Works by Pfeilschifter, Josef

Results: 206

Targeting the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway to Treat Chronic Inflammatory Kidney Diseases.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2014, v. 114, n. 1, p. 44, doi. 10.1111/bcpt.12103

By:

Schwalm, Stephanie;
Pfeilschifter, Josef;
Huwiler, Andrea

Publication type:

Article

Cross-Regulation of the Cellular Redox System, Oxygen, and Sphingolipid Signalling.

Published in:

Metabolites (2218-1989), 2023, v. 13, n. 3, p. 426, doi. 10.3390/metabo13030426

By:

Huwiler, Andrea;
Beck, Karl-Friedrich;
Pfeilschifter, Josef

Publication type:

Article

Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs.

Published in:

Frontiers in Immunology, 2019, p. 1, doi. 10.3389/fimmu.2019.01698

By:

Dreis, Caroline;
Ottenlinger, Florian M.;
Putyrski, Mateusz;
Ernst, Andreas;
Huhn, Meik;
Schmidt, Katrin G.;
Pfeilschifter, Josef M.;
Radeke, Heinfried H.

Publication type:

Article

The role of serum sphingolipids as potential biomarkers of non‐response to direct acting antiviral therapy in chronic hepatitis C virus infection.

Published in:

Journal of Viral Hepatitis, 2023, v. 30, n. 2, p. 138, doi. 10.1111/jvh.13776

By:

Röhrig, Aissa Miriam;
Jakobi, Katja;
Dietz, Julia;
Thomas, Dominique;
Herrmann, Eva;
Welsch, Christoph;
Sarrazin, Christoph;
Pfeilschifter, Josef;
Zeuzem, Stefan;
Grammatikos, Georgios

Publication type:

Article

The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions.

Published in:

Cell Death & Disease, 2022, v. 13, n. 4, p. 1, doi. 10.1038/s41419-022-04829-2

By:

Eichler, Madeleine;
Distler, Ute;
Nasrullah, Usman;
Krishnan, Aswini;
Kaulich, Manuel;
Husnjak, Koraljka;
Eberhardt, Wolfgang;
Rajalingam, Krishnaraj;
Tenzer, Stefan;
Pfeilschifter, Josef;
Imre, Gergely

Publication type:

Article

Serum sphingolipid levels associate with upcoming virologic events and HBV genotype D in a cohort of patients with HBeAg-negative HBV infection.

Published in:

PLoS ONE, 2018, v. 13, n. 11, p. 1, doi. 10.1371/journal.pone.0207293

By:

Mücke, Victoria Therese;
Jakobi, Katja;
Knop, Viola;
Thomas, Dominique;
Mücke, Marcus Maximilian;
Peiffer, Kai-Henrik;
Zeuzem, Stefan;
Sarrazin, Christoph;
Pfeilschifter, Josef;
Grammatikos, Georgios

Publication type:

Article

S1P Lyase siRNA Dampens Malignancy of DLD‐1 Colorectal Cancer Cells.

Published in:

Lipids, 2021, v. 56, n. 2, p. 155, doi. 10.1002/lipd.12282

By:

Faqar‐Uz‐Zaman, Wajiha Farha;
Schmidt, Katrin G.;
Thomas, Dominique;
Pfeilschifter, Josef M.;
Radeke, Heinfried H.;
Schwiebs, Anja

Publication type:

Article

IFN-gamma Impairs Release of IL-8 by IL-1beta-stimulated A549 Lung Carcinoma Cells.

Published in:

BMC Cancer, 2008, v. 8, p. 1, doi. 10.1186/1471-2407-8-265

By:

Boost, Kim A.;
Sadik, Christian D.;
Bachmann, Malte;
Zwissler, Bernhard;
Pfeilschifter, Josef;
Mühl, Heiko

Publication type:

Article

Inhibition of cyclooxygenase-1 and -2 activity in keratinocytes inhibits PGE2 formation and impairs vascular endothelial growth factor release and neovascularisation in skin wounds.

