Works by Pitt, Geoffrey S.

Results: 34

Genetics of cardiac repolarization.

Published in:

Nature Genetics, 2009, v. 41, n. 4, p. 388, doi. 10.1038/ng0409-388

By:

Shah, Svati H.;
Pitt, Geoffrey S.

Publication type:

Article

CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation.

Published in:

Journal of Cell Biology, 2005, v. 171, n. 3, p. 537, doi. 10.1083/jcb.200505155

By:

Hudmon, Andy;
Schulman, Howard;
Tsien, Richard W.;
Kim, James;
Maltez, Janet M.;
Pitt, Geoffrey S.

Publication type:

Article

A CACNA1C Variant Associated with Reduced Voltage-Dependent Inactivation, Increased CaV1.2 Channel Window Current, and Arrhythmogenesis.

Published in:

PLoS ONE, 2014, v. 9, n. 9, p. 1, doi. 10.1371/journal.pone.0106982

By:

Hennessey, Jessica A.;
Boczek, Nicole J.;
Jiang, Yong-Hui;
Miller, Joelle D.;
Patrick, William;
Pfeiffer, Ryan;
Sutphin, Brittan S.;
Tester, David J.;
Barajas-Martinez, Hector;
Ackerman, Michael J.;
Antzelevitch, Charles;
Kanter, Ronald;
Pitt, Geoffrey S.

Publication type:

Article

Long-Term In Vivo Imaging of Multiple Organs at the Single Cell Level.

Published in:

PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0052087

By:

Chen, Benny J.;
Yiqun Jiao;
Ping Zhang;
Sun, Albert Y.;
Pitt, Geoffrey S.;
Deoliveira, Divino;
Drago, Nicholas;
Tong Ye;
Chen Liu;
Chao, Nelson J.

Publication type:

Article

Rem2-Targeted shRNAs Reduce Frequency of Miniature Excitatory Postsynaptic Currents without Altering Voltage-Gated Ca2+ Currents.

Published in:

PLoS ONE, 2011, v. 6, n. 9, p. 1, doi. 10.1371/journal.pone.0025741

By:

Wang, Hong-Gang;
Wang, Chuan;
Pitt, Geoffrey S.

Publication type:

Article

Calmodulin and CaMKII as molecular switches for cardiac ion channels

Published in:

Cardiovascular Research, 2007, v. 73, n. 4, p. 641, doi. 10.1016/j.cardiores.2006.10.019

By:

Pitt, Geoffrey S.

Publication type:

Article

Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity.

Published in:

FASEB Journal, 2019, v. 33, n. 10, p. 1, doi. 10.1096/fj.201901178R

By:

Sinden, Daniel S.;
Holman, Corey D.;
Bare, Curtis J.;
Xiaolu Sun;
Gade, Aravind R.;
Cohen, David E.;
Pitt, Geoffrey S.

Publication type:

Article

Ion Channels under the Sun.

Published in:

FASEB Journal, 2014, v. 28, n. 5, p. 1957, doi. 10.1096/fj.14-0501ufm

By:

Abbott, Geoffrey W.;
Pitt, Geoffrey S.

Publication type:

Article

Essential Cavßmodulatory properties are AID-independent.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 4, p. 372, doi. 10.1038/nsmb909

By:

Maltez, Janet M;
Nunziato, Deborah A;
Kim, James;
Pitt, Geoffrey S

Publication type:

Article

Calmodulin binds to the N-terminal domain of the cardiac sodium channel Nav1.5.

Published in:

Channels (19336950), 2020, v. 14, n. 1, p. 268, doi. 10.1080/19336950.2020.1805999

By:

Wang, Zizun;
Vermij, Sarah H.;
Sottas, Valentin;
Shestak, Anna;
Ross-Kaschitza, Daniela;
Zaklyazminskaya, Elena V.;
Hudmon, Andy;
Pitt, Geoffrey S.;
Rougier, Jean-Sébastien;
Abriel, Hugues

Publication type:

Article

Divide, multitask, and conquer: Coordination in channel regulation.

