Works by Phielix, Esther

Results: 37

Carnitine supplementation improves insulin sensitivity and skeletal muscle acetylcarnitine formation in patients with type 2 diabetes.

Published in:

Diabetes, Obesity & Metabolism, 2025, v. 27, n. 5, p. 2864, doi. 10.1111/dom.16298

By:

Op den Kamp‐Bruls, Yvonne M. H.;
Op den Kamp, Yvo J. M.;
Veeraiah, Pandichelvam;
Zapata Perez, Ruben;
Phielix, Esther;
Havekes, Bas;
Schaart, Gert;
Kornips, Esther;
Berendsen, Bart R. B.;
Virmani, Ashraf;
Wildberger, Joachim E.;
Houtkooper, Riekelt H.;
Hesselink, Matthijs K. C.;
Schrauwen, Patrick;
Schrauwen‐Hinderling, Vera B.

Publication type:

Article

A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31249-9

By:

Vanweert, Froukje;
Neinast, Michael;
Tapia, Edmundo Erazo;
van de Weijer, Tineke;
Hoeks, Joris;
Schrauwen-Hinderling, Vera B.;
Blair, Megan C.;
Bornstein, Marc R.;
Hesselink, Matthijs K. C.;
Schrauwen, Patrick;
Arany, Zoltan;
Phielix, Esther

Publication type:

Article

De effecten van een PPAR-α-agonist (ciprofibraat) op de weefselspecifieke glucoseopname in insulineresistentie; resultaten van een gerandomiseerde dubbelblinde placebogecontroleerde cross-overstudie.

Published in:

Nederlands Tijdschrift voor Diabetologie (NTvD), 2024, v. 22, n. 4, p. 62, doi. 10.1007/s12467-024-1574-7

By:

de Wit-Verheggen, Vera;
Vanweert, Froukje;
Raiko, Juho;
Liénard, Viktor;
Schaart, Gert;
Gemmink, Anne;
Nascimento, Emmani;
Hesselink, Matthijs;
Wildberger, Joachim;
Wierts, Roel;
Joris, Peter;
Haas, Joel;
Montaigne, David;
Staels, Bart;
Phielix, Esther;
Schrauwen, Patrick;
Schrauwen-Hinderling, Vera;
van de Weijer, Tineke

Publication type:

Article

Verbetering van het glucosemetabolisme als gevolg van hogere aminozuurverbranding: Een placebo-gerandomiseerde klinische studie met als doel het vertakte-ketenaminozuurkatabolisme farmacologisch te verhogen in mensen met type 2-diabetes.

Published in:

Nederlands Tijdschrift voor Diabetologie (NTvD), 2023, v. 21, n. 2, p. 12, doi. 10.1007/s12467-023-1218-3

By:

Phielix, Esther

Publication type:

Article

L-carnitine infusion does not alleviate lipid-induced insulin resistance and metabolic inflexibility.

Published in:

PLoS ONE, 2020, v. 15, n. 9, p. 1, doi. 10.1371/journal.pone.0239506

By:

Bruls, Yvonne M. H.;
op den Kamp, Yvo J. M.;
Phielix, Esther;
Lindeboom, Lucas;
Havekes, Bas;
Schaart, Gert;
Moonen-Kornips, Esther;
Wildberger, Joachim E.;
Hesselink, Matthijs K. C.;
Schrauwen, Patrick;
Schrauwen-Hinderling, Vera B.

Publication type:

Article

Passive exposure to heat improves glucose metabolism in overweight humans.

Published in:

Acta Physiologica, 2020, v. 229, n. 4, p. 1, doi. 10.1111/apha.13488

By:

Pallubinsky, Hannah;
Phielix, Esther;
Dautzenberg, Bas;
Schaart, Gert;
Connell, Niels J.;
Wit‐Verheggen, Vera;
Havekes, Bas;
Baak, Marleen A.;
Schrauwen, Patrick;
Marken Lichtenbelt, Wouter D.

Publication type:

Article

Erratum. Effects of the SGLT2 Inhibitor Dapagliflozin on Energy Metabolism in Patients With Type 2 Diabetes: A Randomized, Double-Blind Crossover Trial. Diabetes Care 2021;44:1334-1343.