Published in:

International Wound Journal, 2017, v. 14, n. 1, p. 53, doi. 10.1111/iwj.12550

By:

Goren, Itamar;
Lee, Seo‐Youn;
Maucher, Damian;
Nüsing, Rolf;
Schlich, Thomas;
Pfeilschifter, Josef;
Frank, Stefan

Publication type:

Article

The contribution of the sphingosine 1-phosphate signaling pathway to chronic kidney diseases: recent findings and new perspectives.

Published in:

Pflügers Archiv: European Journal of Physiology, 2024, v. 476, n. 12, p. 1845, doi. 10.1007/s00424-024-03029-5

By:

Schwalm, Stephanie;
Manaila, Roxana;
Oftring, Anke;
Schaefer, Liliana;
von Gunten, Stephan;
Pfeilschifter, Josef

Publication type:

Article

A role for plasma membrane Ca2+ ATPases in regulation of cellular Ca2+ homeostasis by sphingosine kinase-1.

Published in:

Pflügers Archiv: European Journal of Physiology, 2024, v. 476, n. 12, p. 1895, doi. 10.1007/s00424-024-03027-7

By:

Volk, Luisa Michelle;
Bruun, Jan-Erik;
Trautmann, Sandra;
Thomas, Dominique;
Schwalm, Stephanie;
Pfeilschifter, Josef;
zu Heringdorf, Dagmar Meyer

Publication type:

Article

Lipid signaling: facets of a versatile cell communication strategy in health and disease.

Published in:

Pflügers Archiv: European Journal of Physiology, 2024, v. 476, n. 12, p. 1777, doi. 10.1007/s00424-024-03034-8

By:

Gulbins, Erich;
Pfeilschifter, Josef

Publication type:

Article

Atypical sphingosine-1-phosphate metabolites—biological implications of alkyl chain length.

Published in:

Pflügers Archiv: European Journal of Physiology, 2024, v. 476, n. 12, p. 1833, doi. 10.1007/s00424-024-03018-8

By:

Glueck, Melanie;
Lucaciu, Alexandra;
Subburayalu, Julien;
Kestner, Roxane Isabelle;
Pfeilschifter, Waltraud;
Vutukuri, Rajkumar;
Pfeilschifter, Josef

Publication type:

Article

Tribute to Andrea Huwiler (1966–2023).

Published in:

2024

By:

Pfeilschifter, Josef;
Gulbins, Erich

Publication type:

Obituary

The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives.

Published in:

Cells (2073-4409), 2020, v. 9, n. 6, p. 1515, doi. 10.3390/cells9061515

By:

Lucaciu, Alexandra;
Brunkhorst, Robert;
Pfeilschifter, Josef M.;
Pfeilschifter, Waltraud;
Subburayalu, Julien

Publication type:

Article

Identification of TRIM25 as a Negative Regulator of Caspase-2 Expression Reveals a Novel Target for Sensitizing Colon Carcinoma Cells to Intrinsic Apoptosis.

Published in:

Cells (2073-4409), 2019, v. 8, n. 12, p. 1622, doi. 10.3390/cells8121622

By:

Nasrullah, Usman;
Haeussler, Kristina;
Biyanee, Abhiruchi;
Wittig, Ilka;
Pfeilschifter, Josef;
Eberhardt, Wolfgang

Publication type:

Article

Interferon-Beta Increases Plasma Ceramides of Specific Chain Length in Multiple Sclerosis Patients, Unlike Fingolimod or Natalizumab.

Published in:

Frontiers in Pharmacology, 2016, v. 7, p. 1, doi. 10.3389/fphar.2016.00412

By:

Ottenlinger, Florian M.;
Mayer, Christoph A.;
Ferreirós, Nerea;
Schreiber, Yannick;
Schwiebs, Anja;
Schmidt, Katrin G.;
Ackermann, Hanns;
Pfeilschifter, Josef M.;
Radeke, Heinfried H.