Published in:

Channels (19336950), 2017, v. 11, n. 4, p. 268, doi. 10.1080/19336950.2017.1292814

By:

Pablo, Juan Lorenzo;
Pitt, Geoffrey S.

Publication type:

Article

FGF13 modulates the gating properties of the cardiac sodium channel Na v 1.5 in an isoform-specific manner.

Published in:

Channels (19336950), 2016, v. 10, n. 5, p. 410, doi. 10.1080/19336950.2016.1190055

By:

Yang, Jing;
Wang, Zhihua;
Sinden, Daniel S.;
Wang, Xiangchong;
Shan, Bin;
Yu, Xiao;
Zhang, Hailin;
Pitt, Geoffrey S.;
Wang, Chuan

Publication type:

Article

Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development.

Published in:

2013

By:

Ramachandran, Kapil V;
Hennessey, Jessica A;
Barnett, Adam S;
Yin, Xinhe;
Stadt, Harriett A;
Foster, Erika;
Shah, Raj A;
Yazawa, Masayuki;
Dolmetsch, Ricardo E;
Kirby, Margaret L;
Pitt, Geoffrey S

Publication type:

journal article

Calcium influx through L-type Cav1.2 Ca2+ channels regulates mandibular development.

Published in:

Journal of Clinical Investigation, 2013, v. 123, n. 4, p. 1638, doi. 10.1172/JCI66903

By:

Ramachandran, Kapil V.;
Hennessey, Jessica A.;
Barnett, Adam S.;
Xinhe Yin;
Stadt, Harriett A.;
Foster, Erika;
Shah, Raj A.;
Yazawa, Masayuki;
Dolmetsch, Ricardo E.;
Kirby, Margaret L.;
Pitt, Geoffrey S.

Publication type:

Article

Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.98661

By:

Susan Lin;
Gade, Aravind R.;
Hong-Gang Wang;
Niemeyer, James E.;
Galante, Allison;
DiStefano, Isabella;
Towers, Patrick;
Nunez, Jorge;
Maiko Matsui;
Schwartz, Theodore H.;
Rajadhyaksha, Anjali;
Pitt, Geoffrey S.

Publication type:

Article

An update on the journey towards precision medicine in cardiology.

Published in:

European Heart Journal, 2018, v. 39, n. 40, p. 3627, doi. 10.1093/eurheartj/ehy637

By:

Pitt, Geoffrey S

Publication type:

Article

A view from the side-line.

Published in:

European Heart Journal, 2016, v. 37, n. 47, p. 3488, doi. 10.1093/eurheartj/ehw532

By:

Pitt, Geoffrey S.

Publication type:

Article

Genetic variants and disease: correlate or cause?

Published in:

European Heart Journal, 2016, v. 37, n. 18, p. 1476, doi. 10.1093/eurheartj/ehv516

By:

Matsui, Maiko;
Pitt, Geoffrey S.

Publication type:

Article

Cardiovascular precision medicine: hope or hype?

Published in:

European Heart Journal, 2015, v. 36, n. 29, p. 1842, doi. 10.1093/eurheartj/ehv226

By:

Pitt, Geoffrey S.

Publication type:

Article

COMMUNICATION BETWEEN SYNAPSE AND NUCLEUS.

Published in:

1999

By:

Deisseroth, Karl;
Gang-Yi Wu;
Mermelstein, Paul G.;
Pitt, Geoffrey S.;
Zühlke, Roger;
Reuter, Harald;
Tsien, Richard W.

Publication type:

Abstract

Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking.

Published in:

2019

By:

Lin Yang;
Katchman, Alexander;
Kushner, Jared;
Kushnir, Alexander;
Zakharov, Sergey I.;
Bi-xing Chen;
Shuja, Zunaira;
Subramanyam, Prakash;
Guoxia Liu;
Papa, Arianne;
Roybal, Daniel;
Pitt, Geoffrey S.;
Colecraft, Henry;
Marx, Steven O.;
Yang, Lin;
Chen, Bi-Xing;
Liu, Guoxia;
Colecraft, Henry M

Publication type:

journal article

The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.

