Works by Pirinen, Eija

Results: 24

Mitochondrial bioenergetic pathways in blood leukocyte transcriptome decrease after intensive weight loss but are rescued following weight regain in female physique athletes.

Published in:

FASEB Journal, 2021, v. 35, n. 4, p. 1, doi. 10.1096/fj.202002029R

By:

Sarin, Heikki V.;
Pirinen, Eija;
Pietiläinen, Kirsi H.;
Isola, Ville;
Häkkinen, Keijo;
Perola, Markus;
Hulmi, Juha J.

Publication type:

Article

Genetic Manipulation of Polyamine Catabolism in Rodents.

Published in:

Journal of Biochemistry, 2006, v. 139, n. 2, p. 155, doi. 10.1093/jb/mvj035

By:

Jänne, Juhani;
Alhonen, Leena;
Pietilä, Marko;
Keinänen, Tuomo A.;
Uimari, Anne;
Hyvönen, Mervi T.;
Pirinen, Eija;
Järvinen, Aki

Publication type:

Article

Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice.

Published in:

Cardiovascular Research, 2019, v. 115, n. 1, p. 243, doi. 10.1093/cvr/cvy143

By:

Ruotsalainen, Anna-Kaisa;
Lappalainen, Jari P;
Heiskanen, Emmi;
Merentie, Mari;
Sihvola, Virve;
Näpänkangas, Juha;
Lottonen-Raikaslehto, Line;
Kansanen, Emilia;
Adinolfi, Simone;
Kaarniranta, Kai;
Ylä-Herttuala, Seppo;
Jauhiainen, Matti;
Pirinen, Eija;
Levonen, Anna-Liisa

Publication type:

Article

Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.

Published in:

Journal of Cellular & Molecular Medicine, 2010, v. 14, n. 6b, p. 1683, doi. 10.1111/j.1582-4934.2009.00808.x

By:

Vuohelainen, Susanna;
Pirinen, Eija;
Cerrada-Gimenez, Marc;
Keinänen, Tuomo A.;
Uimari, Anne;
Pietil, Marko;
Khomutov, Alex R.;
Jänne, Juhani;
Alhonen, Leena

Publication type:

Article

Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging.

Published in:

Journal of Cellular & Molecular Medicine, 2006, v. 10, n. 4, p. 815, doi. 10.2755/jcmm010.004.02

By:

Niiranen, Kirsi;
Keinänen, Tuomo A.;
Pirinen, Eija;
Heikkinen, Sami;
Tusa, Maija;
Fatrai, Szabolcs;
Suppola, Suvikki;
Pietilä, Marko;
Uimari, Anne;
Laakso, Markku;
Alhonen, Leena;
Jänne, Juhani

Publication type:

Article

Animal disease models generated by genetic engineering of polyamine metabolism.

Published in:

Journal of Cellular & Molecular Medicine, 2005, v. 9, n. 4, p. 865, doi. 10.1111/j.1582-4934.2005.tb00385.x

By:

Jänne, Juhani;
Alhonen, Leena;
Keinänen, Tuomo A.;
Pietilä, Marko;
Uimari, Anne;
Pirinen, Eija;
Hyvönen, Mervi T.;
Järvinen, Aki

Publication type:

Article

NAD+ repletion with niacin counteracts cancer cachexia.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37595-6

By:

Beltrà, Marc;
Pöllänen, Noora;
Fornelli, Claudia;
Tonttila, Kialiina;
Hsu, Myriam Y.;
Zampieri, Sandra;
Moletta, Lucia;
Corrà, Samantha;
Porporato, Paolo E.;
Kivelä, Riikka;
Viscomi, Carlo;
Sandri, Marco;
Hulmi, Juha J.;
Sartori, Roberta;
Pirinen, Eija;
Penna, Fabio

Publication type:

Article

Indole-3-propionic acid promotes hepatic stellate cells inactivation.