Published in:

2022

By:

Kamp, Yvo J.M. Op den;
de Ligt, Marlies;
Dautzenberg, Bas;
Kornips, Esther;
Esterline, Russell;
Hesselink, Matthijs K.C.;
Hoeks, Joris;
Schrauwen-Hinderling, Vera B.;
Havekes, Bas;
Oscarsson, Jan;
Phielix, Esther;
Schrauwen, Patrick

Publication type:

corrected article

Effects of the SGLT2 Inhibitor Dapagliflozin on Energy Metabolism in Patients With Type 2 Diabetes: A Randomized, Double-Blind Crossover Trial.

Published in:

2021

By:

Op den Kamp, Yvo J.M.;
de Ligt, Marlies;
Dautzenberg, Bas;
Kornips, Esther;
Esterline, Russell;
Hesselink, Matthijs K.C.;
Hoeks, Joris;
Schrauwen-Hinderling, Vera B.;
Havekes, Bas;
Oscarsson, Jan;
Phielix, Esther;
Schrauwen, Patrick

Publication type:

journal article

Resveratrol as Add-on Therapy in Subjects With Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial.

Published in:

2016

By:

Timmers, Silvie;
de Ligt, Marlies;
Phielix, Esther;
van de Weijer, Tineke;
Hansen, Jan;
Moonen-Kornips, Esther;
Schaart, Gert;
Kunz, Iris;
Hesselink, Matthijs K C;
Schrauwen-Hinderling, Vera B;
Schrauwen, Patrick

Publication type:

journal article

Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 11, p. 4915, doi. 10.1172/JCI74830

By:

Lindeboom, Lucas;
Nabuurs, Christine I.;
Hoeks, Joris;
Brouwers, Bram;
Phielix, Esther;
Kooi, M. Eline;
Hesselink, Matthijs K. C.;
Wildberger, Joachim E.;
Stevens, Robert D.;
Koves, Timothy;
Muoio, Deborah M.;
Schrauwen, Patrick;
Schrauwen-Hinderling, Vera B.

Publication type:

Article

The tissue‐specific metabolic effects of the PPARα agonist ciprofibrate in insulin‐resistant male individuals: a double‐blind, randomized, placebo‐controlled crossover study.

Published in:

Obesity (19307381), 2023, v. 31, n. 10, p. 2493, doi. 10.1002/oby.23874

By:

de Wit‐Verheggen, Vera H. W.;
Vanweert, Froukje;
Raiko, Juho;
Liénard, Viktor;
Schaart, Gert;
Gemmink, Anne;
Nascimento, Emmani B. M.;
Hesselink, Matthijs K. C.;
Wildberger, Joachim E.;
Wierts, Roel;
Joris, Peter J.;
Haas, Joel;
Montaigne, David;
Staels, Bart;
Phielix, Esther;
Schrauwen, Patrick;
Schrauwen‐Hinderling, Vera B.;
van de Weijer, Tineke

Publication type:

Article

Evaluation of Muscle microRNA Expression in Relation to Human Peripheral Insulin Sensitivity: A Cross-Sectional Study in Metabolically Distinct Subject Groups.

Published in:

Frontiers in Physiology, 2017, p. 1, doi. 10.3389/fphys.2017.00711

By:

Dahlmans, Dennis;
Houzelle, Alexandre;
Jörgensen, Johanna A.;
Phielix, Esther;
Lindeboom, Lucas;
Hesselink, Matthijs K. C.;
Schrauwen, Patrick;
Hoeks, Joris

Publication type:

Article

Supramolecular structure of dietary fat in early life modulates expression of markers for mitochondrial content and capacity in adipose tissue of adult mice.

Published in:

Nutrition & Metabolism, 2017, v. 14, p. 1, doi. 10.1186/s12986-017-0191-5

By:

Kodde, Andrea;
van der Beek, Eline M.;
Phielix, Esther;
Engels, Eefje;
Schipper, Lidewij;
Oosting, Annemarie

Publication type:

Article

Stimulation of Human Whole-Body Energy Expenditure by Salsalate Is Fueled by Higher Lipid Oxidation under Fasting Conditions and by Higher Oxidative Glucose Disposal under Insulin-Stimulated Conditions.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2011, v. 96, n. 5, p. 1415, doi. 10.1210/jc.2010-1816

By:

Meex, Ruth C. R.;
Phielix, Esther;
Moonen-Kornips, Esther;
Schrauwen, Patrick;
Hesselink, Matthijs K. C.