Publication type:

Article

Cytoskeleton-Dependent Transport as a Potential Target for Interfering with Post-transcriptional HuR mRNA Regulons.

Published in:

Frontiers in Pharmacology, 2016, p. 1, doi. 10.3389/fphar.2016.00251

By:

Eberhardt, Wolfgang;
Badawi, Amel;
Biyanee, Abhiruchi;
Pfeilschifter, Josef

Publication type:

Article

Sphingosine-1-Phosphate Receptor-2 Antagonists: Therapeutic Potential and Potential Risks.

Published in:

Frontiers in Pharmacology, 2016, p. 1, doi. 10.3389/fphar.2016.00167

By:

Blankenbach, Kira V.;
Schwalm, Stephanie;
Pfeilschifter, Josef;
zu Heringdorf, Dagmar Meyer;
Bruni, Paola;
Levkau, Bodo

Publication type:

Article

Activation-Induced Cell Death of Dendritic Cells Is Dependent on Sphingosine Kinase 1.

Published in:

Frontiers in Pharmacology, 2016, p. 1, doi. 10.3389/fphar.2016.00094

By:

Schwiebs, Anja;
Friesen, Olga;
Katzy, Elisabeth;
Ferreirós, Nerea;
Pfeilschifter, Josef M.;
Radeke, Heinfried H.;
Bossù, Paola;
Matrone, Carmela

Publication type:

Article

Though Active on RINm5F Insulinoma Cells and Cultured Pancreatic Islets, Recombinant IL-22 Fails to Modulate Cytotoxicity and Disease in a Protocol of Streptozotocin-Induced Experimental Diabetes.

Published in:

Frontiers in Pharmacology, 2016, v. 6, p. 1, doi. 10.3389/fphar.2015.00317

By:

Berner, Anika;
Bachmann, Malte;
Bender, Christine;
Pfeilschifter, Josef;
Christen, Urs;
Mühl, Heiko

Publication type:

Article

Inducible NO synthase and antibacterial host defence in times of Th17/Th22/T22 immunity.

Published in:

Cellular Microbiology, 2011, v. 13, n. 3, p. 340, doi. 10.1111/j.1462-5822.2010.01559.x

By:

Mühl, Heiko;
Bachmann, Malte;
Pfeilschifter, Josef

Publication type:

Article

Interleukin-18 secretion and Th1-like cytokine responses in human peripheral blood mononuclear cells under the influence of the toll-like receptor-5 ligand flagellin.

Published in:

Cellular Microbiology, 2006, v. 8, n. 2, p. 289, doi. 10.1111/j.1462-5822.2005.00621.x

By:

Bachmann, Malte;
Horn, Katharina;
Poleganov, Marco A.;
Paulukat, Jens;
Nold, Marcel;
Pfeilschifter, Josef;
Mühl, Heiko

Publication type:

Article

The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma.

Published in:

Carcinogenesis, 2011, v. 32, n. 11, p. 1713, doi. 10.1093/carcin/bgr195

By:

Doberstein, Kai;
Pfeilschifter, Josef;
Gutwein, Paul

Publication type:

Article

High-constitutive HuR phosphorylation at Ser 318 by PKCδ propagates tumor relevant functions in colon carcinoma cells.

Published in:

Carcinogenesis, 2011, v. 32, n. 5, p. 676, doi. 10.1093/carcin/bgr024

By:

Doller, Anke;
Winkler, Christine;
Azrilian, Irina;
Schulz, Sebastian;
Hartmann, Sylvia;
Pfeilschifter, Josef;
Eberhardt, Wolfgang

Publication type:

Article

L1-CAM expression in ccRCC correlates with shorter patients survival times and confers chemoresistance in renal cell carcinoma cells.