Published in:

Journal of Translational Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12967-025-06266-z

By:

Ilha, Mariana;
Sehgal, Ratika;
Matilainen, Johanna;
Rilla, Kirsi;
Kaminska, Dorota;
Gandhi, Shrey;
Männistö, Ville;
Ling, Charlotte;
Romeo, Stefano;
Pajukanta, Päivi;
Pirinen, Eija;
Virtanen, Kirsi A.;
Pietiläinen, Kirsi H.;
Vaittinen, Maija;
Pihlajamäki, Jussi

Publication type:

Article

Dose-dependent CHCHD10 dysregulation dictates motor neuron disease severity and alters creatine metabolism.

Published in:

Acta Neuropathologica Communications, 2025, v. 13, n. 1, p. 1, doi. 10.1186/s40478-025-02039-3

By:

Harjuhaahto, Sandra;
Jokela, Manu;
Rajendran, Jayasimman;
Rokka, Minea;
Hu, Bowen;
Kvist, Jouni;
Zhang, Fuping;
Zárybnický, Tomáš;
Haimilahti, Kimmo;
Euro, Liliya;
Pirinen, Eija;
Huber, Nadine;
Herukka, Sanna-Kaisa;
Haapasalo, Annakaisa;
Kuuluvainen, Emilia;
Gopalakrishnan, Swetha;
Katajisto, Pekka;
Hietakangas, Ville;
Burg, Thibaut;
Van Den Bosch, Ludo

Publication type:

Article

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3.

Published in:

EMBO Molecular Medicine, 2014, v. 6, n. 6, p. 721, doi. 10.1002/emmm.201403943

By:

Khan, Nahid A;
Auranen, Mari;
Paetau, Ilse;
Pirinen, Eija;
Euro, Liliya;
Forsström, Saara;
Pasila, Lotta;
Velagapudi, Vidya;
Carroll, Christopher J;
Auwerx, Johan;
Suomalainen, Anu

Publication type:

Article

Disturbed Keratinocyte Differentiation in Transgenic Mice and Organotypic Keratinocyte Cultures as a Result of Spermidine/SpermineN1-Acetyltransferase Overexpression.

Published in:

Journal of Investigative Dermatology, 2005, v. 124, n. 3, p. 596, doi. 10.1111/j.0022-202X.2005.23636.x

By:

Pietilä, Marko;
Pirinen, Eija;
Keskitalo, Salla;
Juutinen, Sisko;
Pasonen-Seppänen, Sanna;
Keinänen, Tuomo;
Alhonen, Leena;
Jänne, Juhani

Publication type:

Article

Weight Loss Is Associated With Increased NAD(+)/SIRT1 Expression But Reduced PARP Activity in White Adipose Tissue.

Published in:

2016

By:

Rappou, Elisabeth;
Jukarainen, Sakari;
Rinnankoski-Tuikka, Rita;
Kaye, Sanna;
Heinonen, Sini;
Hakkarainen, Antti;
Lundbom, Jesper;
Lundbom, Nina;
Saunavaara, Virva;
Rissanen, Aila;
Virtanen, Kirsi A;
Pirinen, Eija;
Pietiläinen, Kirsi H

Publication type:

journal article

Obesity Is Associated With Low NAD(+)/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins.

Published in:

2016

By:

Jukarainen, Sakari;
Heinonen, Sini;
Rämö, Joel T;
Rinnankoski-Tuikka, Rita;
Rappou, Elisabeth;
Tummers, Mark;
Muniandy, Maheswary;
Hakkarainen, Antti;
Lundbom, Jesper;
Lundbom, Nina;
Kaprio, Jaakko;
Rissanen, Aila;
Pirinen, Eija;
Pietiläinen, Kirsi H

Publication type:

journal article

Enhanced Polyamine Catabolism Alters Homeostatic Control of White Adipose Tissue Mass, Energy Expenditure, and Glucose Metabolism.

