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Short-term Calorie Restriction and 17α-Estradiol Administration Elicit Divergent Effects on Proteostatic Processes and Protein Content in Metabolically Active Tissues.
Published in:
2020
By:
- Miller, Benjamin F;
- Pharaoh, Gavin A;
- Hamilton, Karyn L;
- Peelor, Fredrick F;
- Kirkland, James L;
- Freeman, Willard M;
- Mann, Shivani N;
- Kinter, Michael;
- Price, John C;
- Stout, Michael B
Publication type:
journal article
Restoration of Sarcoplasmic Reticulum Ca 2+ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 1, p. 37, doi. 10.3390/ijms22010037
By:
- Qaisar, Rizwan;
- Pharaoh, Gavin;
- Bhaskaran, Shylesh;
- Xu, Hongyang;
- Ranjit, Rojina;
- Bian, Jan;
- Ahn, Bumsoo;
- Georgescu, Constantin;
- Wren, Jonathan D.;
- Van Remmen, Holly
Publication type:
Article
Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance.
Published in:
EMBO Reports, 2018, v. 19, n. 3, p. 1, doi. 10.15252/embr.201745009
By:
- Bhaskaran, Shylesh;
- Pharaoh, Gavin;
- Ranjit, Rojina;
- Murphy, Ashley;
- Matsuzaki, Satoshi;
- Nair, Binoj C.;
- Forbes, Brittany;
- Gispert, Suzana;
- Auburger, Georg;
- Humphries, Kenneth M.;
- Kinter, Michael;
- Griffin, Timothy M.;
- Deepa, Sathyaseelan S.
Publication type:
Article
The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT).
Published in:
GeroScience, 2023, v. 45, n. 6, p. 3529, doi. 10.1007/s11357-023-00861-y
By:
- Pharaoh, Gavin;
- Kamat, Varun;
- Kannan, Sricharan;
- Stuppard, Rudolph S.;
- Whitson, Jeremy;
- Martín-Pérez, Miguel;
- Qian, Wei-Jun;
- MacCoss, Michael J.;
- Villén, Judit;
- Rabinovitch, Peter;
- Campbell, Matthew D.;
- Sweet, Ian R.;
- Marcinek, David J.
Publication type:
Article
Molecular changes in transcription and metabolic pathways underlying muscle atrophy in the CuZnSOD null mouse model of sarcopenia.
Published in:
GeroScience, 2020, v. 42, n. 4, p. 1101, doi. 10.1007/s11357-020-00189-x
By:
- Sataranatarajan, Kavithalakshmi;
- Pharaoh, Gavin;
- Brown, Jacob L.;
- Ranjit, Rojina;
- Piekarz, Katarzyna M.;
- Street, Kaitlyn;
- Wren, Jonathan D.;
- Georgescu, Constantin;
- Kinter, Caroline;
- Kinter, Michael;
- Freeman, Willard M.;
- Richardson, Arlan;
- Van Remmen, Holly
Publication type:
Article
Targeting cPLA<sub>2</sub> derived lipid hydroperoxides as a potential intervention for sarcopenia.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-70792-7
By:
- Pharaoh, Gavin;
- Brown, Jacob L.;
- Sataranatarajan, Kavithalakshmi;
- Kneis, Parker;
- Bian, Jan;
- Ranjit, Rojina;
- Hadad, Niran;
- Georgescu, Constantin;
- Rabinovitch, Peter;
- Ran, Qitao;
- Wren, Jonathan D.;
- Freeman, Willard;
- Kinter, Michael;
- Richardson, Arlan;
- Van Remmen, Holly
Publication type:
Article
Metabolic and Stress Response Changes Precede Disease Onset in the Spinal Cord of Mutant SOD1 ALS Mice.
Published in:
Frontiers in Neuroscience, 2019, p. N.PAG, doi. 10.3389/fnins.2019.00487
By:
- Pharaoh, Gavin;
- Sataranatarajan, Kavithalakshmi;
- Street, Kaitlyn;
- Hill, Shauna;
- Gregston, Jake;
- Ahn, Bumsoo;
- Kinter, Caroline;
- Kinter, Michael;
- Van Remmen, Holly
Publication type:
Article
Determining the contributions of protein synthesis and breakdown to muscle atrophy requires non‐steady‐state equations.