Published in:

Carcinogenesis, 2011, v. 32, n. 3, p. 262, doi. 10.1093/carcin/bgq249

By:

Doberstein, Kai;
Wieland, Anja;
Lee, Sophia B. Boyoung;
Blaheta, Roman A. Alexander;
Wedel, Steffen;
Moch, Holger;
Schraml, Peter;
Pfeilschifter, Josef;
Kristiansen, Glen;
Gutwein, Paul

Publication type:

Article

New insights into the mechanism for clearance of apoptotic cells.

Published in:

BioEssays, 2000, v. 22, n. 10, p. 878, doi. 10.1002/1521-1878(200010)22:10<878::AID-BIES2>3.0.CO;2-J

By:

Messmer, Udo K.;
Pfeilschifter, Josef

Publication type:

Article

Simultaneous and Dose Dependent Melanoma Cytotoxic and Immune Stimulatory Activity of Betulin.

Published in:

PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0118802

By:

Pfarr, Kathrin;
Danciu, Corina;
Arlt, Olga;
Neske, Christina;
Dehelean, Cristina;
Pfeilschifter, Josef M.;
Radeke, Heinfried H.

Publication type:

Article

FTY720 Treatment in the Convalescence Period Improves Functional Recovery and Reduces Reactive Astrogliosis in Photothrombotic Stroke.

Published in:

PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0070124

By:

Brunkhorst, Robert;
Kanaan, Nathalie;
Koch, Alexander;
Ferreirós, Nerea;
Mirceska, Ana;
Zeiner, Pia;
Mittelbronn, Michel;
Derouiche, Amin;
Steinmetz, Helmuth;
Foerch, Christian;
Pfeilschifter, Josef;
Pfeilschifter, Waltraud

Publication type:

Article

Blockade but Not Overexpression of the Junctional Adhesion Molecule C Influences Virus-Induced Type 1 Diabetes in Mice.

Published in:

PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0054675

By:

Christen, Selina;
Coppieters, Ken;
Rose, Kerstin;
Holdener, Martin;
Bayer, Monika;
Pfeilschifter, Josef M.;
Hintermann, Edith;
von Herrath, Matthias G.;
Aurrand-Lions, Michel;
Imhof, Beat A.;
Christen, Urs;
Maedler, Kathrin

Publication type:

Article

No Influence of Dabigatran Anticoagulation on Hemorrhagic Transformation in an Experimental Model of Ischemic Stroke.

Published in:

PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0040804

By:

Bohmann, Ferdinand;
Mirceska, Ana;
Pfeilschifter, Josef;
Lindhoff-Last, Edelgard;
Steinmetz, Helmuth;
Foerch, Christian;
Pfeilschifter, Waltraud

Publication type:

Article

IL-27 Regulates IL-18 Binding Protein in Skin Resident Cells.

Published in:

PLoS ONE, 2012, v. 7, n. 6, p. 1, doi. 10.1371/journal.pone.0038751

By:

Wittmann, Miriam;
Doble, Rosella;
Bachmann, Malte;
Pfeilschifter, Josef;
Werfel, Thomas;
Mühl, Heiko

Publication type:

Article

Warfarin Anticoagulation Exacerbates the Risk of Hemorrhagic Transformation after rt-PA Treatment in Experimental Stroke: Therapeutic Potential of PCC.

Published in:

PLoS ONE, 2011, v. 6, n. 10, p. 1, doi. 10.1371/journal.pone.0026087

By:

Pfeilschifter, Waltraud;
Spitzer, Daniel;
Pfeilschifter, Josef;
Steinmetz, Helmuth;
Foerch1, Christian

Publication type:

Article

PAX2 Regulates ADAM10 Expression and Mediates Anchorage-Independent Cell Growth of Melanoma Cells.

Published in:

PLoS ONE, 2011, v. 6, n. 8, p. 1, doi. 10.1371/journal.pone.0022312

By:

Sophia Boyoung Lee;
Doberstein, Kai;
Baumgarten, Peter;
Wieland, Anja;
Ungerer, Christopher;
Bü rger, Claudia;
Hardt, Katja;
Boehncke, Wolf-Henning;
Pfeilschifter, Josef;
Mihic-Probst, Daniela;
Mittelbronn, Michel;
Gutwein, Paul

Publication type:

Article

Failure of Interferon γ to Induce the Anti-Inflammatory Interleukin 18 Binding Protein in Familial Hemophagocytosis.