Publication type:

Article

Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women.

Published in:

Diabetologia, 2021, v. 64, n. 12, p. 2817, doi. 10.1007/s00125-021-05558-5

By:

Remie, Carlijn M. E.;
Janssens, Georges E.;
Bilet, Lena;
van Weeghel, Michel;
Duvivier, Bernard M. F. M.;
de Wit, Vera H. W.;
Connell, Niels J.;
Jörgensen, Johanna A.;
Schomakers, Bauke V.;
Schrauwen-Hinderling, Vera B.;
Hoeks, Joris;
Hesselink, Matthijs K. C.;
Phielix, Esther;
Houtkooper, Riekelt H.;
Schrauwen, Patrick

Publication type:

Article

One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension.

Published in:

Diabetologia, 2020, v. 63, n. 6, p. 1211, doi. 10.1007/s00125-020-05128-1

By:

Bilet, Lena;
Phielix, Esther;
van de Weijer, Tineke;
Gemmink, Anne;
Bosma, Madeleen;
Moonen-Kornips, Esther;
Jorgensen, Johanna A.;
Schaart, Gert;
Zhang, Dongyan;
Meijer, Kenneth;
Hopman, Maria;
Hesselink, Matthijs K. C.;
Ouwens, D. Margriet;
Shulman, Gerald I.;
Schrauwen-Hinderling, Vera B.;
Schrauwen, Patrick

Publication type:

Article

ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity.

Published in:

Diabetologia, 2016, v. 59, n. 5, p. 1030, doi. 10.1007/s00125-016-3885-8

By:

Sparks, Lauren;
Gemmink, Anne;
Phielix, Esther;
Bosma, Madeleen;
Schaart, Gert;
Moonen-Kornips, Esther;
Jörgensen, Johanna;
Nascimento, Emmani;
Hesselink, Matthijs;
Schrauwen, Patrick;
Hoeks, Joris

Publication type:

Article

Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes.

Published in:

Nutrition & Diabetes, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41387-022-00213-3

By:

Vanweert, Froukje;
Schrauwen, Patrick;
Phielix, Esther

Publication type:

Article

Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver.

Published in:

2017

By:

Jelenik, Tomas;
Kaul, Kirti;
Séquaris, Gilles;
Flögel, Ulrich;
Phielix, Esther;
Kotzka, Jörg;
Knebel, Birgit;
Fahlbusch, Pia;
Hörbelt, Tina;
Lehr, Stefan;
Reinbeck, Anna Lena;
Müller-Wieland, Dirk;
Esposito, Irene;
Shulman, Gerald I.;
Szendroedi, Julia;
Roden, Michael

Publication type:

journal article

Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans.

Published in:

2015

By:

van de Weijer, Tineke;
Phielix, Esther;
Bilet, Lena;
Williams, Evan G;
Ropelle, Eduardo R;
Bierwagen, Alessandra;
Livingstone, Roshan;
Nowotny, Peter;
Sparks, Lauren M;
Paglialunga, Sabina;
Szendroedi, Julia;
Havekes, Bas;
Moullan, Norman;
Pirinen, Eija;
Hwang, Jong-Hee;
Schrauwen-Hinderling, Vera B;
Hesselink, Matthijs K C;
Auwerx, Johan;
Roden, Michael;
Schrauwen, Patrick

Publication type:

journal article

Evidence for a Direct Effect of the NAD<sup>+</sup> Precursor Acipimox on Muscle Mitochondrial Function in Humans.