Published in:

Molecular & Cellular Biology, 2007, v. 27, n. 13, p. 29, doi. 10.1128/MCB.02034-06

By:

Pirinen, Eija;
Kuulasmaa, Teemu;
Pietilä, Marko;
Heikkinen, Sami;
Tusa, Maija;
Itkonen, Paula;
Boman, Susanna;
Skommer, Joanna;
Virkamäki, Antti;
Hohtola, Esa;
Kettunen, Mikko;
Fatrai, Szabolcs;
Kansanen, Emilia;
Koota, Suvi;
Niiranen, Kirsi;
Parkkinen, Jyrki;
Levonen, Anna-Liisa;
Ylä-Herttuala, Seppo;
Hiltunen, J. Kalervo;
Alhonen, Leena

Publication type:

Article

The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis.

Published in:

Amino Acids, 2012, v. 42, n. 2/3, p. 427, doi. 10.1007/s00726-011-1013-0

By:

Koponen, Taina;
Cerrada-Gimenez, Marc;
Pirinen, Eija;
Hohtola, Esa;
Paananen, Jussi;
Vuohelainen, Susanna;
Tusa, Maija;
Pirnes-Karhu, Sini;
Heikkinen, Sami;
Virkamäki, Antti;
Uimari, Anne;
Alhonen, Leena;
Laakso, Markku

Publication type:

Article

Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis.

Published in:

Amino Acids, 2010, v. 38, n. 2, p. 549, doi. 10.1007/s00726-009-0416-7

By:

Pirinen, Eija;
Gylling, Helena;
Itkonen, Paula;
Yaluri, Nagendra;
Heikkinen, Sami;
Pietilä, Marko;
Kuulasmaa, Teemu;
Tusa, Maija;
Cerrada-Gimenez, Marc;
Pihlajamäki, Jussi;
Alhonen, Leena;
Jänne, Juhani;
Miettinen, Tatu A.;
Laakso, Markku

Publication type:

Article

Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00566-9

By:

Item, Flurin;
Wueest, Stephan;
Lemos, Vera;
Stein, Sokrates;
Lucchini, Fabrizio C.;
Denzler, Rémy;
Fisser, Muriel C.;
Challa, Tenagne D.;
Pirinen, Eija;
Youngsoo Kim;
Hemmi, Silvio;
Gulbins, Erich;
Gross, Atan;
O'Reilly, Lorraine A.;
Stoffel, Markus;
Auwerx, Johan;
Konrad, Daniel

Publication type:

Article

NAD+ repletion produces no therapeutic effect in mice with respiratory chain complex III deficiency and chronic energy deprivation.

Published in:

FASEB Journal, 2018, v. 32, n. 11, p. 5913, doi. 10.1096/fj.201800090R

By:

Purhonen, Janne;
Rajendran, Jayasimman;
Tegelberg, Saara;
Smolander, Olli-Pekka;
Pirinen, Eija;
Kallijärvi, Jukka;
Fellman, Vineta

Publication type:

Article

Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans.

Published in:

2015

By:

van de Weijer, Tineke;
Phielix, Esther;
Bilet, Lena;
Williams, Evan G;
Ropelle, Eduardo R;
Bierwagen, Alessandra;
Livingstone, Roshan;
Nowotny, Peter;
Sparks, Lauren M;
Paglialunga, Sabina;
Szendroedi, Julia;
Havekes, Bas;
Moullan, Norman;
Pirinen, Eija;
Hwang, Jong-Hee;
Schrauwen-Hinderling, Vera B;
Hesselink, Matthijs K C;
Auwerx, Johan;
Roden, Michael;
Schrauwen, Patrick

Publication type:

journal article

Evidence for a Direct Effect of the NAD+ Precursor Acipimox on Muscle Mitochondrial Function in Humans.

Published in:

Diabetes, 2015, v. 64, n. 4, p. 1193, doi. 10.2337/db14-0667

By:

van de Weijer, Tineke;
Phielix, Esther;
Bilet, Lena;
Williams, Evan G.;
Ropelle, Eduardo R.;
Bierwagen, Alessandra;
Livingstone, Roshan;
Nowotny, Peter;
Sparks, Lauren M.;
Paglialunga, Sabina;
Szendroedi, Julia;
Havekes, Bas;
Moullan, Norman;
Pirinen, Eija;
Jong-Hee Hwang;
Schrauwen-Hinderling, Vera B.;
Hesselink, Matthijs K. C.;
Auwerx, Johan;
Roden, Michael;
Schrauwen, Patrick

Publication type:

Article

Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults.