Published in:

PLoS ONE, 2010, v. 5, n. 1, p. 1, doi. 10.1371/journal.pone.0008663

By:

Nold-Petry, Claudia A.;
Lehrnbecher, Thomas;
Jarisch, Andrea;
Schwabe, Dirk;
Pfeilschifter, Josef M.;
Muhl, Heiko;
Nold, Marcel F.

Publication type:

Article

Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis.

Published in:

Cardiovascular Research, 2015, v. 106, n. 2, p. 284, doi. 10.1093/cvr/cvv098

By:

Awwad, Khader;
Hu, Jiong;
Shi, Lei;
Mangels, Nicole;
Malik, Randa Abdel;
Zippel, Nina;
Fisslthaler, Beate;
Eble, Johannes A.;
Pfeilschifter, Josef;
Popp, Rüdiger;
Fleming, Ingrid

Publication type:

Article

The cyclopentenone prostaglandin 15-deoxy-Δ12,14-prostaglandin J2 ameliorates ischemic acute renal failure

Published in:

Cardiovascular Research, 2004, v. 61, n. 3, p. 630, doi. 10.1016/j.cardiores.2003.10.024

By:

Chatterjee, Prabal Kumar;
Patel, Nimesh S.A.;
Cuzzocrea, Salvatore;
Brown, Paul A.J.;
Stewart, Keith N.;
Mota-Filipe, Helder;
Britti, Domenico;
Eberhardt, Wolfgang;
Pfeilschifter, Josef;
Thiemermann, Christoph

Publication type:

Article

S1P d20:1, an endogenous modulator of S1P d18:1/S1P2‐dependent signaling.

Published in:

FASEB Journal, 2020, v. 34, n. 3, p. 3932, doi. 10.1096/fj.201902391R

By:

Vutukuri, Rajkumar;
Koch, Alexander;
Trautmann, Sandra;
Schreiber, Yannick;
Thomas, Dominique;
Mayser, Franziska;
Meyer zu Heringdorf, Dagmar;
Pfeilschifter, Josef;
Pfeilschifter, Waltraud;
Brunkhorst, Robert

Publication type:

Article

Nitric oxide down-regulates the expression of the catalytic NADPH oxidase subunit Nox1 in rat renal mesangial cells.

Published in:

FASEB Journal, 2006, v. 20, n. 1, p. 139, doi. 10.1096/fj.05-3791fje

By:

Plešková, Miriam;
Beck, Karl-Friedrich;
Behrens, Meik Helmut;
Huwiler, Andrea;
Fichtlscherer, Birgit;
Wingerter, Oliver;
Brandes, Raif P.;
Mülsch, Alexander;
Pfeilschifter, Josef

Publication type:

Article

Wound inflammation in diabetic ob/ob mice: functional coupling of prostaglandin biosynthesis to cyclooxygenase-1 activity in diabetes-impaired wound healing.

Published in:

2005

By:

Kämpfer, Heiko;
Schmidt, Ronald;
Geisslinger, Gerd;
Pfeilschifter, Josef;
Frank, Stefan;
Kämpfer, Heiko

Publication type:

journal article

Leptin and wound inflammation in diabetic ob/ob mice: differential regulation of neutrophil and macrophage influx and a potential role for the scab as a sink for inflammatory cells and mediators.

Published in:

2003

By:

Goren, Itamar;
Kämpfer, Heiko;
Pfeilschifter, Josef;
Frank, Stefan;
Podda, Maurizio;
Kämpfer, Heiko

Publication type:

journal article

Nitric Oxide Signalling with a Special Focus on Lipid-Derived Mediators.