Published in:

2018

By:

Abraham, Dennis M.;
Lee, Teresa E.;
Watson, Lewis J.;
Lan Mao;
Chandok, Gurangad S.;
Hong-Gang Wang;
Frangakis, Stephan;
Pitt, Geoffrey S.;
Shah, Svati H.;
Wolf, Matthew J.;
Rockman, Howard A.;
Mao, Lan;
Chandok, Gurangad;
Wang, Hong-Gang

Publication type:

journal article

Fibroblast Growth Factor Homologous Factors.

Published in:

Neuroscientist, 2016, v. 22, n. 1, p. 19, doi. 10.1177/1073858414562217

By:

Pablo, Juan L.;
Pitt, Geoffrey S.

Publication type:

Article

Calmodulin supports both inactivation and facilitation of L-type calcium channels.

Published in:

Nature, 1999, v. 399, n. 6732, p. 159, doi. 10.1038/20200

By:

Zuhlke, Roger D.;
Pitt, Geoffrey S.;
Deisseroth, Karl;
Tsien, Richard W.;
Reuter, Harald

Publication type:

Article

Structural analyses of Ca2+/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation.

Published in:

Nature Communications, 2014, v. 5, n. 9, p. 4896, doi. 10.1038/ncomms5896

By:

Wang, Chaojian;
Chung, Ben C.;
Yan, Haidun;
Wang, Hong-Gang;
Lee, Seok-Yong;
Pitt, Geoffrey S.

Publication type:

Article

α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current.

Published in:

PLoS ONE, 2016, v. 11, n. 3, p. 1, doi. 10.1371/journal.pone.0152355

By:

Choi, Jong-Il;
Wang, Chaojian;
Thomas, Matthew J.;
Pitt, Geoffrey S.

Publication type:

Article

Sudden unexpected death in epilepsy: respiratory vs. cardiac contributions.

Published in:

Cardiovascular Research, 2024, v. 120, n. 18, p. 2385, doi. 10.1093/cvr/cvae170

By:

Lin, Susan;
Schwartz, Theodore H;
Pitt, Geoffrey S

Publication type:

Article

Increased Ca2+ signaling through CaV1.2 induces tendon hypertrophy with increased collagen fibrillogenesis and biomechanical properties.

Published in:

FASEB Journal, 2023, v. 37, n. 7, p. 1, doi. 10.1096/fj.202300607R

By:

Li, Haiyin;
Korcari, Antonion;
Ciufo, David;
Mendias, Christopher L.;
Rodeo, Scott A.;
Buckley, Mark R.;
Loiselle, Alayna E.;
Pitt, Geoffrey S.;
Cao, Chike

Publication type:

Article

Na+ channel function, regulation, structure, trafficking and sequestration.

Published in:

Journal of Physiology, 2015, v. 593, n. 6, p. 1347, doi. 10.1113/jphysiol.2014.281428

By:

Chen‐Izu, Ye;
Shaw, Robin M.;
Pitt, Geoffrey S.;
Yarov‐Yarovoy, Vladimir;
Sack, Jon T.;
Abriel, Hugues;
Aldrich, Richard W.;
Belardinelli, Luiz;
Cannell, Mark B.;
Catterall, William A.;
Chazin, Walter J.;
Chiamvimonvat, Nipavan;
Deschenes, Isabelle;
Grandi, Eleonora;
Hund, Thomas J.;
Izu, Leighton T.;
Maier, Lars S.;
Maltsev, Victor A.;
Marionneau, Celine;
Mohler, Peter J.

Publication type:

Article

A Natural History Study of Timothy Syndrome.

Published in:

Orphanet Journal of Rare Diseases, 2024, v. 19, n. 1, p. 1, doi. 10.1186/s13023-024-03445-x

By:

Timothy, Katherine W.;
Bauer, Rosemary;
Larkin, Kerry A.;
Walsh, Edward P.;
Abrams, Dominic J.;
Gonzalez Corcia, Cecilia;
Valsamakis, Alexandra;
Pitt, Geoffrey S.;
Dick, Ivy E.;
Golden, Andy

Publication type:

Article

Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins.

