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In vitro and clinical investigations to determine the drug-drug interaction potential of entrectinib, a small molecule inhibitor of neurotrophic tyrosine receptor kinase (NTRK).
- Published in:
- Investigational New Drugs, 2022, v. 40, n. 1, p. 68, doi. 10.1007/s10637-021-01156-9
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- Article
Characterization of the pharmacokinetics of entrectinib and its active M5 metabolite in healthy volunteers and patients with solid tumors.
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- Investigational New Drugs, 2021, v. 39, n. 3, p. 803, doi. 10.1007/s10637-020-01047-5
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- Article
From waterfall plots to spaghetti plots in early oncology clinical development.
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- Pharmaceutical Statistics, 2019, v. 18, n. 5, p. 526, doi. 10.1002/pst.1944
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- Publication type:
- Article
Case report of a fatal rectal haemorrhage in a person with severe haemophilia A receiving emicizumab and high‐dose bypassing agents in the HAVEN 1 study.
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- Haemophilia, 2020, v. 26, n. 6, p. e340, doi. 10.1111/hae.14110
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- Article
A Consideration of Fixed Dosing Versus Body Size‐Based Dosing Strategies for Chimeric Antigen Receptor T‐Cell Therapies.
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- Clinical Pharmacology in Drug Development, 2022, v. 11, n. 10, p. 1130, doi. 10.1002/cpdd.1171
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- Article
Effect of Food and Esomeprazole on the Pharmacokinetics of Alectinib, a Highly Selective ALK Inhibitor, in Healthy Subjects.
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- Clinical Pharmacology in Drug Development, 2017, v. 6, n. 4, p. 388, doi. 10.1002/cpdd.296
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- Article
Clinical Drug-Drug Interactions Through Cytochrome P450 3A (CYP3A) for the Selective ALK Inhibitor Alectinib.
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- Clinical Pharmacology in Drug Development, 2017, v. 6, n. 3, p. 280, doi. 10.1002/cpdd.298
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- Article
Effect of the Wetting Agent Sodium Lauryl Sulfate on the Pharmacokinetics of Alectinib: Results From a Bioequivalence Study in Healthy Subjects.
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- Clinical Pharmacology in Drug Development, 2017, v. 6, n. 3, p. 266, doi. 10.1002/cpdd.299
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- Publication type:
- Article
Therapeutically-induced stable disease in oncology early clinical trials.
- Published in:
- PLoS ONE, 2020, v. 15, n. 5, p. 1, doi. 10.1371/journal.pone.0233882
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- Article
Population Pharmacokinetics and Exposure–Response Analysis of Tremelimumab 300 mg Single Dose Combined with Durvalumab 1500 mg Q4W (STRIDE) in Patients with Unresectable Hepatocellular Carcinoma.
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- Journal of Clinical Pharmacology, 2023, v. 63, n. 11, p. 1221, doi. 10.1002/jcph.2288
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- Article
Population Pharmacokinetics of Monalizumab in Patients With Advanced Solid Tumors.
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- Journal of Clinical Pharmacology, 2023, v. 63, n. 7, p. 817, doi. 10.1002/jcph.2220
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- Article
Predicted limited redistribution of T cells to secondary lymphoid tissue correlates with increased risk of haematological malignancies in asplenic patients.
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- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-95225-x
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- Article
Application of CYP3A4 in vitro data to predict clinical drug–drug interactions; predictions of compounds as objects of interaction.
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- British Journal of Clinical Pharmacology, 2008, v. 65, n. 5, p. 680, doi. 10.1111/j.1365-2125.2007.03070.x
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- Article
Dynamics, Bifurcations and Normal Forms in Arrays of Magnetostrictive Energy Harvesters with All-to-All Coupling.
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- International Journal of Bifurcation & Chaos in Applied Sciences & Engineering, 2015, v. 25, n. 2, p. -1, doi. 10.1142/S0218127415500261
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- Article
Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels.
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- 2016
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- Publication type:
- journal article
Clinical Pharmacology Strategies for Bispecific Antibody Development: Learnings from FDA‐Approved Bispecific Antibodies in Oncology.
- Published in:
- Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 2, p. 315, doi. 10.1002/cpt.3308
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- Publication type:
- Article
Population Pharmacokinetics and Exposure–Response Analysis for the CTLA‐4 Inhibitor Tremelimumab in Metastatic NSCLC Patients in the Phase III POSEIDON Study.
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- Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 6, p. 1375, doi. 10.1002/cpt.3063
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- Article
PK/PD Mediated Dose Optimization of Emactuzumab, a CSF1R Inhibitor, in Patients With Advanced Solid Tumors and Diffuse‐Type Tenosynovial Giant Cell Tumor.
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- Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 3, p. 616, doi. 10.1002/cpt.1964
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- Article
The role of clinical pharmacology across novel treatment modalities.
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- Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 3, p. 413, doi. 10.1002/cpt.1756
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- Article
Model‐Based Assessments of CYP‐Mediated Drug–Drug Interaction Risk of Alectinib: Physiologically Based Pharmacokinetic Modeling Supported Clinical Development.
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- Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 3, p. 505, doi. 10.1002/cpt.956
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- Article
Entrectinib dose confirmation in pediatric oncology patients: pharmacokinetic considerations.
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- Cancer Chemotherapy & Pharmacology, 2023, v. 91, n. 3, p. 239, doi. 10.1007/s00280-023-04510-1
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- Article
The potential and pitfalls of artificial intelligence in clinical pharmacology.
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- CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 3, p. 279, doi. 10.1002/psp4.12902
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- Article
Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network.
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- CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 5, p. 259, doi. 10.1002/psp4.12381
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- Article
Models and Machines: How Deep Learning Will Take Clinical Pharmacology to the Next Level.
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- CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 3, p. 131, doi. 10.1002/psp4.12377
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- Publication type:
- Article