Published in:

Diabetes, 2015, v. 64, n. 4, p. 1193, doi. 10.2337/db14-0667

By:

van de Weijer, Tineke;
Phielix, Esther;
Bilet, Lena;
Williams, Evan G.;
Ropelle, Eduardo R.;
Bierwagen, Alessandra;
Livingstone, Roshan;
Nowotny, Peter;
Sparks, Lauren M.;
Paglialunga, Sabina;
Szendroedi, Julia;
Havekes, Bas;
Moullan, Norman;
Pirinen, Eija;
Jong-Hee Hwang;
Schrauwen-Hinderling, Vera B.;
Hesselink, Matthijs K. C.;
Auwerx, Johan;
Roden, Michael;
Schrauwen, Patrick

Publication type:

Article

Tissue-Specific Differences in the Development of Insulin Resistance in a Mouse Model for Type 1 Diabetes.

Published in:

Diabetes, 2014, v. 63, n. 11, p. 3856, doi. 10.2337/db13-1794

By:

Jelenik, Tomas;
Séquaris, Gilles;
Kaul, Kirti;
Ouwens, D. Margriet;
Phielix, Esther;
Kotzka, Jörg;
Knebel, Birgit;
Weiß, Jürgen;
Reinbeck, Anna Lena;
Janke, Linda;
Nowotny, Peter;
Partke, Hans-Joachim;
Dongyan Zhang;
Shulman, Gerald I.;
Szendroedi, Julia;
Roden, Michael

Publication type:

Article

Mechanisms Underlying the Onset of Oral Lipid-Induced Skeletal Muscle Insulin Resistance in Humans.

Published in:

Diabetes, 2013, v. 62, n. 7, p. 2240, doi. 10.2337/db12-1179

By:

Nowotny, Bettina;
Zahiragic, Lejla;
Krog, Dorothea;
Nowotny, Peter J.;
Herder, Christian;
Carstensen, Maren;
Yoshimura, Toru;
Szendroedi, Julia;
Phielix, Esther;
Schadewaldt, Peter;
Schloot, Nanette C.;
Shulman, Gerald I.;
Roden, Michael

Publication type:

Article

Assessing Multiple Features of Mitochondrial Function.

Published in:

2013

By:

Phielix, Esther;
Roden, Michael

Publication type:

Opinion

High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance.

Published in:

2012

By:

Phielix E;
Meex R;
Ouwens DM;
Sparks L;
Hoeks J;
Schaart G;
Moonen-Kornips E;
Hesselink MK;
Schrauwen P;
Phielix, Esther;
Meex, Ruth;
Ouwens, D Margriet;
Sparks, Lauren;
Hoeks, Joris;
Schaart, Gert;
Moonen-Kornips, Esther;
Hesselink, Matthijs K C;
Schrauwen, Patrick

Publication type:

journal article

High Oxidative Capacity Due to Chronic Exercise Training Attenuates Lipid-Induced Insulin Resistance.

Published in:

Diabetes, 2012, v. 61, n. 10, p. 2472, doi. 10.2337/db11-1832

By:

Phielix, Esther;
Meex, Ruth;
Ouwens, D. Margriet;
Sparks, Lauren;
Hoeks, Joris;
Schaart, Gert;
Moonen-Kornips, Esther;
Hesselink, Matthijs K. C.;
Schrauwen, Patrick

Publication type:

Article

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity.

Published in:

Diabetes, 2010, v. 59, n. 3, p. 572, doi. 10.2337/db09-1322

By:

Meex, Ruth C. R.;
Schrauwen-Hinderling, Vera B.;
Moonen-Kornips, Esther;
Schaart, Gert;
Mensink, Marco;
Phielix, Esther;
Weijer, Tineke van de;
Sels, Jean-Pierre;
Schrauwen, Patrick;
Hesselink, Matthijs K. C.

Publication type:

Article

Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients.

Published in:

Diabetes, 2008, v. 57, n. 11, p. 2943, doi. 10.2337/db08-0391

By:

Phielix, Esther;
Schrauwen-Hinderling, Vera B.;
Mensink, Marco;
Lenaers, Ellen;
Meex, Ruth;
Hoeks, Joris;
Kooi, Marianne Eline;
Moonen-Kornips, Esther;
Sels, Jean-Pierre;
Hesselink, Matthijs K. C.;
Schrauwen, Patrick

Publication type:

Article

Reduction of non-esterified fatty acids improves insulin sensitivity and lowers oxidative stress, but fails to restore oxidative capacity in type 2 diabetes: a randomised clinical trial.