Published in:

Transgenic Research, 2011, v. 20, n. 2, p. 387, doi. 10.1007/s11248-010-9422-5

By:

Cerrada-Gimenez, Marc;
Pietilä, Marko;
Loimas, Suvikki;
Pirinen, Eija;
Hyvönen, Mervi T.;
Keinänen, Tuomo A.;
Jänne, Juhani;
Alhonen, Leena

Publication type:

Article

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

Published in:

Nature, 2014, v. 508, n. 7495, p. 258, doi. 10.1038/nature13198

By:

Kraus, Daniel;
Yang, Qin;
Kong, Dong;
Banks, Alexander S.;
Zhang, Lin;
Rodgers, Joseph T.;
Pirinen, Eija;
Pulinilkunnil, Thomas C.;
Gong, Fengying;
Wang, Ya-chin;
Cen, Yana;
Sauve, Anthony A.;
Asara, John M.;
Peroni, Odile D.;
Monia, Brett P.;
Bhanot, Sanjay;
Alhonen, Leena;
Puigserver, Pere;
Kahn, Barbara B.

Publication type:

Article

Preventing White Adipocyte Browning during Differentiation In Vitro: The Effect of Differentiation Protocols on Metabolic and Mitochondrial Phenotypes.

Published in:

Stem Cells International, 2022, p. 1, doi. 10.1155/2022/3308194

By:

Herbers, Elena;
Patrikoski, Mimmi;
Wagner, Anita;
Jokinen, Riikka;
Hassinen, Antti;
Heinonen, Sini;
Miettinen, Susanna;
Peltoniemi, Hilkka;
Pirinen, Eija;
Pietiläinen, Kirsi H.

Publication type:

Article

Sirtuins as regulators of metabolism and healthspan.

Published in:

Nature Reviews Molecular Cell Biology, 2012, v. 13, n. 4, p. 225, doi. 10.1038/nrm3293

By:

Houtkooper, Riekelt H.;
Pirinen, Eija;
Auwerx, Johan

Publication type:

Article

Works by Pirinen, Eija

Mitochondrial bioenergetic pathways in blood leukocyte transcriptome decrease after intensive weight loss but are rescued following weight regain in female physique athletes.

Genetic Manipulation of Polyamine Catabolism in Rodents.

Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice.

Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.

Mice with targeted disruption of spermidine/spermine N<sup>1</sup>-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging.

Animal disease models generated by genetic engineering of polyamine metabolism.

NAD<sup>+</sup> repletion with niacin counteracts cancer cachexia.

Indole-3-propionic acid promotes hepatic stellate cells inactivation.

Dose-dependent CHCHD10 dysregulation dictates motor neuron disease severity and alters creatine metabolism.

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3.

Disturbed Keratinocyte Differentiation in Transgenic Mice and Organotypic Keratinocyte Cultures as a Result of Spermidine/SpermineN<sup>1</sup>-Acetyltransferase Overexpression.

Weight Loss Is Associated With Increased NAD(+)/SIRT1 Expression But Reduced PARP Activity in White Adipose Tissue.

Obesity Is Associated With Low NAD(+)/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins.

Enhanced Polyamine Catabolism Alters Homeostatic Control of White Adipose Tissue Mass, Energy Expenditure, and Glucose Metabolism.

The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis.

Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis.

Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function.

NAD<sup>+</sup> repletion produces no therapeutic effect in mice with respiratory chain complex III deficiency and chronic energy deprivation.

Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans.

Evidence for a Direct Effect of the NAD<sup>+</sup> Precursor Acipimox on Muscle Mitochondrial Function in Humans.

Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults.

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

Preventing White Adipocyte Browning during Differentiation In Vitro: The Effect of Differentiation Protocols on Metabolic and Mitochondrial Phenotypes.

Sirtuins as regulators of metabolism and healthspan.