Published in:

Protein Science: A Publication of the Protein Society, 2016, v. 25, n. 9, p. 1573, doi. 10.1002/pro.2960

By:

Pitt, Geoffrey S.;
Lee, Seok ‐ Yong

Publication type:

Article

Ca2+/CaM Controls Ca2+-Dependent Inactivation of NMDA Receptors by Dimerizing the NR1 C Termini.

Published in:

Journal of Neuroscience, 2008, v. 28, n. 8, p. 1865, doi. 10.1523/JNEUROSCI.5417-07.2008

By:

Chaojian Wang;
Hong-Gang Wang;
Hui Xie;
Pitt, Geoffrey S.

Publication type:

Article

Ca2+/Calmodulin Regulates Trafficking of CaV1.2 Ca2+ Channels in Cultured Hippocampal Neurons.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 34, p. 9086, doi. 10.1523/JNEUROSCI.1720-07.2007

By:

Hong-Gang Wang;
George, Meena S.;
Kim, James;
Chaojian Wang;
Pitt, Geoffrey S.

Publication type:

Article

Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction.

Published in:

PLoS Genetics, 2012, v. 8, n. 12, p. 1, doi. 10.1371/journal.pgen.1003113

By:

Lodder, Elisabeth M.;
Scicluna, Brendon P.;
Milano, Annalisa;
Sun, Albert Y.;
Hao Tang;
Remme, Carol Ann;
Moerland, Perry D.;
Tanck, Michael W. T.;
Pitt, Geoffrey S.;
Marchuk, Douglas A.;
Bezzina, Connie R.

Publication type:

Article

Works by Pitt, Geoffrey S.

Genetics of cardiac repolarization.

CaMKII tethers to L-type Ca<sup>2+</sup> channels, establishing a local and dedicated integrator of Ca<sup>2+</sup> signals for facilitation.

A CACNA1C Variant Associated with Reduced Voltage-Dependent Inactivation, Increased Ca<sub>V</sub>1.2 Channel Window Current, and Arrhythmogenesis.

Long-Term In Vivo Imaging of Multiple Organs at the Single Cell Level.

Rem2-Targeted shRNAs Reduce Frequency of Miniature Excitatory Postsynaptic Currents without Altering Voltage-Gated Ca2+ Currents.

Calmodulin and CaMKII as molecular switches for cardiac ion channels

Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity.

Ion Channels under the Sun.

Essential Ca<sub>v</sub>ßmodulatory properties are AID-independent.

Calmodulin binds to the N-terminal domain of the cardiac sodium channel Na<sub>v</sub>1.5.

Divide, multitask, and conquer: Coordination in channel regulation.

FGF13 modulates the gating properties of the cardiac sodium channel Na v 1.5 in an isoform-specific manner.

Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development.

Calcium influx through L-type Ca<sub>v</sub>1.2 Ca<sup>2+</sup> channels regulates mandibular development.

Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism.

An update on the journey towards precision medicine in cardiology.

A view from the side-line.

Genetic variants and disease: correlate or cause?

Cardiovascular precision medicine: hope or hype?

COMMUNICATION BETWEEN SYNAPSE AND NUCLEUS.

Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking.

The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.

Fibroblast Growth Factor Homologous Factors.

Calmodulin supports both inactivation and facilitation of L-type calcium channels.

Structural analyses of Ca<sup>2+</sup>/CaM interaction with Na<sub>V</sub> channel C-termini reveal mechanisms of calcium-dependent regulation.

α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current.

Sudden unexpected death in epilepsy: respiratory vs. cardiac contributions.

Increased Ca<sup>2+</sup> signaling through Ca<sub>V</sub>1.2 induces tendon hypertrophy with increased collagen fibrillogenesis and biomechanical properties.

Na<sup>+</sup> channel function, regulation, structure, trafficking and sequestration.

A Natural History Study of Timothy Syndrome.

Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins.

Ca<sup>2+</sup>/CaM Controls Ca<sup>2+</sup>-Dependent Inactivation of NMDA Receptors by Dimerizing the NR1 C Termini.

Ca<sup>2+</sup>/Calmodulin Regulates Trafficking of Ca<sub>V</sub>1.2 Ca<sup>2+</sup> Channels in Cultured Hippocampal Neurons.

Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction.