

Powell, Emily;
Jiansu Shao;
Yuan Yuan;
Hsiang-Chun Chen;
Shirong Cai;
Echeverria, Gloria V.;
Mistry, Nipun;
Decker, Keith F.;
Schlosberg, Christopher;
Kim-Anh Do;
Edwards, John R.;
Han Liang;
Piwnica-Worms, David;
Piwnica-Worms, Helen;
Shao, Jiansu;
Yuan, Yuan;
Chen, Hsiang-Chun;
Cai, Shirong;
Do, Kim-Anh;
Liang, Han

Publication type:

journal article

Fools rush in.

Published in:

Nature, 1999, v. 401, n. 6753, p. 535, doi. 10.1038/44029

By:

Piwnica-Worms, Helen

Publication type:

Article

Dual phosphorylation controls Cdc25 phosphatases and mitotic entry.

Published in:

Nature Cell Biology, 2003, v. 5, n. 6, p. 545, doi. 10.1038/ncb994

By:

Bulavin, Dmitry V.;
Higashimoto, Yuichiro;
Demidenko, Zoya N.;
Meek, Sarah;
Graves, Paul;
Phillips, Crissy;
Zhao, Hui;
Moody, Sally A.;
Appella, Ettore;
Piwnica-Worms, Helen;
Fornace, Albert J.

Publication type:

Article

Contributions Made by CDC25 Phosphatases to Proliferation of Intestinal Epithelial Stem and Progenitor Cells.

Published in:

PLoS ONE, 2011, v. 6, n. 1, p. 1, doi. 10.1371/journal.pone.0015561

By:

Lee, Gwanghee;
Origanti, Sofia;
White, Lynn S.;
Sun, Jinwu;
Stappenbeck, Thaddeus S.;
Piwnica-Worms, Helen

Publication type:

Article

A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis.

Published in:

NPJ Breast Cancer, 2018, v. 4, n. 1, p. N.PAG, doi. 10.1038/s41523-018-0062-x

By:

Powell, Emily;
Shao, Jiansu;
Picon, Hector M.;
Bristow, Christopher;
Ge, Zhongqi;
Peoples, Michael;
Robinson, Frederick;
Jeter-Jones, Sabrina L.;
Schlosberg, Christopher;
Grzeskowiak, Caitlin L.;
Yang, Fei;
Wu, Yun;
Wistuba, Ignacio;
Moulder, Stacy L.;
Symmans, William F.;
Scott, Kenneth L.;
Edwards, John R.;
Liang, Han;
Heffernan, Timothy P.;
Piwnica-Worms, Helen

Publication type:

Article

A comprehensive overview of metaplastic breast cancer: clinical features and molecular aberrations.

Published in:

2020

By:

Reddy, Tejaswini P.;
Rosato, Roberto R.;
Li, Xiaoxian;
Moulder, Stacy;
Piwnica-Worms, Helen;
Chang, Jenny C.

Publication type:

journal article

New Role for hPar-1 Kinases EMK and C-TAK1 in Regulating Localization and Activity of Class IIa Histone Deacetylases.

Published in:

Molecular & Cellular Biology, 2006, v. 26, n. 19, p. 7, doi. 10.1128/MCB.00231-06

By:

Dequiedt, Franck;
Martin, Maud;
Von Blume, Julia;
Vertommen, Didier;
Lecomte, Emily;
Mari, Nathalie;
Heinen, Marie-France;
Bachmann, Malte;
Twizere, Jean-Claude;
Huang, Mei Chris;
Rider, Mark H.;
Piwnica-Worms, Helen;
Seufferlein, Thomas;
Kettmann, Richard

Publication type:

Article

Normal Cell Cycle and Checkpoint Responses in Mice and Cells Lacking Cdc25B and Cdc25C Protein Phosphatases.

Published in:

Molecular & Cellular Biology, 2005, v. 25, n. 7, p. 2853, doi. 10.1128/MCB.25.7.2853-2860.2005

By:

Ferguson, Angela M.;
White, Lynn S.;
Donovan, Peter J.;
Piwnica-Worms, Helen

Publication type:

Article

Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding.

Published in:

Molecular & Cellular Biology, 2003, v. 23, n. 21, p. 7488, doi. 10.1128/MCB.23.21.7488-7497.2003

By:

Mei-Shya Chen, Saïd;
Ryan, Christine E.;
Piwnica-Worms, Helen

Publication type:

Article

The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-14304-1

By:

Hu, Xiaohui;
Harvey, Samuel E.;
Zheng, Rong;
Lyu, Jingyi;
Grzeskowiak, Caitlin L.;
Powell, Emily;
Piwnica-Worms, Helen;
Scott, Kenneth L.;
Cheng, Chonghui

Publication type:

Article