Published in:

Diabetologia, 2014, v. 57, n. 3, p. 572, doi. 10.1007/s00125-013-3127-2

By:

Phielix, Esther;
Jelenik, Tomas;
Nowotny, Peter;
Szendroedi, Julia;
Roden, Michael

Publication type:

Article

Metabolic responses to mild cold acclimation in type 2 diabetes patients.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-21813-0

By:

Remie, Carlijn M. E.;
Moonen, Michiel P. B.;
Roumans, Kay H. M.;
Nascimento, Emmani B. M.;
Gemmink, Anne;
Havekes, Bas;
Schaart, Gert;
Kornips, Esther;
Joris, Peter J.;
Schrauwen-Hinderling, Vera B.;
Hoeks, Joris;
Kersten, Sander;
Hesselink, Matthijs K. C.;
Phielix, Esther;
Lichtenbelt, Wouter D. van Marken;
Schrauwen, Patrick

Publication type:

Article

Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15684-0

By:

Roumans, Kay H. M.;
Lindeboom, Lucas;
Veeraiah, Pandichelvam;
Remie, Carlijn M. E.;
Phielix, Esther;
Havekes, Bas;
Bruls, Yvonne M. H.;
Brouwers, Martijn C. G. J.;
Ståhlman, Marcus;
Alssema, Marjan;
Peters, Harry P. F.;
de Mutsert, Renée;
Staels, Bart;
Taskinen, Marja-Riitta;
Borén, Jan;
Schrauwen, Patrick;
Schrauwen-Hinderling, Vera B.

Publication type:

Article

Relationship of C5L2 Receptor to Skeletal Muscle Substrate Utilization.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0057494

By:

Roy, Christian;
Paglialunga, Sabina;
Schaart, Gert;
Moonen-Kornips, Esther;
Meex, Ruth C.;
Phielix, Esther;
Hoeks, Joris;
Hesselink, Matthijs K. C.;
Cianflone, Katherine;
Schrauwen, Patrick

Publication type:

Article

Relationships between Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes Mellitus.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0051648

By:

van de Weijer, Tineke;
Sparks, Lauren Marie;
Phielix, Esther;
Meex, Ruth Carla;
van Herpen, Noud Antonius;
Hesselink, Matthijs Karel C.;
Schrauwen, Patrick;
Schrauwen-Hinderling, Vera Bettina

Publication type:

Article

1263-P: Nutritional Reprogramming of Hepatic Metabolism by Feeding a Diet Containing Large, Phospholipid-Coated Lipid Droplets in Early Life Protects against Western Style Diet–Induced Insulin Resistance in Adult Mice.

Published in:

Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-1263-P

By:

JELENIK, TOMAS;
KODDE, ANDREA;
PESTA, DOMINIK;
ROHBECK, ELISABETH;
DEWIDAR, BEDAIR;
PHIELIX, ESTHER;
OOSTING, ANNEMARIE;
VAN DER BEEK, ELINE M.;
RODEN, MICHAEL

Publication type:

Article

Enhanced lipid-but not carbohydrate-supported mitochondrial respiration in skeletal muscle of PGC-1α overexpressing mice.

Published in:

Journal of Cellular Physiology, 2012, v. 227, n. 3, p. 1026, doi. 10.1002/jcp.22812

By:

Hoeks, Joris;
Arany, Zolt;
Phielix, Esther;
Moonen-Kornips, Esther;
Hesselink, Matthijs K.C.;
Schrauwen, Patrick

Publication type:

Article

Mitochondrial Function and Insulin Resistance during Aging - A Mini-Review.

Published in:

Gerontology, 2011, v. 57, n. 5, p. 387, doi. 10.1159/000317691

By:

Phielix, Esther;
Szendroedi, Julia;
Roden, Michael

Publication type:

Article

Elevated Plasma Branched-Chain Amino Acid Levels Correlate With Type 2 Diabetes-Related Metabolic Disturbances.

Published in:

2021

By:

Vanweert, Froukje;
de Ligt, Marlies;
Hoeks, Joris;
Hesselink, Matthijs K. C.;
Schrauwen, Patrick;
Phielix, Esther

Publication type:

journal article