Published in:
Journal of Cachexia, Sarcopenia & Muscle, 2021, v. 12, n. 6, p. 1764, doi. 10.1002/jcsm.12772
By:
- Kobak, Kamil A.;
- Lawrence, Marcus M.;
- Pharaoh, Gavin;
- Borowik, Agnieszka K.;
- Peelor, Frederick F.;
- Shipman, Patrick D.;
- Griffin, Timothy M.;
- Van Remmen, Holly;
- Miller, Benjamin F.
Publication type:
Article
Cancer cachexia in a mouse model of oxidative stress.
Published in:
Journal of Cachexia, Sarcopenia & Muscle, 2020, v. 11, n. 6, p. 1688, doi. 10.1002/jcsm.12615
By:
- Brown, Jacob L.;
- Lawrence, Marcus M.;
- Ahn, Bumsoo;
- Kneis, Parker;
- Piekarz, Katarzyna M.;
- Qaisar, Rizwan;
- Ranjit, Rojina;
- Bian, Jan;
- Pharaoh, Gavin;
- Brown, Chase;
- Peelor, Fredrick F.;
- Kinter, Michael T.;
- Miller, Benjamin F.;
- Richardson, Arlan;
- Van Remmen, Holly
Publication type:
Article
Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching.
Published in:
Journal of Cachexia, Sarcopenia & Muscle, 2019, v. 10, n. 2, p. 411, doi. 10.1002/jcsm.12375
By:
- Ahn, Bumsoo;
- Ranjit, Rojina;
- Premkumar, Pavithra;
- Pharaoh, Gavin;
- Piekarz, Katarzyna M.;
- Matsuzaki, Satoshi;
- Claflin, Dennis R.;
- Riddle, Kaitlyn;
- Judge, Jennifer;
- Bhaskaran, Shylesh;
- Satara Natarajan, Kavithalakshmi;
- Barboza, Erika;
- Wronowski, Benjamin;
- Kinter, Michael;
- Humphries, Kenneth M.;
- Griffin, Timothy M.;
- Freeman, Willard M.;
- Richardson, Arlan;
- Brooks, Susan V.;
- Van Remmen, Holly
Publication type:
Article
Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function.
Published in:
Molecular Neurobiology, 2020, v. 57, n. 3, p. 1317, doi. 10.1007/s12035-019-01821-4
By:
- Pharaoh, Gavin;
- Owen, Daniel;
- Yeganeh, Alexander;
- Premkumar, Pavithra;
- Farley, Julie;
- Bhaskaran, Shylesh;
- Ashpole, Nicole;
- Kinter, Michael;
- Van Remmen, Holly;
- Logan, Sreemathi
Publication type:
Article
Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervation.
Published in:
JCSM Rapid Communications, 2021, v. 4, n. 1, p. 75, doi. 10.1002/rco2.29
By:
- Pharaoh, Gavin;
- Brown, Jacob;
- Ranjit, Rojina;
- Ungvari, Zoltan;
- Van Remmen, Holly
Publication type:
Article
Lifelong reduction in complex IV induces tissue‐specific metabolic effects but does not reduce lifespan or healthspan in mice.
Published in:
Aging Cell, 2018, v. 17, n. 4, p. 1, doi. 10.1111/acel.12769
By:
- Deepa, Sathyaseelan S.;
- Pharaoh, Gavin;
- Kinter, Michael;
- Diaz, Vivian;
- Fok, Wilson C.;
- Riddle, Kaitlyn;
- Pulliam, Daniel;
- Hill, Shauna;
- Fischer, Kathleen E.;
- Soto, Vanessa;
- Georgescu, Constantin;
- Wren, Jonathan D.;
- Viscomi, Carlo;
- Richardson, Arlan;
- Van Remmen, Holly
Publication type:
Article

Found: 13