Published in:

Biological Chemistry, 2003, v. 384, n. 10/11, p. 1379, doi. 10.1515/BC.2003.154

By:

Huwiler, Andrea;
Pfeilschifter, Josef

Publication type:

Article

Differential expression of CD8 defines phenotypically distinct cytotoxic T cells in cancer and multiple sclerosis.

Published in:

Clinical & Translational Medicine, 2022, v. 12, n. 12, p. 1, doi. 10.1002/ctm2.1068

By:

Burkard, Tobias;
Herrero San Juan, Martina;
Dreis, Caroline;
Kiprina, Anastasiia;
Namgaladze, Dmitry;
Siebenbrodt, Kai;
Luger, Sebastian;
Foerch, Christian;
Pfeilschifter, Josef M.;
Weigert, Andreas;
Radeke, Heinfried H.

Publication type:

Article

A Prominent Role of Interleukin-18 in Acetaminophen-Induced Liver Injury Advocates Its Blockage for Therapy of Hepatic Necroinflammation.

Published in:

Frontiers in Immunology, 2018, p. 1, doi. 10.3389/fimmu.2018.00161

By:

Bachmann, Malte;
Pfeilschifter, Josef;
Mühl, Heiko

Publication type:

Article

Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study.

Published in:

Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.01242

By:

Schmidt, Katrin G.;
Juan, Martina Herrero San;
Trautmann, Sandra;
Berninger, Lucija;
Schwiebs, Anja;
Ottenlinger, Florian M.;
Thomas, Dominique;
Zaucke, Frank;
Pfeilschifter, Josef M.;
Radeke, Heinfried H.

Publication type:

Article

Type I Interferon Supports Inducible Nitric Oxide Synthase in Murine Hepatoma Cells and Hepatocytes and during Experimental Acetaminophen-Induced Liver Damage.

Published in:

Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.00890

By:

Bachmann, Malte;
Waibler, Zoe;
Pleli, Thomas;
Pfeilschifter, Josef;
Mühl, Heiko

Publication type:

Article

Hypothermia Promotes Interleukin-22 Expression and Fine-Tunes its Biological Activity.

Published in:

Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fmmu.2017.00742

By:

Chichelnitskiy, Evgeny;
Himmelseher, Britta;
Bachmann, Malte;
Pfeilschifter, Josef;
Mühl, Heiko

Publication type:

Article

The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death.

Published in:

British Journal of Pharmacology, 2014, v. 171, n. 24, p. 5829, doi. 10.1111/bph.12886

By:

Pastukhov, Oleksandr;
Schwalm, Stephanie;
Zangemeister ‐ Wittke, Uwe;
Fabbro, Doriano;
Bornancin, Frederic;
Japtok, Lukasz;
Kleuser, Burkhard;
Pfeilschifter, Josef;
Huwiler, Andrea

Publication type:

Article

IL-22 in tissue-protective therapy.

Published in:

British Journal of Pharmacology, 2013, v. 169, n. 4, p. 761, doi. 10.1111/bph.12196

By:

Mühl, Heiko;
Scheiermann, Patrick;
Bachmann, Malte;
Härdle, Lorena;
Heinrichs, Anika;
Pfeilschifter, Josef

Publication type:

Article

Platelet-derived growth factor-BB induces cystathionine γ-lyase expression in rat mesangial cells via a redox-dependent mechanism.

Published in:

British Journal of Pharmacology, 2012, v. 166, n. 8, p. 2231, doi. 10.1111/j.1476-5381.2012.01949.x

By:

Hassan, Mohamed I.;
Boosen, Meike;
Schaefer, Liliana;
Kozlowska, Jowita;
Eisel, Florian;
von Knethen, Andreas;
Beck, Martina;
Hemeida, Ramadan A. M.;
El-Moselhy, Mohamed A. M.;
Hamada, Farid M. A.;
Beck, Karl-Friedrich;
Pfeilschifter, Josef

Publication type:

Article